Research project

Development of retinal spectrometry for the identification of new early biomarkers of Parkinson's disease

Project Description

The regulation of retinal blood flow and oxygenation are recognized as root causes of the majority of ocular diseases, such as glaucoma. There is thus a huge interest in measuring these parameters in vivo, ideally using non-invasive methods. Retnia's technology, based on optical spectroscopy, enables such non-invasive measurements in laboratory and clinical settings. Recently, there has been growing evidence that many neurodegenerative diseases also have an effect on the retina, which is part of the central nervous system. Of the many neurodegenerative diseases that could possibly be sensed in the eye, Parkinson's disease (PD) stands out, due to the retina's similarities to the substantia nigra, a midbrain region that is known to degenerate in PD. PD affects more than 100 000 Canadians and is considered as the second most common neurodegenerative disease.

Some disease-modifying treatments exist but drugs that have been tested have provided disappointing results. This can be largely explained by the fact that the cardinal symptoms of PD typically manifest only when more than half of dopaminergic neurons in the substantia nigra are lost. Therefore, early biomarkers of PD are urgently needed to succeed in disease-modifying therapies. In the proposed research project, we will use
Retnia's multimodal imaging device to perform spectroscopy on the retina of healthy and parkinsonian monkeys in order to identify and locate optical biomarkers in the form of hemoglobin and melanin retinal content and abnormalities, for early detection of PD.

Research Field

- Physics
- Physical Engineering
- Neurophotonics
- Biophotonics

Research Supervisor

Daniel Côté

Research Environment

CERVO research Centre

Web Site


Related Programs

Doctorate in Biophotonics

Program description

Financial aid available*

Financial aid related to research project

Information unavailable

Program-Specific Financial Aid

Graduate Studies Awards

Plan Steps Incentive
Progression studentship
7 x $500
Doctoral exam or seminar presentation
$750
Doctoral exam, seminar or conference
$1,000
Publication
$750
Communication
$1,000
Initial thesis submission
$1,000*
Total $8,500

*A $ 500 bonus will be added to the studentship for graduation if the initial deposit is made before the session that precedes the maximum qualifying session.

Université Laval: Student Financial Aid

Funding source Amount
Université Laval Doctoral Admission Scholarship  $2,000
Leadership and Sustainable Development Scholarships 
3 x $10,000
Mobility Grant for Out-of-Province Internships (in French)
$1,000
Graduate Scholarships from Granting Agencies   
$21,000 to $50,000$
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Supplemental Tuition Fee Exemption Scholarship Program: Entitles international students to pay Canadian student tuition fees, for overall savings of around $30,000.

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Doctorate in Physics

Program description

Financial aid available*

Financial aid related to research project

Information unavailable

Program-Specific Financial Aid

Graduate Studies Awards

Plan Steps Incentive
Progression studentship
7 x $500
Doctoral exam or seminar presentation
$750
Doctoral exam, seminar or conference
$1,000
Publication
$750
Communication
$1,000
Initial thesis submission
$1,000*
Total $8,500

*A $ 500 bonus will be added to the studentship for graduation if the initial deposit is made before the session that precedes the maximum qualifying session.

Université Laval: Student Financial Aid

Funding source Amount
Université Laval Doctoral Admission Scholarship  $2,000
Leadership and Sustainable Development Scholarships 
3 x $10,000
Mobility Grant for Out-of-Province Internships (in French)
$1,000
Graduate Scholarships from Granting Agencies   
$21,000 to $50,000$
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Supplemental Tuition Fee Exemption Scholarship Program: Entitles international students to pay Canadian student tuition fees, for overall savings of around $30,000.

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Master's in Biophotonics - with dissertation

Program description

Financial aid available*

Financial aid related to research project

Information unavailable

Program-Specific Financial Aid

Graduate Studies Awards

Plan Steps Incentive
Evaluated activity
$650
Achievement scholarship
$1,000
Total $1,650

Université Laval: Student Financial Aid

Sources de financement Montant
Leadership and Sustainable Development Scholarships 2 x $5,000
Mobility Grant for Out-of-Province Internships (in French)
$1,000
Graduate Scholarships from Granting Agencies
$14,100 to $21,000
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Master's Scholarships for International StudentsThese scholarships are available in a number of programs to students from Africa and Europe, excluding France. This scholarship of $7,000 per year is awarded based on university academic achievement * Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Master's in Physics - with dissertation

Program description

Financial aid available*

Financial aid related to research project

Information unavailable

Program-Specific Financial Aid

Graduate Studies Awards

Plan Steps Incentive
Evaluated activity
$650
Achievement scholarship
$1,000
Total $1,650

Université Laval: Student Financial Aid

Sources de financement Montant
Leadership and Sustainable Development Scholarships 2 x $5,000
Mobility Grant for Out-of-Province Internships (in French)
$1,000
Graduate Scholarships from Granting Agencies
$14,100 to $21,000
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Master's Scholarships for International StudentsThese scholarships are available in a number of programs to students from Africa and Europe, excluding France. This scholarship of $7,000 per year is awarded based on university academic achievement * Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Desired Profile

- Physics
- Physics Engineering

Requirements and Conditions

We are looking for enthusiastic, rigorous, hard-working, proactive, sociable students interested by the neuroimaging and qualified students with the following qualifications: B.Sc. or M.Sc. in a relevant discipline.

Required Documentation

- Cover letter
- Curriculum vitæ

Find Out More

Daniel Côté
Chercheur
Centre de recherche CERVO
daniel.cote@crulrg.ulaval.ca