Mathieu Laplante

• Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (Affilié à l’Université Laval)
• Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (Reconnu FRQ - secteur santé)
• Centre de recherche sur le cancer
• Centre de recherche sur les protéines PROTEO-ULaval

Financements des 2 dernières années

• Alona Kolnohuz, Doctorat en médecine moléculaire
• Beisy Laborit Labrada, Doctorat en médecine moléculaire
• Fatima Hjeij, Doctorat en médecine moléculaire
• Laura Tribouillard, Doctorat en médecine moléculaire
• Moloud Akbarzadeh, Doctorat en médecine moléculaire
• Rohail Bhatti, Doctorat en médecine moléculaire
• Romain Devillers, Doctorat en médecine moléculaire

Encadrements des 5 dernières années

• Audrey Poirier, Doctorat en médecine moléculaire
• Charles Colas, Doctorat en médecine moléculaire
• Manal Al Dow, Doctorat en médecine moléculaire
• Nolwenn Samson, Doctorat en médecine moléculaire

Travaux de recherche des 5 dernières années

PITX2 is enriched in highly adipogenic brown preadipocytes. microPublication biology, 2025. Al Dow M, Colas C, Secco B, Kolnohuz A, Samson N, Poirier A, Villot R, Belley L, Chadel B, Tribouillard L, Dufour A, Mouchiroud M, Gélinas Y, Morissette MC, Laplante M. DOI 10.17912/micropub.biology.001570

Generation and characterization of a Cre-inducible ZNF768 overexpression mouse model SCIENTIFIC REPORTS, 2025. DOI 10.1038/S41598-025-03110-8

ZNF768 loss amplifies p53 action and reduces lung tumorigenesis in mice ONCOGENE, 2025. DOI 10.1038/S41388-025-03352-W

Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis OBESITY, 2025. DOI 10.1002/OBY.24224

ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression JOURNAL OF CELL BIOLOGY, 2025. DOI 10.1083/JCB.202311194

Computational analysis of whole slide images predicts PD-L1 expression and progression-free survival in immunotherapy-treated non-small cell lung cancer patients JOURNAL OF TRANSLATIONAL MEDICINE, 2025. DOI 10.1186/S12967-025-06487-2

A clinically relevant variant of SHP-1 preserves glucose homeostasis and hepatic insulin sensitivity during aging despite B cell infiltration and matrix deposition DIABETOLOGIA, 2024.

Recent insights into the causes and consequences of chromosome mis-segregation ONCOGENE, 2024. DOI 10.1038/S41388-024-03163-5

HSDL2 links nutritional cues to bile acid and cholesterol homeostasis SCIENCE ADVANCES, 2024. DOI 10.1126/SCIADV.ADK9681

Regulation of PPARγ2 Stability and Activity by SHP-1 MOLECULAR AND CELLULAR BIOLOGY, 2024. DOI 10.1080/10985549.2024.2354959

Exploring the Role of EMPRD on Metabolic Regulation OBESITY, 2023.

Identification of a New E3 Ubiquitin Ligase Regulating Hepatic Metabolism in Response to Fasting OBESITY, 2023.

SHP-1 phosphatase acts as a coactivator of<i> PCK1</i> transcription to control gluconeogenesis JOURNAL OF BIOLOGICAL CHEMISTRY, 2023. DOI 10.1016/J.JBC.2023.105164

Gnotobiotic mice housing conditions critically influence the phenotype associated with transfer of faecal microbiota in a context of obesity GUT, 2023. DOI 10.1136/GUTJNL-2021-326475

DEPTOR loss impairs brown adipocyte development <i>in vitro</i> but has limited impacts in mice MOLECULAR METABOLISM, 2023. DOI 10.1016/J.MOLMET.2022.101660

IL-6 Trans-Signaling Is Increased in Diabetes, Impacted by Glucolipotoxicity, and Associated With Liver Stiffness and Fibrosis in Fatty Liver Disease DIABETES, 2023. DOI 10.2337/DB23-0171

SDR CHARACTERIZATION IN HEPATIC METABOLISM HEPATOLOGY, 2023.

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1 SCIENCE, 2022. DOI 10.1126/SCIENCE.ABG6621

mTORC1 takes control of lysosomal lipid breakdown NATURE METABOLISM, 2022. DOI 10.1038/S42255-022-00702-W

The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage NATURE COMMUNICATIONS, 2022. DOI 10.1038/S41467-021-27934-W

Adipocyte-specific <i>Nos2</i> deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice MOLECULAR METABOLISM, 2022. DOI 10.1016/J.MOLMET.2022.101437

DEPTOR: A Novel Endothelial-Specific Regulator of Cell-Intrinsic Anti-Inflammation Following Transplantation. AMERICAN JOURNAL OF TRANSPLANTATION, 2022.

Glycerol contained in vaping liquids affects the liver and aspects of energy homeostasis in a sex-dependent manner PHYSIOLOGICAL REPORTS, 2022. DOI 10.14814/PHY2.15146

Plasma sgp130 is an independent predictor of non-alcoholic fatty liver disease severity JOURNAL OF HEPATOLOGY, 2022.

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling NATURE COMMUNICATIONS, 2021. DOI 10.1038/S41467-021-23857-8

ZNF768 Expression Associates with High Proliferative Clinicopathological Features in Lung Adenocarcinoma CANCERS, 2021. DOI 10.3390/CANCERS13164136

Association between Visceral Adipocyte Size, Liver Steatosis and the Cardiometabolic Risk Profile OBESITY, 2021.

Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2021. DOI 10.1152/AJPENDO.00587.2020

Control of adipogenic commitment by a STAT3-VSTM2A axis AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2021. DOI 10.1152/AJPENDO.00314.2020

ZNF768: controlling cellular senescence and proliferation with ten fingers MOLECULAR & CELLULAR ONCOLOGY, 2021. DOI 10.1080/23723556.2021.1985930

ZNF768 links oncogenic RAS to cellular senescence NATURE COMMUNICATIONS, 2021. DOI 10.1038/S41467-021-24932-W

Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2021. DOI 10.1152/AJPENDO.00272.2020