Mohamed Chahine

• Centre de recherche CERVO (Affilié à l’Université Laval)
• Centre thématique de recherche en neurosciences
• Groupe de recherche en écologie buccale

Financements des 2 dernières années

• Cyrielle Jajkiewicz, Stage postdoctoral en médecine
• Fabien Sourisseau, Doctorat en sciences cliniques et biomédicales
• Marion Pierre, Stage postdoctoral en médecine
• Quentin Plumereau, Doctorat en sciences cliniques et biomédicales
• Vamsi Krishna Murthy Ginjupalli, Doctorat en sciences cliniques et biomédicales

Encadrements des 5 dernières années

• Charles-Albert Chapotte-Baldacci, Stage postdoctoral en biologie cellulaire et moléculaire
• Marion Pierre, Doctorat en sciences cliniques et biomédicales
• Mohammed Djemai, Doctorat en sciences cliniques et biomédicales
• Thiéry De Serres-Bérard, Doctorat en neurosciences

Travaux de recherche des 5 dernières années

Antisense-Mediated Gene Therapy Targeting DMPK Restores Cardiac Ion Channel Function and Electrical Stability in Myotonic Dystrophy Type 1 Heart Rhythm, 2026. Marion Pierre, Fabien Sourisseau, Dominic Jauvin, Valérie Pouliot, Michele Carrer, Paymaan Jafar-Nejad, Mohamed Boutjdir, Mohamed Chahine. DOI 10.1016/j.hrthm.2026.06.003

Cardiac organoids bridge translational gaps in 3R-compliant safety testing Stem Cell Research, 2026. Cyrielle Jajkiewicz, Mohamed Chahine. DOI 10.1016/j.scr.2026.104039

Generation of a lymphoblastoid-derived induced pluripotent stem cell line (CBRCULi021-A) from a healthy donor for disease modeling Stem Cell Research, 2026. Cyrielle Jajkiewicz, Mohamed Chahine. DOI 10.1016/j.scr.2026.104020

Therapeutic Strategies Targeting the Molecular Pathogenesis of Myotonic Dystrophy Type 1: Current Status and Future Directions Molecular Diagnosis & Therapy, 2026. Mohamed Chahine, Vamsi Krishna Murthy Ginjupalli, Dominic Jauvin, Mohamed Boutjdir. DOI 10.1007/s40291-026-00848-3

Revisiting viral reprogramming: Measles virus as a robust platform for high-quality iPSC generation Molecular Therapy Advances, 2026. Mohamed Taha Moutaoufik, Mohamed Chahine. DOI 10.1016/j.omta.2026.201759

Modeling myotonic dystrophy type 1 with hiPSCs-derived cardiac organoids reveals key disease mechanisms Heart Rhythm, 2026. Cyrielle Jajkiewicz, Valérie Pouliot, Mohamed Chahine. DOI 10.1016/j.hrthm.2026.02.013

C-Terminus of Cav1.3 L-Type Ca2+ Channel Upregulates Its Own Gene Expression Cells, 2026. Yvonne Sleiman, Ujala Srivastava, Jean-Baptiste Reisqs, Raj Wadgaonkar, Yongxia Sarah Qu, Valérie Pouliot, Mohamed Chahine, Mohamed Boutjdir. DOI 10.3390/cells15090828

Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence Journal of General Physiology, 2026. Thierry Cens, Matthieu Rousset, Claudine Menard, Mohamed Chahine, Claude Collet, Jean-Christophe Sandoz, Alain Chavanieu, Sebastien Estaran, Jean-Baptiste Thibaud, Patrick Bois, Pierre Charnet. DOI 10.1085/jgp.202413712

AAV-mediated DMPK silencing: A defining moment in myotonic dystrophy type 1 therapeutics Molecular Therapy, 2025. Mohamed Chahine. DOI 10.1016/j.ymthe.2025.10.063

Cardiac Involvement in Myotonic Dystrophy Type 1: Mechanisms, Clinical Perspectives, and Emerging Therapeutic Strategies International Journal of Molecular Sciences, 2025. Vamsi Krishna Murthy Ginjupalli, Jean-Baptiste Reisqs, Michael Cupelli, Mohamed Chahine, Mohamed Boutjdir. DOI 10.3390/ijms262210992

C-terminus of Cav1.3 L-Type Ca2+ Channel Upregulates its Own Gene Expression 2025. Yvonne Sleiman, Ujala Srivastava, Jean-Baptiste Reisqs, Raj Wadgaonkar, Yongxia Sarah Qu, Valerie Pouliot, Mohamed Chahine, Mohamed Boutjdir. DOI 10.22541/au.175859123.35837668/v1

Functional validation of the Nav1.5/R1432G Brugada syndrome variant using a Nav1.5 knockout iPSC-derived cardiomyocyte model Biochemical and Biophysical Research Communications, 2025. Quentin Plumereau, Valérie Pouliot, Mohamed Chahine. DOI 10.1016/j.bbrc.2025.152586

Exploring SCN5A variants associated with atrial fibrillation in atrial cardiomyocytes derived from human induced pluripotent stem cells: A characterization study Heart Rhythm, 2025. Marion Pierre, Mohammed Djemai, Valérie Pouliot, Hugo Poulin, Michael H. Gollob, Mohamed Chahine. DOI 10.1016/j.hrthm.2024.09.013

Generation of a control induced pluripotent stem cell line (CBRCULi014-A) derived from the lymphoblastoid cells of a pediatric individual Stem Cell Research, 2024. Thiéry De Serres-Bérard, Valérie Pouliot, Jack Puymirat, Mohamed Chahine. DOI 10.1016/j.scr.2024.103587

Impacts of DCM-linked gating pore currents on the electrophysiological characteristics of hiPSC-CM monolayers Biochemical and Biophysical Research Communications, 2024. Mohammed Djemai, Maroua Jalouli, Mohamed Chahine. DOI 10.1016/j.bbrc.2024.150175

Generation of a lymphoblastoid-derived induced pluripotent stem cell line (CBRCULi015-A) from a patient with congenital myotonic dystrophy Stem Cell Research, 2024. Thiéry De Serres-Bérard, Dominic Jauvin, Valérie Pouliot, Jack Puymirat, Mohamed Chahine. DOI 10.1016/j.scr.2024.103430

Arrhythmias and ion channelopathies causing sudden cardiac death in Hispanic/Latino and Indigenous populations 2024. Mohamed Boutjdir, Sahil Zaveri, Mohamed Chahine. DOI 10.22541/au.171300659.94084184/v1

Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A) Stem Cell Research, 2024. Mohammed Djemai, Dominic Jauvin, Hugo Poulin, Charles-Albert Chapotte-Baldacci, Mohamed Chahine. DOI 10.1016/j.scr.2024.103308

Generation of induced pluripotent stem cell lines from pediatric patients with congenital myotonic dystrophy (CBRCULi012-A and CBRCULi013-A) and age-matched controls (CBRCULi010-A and CBRCULi011-A) Stem Cell Research, 2023. Thiéry De Serres-Bérard, Dominic Jauvin, Jack Puymirat, Mohamed Chahine. DOI 10.1016/j.scr.2023.103234

Lymphoblastoid cell lines derived from iPSCs of a myotonic dystrophy type 1 patient carrying 700 CTG repeats (CBRCULi007-A) and a control (CBRCULi006-A) Stem Cell Research, 2023. Mohamed Chahine, Dominic Jauvin, Marion Pierre, Jack Puymirat, Mohamed Boutjdir. DOI 10.1016/j.scr.2023.103148

Optical Mapping of Cardiomyocytes in Monolayer Derived from Induced Pluripotent Stem Cells Cells, 2023. Mohammed Djemai, Michael Cupelli, Mohamed Boutjdir, Mohamed Chahine. DOI 10.3390/cells12172168

Generation of four myotonic dystrophy type 1 patient iPSC lines (CBRCULi002-A, CBRCULi003-A, CBRCULi004-A, CBRCULi005-A) and a control (CBRCULi001-A) derived from lymphoblastoids cell lines Stem Cell Research, 2023. Dominic Jauvin, Marion Pierre, Mohamed Boutjdir, Jack Puymirat, Mohamed Chahine. DOI 10.1016/j.scr.2023.103037

Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1 Gene Therapy, 2022. Siham Ait Benichou, Dominic Jauvin, Thiéry De Serres-Bérard, Marion Pierre, Karen K. Ling, C. Frank Bennett, Frank Rigo, Genevieve Gourdon, Mohamed Chahine, Jack Puymirat. DOI 10.1038/s41434-022-00316-7

Recent Progress and Challenges in the Development of Antisense Therapies for Myotonic Dystrophy Type 1 International Journal of Molecular Sciences, 2022. Thiéry De Serres-Bérard, Siham Ait Benichou, Dominic Jauvin, Mohamed Boutjdir, Jack Puymirat, Mohamed Chahine. DOI 10.3390/ijms232113359

Enhanced Delivery of Ligand-Conjugated Antisense Oligonucleotides (C16-HA-ASO) Targeting Dystrophia Myotonica Protein Kinase Transcripts for the Treatment of Myotonic Dystrophy Type 1 Human Gene Therapy, 2022. Siham Ait Benichou, Dominic Jauvin, Thiéry De Serres-Bérard, Frank Bennett, Frank Rigo, Genevieve Gourdon, Mohamed Boutjdir, Mohamed Chahine, Jack Puymirat. DOI 10.1089/hum.2022.069

SCN2A-related epilepsy of infancy with migrating focal seizures: report of a variant with apparent gain- and loss-of-function effects Journal of Neurophysiology, 2022. Xiao-Ru Yang, Vamsi Krishna Murthy Ginjupalli, Olivier Theriault, Hugo Poulin, Juan Pablo Appendino, Ping Yee Billie Au, Mohamed Chahine. DOI 10.1152/jn.00309.2021

Racial Disparities in Ion Channelopathies and Inherited Cardiovascular Diseases Associated With Sudden Cardiac Death Journal of the American Heart Association, 2022. Mohamed Chahine, John M. Fontaine, Mohamed Boutjdir. DOI 10.1161/JAHA.121.023446

NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis eneuro, 2022. Jeremy B. Hui, Jose Cesar Hernandez Silva, Mari Carmen Pelaez, Myriam Sévigny, Janani Priya Venkatasubramani, Quentin Plumereau, Mohamed Chahine, Christophe D. Proulx, Chantelle F. Sephton, Paul A. Dutchak. DOI 10.1523/ENEURO.0317-21.2022

R1617Q epilepsy mutation slows NaV1.6 sodium channel inactivation and increases the persistent current and neuronal firing The Journal of Physiology, 2021. Hugo Poulin, Mohamed Chahine. DOI 10.1113/JP280838