Sylvain Moineau

• Centre de recherche CERVO (Affilié à l’Université Laval)
• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche sur les protéines PROTEO-ULaval
• Centre Nutrition, santé et société
• Groupe de recherche en écologie buccale

Financements des 2 dernières années

• Audrey Addablah, Stage postdoctoral en microbiologie
• Carlee Morency, Maîtrise en microbiologie - avec mémoire
• Carlee Morency, Doctorat en microbiologie
• Christina Rossignol-Garon, Maîtrise en microbiologie - avec mémoire
• Elodie Fortin-Hurtubise, Maîtrise en microbiologie - avec mémoire
• Fanny Botella, Maîtrise en sciences animales - avec mémoire
• Gabriel Byatt, Doctorat en microbiologie
• Justine Lefrançois, Maîtrise en microbiologie - avec mémoire
• Lia Normand, Maîtrise en biochimie - avec mémoire
• Mathis Laganière, Maîtrise en microbiologie - avec mémoire
• Mégane Bertrand, Maîtrise en microbiologie - avec mémoire
• Samuel Roussel, Maîtrise en philosophie - avec mémoire
• Zacharie Morneau, Doctorat en biochimie
• Zacharie Morneau, Maîtrise en biochimie - avec mémoire

Encadrements des 5 dernières années

• Adeline Pastuszka, Stage postdoctoral en microbiologie
• Alessandra Gonçalves de Melo, Stage postdoctoral en microbiologie
• Alice Perrault-Jolicoeur, Maîtrise en microbiologie - avec mémoire
• Alice Perrault-Jolicoeur, Doctorat en microbiologie
• Audrey Leprince, Stage postdoctoral en microbiologie
• Cécile Marie Philippe, Stage postdoctoral en microbiologie
• Damitha Koswaththa Muhandiramlage, Stage postdoctoral en microbiologie
• Frank Kilian Oechslin, Stage postdoctoral en microbiologie
• Gabriel Bernier, Maîtrise en microbiologie - avec mémoire
• Gabriel Byatt, Maîtrise en microbiologie - avec mémoire
• Jean-Philippe Songpadith, Maîtrise en médecine moléculaire - avec mémoire
• Laurence Hotte-de Launière, Maîtrise en microbiologie - avec mémoire
• Laurie Doré, Maîtrise en microbiologie - avec mémoire
• Martina Scarrone Murissich, Doctorat en microbiologie
• Moïra Dion, Doctorat en microbiologie
• Nava Hosseini, Doctorat en microbiologie
• Nicolas Lemire, Maîtrise en microbiologie - avec mémoire
• Thomas Pitot, Doctorat en microbiologie
• Vincent Somerville, Stage postdoctoral en microbiologie
• Xiaojun Zhu, Doctorat en biochimie

Travaux de recherche des 5 dernières années

Phage host range: determinants, dynamics and applications Nature Reviews Microbiology, 2026. Audrey Leprince, Vincent Somerville, Audrey A. Addablah, Carlee Morency, Sylvain Moineau. DOI 10.1038/s41579-026-01306-x

Isolation and characterization of novel filamentous phages from Swiss-type cheeses infecting the Gram-positive bacterium Propionibacterium freudenreichii 2026. Noel Grosset, Aurélie Nicolas, Julien Jardin, Frank Oechslin, Antoine Culot, Sylvain Moineau, Michel Gautier, Éric GUÉDON. DOI 10.64898/2026.07.11.737922

Optimization of bacterial colonization in the gut of axenic and conventional zebrafish larvae using live food Microbiology Spectrum, 2026. Gabriel Byatt, Cédric Goffard, Jeffrey K. Cornuault, Mado Lemieux, Paul De Koninck, Marie-Eve Paquet, Sylvain Moineau. DOI 10.1128/spectrum.02853-25

Identification of chalcopyrite-binding peptides for flotation applications using phage display and deep sequencing Journal of Biotechnology, 2026. Barbara Mejia Bohorquez, Thierry Vincent, Denise Tremblay, Sylvain Moineau, Alain Garnier. DOI 10.1016/j.jbiotec.2026.03.001

Phage satellites induced by virulent phages are mobilized by natural competence leading to phage resistance in a new host Nature Communications, 2026. Carlee Morency, Geneviève M. Rousseau, Zacharie Morneau, Sylvain Moineau. DOI 10.1038/s41467-026-72928-1

Microbial community dynamics in a traditional Swiss mountain cheese over 142 years of cheesemaking 2026. Vincent Somerville, Marco Meola, Abigail Nunes-Richards, Johan Bengtsson-Palme, Judith Neukamm, Kerttu Majander, Marta Pla-Díaz, Meral Turgay, Sylvain Moineau, Monika Haueter, Hélène Berthoud, Ueli von Ah, Petra Lüdin, Verena J. Schuenemann, Noam Shani. DOI 10.64898/2026.02.26.708305

Complete genome of five Acinetobacter baumannii phages Microbiology Resource Announcements, 2025. Martina Scarrone, Dann Turner, Johannes Wittmann, Christine Rohde, Simon J. Labrie, Denise M. Tremblay, Sylvain Moineau. DOI 10.1128/mra.00463-25

Strengthening phage resistance of Streptococcus thermophilus by leveraging complementary defense systems Nature Communications, 2025. Audrey Leprince, Justine Lefrançois, Anne M. Millen, Damian Magill, Philippe Horvath, Dennis A. Romero, Geneviève M. Rousseau, Sylvain Moineau. DOI 10.1038/s41467-025-62408-3

In silico and in vitro comparative analysis of 79 Acinetobacter baumannii clinical isolates Microbiology Spectrum, 2025. Martina Scarrone, Dann Turner, Moïra Dion, Denise Tremblay, Sylvain Moineau. DOI 10.1128/spectrum.02849-24

Insight into crRNA Processing in Streptococcus mutans P42S and Application of SmutCas9 in Genome Editing International Journal of Molecular Sciences, 2025. Cas Mosterd, Sylvain Moineau. DOI 10.3390/ijms26052005

Viral niche-partitioning: Comparative genomics of Giant Viruses across environmental gradients in a High Arctic freshwater-saltwater lake 2024. Thomas M Pitot, Catherine Girard, Josephine Z Rapp, Vincent Somerville, Alexander I Culley, Warwick F Vincent, Sylvain Moineau, Simon Roux. DOI 10.1093/ismeco/ycae155

The double play of a phage HTH regulator Trends in Microbiology, 2024. Zacharie Morneau, Sylvain Moineau. DOI 10.1016/j.tim.2024.09.005

Strengthening Phage Resistance of Streptococcus thermophilus by Leveraging Complementary Defense Systems 2024. Audrey Leprince, Justine Lefrançois, Damian Magill, Philippe Horvath, Dennis Romero, Geneviève M. Rousseau, Sylvain Moineau. DOI 10.1101/2024.10.22.618286

High throughput platform technology for rapid target identification in personalized phage therapy Nature Communications, 2024. Fereshteh Bayat, Arwa Hilal, Mathura Thirugnanasampanthar, Denise Tremblay, Carlos D. M. Filipe, Sylvain Moineau, Tohid F. Didar, Zeinab Hosseinidoust. DOI 10.1038/s41467-024-49710-2

Virulence-associated factors as targets for phage infection Current Opinion in Microbiology, 2024. Alessandra G de Melo, Carlee Morency, Sylvain Moineau. DOI 10.1016/j.mib.2024.102471

Centroid of the bacterial growth curves: a metric to assess phage efficiency Communications Biology, 2024. Nava Hosseini, Mahdi Chehreghani, Sylvain Moineau, Steve J. Charette. DOI 10.1038/s42003-024-06379-z

Building pyramids against the evolutionary emergence of pathogens Proceedings of the Royal Society B: Biological Sciences, 2024. Sylvain Gandon, Martin Guillemet, François Gatchitch, Antoine Nicot, Ariane C. Renaud, Denise M. Tremblay, Sylvain Moineau. DOI 10.1098/rspb.2023.1529

Complete genome of Escherichia phages Carena and JoYop Microbiology Resource Announcements, 2024. Audrey A. Addablah, Solange E. Ngazoa-Kakou, Emmanuella A. Adioumani, Simon J. Labrie, Denise M. Tremblay, Damitha Gunathilake, Sylvain Moineau. DOI 10.1128/mra.01233-23

Fermentation Practices Select for Thermostable Endolysins in Phages Molecular Biology and Evolution, 2024. Frank Oechslin, Xiaojun Zhu, Carlee Morency, Vincent Somerville, Rong Shi, Sylvain Moineau. DOI 10.1093/molbev/msae055

Diversity of Salmonella enterica phages isolated from chicken farms in Kenya Microbiology Spectrum, 2024. K. M. Damitha Gunathilake, Angela Makumi, Stéphanie Loignon, Denise Tremblay, Simon Labrie, Nicholas Svitek, Sylvain Moineau. DOI 10.1128/spectrum.02729-23

Four additional natural 7-deazaguanine derivatives in phages and how to make them 2023. Liang Cui, Sylvain Moineau, Valerie de Crecy-Lagard, Matthew Sullivan, Yan-Jiun Lee, Andrew Mulholland, Peter Weigele, Laura Martínez-Alvarez, Xu Peng, Seetharamsingh Balamkundu, Hong Ye, Jacob Hourihan, Astrid Rausch, Christopher Hauß, Emelie Nilsson, Matthias Hötzinger, Karin Holmfeldt, Weijia Zhang, Denise Tremblay, Natalie Solonenko, Peter Dedon, Geoffrey Hutinet. DOI 10.1093/nar/gkad657

The never-ending battle between lactic acid bacteria and their phages FEMS Microbiology Reviews, 2023. Cécile Philippe, Jeffrey K Cornuault, Alessandra G de Melo, Rachel Morin-Pelchat, Alice P Jolicoeur, Sylvain Moineau. DOI 10.1093/femsre/fuad035

Multimodal CMOS Biosensor for Microbial Growth Monitoring IEEE Sensors Journal, 2023. S. Nazila Hosseini, Mohammad Makhdoumi Akram, Partha Sarati Das, Vahid Khojasteh Lazarjan, Denise M. Tremblay, Sylvain Moineau, Younès Messaddeq, Benoit Gosselin. DOI 10.1109/JSEN.2023.3272620

Insight into the Binding Mechanisms of Quartz-Selective Peptides: Toward Greener Flotation Processes ACS Applied Materials & Interfaces, 2023. Abolfazl Alizadeh Sahraei, Barbara Mejia Bohorquez, Denise Tremblay, Sylvain Moineau, Alain Garnier, Faïçal Larachi, Patrick Lagüe. DOI 10.1021/acsami.3c01275

Gender-Responsive Design of Bacteriophage Products to Enhance Adoption by Chicken Keepers in Kenya Viruses, 2023. Zoë A. Campbell, Nelly Njiru, Amos Lucky Mhone, Angela Makumi, Sylvain Moineau, Nicholas Svitek. DOI 10.3390/v15030746

In through the Out Door: A Functional Virulence Factor Secretion System Is Necessary for Phage Infection in Ralstonia solanacearum mBio, 2022. André da Silva Xavier, Alessandra G. de Melo, Connor G. Hendrich, Denise M. Tremblay, Geneviève M. Rousseau, Pier-Luc Plante, Katrina T. Forest, Poliane Alfenas-Zerbini, Caitilyn Allen, Sylvain Moineau. DOI 10.1128/mbio.01475-22

Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution Nature Communications, 2022. Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T. Huiskonen. DOI 10.1038/s41467-022-35123-6

Development of Antimicrobial Paper Coatings Containing Bacteriophages and Silver Nanoparticles for Control of Foodborne Pathogens Viruses, 2022. Thanh Tung Lai, Thi Thanh Ha Pham, Marijn van Lingen, Gabrielle Desaulniers, Guy Njamen, Balázs Tolnai, Tarik Jabrane, Sylvain Moineau, Simon Barnabé. DOI 10.3390/v14112478

Genome Sequence of SN1, a Bacteriophage That Infects Sphaerotilus natans and Pseudomonas aeruginosa Microbiology Resource Announcements, 2022. K. M. Damitha Gunathilake, Denise M. Tremblay, Pier-Luc Plante, Ellen C. Jensen, Kenneth W. Nickerson, Sylvain Moineau. DOI 10.1128/mra.00478-22

Salmonella Enteritidis Bacteriophages Isolated from Kenyan Poultry Farms Demonstrate Time-Dependent Stability in Environments Mimicking the Chicken Gastrointestinal Tract Viruses, 2022. Amos Lucky Mhone, Angela Makumi, Josiah Odaba, Linda Guantai, K. M. Damitha Gunathilake, Stéphanie Loignon, Caroline Wangari Ngugi, Juliah Khayeli Akhwale, Sylvain Moineau, Nicholas Svitek. DOI 10.3390/v14081788

Competition and coevolution drive the evolution and the diversification of CRISPR immunity Nature Ecology & Evolution, 2022. Martin Guillemet, Hélène Chabas, Antoine Nicot, François Gatchich, Enrique Ortega-Abboud, Cornelia Buus, Lotte Hindhede, Geneviève M. Rousseau, Thomas Bataillon, Sylvain Moineau, Sylvain Gandon. DOI 10.1038/s41559-022-01841-9

Author Correction: A truncated anti-CRISPR protein prevents spacer acquisition but not interference Nature Communications, 2022. Cécile Philippe, Carlee Morency, Pier-Luc Plante, Edwige Zufferey, Rodrigo Achigar, Denise M. Tremblay, Geneviève M. Rousseau, Adeline Goulet, Sylvain Moineau. DOI 10.1038/s41467-022-31631-7

New Vista into Origins of Viruses from a Prototypic ssDNA Phage 2022. Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, M Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha Huiskonen. DOI 10.21203/rs.3.rs-1699690/v1

A truncated anti-CRISPR protein prevents spacer acquisition but not interference Nature Communications, 2022. Cécile Philippe, Carlee Morency, Pier-Luc Plante, Edwige Zufferey, Rodrigo Achigar, Denise M. Tremblay, Geneviève M. Rousseau, Adeline Goulet, Sylvain Moineau. DOI 10.1038/s41467-022-30310-x

Zebrafish: a big fish in the study of the gut microbiota Current Opinion in Biotechnology, 2022. Jeffrey K Cornuault, Gabriel Byatt, Marie-Eve Paquet, Paul De Koninck, Sylvain Moineau. DOI 10.1016/j.copbio.2021.09.007

Analysis of viromes and microbiomes from pig fecal samples reveals that phages and prophages rarely carry antibiotic resistance genes ISME Communications, 2021. Maud Billaud, Quentin Lamy-Besnier, Julien Lossouarn, Elisabeth Moncaut, Moira B Dion, Sylvain Moineau, Fatoumata Traoré, Emmanuelle Le Chatelier, Catherine Denis, Jordi Estelle, Caroline Achard, Olivier Zemb, Marie-Agnès Petit. DOI 10.1038/s43705-021-00054-8

Phage Cocktail Development against Aeromonas salmonicida subsp. salmonicida Strains Is Compromised by a Prophage Viruses, 2021. Nava Hosseini, Valérie E. Paquet, Mahdi Chehreghani, Sylvain Moineau, Steve J. Charette. DOI 10.3390/v13112241

Primed CRISPR-Cas Adaptation and Impaired Phage Adsorption in Streptococcus mutans mSphere, 2021. Cas Mosterd, Sylvain Moineau. DOI 10.1128/mSphere.00185-21

Genomic diversity and CRISPR‐Cas systems in the cyanobacterium Nostoc in the High Arctic Environmental Microbiology, 2021. Anne D. Jungblut, Frédéric Raymond, Moïra B. Dion, Sylvain Moineau, Vani Mohit, Guillaume Quang Nguyen, Maxime Déraspe, Élina Francovic‐Fontaine, Connie Lovejoy, Alexander I. Culley, Jacques Corbeil, Warwick F. Vincent. DOI 10.1111/1462-2920.15481

Cooperation between Different CRISPR-Cas Types Enables Adaptation in an RNA-Targeting System mBio, 2021. Ville Hoikkala, Janne Ravantti, César Díez-Villaseñor, Marja Tiirola, Rachel A. Conrad, Mark J. McBride, Sylvain Moineau, Lotta-Riina Sundberg. DOI 10.1128/mBio.03338-20

Streamlining CRISPR spacer-based bacterial host predictions to decipher the viral dark matter Nucleic Acids Research, 2021. Moïra B Dion, Pier-Luc Plante, Edwige Zufferey, Shiraz A Shah, Jacques Corbeil, Sylvain Moineau. DOI 10.1093/nar/gkab133

Functional Study of the Type II-A CRISPR-Cas System of Streptococcus agalactiae Hypervirulent Strains The CRISPR Journal, 2021. Adeline Pastuszka, Clémence Beauruelle, Emilie Camiade, Geneviève M. Rousseau, Sylvain Moineau, Laurent Mereghetti, Philippe Horvath, Philippe Lanotte. DOI 10.1089/crispr.2020.0145

Ectopic Spacer Acquisition in <i>Streptococcus thermophilus</i> CRISPR3 Array Microorganisms, 2021. Rodrigo Achigar, Martina Scarrone, Geneviève M. Rousseau, Cécile Philippe, Felipe Machado, Valentina Duvós, María Pía Campot, Moïra B. Dion, Yuyu Shao, María Julia Pianzzola, Sylvain Moineau. DOI 10.3390/microorganisms9030512