Jean-François Paquin

• Centre de recherche sur les protéines PROTEO-ULaval

Financements des 2 dernières années

• Chloé Depoumps, Maîtrise en chimie - avec mémoire
• Kiran Pedduri, Doctorat en chimie
• Laurianne Verret, Doctorat en chimie
• Marie-Rose Ouellet-Du Berger, Doctorat en chimie
• Marie-Rose Ouellet-Du Berger, Maîtrise en chimie - avec mémoire
• Maxim Boucher, Maîtrise en chimie - avec mémoire
• Maxim Boucher, Doctorat en chimie
• Modibo Diawara, Doctorat en chimie
• Nicolas DeGrâce, Maîtrise en chimie - avec mémoire
• Pascal Paquin, Doctorat en chimie
• Pascal Paquin, Maîtrise en chimie - avec mémoire
• Raphaël Pronovost, Maîtrise en chimie - avec mémoire
• Raphaël Pronovost, Doctorat en chimie

Encadrements des 5 dernières années

• Kelly Burchell-Reyes, Doctorat en chimie
• Laurianne Verret, Maîtrise en chimie - avec mémoire
• Olivier Thibeault, Maîtrise en chimie - avec mémoire
• Raphaël Gauthier, Doctorat en chimie
• Raphaël Gauthier, Maîtrise en chimie - avec mémoire
• Rémy Ferlet, Doctorat en chimie
• Vincent Mastalerz, Doctorat en chimie
• Xavier Bertrand, Doctorat en chimie
• Xavier Bertrand, Maîtrise en chimie - avec mémoire

Travaux de recherche des 5 dernières années

Regioselective gold-catalyzed addition of phenols, alcohols and carboxylic acids to 2,2,2-trifluoroethyl-substituted alkynes Journal of Fluorine Chemistry, 2026. Raphaël Pronovost, Raphaël Gauthier, Nikolaos V. Tzouras, Steven P. Nolan, Jean-François Paquin. DOI 10.1016/j.jfluchem.2026.110589

Organophotoredox-Catalyzed Alkylation of Vinylsulfur Pentafluoride: Expanding Access to SF5-Containing Aliphatic Molecules Organic Letters, 2026. Laurianne Verret, Pascal Paquin, Martin Le Roy, Maxim Boucher, Éric Biron, Guillaume Bélanger-Chabot, Jean-François Morin, Jean-François Paquin. DOI 10.1021/acs.orglett.6c00153

Simplified Protocol Conditions for the Gold-Catalyzed Hydrofluorination of Terminal Aliphatic Alkynes The Journal of Organic Chemistry, 2026. Raphaël Pronovost, Claudia Gagnon, Nikolaos V. Tzouras, Steven P. Nolan, Jean-François Paquin. DOI 10.1021/acs.joc.5c02743

Exploiting diphenylmethanone O-(2-(pentafluoro-λ6-sulfanyl)acetyl) oxime as a novel CH2SF5 radical transfer agent for the synthesis of γ-SF5 imines Chemical Communications, 2026. Marie-Rose Ouellet-Du Berger, Tania, Julien Cayouette, Jean-Philippe Bouillon, Jean-François Paquin. DOI 10.1039/D6CC04467K

2.5 Hydrofluorination of Alkenes and Alkynes 2026. X. Bertrand, J.-F. Paquin. DOI 10.1055/sos-SD-244-00043

2 Introduction 2026. J.-F. Paquin. DOI 10.1055/sos-SD-244-00360

Thieme Cheminar: Modern Strategies in Organofluorine Chemistry 2025. Besset Tatiana, Jean-François Paquin, Kevin Lam. DOI 10.52843/cassyni.jnxk2s

Unveiling Routes to Fluorinated Molecules 2025. Besset Tatiana, Jean-François Paquin. DOI 10.52843/cassyni.jnxk2s.1

Noyori–Ikariya Asymmetric Transfer Hydrogenation of Prochiral α-CF3 and α-SF5 Ketones ACS Organic & Inorganic Au, 2025. Kelly Burchell-Reyes, Chloé Depoumps, Jean-François Paquin. DOI 10.1021/acsorginorgau.5c00038

Gold‐Catalyzed Synthesis of Substituted 4‐Pentafluorosulfanyl‐1,3‐Oxazoles European Journal of Organic Chemistry, 2025. Pascal Paquin, Nicolas DeGrâce, Guillaume Bélanger‐Chabot, Jean‐François Paquin. DOI 10.1002/ejoc.202500348

Exploration towards the bromopentafluorosulfanylation reaction of terminal alkynes Journal of Fluorine Chemistry, 2025. Marie-Rose Ouellet-Du Berger, Jean-Philippe Bouillon, Jean-François Paquin. DOI 10.1016/j.jfluchem.2024.110386

Exploration of 2-(pentafluoro-λ6-sulfanyl)ethane-1-sulfonyl chloride as a novel pentafluorosulfanylation reagent Journal of Fluorine Chemistry, 2025. Laurianne Verret, Kelly Burchell-Reyes, Jean-François Morin, Jean-François Paquin. DOI 10.1016/j.jfluchem.2024.110387

Fluorohydrins and where to find them: recent asymmetric syntheses of β-fluoro alcohols and their derivatives Organic & Biomolecular Chemistry, 2025. Kelly Burchell-Reyes, Jean-François Paquin. DOI 10.1039/D5OB00330J

Synthesis of 2‐(Pentafluoro‐λ6‐sulfanyl)acetamides and Impact of the Fluorinated Group on the Lipophilicity European Journal of Organic Chemistry, 2024. Vincent Mastalerz, Laurianne Verret, Jean‐François Paquin. DOI 10.1002/ejoc.202400956

Improved conditions for the synthesis of tertiary fluorides using a KF/H2SO4 combination Journal of Fluorine Chemistry, 2024. Xavier Bertrand, Doria Aissaoui, Océane Meryem Col, Mathieu Pucheault, Laurent Chabaud, Jean-François Paquin. DOI 10.1016/j.jfluchem.2024.110338

19F solid-state NMR approaches to probe antimicrobial peptide interactions with membranes in whole cells Biochimica et Biophysica Acta (BBA) - Biomembranes, 2024. Kiran Kumar, Alexandre A. Arnold, Raphaël Gauthier, Marius Mamone, Jean-François Paquin, Dror E. Warschawski, Isabelle Marcotte. DOI 10.1016/j.bbamem.2023.184269

Synthesis of Substituted Pentafluorosulfanylpyrazoles Under Flow Conditions The Journal of Organic Chemistry, 2024. Pascal Paquin, Nicolas DeGrâce, Guillaume Bélanger-Chabot, Jean-François Paquin. DOI 10.1021/acs.joc.3c02295

20.1.5 Acid Fluorides (Update 2023) 2024. M.-R. Ouellet-Du Berger, J.-F. Paquin. DOI 10.1055/sos-SD-120-00077

Gold-catalyzed hydrofluorination of terminal alkynes using potassium bifluoride (KHF2) Chemical Communications, 2024. Raphaël Pronovost, Mathis Rion, Nikolaos V. Tzouras, Steven P. Nolan, Jean-François Paquin. DOI 10.1039/D4CC05049E

Metal‐Free Defluoroborylation of 3,3‐Difluoropropenes European Journal of Organic Chemistry, 2023. Rémy Ferlet, Mathieu Pucheault, Laurent Chabaud, Jean‐François Paquin. DOI 10.1002/ejoc.202300731

Synthesis of Tertiary Fluorides through an Acid-Mediated Deoxyfluorination of Tertiary Alcohols The Journal of Organic Chemistry, 2023. Xavier Bertrand, Mathieu Pucheault, Laurent Chabaud, Jean-François Paquin. DOI 10.1021/acs.joc.3c01558

Hydrofluorination of Alkynes: From (E) to (Z) Chemistry – A European Journal, 2023. Raphaël Gauthier, Jean‐François Paquin. DOI 10.1002/chem.202301896

Light-activation of SF5Cl for the atom transfer radical addition onto alkenes and alkynes Journal of Fluorine Chemistry, 2023. Marie-Rose Ouellet-Du Berger, Maxim Boucher, Jean-François Paquin. DOI 10.1016/j.jfluchem.2023.110131

Exploration toward the synthesis of aliphatic SF5-containing compounds using the Kolbe reaction Journal of Fluorine Chemistry, 2023. Vincent Mastalerz, Kevin Lam, Jean-François Paquin. DOI 10.1016/j.jfluchem.2023.110113

Rhodium-Catalyzed Intramolecular Cyclopropanation of Trifluoromethyl- and Pentafluorosulfanyl-Substituted Allylic Cyanodiazoacetates Organic Letters, 2023. Lauriane C. Peyrical, Marie-Rose Ouellet-Du Berger, Maxim Boucher, Mélodie Birepinte, Jean-François Paquin, André B. Charette. DOI 10.1021/acs.orglett.3c00642

Exploiting the inductive effect of the trifluoromethyl group: regioselective gold-catalyzed hydration of 2,2,2-trifluoroethyl-substituted alkynes Chemical Communications, 2023. Raphaël Gauthier, Nikolaos V. Tzouras, Steven P. Nolan, Jean-François Paquin. DOI 10.1039/D3CC02034G

Room temperature deoxofluorination of aromatic aldehydes with XtalFluor-E under highly concentrated conditions Organic & Biomolecular Chemistry, 2023. Olivier Thibeault, Marie-Rose Ouellet-Du Berger, Marie Gonay, Jean-François Paquin. DOI 10.1039/D3OB00859B

Hydrohalogenation of Unactivated Alkenes Using a Methanesulfonic Acid/Halide Salt Combination Synthesis, 2022. Jean-François Paquin, Xavier Bertrand, Pascal Paquin, Laurent Chabaud. DOI 10.1055/s-0040-1719856

Gold N‐Heterocyclic Carbene Catalysts for the Hydrofluorination of Alkynes Using Hydrofluoric Acid: Reaction Scope, Mechanistic Studies and the Tracking of Elusive Intermediates Chemistry – A European Journal, 2022. Raphaël Gauthier, Nikolaos V. Tzouras, Ziyun Zhang, Sandrine Bédard, Marina Saab, Laura Falivene, Kristof Van Hecke, Luigi Cavallo, Steven P. Nolan, Jean‐François Paquin. DOI 10.1002/chem.202103886

Photoinitiated anti‐Hydropentafluorosulfanylation of Terminal Alkynes Angewandte Chemie, 2022. Mélodie Birepinte, Pier Alexandre Champagne, Jean‐François Paquin. DOI 10.1002/ange.202112575

Synthesis of N-(2-SF5-ethyl)amines and impact of the SF5 substituent on their basicity and lipophilicity Tetrahedron, 2021. Audrey Gilbert, Pauline Langowski, Jean-François Paquin. DOI 10.1016/j.tet.2021.132424

Correction: Amine–borane complex-initiated SF5Cl radical addition on alkenes and alkynes Beilstein Journal of Organic Chemistry, 2021. Audrey Gilbert, Pauline Langowski, Marine Delgado, Laurent Chabaud, Mathieu Pucheault, Jean-François Paquin. DOI 10.3762/bjoc.17.120

Hydrofluorination of Alkenes: A Review Chemistry – An Asian Journal, 2021. Xavier Bertrand, Laurent Chabaud, Jean‐François Paquin. DOI 10.1002/asia.202001403

Electron donor-acceptor (EDA)-complex enabled SF5Cl addition on alkenes and alkynes Journal of Fluorine Chemistry, 2021. Audrey Gilbert, Mélodie Birepinte, Jean-François Paquin. DOI 10.1016/j.jfluchem.2021.109734

Recent Advances in the Synthesis of Acyl Fluorides Synthesis, 2021. Marie Gonay, Chloé Batisse, Jean-François Paquin. DOI 10.1055/s-0040-1705951