Répertoire du corps professoral

Repurposing bicalutamide to improve the response to immune checkpoint inhibition for treatment of advanced urothelial carcinoma
Programme: UpCycle 2.1
Organisme(s) subventionnaire(s): Société de recherche sur le cancer
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 août 2022 au 31 juillet 2026

Targeting sex steroids to improve the response to bladder cancer immunotherapy
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2021 au 30 septembre 2026

En route towards prebiotic clinical trials for enhancement of immunotherapies in bladder and prostate cancers
Programme: Transformational Research
Organisme(s) subventionnaire(s): Weston Family Foundation
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juin 2020 au 30 avril 2024

Financements des 2 dernières années

Projet de recherche fondamentale en vue d'assurer la gestion de la Biobanque
Organisme(s) subventionnaire(s): Fondation du CHU de Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 20 septembre 2022 au 19 septembre 2023

Impact of lifestyle on gut barrier function, bacterial translocation and risk of prostate cancer
Organisme(s) subventionnaire(s): Weston Family Foundation
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 septembre 2020 au 30 avril 2023

Jalal Laaraj, Doctorat en microbiologie-immunologie

Encadrements terminés dans les 5 dernières années

Nikunj Gevariya, Doctorat en biologie cellulaire et moléculaire

Oscar Eduardo Molina, Doctorat en biologie cellulaire et moléculaire

Fahimeh Aeineh Negin, Maîtrise en microbiologie-immunologie - avec mémoire

Publications des 5 dernières années

Northeastern Section of the American Urological Association 73rd Annual Meeting Abstracts. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021/09. DOI 10.5489/cuaj.7599

Genome-wide germline correlates of the epigenetic landscape of prostate cancer. Nature medicine, 2019/10. Houlahan KE, Shiah YJ, Gusev A, Yuan J, Ahmed M, Shetty A, Ramanand SG, Yao CQ, Bell C, O'Connor E, Huang V, Fraser M, Heisler LE, Livingstone J, Boutros PC. DOI 10.1038/s41591-019-0579-z

Widespread and Functional RNA Circularization in Localized Prostate Cancer. Cell, 2019/02. Chen S, Huang V, Xu X, Livingstone J, Soares F, Jeon J, Zeng Y, Hua JT, Petricca J, Guo H, Wang M, Yousif F, Zhang Y, Donmez N, Ahmed M, Volik S, He HH. DOI 10.1016/j.cell.2019.01.025

The Terry Fox Research Institute Canadian Prostate Cancer Biomarker Network: an analysis of a pan-Canadian multi-center cohort for biomarker validation. BMC urology, 2018/09. Ouellet V, Aprikian A, Bergeron A, Brimo F, Bristow RG, Chevalier S, Drachenberg D, Fazli L, Fleshner NE, Gleave M, Karakiewicz P, Klotz L, Saad F. DOI 10.1186/s12894-018-0392-x

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers. Cancer cell, 2018/04. Berger AC, Korkut A, Kanchi RS, Hegde AM, Lenoir W, Liu W, Liu Y, Fan H, Shen H, Ravikumar V, Rao A, Schultz A, Li X, Sumazin P, Williams C, Akbani R. DOI 10.1016/j.ccell.2018.03.014

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples. Cell, 2018/04. Chen H, Li C, Peng X, Zhou Z, Weinstein JN, Cancer Genome Atlas Research Network, Liang H. DOI 10.1016/j.cell.2018.03.027

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics. Cell, 2018/04. Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee AV, Omberg L, Wolf DM, Shriver CD, Hu H. DOI 10.1016/j.cell.2018.02.052

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer. Cell, 2018/04. Hoadley KA, Yau C, Hinoue T, Wolf DM, Lazar AJ, Drill E, Shen R, Taylor AM, Cherniack AD, Thorsson V, Akbani R, Bowlby R, Wong CK, Wiznerowicz M, Laird PW. DOI 10.1016/j.cell.2018.03.022

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer cell, 2018/04. Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatila W, Akbani R, Laird PW. DOI 10.1016/j.ccell.2018.03.010

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers. Cell reports, 2018/04. Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ, Ding L. DOI 10.1016/j.celrep.2018.03.050

Genomic and Functional Approaches to Understanding Cancer Aneuploidy. Cancer cell, 2018/04. Taylor AM, Shih J, Ha G, Gao GF, Zhang X, Berger AC, Schumacher SE, Wang C, Hu H, Liu J, Lazar AJ, Cancer Genome Atlas Research Network, Meyerson M. DOI 10.1016/j.ccell.2018.03.007

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. Cell reports, 2018/04. Ge Z, Leighton JS, Wang Y, Peng X, Chen Z, Chen H, Sun Y, Yao F, Li J, Zhang H, Liu J, Shriver CD, Hu H, Cancer Genome Atlas Research Network, Liang H. DOI 10.1016/j.celrep.2018.03.047

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context. Cell reports, 2018/04. Chiu HS, Somvanshi S, Patel E, Chen TW, Singh VP, Zorman B, Patil SL, Pan Y, Chatterjee SS, Cancer Genome Atlas Research Network, Sood AK, Sumazin P. DOI 10.1016/j.celrep.2018.03.064

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics. Cell, 2018/04. Ding L, Bailey MH, Porta-Pardo E, Thorsson V, Colaprico A, Bertrand D, Gibbs DL, Weerasinghe A, Huang KL, Tokheim C, Cortés-Ciriano I, Jayasinghe R, Cancer Genome Atlas Research Network. DOI 10.1016/j.cell.2018.03.033

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types. Cell reports, 2018/04. Seiler M, Peng S, Agrawal AA, Palacino J, Teng T, Zhu P, Smith PG, Cancer Genome Atlas Research Network, Buonamici S, Yu L. DOI 10.1016/j.celrep.2018.01.088

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Cancer cell, 2018/04. Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Cancer Genome Atlas Research Network, Xie W, Yang D. DOI 10.1016/j.ccell.2018.03.006

Identification of Morphologic Criteria Associated with Biochemical Recurrence in Intraductal Carcinoma of the Prostate. Cancers, 2021/12. Diop MK, Albadine R, Kougioumoutzakis A, Delvoye N, Hovington H, Bergeron A, Fradet Y, Saad F, Trudel D. DOI 10.3390/cancers13246243

Résumés AUQ 2021. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021/11. DOI 10.5489/cuaj.7674

Identification of Abundant and Functional dodecaRNAs (doRNAs) Derived from Ribosomal RNA. International journal of molecular sciences, 2021/09. Lambert M, Benmoussa A, Diallo I, Ouellet-Boutin K, Dorval V, Majeau N, Joly-Beauparlant C, Droit A, Bergeron A, Têtu B, Fradet Y, Pouliot F, Provost P. DOI 10.3390/ijms22189757

Identification of intraductal carcinoma of the prostate on tissue specimens using Raman micro-spectroscopy: A diagnostic accuracy case-control study with multicohort validation. PLoS medicine, 2020/08. Grosset AA, Dallaire F, Nguyen T, Birlea M, Wong J, Daoust F, Roy N, Kougioumoutzakis A, Azzi F, Aubertin K, Kadoury S, Latour M, Albadine R, Trudel D. DOI 10.1371/journal.pmed.1003281

Immune-focused multi-omics analysis of prostate cancer: leukocyte Ig-Like receptors are associated with disease progression OncoImmunology, 2020/01/01. Benjamin Vittrant, Alain Bergeron, Oscar Eduardo Molina, Mickael Leclercq, Xavier-Philippe Légaré, Hélène Hovington, Valérie Picard, Marie-Laure Martin-Magniette, Julie Livingstone, Paul C. Boutros, Colin Collins, Yves Fradet, Arnaud Droit. DOI 10.1080/2162402X.2020.1851950

The Immune Landscape of Cancer. Immunity, 2019/08. Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, Porta-Pardo E, Gao GF, Plaisier CL, Eddy JA, Ziv E, Culhane AC, Paull EO, Shmulevich I. DOI 10.1016/j.immuni.2019.08.004

Large-Scale Automatic Feature Selection for Biomarker Discovery in High-Dimensional OMICs Data. Frontiers in genetics, 2019/05. Leclercq M, Vittrant B, Martin-Magniette ML, Scott Boyer MP, Perin O, Bergeron A, Fradet Y, Droit A. DOI 10.3389/fgene.2019.00452

Retrospective study on the benefit of adjuvant radiotherapy in men with intraductal carcinoma of prostate. Radiation oncology (London, England), 2019/04. Trinh VQ, Benzerdjeb N, Chagnon-Monarque S, Dionne N, Delouya G, Kougioumoutzakis A, Sirois J, Albadine R, Latour M, Mes-Masson AM, Hovington H, Trudel D. DOI 10.1186/s13014-019-1267-3

Abstraits AUQ 2018 Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2018/10. Naud E, Ramsay S, Moore K, Bolduc S, Rompré-Brodeur A, Ayoub M, Shinde S, Piccirilo C, Seuntjens J, Mansure J, Kassouf W, Lemire F, Rouleau M, Saad F.

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients. Cancer cell, 2018/08. Kahles A, Lehmann KV, Toussaint NC, Hüser M, Stark SG, Sachsenberg T, Stegle O, Kohlbacher O, Sander C, Cancer Genome Atlas Research Network, Rätsch G. DOI 10.1016/j.ccell.2018.07.001

Omega-3 fatty acids decrease prostate cancer progression associated with an anti-tumor immune response in eugonadal and castrated mice. The Prostate, 2018/08. Gevariya N, Besançon M, Robitaille K, Picard V, Diabaté L, Alesawi A, Julien P, Fradet Y, Bergeron A, Fradet V. DOI 10.1002/pros.23706

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell reports, 2018/06. Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Linehan WM. DOI 10.1016/j.celrep.2018.06.032

Comprehensive Characterization of Cancer Driver Genes and Mutations. Cell, 2018/04. Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Ng PK, Jeong KJ, Cao S, Wang Z, Ding L. DOI 10.1016/j.cell.2018.02.060

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation. Cell, 2018/04. Malta TM, Sokolov A, Gentles AJ, Burzykowski T, Poisson L, Weinstein JN, Kamińska B, Huelsken J, Omberg L, Gevaert O, Colaprico A, Czerwińska P, Wiznerowicz M. DOI 10.1016/j.cell.2018.03.034

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. Cell reports, 2018/04. Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi PL, Wang Y, Cheng F, Tan L, Mojumdar K, Du D, Ge Z, Li J, Thomas GV, Birsoy K, Liu L, Zhang H, Zhao Z, Liang H. DOI 10.1016/j.celrep.2018.03.077

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images. Cell reports, 2018/04. Saltz J, Gupta R, Hou L, Kurc T, Singh P, Nguyen V, Samaras D, Shroyer KR, Zhao T, Batiste R, Van Arnam J, Cancer Genome Atlas Research Network, Thorsson V. DOI 10.1016/j.celrep.2018.03.086

Systematic Analysis of Splice-Site-Creating Mutations in Cancer. Cell reports, 2018/04. Jayasinghe RG, Cao S, Gao Q, Wendl MC, Vo NS, Reynolds SM, Zhao Y, Climente-González H, Chai S, Wang F, Varghese R, Huang M, Liang WW, Ding L. DOI 10.1016/j.celrep.2018.03.052

The Immune Landscape of Cancer. Immunity, 2018/04. Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, Porta-Pardo E, Gao GF, Plaisier CL, Eddy JA, Ziv E, Culhane AC, Paull EO, Shmulevich I. DOI 10.1016/j.immuni.2018.03.023

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines. Cell systems, 2018/03. Ellrott K, Bailey MH, Saksena G, Covington KR, Kandoth C, Stewart C, Hess J, Ma S, Chiotti KE, McLellan M, Sofia HJ, Hutter C, Getz G, Wheeler D, Cancer Genome Atlas Research Network. DOI 10.1016/j.cels.2018.03.002

Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype. Clinical and translational medicine, 2022/01. Boibessot C, Molina O, Lachance G, Tav C, Champagne A, Neveu B, Pelletier JF, Pouliot F, Fradet V, Bilodeau S, Fradet Y, Bergeron A, Toren P. DOI 10.1002/ctm2.581

Dimensional reduction based on peak fitting of Raman micro spectroscopy data improves detection of prostate cancer in tissue specimens. Journal of biomedical optics, 2021/11. Plante A, Dallaire F, Grosset AA, Nguyen T, Birlea M, Wong J, Daoust F, Roy N, Kougioumoutzakis A, Azzi F, Aubertin K, Kadoury S, Latour M, Leblond F. DOI 10.1117/1.jbo.26.11.116501

Using ex vivo culture to assess dynamic phenotype changes in human prostate macrophages following exposure to therapeutic drugs. Scientific reports, 2021/09. Boibessot C, Joncas FH, Park A, Berrehail Z, Pelletier JF, Gris T, Bergeron A, Toren P. DOI 10.1038/s41598-021-98903-y

Omega-3 Eicosapentaenoic Acid Reduces Prostate Tumor Vascularity. Molecular cancer research : MCR, 2020/12. Gevariya N, Lachance G, Robitaille K, Joly Beauparlant C, Beaudoin L, Fournier É, Fradet Y, Droit A, Julien P, Marette A, Bergeron A, Fradet V. DOI 10.1158/1541-7786.mcr-20-0316

Identification of a Transcriptomic Prognostic Signature by Machine Learning Using a Combination of Small Cohorts of Prostate Cancer. Frontiers in genetics, 2020/11. Vittrant B, Leclercq M, Martin-Magniette ML, Collins C, Bergeron A, Fradet Y, Droit A. DOI 10.3389/fgene.2020.550894

Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growth. Prostaglandins, leukotrienes, and essential fatty acids, 2020/11. Bilodeau JF, Gevariya N, Larose J, Robitaille K, Roy J, Oger C, Galano JM, Bergeron A, Durand T, Fradet Y, Julien P, Fradet V. DOI 10.1016/j.plefa.2020.102215

Northeastern Section of the AUA 72nd Annual Meeting Abstracts Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020/09. Donnelly L, Tang J, Lian F, Higgins P, Samarakoon R, Doersch K, Abston K, Kim H, Li X, Bjazevic J, Spierling A, Al K, Razvi H, Burton J, Bjazevic J, Skog J.

Androgen receptor and immune cell PD-L1 expression in bladder tumors predicts disease recurrence and survival. World journal of urology, 2020/07. Toren P, Brisson H, Simonyan D, Hovington H, Lacombe L, Bergeron A, Fradet Y. DOI 10.1007/s00345-020-03358-x

Validation of the prognostic value of NF-κB p65 in prostate cancer: A retrospective study using a large multi-institutional cohort of the Canadian Prostate Cancer Biomarker Network. PLoS medicine, 2019/07. Grosset AA, Ouellet V, Caron C, Fragoso G, Barrès V, Delvoye N, Latour M, Aprikian A, Bergeron A, Chevalier S, Fazli L, Fleshner N, Gleave M, Canadian Prostate Cancer Biomarker Network. DOI 10.1371/journal.pmed.1002847

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer. Cell reports, 2018/10. Wang Y, Xu X, Maglic D, Dill MT, Mojumdar K, Ng PK, Jeong KJ, Tsang YH, Moreno D, Bhavana VH, Peng X, Ge Z, Chen H, Li J, Chen Z, Zhang H, Han L, Liang H. DOI 10.1016/j.celrep.2018.10.001

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily. Cell systems, 2018/09. Korkut A, Zaidi S, Kanchi RS, Rao S, Gough NR, Schultz A, Li X, Lorenzi PL, Berger AC, Robertson G, Kwong LN, Datto M, Roszik J, Ling S, Ravikumar V, Akbani R. DOI 10.1016/j.cels.2018.08.010

Comprehensive Characterization of Cancer Driver Genes and Mutations. Cell, 2018/08. Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Kwok-Shing Ng P, Jeong KJ, Ding L. DOI 10.1016/j.cell.2018.07.034

2018 CUA Abstracts. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2018/06.

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. Cell reports, 2018/04. Knijnenburg TA, Wang L, Zimmermann MT, Chambwe N, Gao GF, Cherniack AD, Fan H, Shen H, Way GP, Greene CS, Liu Y, Akbani R, Feng B, Donehower LA, Wang C. DOI 10.1016/j.celrep.2018.03.076

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas. Cell reports, 2018/04. Campbell JD, Yau C, Bowlby R, Liu Y, Brennan K, Fan H, Taylor AM, Wang C, Walter V, Akbani R, Byers LA, Creighton CJ, Coarfa C, Shih J, Cherniack AD, Van Waes C. DOI 10.1016/j.celrep.2018.03.063

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas. Cell reports, 2018/04. Way GP, Sanchez-Vega F, La K, Armenia J, Chatila WK, Luna A, Sander C, Cherniack AD, Mina M, Ciriello G, Schultz N, Greene CS. DOI 10.1016/j.celrep.2018.03.046

Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell, 2018/04. Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Schultz N. DOI 10.1016/j.cell.2018.03.035

Pathogenic Germline Variants in 10,389 Adult Cancers. Cell, 2018/04. Huang KL, Mashl RJ, Wu Y, Ritter DI, Wang J, Oh C, Paczkowska M, Reynolds S, Wyczalkowski MA, Oak N, Scott AD, Krassowski M, Cherniack AD, Ding L. DOI 10.1016/j.cell.2018.03.039

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell reports, 2018/04. Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Linehan WM. DOI 10.1016/j.celrep.2018.03.075

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas. Cell systems, 2018/03. Schaub FX, Dhankani V, Berger AC, Trivedi M, Richardson AB, Shaw R, Zhao W, Zhang X, Ventura A, Liu Y, Ayer DE, Hurlin PJ, Cherniack AD, Eisenman RN, Cancer Genome Atlas Network. DOI 10.1016/j.cels.2018.03.003

The impact of intraductal carcinoma of the prostate on the site and timing of recurrence and cancer-specific survival. The Prostate, 2018/03. Trinh VQ, Sirois J, Benzerdjeb N, Mansoori BK, Grosset AA, Albadine R, Latour M, Mes-Masson AM, Hovington H, Bergeron A, Ladouceur M, Fradet Y, Saad F, Trudel D. DOI 10.1002/pros.23513