Research project

High resolution guided imaging project in the treatment of Parkinson's disease

Project Description

Deep brain stimulation's effectiveness relies on the ability of the stimulating electrode to be properly placed within a specific target area of the brain. Optical guidance techniques that can increase the accuracy of the procedure, without causing any additional harm, are therefore of great interest.

We have designed optical fiber-based device that is small enough to be placed within commercially available DBS stimulating electrodes' hollow cores and that is capable of sensing biological information from the surrounding tissue, using low power white light. With this probe, we have shown the ability to distinguish white and grey matter during stereotactic DBS lead implantations on both ex-vivo non-human-primate intact heads, as well as on in-vivo non-human-primates. The in-vivo measurements allowed us to compare simultaneously acquired optical data and neuronal activity using microelectrode recordings.

We are in the process of further advancing the procedure using other optical modalities such as spontaneous and coherent Raman spectroscopy - capable of providing molecular composition of the tissue. The addition of these modalities should increase the resolution of our electrode localization and provide the surgeon with regional specificity of the DBS surgical targets. The end goal will be to deploy this technology during deep brain stimulation neurosurgery in humans, leading to an increase in the accuracy and therefore efficacy of the procedure.

Research Field

- Neurosurgery-
- Dbs
- Parkinson
- Optical fibers
- Coherent raman
- Reflectance
- Spectroscopy

Research Supervisor

Daniel Côté

Research Environment

CERVO Research Centre

To find out more about our laboratory visit our website at: http://www.dcclab.ca/en/

Web Site


Related Programs

Master's in Biophotonics - with dissertation

Program description

Financial aid available*

Financial aid related to research project

$17500 per year for 2 years.

Program-Specific Financial Aid

Graduate Studies Awards

Plan Steps Incentive
Evaluated activity
$650
Achievement scholarship
$1,000
Total $1,650

Université Laval: Student Financial Aid

Sources de financement Montant
Leadership and Sustainable Development Scholarships 2 x $5,000
Mobility Grant for Out-of-Province Internships (in French)
$1,000
Graduate Scholarships from Granting Agencies
$14,100 to $21,000
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Master's Scholarships for International StudentsThese scholarships are available in a number of programs to students from Africa and Europe, excluding France. This scholarship of $7,000 per year is awarded based on university academic achievement * Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Master's in Medical Physics - with dissertation

Program description

Financial aid available*

Financial aid related to research project

$17500 per year for 2 years.

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Master's in Physics - with dissertation

Program description

Financial aid available*

Financial aid related to research project

$17500 per year for 2 years.

Program-Specific Financial Aid

Graduate Studies Awards

Plan Steps Incentive
Evaluated activity
$650
Achievement scholarship
$1,000
Total $1,650

Université Laval: Student Financial Aid

Sources de financement Montant
Leadership and Sustainable Development Scholarships 2 x $5,000
Mobility Grant for Out-of-Province Internships (in French)
$1,000
Graduate Scholarships from Granting Agencies
$14,100 to $21,000
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Master's Scholarships for International StudentsThese scholarships are available in a number of programs to students from Africa and Europe, excluding France. This scholarship of $7,000 per year is awarded based on university academic achievement * Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Desired Profile

- Biology
- Physics
- Physics Engineering

Requirements and Conditions

Expected start date: as soon as possible

Required Documentation

- Cover letter
- Curriculum vitæ
- Student transcript

Application Deadline

October 31, 2019

Find Out More

Daniel Côté
Chercheur
Centre de recherche CERVO
daniel.cote@crulrg.ulaval.ca