Répertoire du corps professoral
Guy Boivin
Médecin clinicien enseignant titulaire
guy.boivin@fmed.ulaval.ca
Pavillon Ferdinand-Vandry
1050, avenue de la Médecine
Génération et évaluation du vaccin trivalent Metavac-RSV-PIV-3(sous-projet A)
Programme: Projets de maturation technologique PSO – volet 2d
Organisme(s) subventionnaire(s): Vaxxel SAS, Ministère de l'Économie et de l'Innovation et de l'énergie
Type de financement: Subvention
Établissement tête: Université Laval
Du 7 novembre 2024
au 7 août 2025
Modulation des réponses immunitaires à la vaccination contre la COVID-19 par une intervention sur le microbiote intestinal
Programme: Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université de Sherbrooke
Du 25 septembre 2024
au 25 décembre 2029
Antiviral drug resistance in avian influenza viruses
Programme: Subvention catalyseur : Recherche « Une seule santé » sur la grippe aviaire
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2024
au 31 mars 2027
Mise au point d'un modèle animal pour l'infection avec le virus parainfluenza-3
Programme: Développement de la recherche (FC)
Organisme(s) subventionnaire(s): CHU de Québec – Université Laval – CHUL
Type de financement: Subvention
Établissement tête: Université Laval
Du 10 janvier 2024
au 10 janvier 2026
Identification of innate immune pathways as targets for immunomodulatory therapy in herpes simplex virus encephalitis
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2023
au 30 septembre 2028
Laboratoire international associé (LIA) sur la pathogenèse, le traitement et la prévention des infections virales respiratoires (LIA RespiVIR)
Programme: Laboratoire international associé (LIA)
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 27 juillet 2021
au 26 juillet 2026
Financements des 2 dernières années
Potentiel thérapeutique des protectines contre les infections grippales
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2024
au 31 mars 2025
Deciphering the role of antiviral innate immune mechanisms among respiratory viruses
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2024
au 31 mars 2025
Characterization of Seasonal Influenza Vaccination Cross-Type Activity on Avian H5Nx
Programme: Subvention catalyseur : Recherche « Une seule santé » sur la grippe aviaire
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université d'Ottawa
Du 1 avril 2024
au 31 mars 2025
Antiviral Resistance and Benefits of Combination Therapy for Influenza Viruses
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2023
au 29 février 2024
Plateforme de laboratoire de niveau de confinement 3 pour la recherche sur les virus émergents
Programme: Appel de projets en appui aux plateformes technologiques stratégiques
Organisme(s) subventionnaire(s): CHU de Québec – Université Laval – CHUL, Ministère de l'Économie et de l'Innovation
Type de financement: Subvention
Établissement tête: Université Laval
Du 31 janvier 2023
au 31 mars 2025
Relationship between COVID-19 and Parkinson’s disease in a mouse model
Programme: Programme de projets pilotes
Organisme(s) subventionnaire(s): Parkinson Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2022
au 31 mars 2024
Évaluation des interactions entre des virus respiratoires
Programme: Développement de la recherche (FC)
Organisme(s) subventionnaire(s): CHU de Québec – Université Laval – CHUL
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 février 2022
au 31 janvier 2025
CHOIR study: Children and Older Teens Immune Response to SARS-CoV-2 in Montreal
Programme: Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université de Montréal
Du 1 décembre 2021
au 31 mars 2025
Manufacturing of antigens and adjuvants for development of vaccines (MAAV)
Programme: Fonds d'innovation (FI)
Organisme(s) subventionnaire(s): Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux, Fondation du CHU de Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2021
au 31 mars 2024
Changement de paradigme dans la conduite d'essais cliniques
Organisme(s) subventionnaire(s): Ministère de l'Économie et de l'Innovation
Type de financement: Subvention
Établissement tête: Université de Montréal
Du 1 avril 2021
au 31 mars 2024
SO05 QC07, Sentinel surveillance for confirmed and suspected cases of covid-19/covsars-2 acute respiratory disease, covid-19 vaccine effectiveness and adverse events following sars-cv-2 vaccines: A study of the Serious Outcomes Surveillance
Programme: Réseau canadien de recherche sur l’immunisation
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2021
au 30 septembre 2023
Innovative therapeutic approaches for the 2019-novel coronavirus
Programme: Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19)
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada, INACTIF Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC)
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2021
au 31 mars 2024
A research program on the pathogenesis, treatment and prevention of respiratory and herpes viruses
Programme: Subventions Fondation
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2016
au 30 juin 2023
Encadrements terminés dans les 5 dernières années
Publications des 5 dernières années
Influenza A virus interferes with respiratory syncytial virus in mice and reconstituted human airway epithelium Microbiology Spectrum, 2025/05/14. Shella Gilbert-Girard, Jocelyne Piret, Chantal Rhéaume, Julie Carbonneau, Nathalie Goyette, Christian Couture, Guy Boivin. DOI 10.1128/spectrum.03187-24
Oseltamivir Reduces 30-Day Mortality in Older Adults With Influenza: A Pooled Analysis From the 2012–2019 Serious Outcomes Surveillance Network of the Canadian Immunization Research Network Open Forum Infectious Diseases, 2025/01/31. Henrique Pott, Melissa K Andrew, Zachary Shaffelburg, Michaela K Nichols, Lingyun Ye, May ElSherif, Todd F Hatchette, Jason J LeBlanc, Ardith Ambrose, Guy Boivin, William Bowie, Jennie Johnstone, Kevin Katz, Phillipe Lagacé-Wiens, Mark Loeb, Anne McCarthy, Allison McGeer, Andre Poirier, Jeff Powis, David Richardson, Makeda Semret, Stephanie Smith, Daniel Smyth, Grant Stiver, Sylvie Trottier, Louis Valiquette, Duncan Webster, Shelly A McNeil. DOI 10.1093/ofid/ofaf058
Parental decisions regarding the vaccination of children and adolescents against SARS-CoV-2 from 2020 to 2023: A descriptive longitudinal study of parents and children in Montreal, Canada Vaccine, 2025/01. Katia Charland, Caroline Quach, Jesse Papenburg, Laura Pierce, Cat Tuong Nguyen, Adrien Saucier, Margot Barbosa Da Torre, Marie-Ève Hamelin, Julie Carbonneau, Guy Boivin, Kate Zinszer. DOI 10.1016/j.vaccine.2024.126489
Fitness of SARS-CoV-2 Omicron Subvariants in Respiratory and Gastrointestinal Cell Lines as Determined by Reverse-Transcription Droplet Digital PCR and Whole-Genome Sequencing The Journal of Infectious Diseases, 2024/11/09. Mathilde Hénaut, Julie Carbonneau, Inès Levade, Guy Boivin. DOI 10.1093/infdis/jiae554
Viral Loads of Pneumoviruses: Correlation With Coinfection Rates and Disease Severity Journal of Medical Virology, 2024/11. Sarah Talah, Julie Carbonneau, Marie‐Eve Hamelin, Rodica Gilca, Guy Boivin. DOI 10.1002/jmv.70054
Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database (CHARMD) Antiviral Research, 2024/11. Valentin Tilloy, Daniel Diaz Gonzalez, Lisa Laplace, Emilien Bisserier, Sunwen Chou, William D. Rawlinson, Guy Boivin, Fausto Baldanti, Tiziana Lazzarotto, Graciela Andrei, Hans H. Hirsch, María Ángeles Marcos, Detlef Michel, Sébastien Hantz, sophie Alain. DOI 10.1016/j.antiviral.2024.106016
Predicting major clinical events among Canadian adults with laboratory-confirmed influenza infection using the influenza severity scale Scientific Reports, 2024/08/08. Henrique Pott, Jason J. LeBlanc, May ElSherif, Todd F. Hatchette, Shelly A. McNeil, Melissa K. Andrew, the Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN), Guy Boivin, Sylvie Trottier, Francisco Diaz-Mitoma, Chris Verschoor, Grant Stiver, William Bowie, Karen Green, Allison McGeer, Jennie Johnstone, Mark Loeb, Kevin Katz, Phillipe Lagacé-Wiens, Bruce Light, Anne McCarthy, Andre Poirier, Jeff Powis, David Richardson, Makeda Semret, Stephanie Smith, Geoff Taylor, Daniel Smyth, Louis Valiquette, Duncan Webster. DOI 10.1038/s41598-024-67931-9
SARS-CoV-2 seroprevalence and mental health of school staff: a cross-sectional study of schools from four areas of Montreal, Quebec in 2021 BMJ Open, 2024/08. Katia Charland, Matteo Pannunzio, Eleanor Greenspan-Ardman, Adrien Saucier, Laura Pierce, Marie-Eve Hamelin, Margot Barbosa Da Torre, Julie Carbonneau, Cat Tuong Nguyen, Gaston De Serres, Jesse Papenburg, Guy Boivin, Caroline Quach, Kate Zinszer. DOI 10.1136/bmjopen-2023-081838
Viral interference between severe acute respiratory syndrome coronavirus 2 and influenza A viruses PLOS Pathogens, 2024/07/22. Shella Gilbert-Girard, Jocelyne Piret, Julie Carbonneau, Mathilde Hénaut, Nathalie Goyette, Guy Boivin. DOI 10.1371/journal.ppat.1012017
Mucosal bivalent live attenuated vaccine protects against human metapneumovirus and respiratory syncytial virus in mice npj Vaccines, 2024/06/19. Daniela Ogonczyk-Makowska, pauline brun, Clémence Vacher, Caroline Chupin, Clément Droillard, Julie Carbonneau, Emilie Laurent, Victoria Dulière, Aurélien Traversier, Olivier Terrier, Thomas Julien, Marie Galloux, stephane paul, Jean-François Eléouët, Julien Fouret, Marie-Eve Hamelin, Andrés Pizzorno, Guy Boivin, Manuel Rosa-Calatrava, Julia Dubois. DOI 10.1038/s41541-024-00899-9
The Changing Landscape of Respiratory Viruses Contributing to Hospitalizations in Quebec, Canada: Results From an Active Hospital-Based Surveillance Study JMIR Public Health and Surveillance, 2024/05/06. Rodica Gilca, Rachid Amini, Sara Carazo, Radhouene Doggui, Charles Frenette, Guy Boivin, Hugues Charest, Jeannot Dumaresq. DOI 10.2196/40792
Impact of COVID-19 and Vaccination During Pregnancy on Placenta-Mediated Complications (COVIGRO Study) Journal of Obstetrics and Gynaecology Canada, 2024/04. Louise Ghesquiere, Guy Boivin, Brielle Demuth, Yves Giguere, Jean-Claude Forest, Marie-Eve Hamelin, Gina Muckle, Julie Carbonneau, Emmanuel Bujold. DOI 10.1016/j.jogc.2023.102291
A protectin DX (PDX) analog with in vitro activity against influenza A(H1N1) viruses Journal of Medical Virology, 2024/02/25. Nicolas Fortin, Mathilde Hénaut, Nathalie Goyette, René Maltais, Jean‐Yves Sancéau, André Marette, Donald Poirier, Yacine Abed, Guy Boivin. DOI 10.1002/jmv.29484
Viral interference between severe acute respiratory syndrome coronavirus 2 and influenza A viruses 2024/02/03. Shella Gilbert-Girard, Jocelyne Piret, Julie Carbonneau, Mathilde Hénaut, Nathalie Goyette, Guy Boivin. DOI 10.1101/2024.02.02.578538
Management of Cytomegalovirus Infections in the Era of the Novel Antiviral Players, Letermovir and Maribavir Infectious Disease Reports, 2024/01/18. Jocelyne Piret, Guy Boivin. DOI 10.3390/idr16010005
Herpes Simplex Virus 1 Infection Does Not Increase Amyloid-β Pathology in APP/PS1 Mice Journal of Alzheimer's Disease, 2024/01/02. Lina Lapeyre, Jocelyne Piret, Chantal Rhéaume, Vincent Pons, Olus Uyar, Paul Préfontaine, Serge Rivest, Guy Boivin. DOI 10.3233/jad-230746
Omicron incidence and seroprevalence among children in Montreal, Canada, in early 2023: final results from the longitudinal EnCORE serology study Epidemiology and Infection, 2024. Katia Charland, Laura Pierce, Adrien Saucier, Marie-Ève Hamelin, Margot Barbosa Da Torre, Julie Carbonneau, Cat Tuong Nguyen, Gaston De Serres, Jesse Papenburg, Guy Boivin, Caroline Quach, Kate Zinszer. DOI 10.1017/s0950268824000797
The impact of trained immunity in respiratory viral infections Reviews in Medical Virology, 2024/01. Jocelyne Piret, Guy Boivin. DOI 10.1002/rmv.2510
The possibility of spreading herpes simplex virus type 1 via food handling and sharing Journal of Applied Microbiology, 2023/10/04. Gabrielle Pageau, Marianne Levasseur, Teresa Paniconi, Eric Jubinville, Valérie Goulet-Beaulieu, Guy Boivin, Julie Jean. DOI 10.1093/jambio/lxad224
Vaccine Effectiveness of non-adjuvanted and adjuvanted trivalent inactivated influenza vaccines in the prevention of influenza-related hospitalization in older adults: A pooled analysis from the Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN) Vaccine, 2023/10. POTT, H, Melissa Andrew, Zachary Shaffelburg, Michaela K. Nichols, Lingyun Ye, May ElSherif, Todd Hatchette, Jason LeBlanc, Ardith Ambrose, Guy Boivin, William Bowie, Jennie Johnstone, Kevin Katz, Phillipe Lagacé-Wiens, Mark Loeb, Anne McCarthy, Allison McGeer, Andre Poirier, Jeff Powis, David Richardson, Makeda Semret, Stephanie Smith, Daniel Smyth, Grant Stiver, Sylvie Trottier, Louis Valiquette, Duncan Webster, Shelly A. McNeil. DOI 10.1016/j.vaccine.2023.08.070
In-vivo and human evidence for potential efficacy of therapeutic polyclonal RSV neutralizing antibodies for palivizumab-resistant RSV infections Virology, 2023/09. Kacy Ramirez, James Mond, Jesse Papenburg, Guy Boivin, Brian E. Gilbert, Ann R. Falsey, Bindiya Bagga, John P. DeVincenzo. DOI 10.1016/j.virol.2023.07.007
Infection‐induced seroconversion and seroprevalence of SARS‐CoV‐2 among a cohort of children and youth in Montreal, Canada Influenza and Other Respiratory Viruses, 2023/08. Kate Zinszer, Katia Charland, Laura Pierce, Adrien Saucier, Marie‐Ève Hamelin, Margot Barbosa Da Torre, Julie Carbonneau, Cat Tuong Nguyen, Gaston De Serres, Jesse Papenburg, Guy Boivin, Caroline Quach. DOI 10.1111/irv.13186
In vitro fitness of SARS-CoV-2 variants as assessed by competition experiments followed by ddRT-PCR and whole genome sequencing Journal of Clinical Virology, 2023/08. Mathilde Hénaut, Julie Carbonneau, Chantal Rhéaume, Ines Levade, Guy Boivin. DOI 10.1016/j.jcv.2023.105517
Rapid and Technically Simple Detection of SARS-CoV-2 Variants Using CRISPR Cas12 and Cas13 The CRISPR Journal, 2023/08/01. Gabriel Lamothe, Julie Carbonneau, Charles Joly Beauparlant, Thierry Vincent, Patrik Quessy, Anthony Guedon, Gary Kobinger, Jean-Francois Lemay, Guy Boivin, Arnaud Droit, Nathalie Turgeon, Jacques P. Tremblay. DOI 10.1089/crispr.2023.0007
Treatment of COVID-19 symptoms with over the counter (OTC) medicines used for treatment of common cold and flu Clinical Infection in Practice, 2023/07. Ronald Eccles, Guy Boivin, Benjamin J Cowling, Andrew Pavia, Rangaraj Selvarangan. DOI 10.1016/j.clinpr.2023.100230
Pre-Omicron seroprevalence, seroconversion, and seroreversion of infection-induced SARS-CoV-2 antibodies among a cohort of children and teenagers in Montréal, Canada International Journal of Infectious Diseases, 2023/06. Kate Zinszer, Katia Charland, Laura Pierce, Adrien Saucier, Britt McKinnon, Marie-Ève Hamelin, Islem Cheriet, Margot Barbosa Da Torre, Julie Carbonneau, Cat Tuong Nguyen, Gaston De Serres, Jesse Papenburg, Guy Boivin, Caroline Quach. DOI 10.1016/j.ijid.2023.03.036
Viral Fitness of Baloxavir-Resistant Recombinant Influenza B/Victoria- and B/Yamagata-like Viruses Harboring the I38T PA Change, In Vitro, Ex Vivo and in Guinea Pigs Microorganisms, 2023/04/22. Amel Saim-Mamoun, Julie Carbonneau, Chantal Rhéaume, Yacine Abed, Guy Boivin. DOI 10.3390/microorganisms11051095
Duration of isolation and contagiousness in coronavirus disease 2019 (COVID-19) patients receiving tocilizumab and dexamethasone: A case series Infection Control & Hospital Epidemiology, 2023/04. Florence Côté, Guy Boivin, Vilayvong Loungnarath, Annie Ruest, Julie Bestman-Smith, Julie Carbonneau, Marie-Ève Hamelin, Marie-Claude Roy. DOI 10.1017/ice.2022.14
Influence of letermovir treatment on gut inflammation in people living with HIV on antiretroviral therapy: protocol of the open-label controlled randomised CIAO study BMJ Open, 2023/01. Léna Royston, Stéphane Isnard, Carolina A. Berini, Simeng Bu, Peter L. Lakatos, Talat Bessissow, Nicolas Chomont, Marina Klein, Bertrand Lebouché, Alexandra de Pokomandy, Nadine Kronfli, Cecilia T. Costiniuk, Rejean Thomas, Cécile Tremblay, Guy Boivin, Jean-Pierre Routy. DOI 10.1136/bmjopen-2022-067640
Symptomatology during previous SARS-CoV-2 infection and serostatus before vaccination influence the immunogenicity of BNT162b2 COVID-19 mRNA vaccine Frontiers in Immunology, 2022/10/14. Sabryna Nantel, Benoîte Bourdin, Kelsey Adams, Julie Carbonneau, Henintsoa Rabezanahary, Marie-Ève Hamelin, Deirdre McCormack, Patrice Savard, Yves Longtin, Matthew P. Cheng, Gaston De Serres, Jacques Corbeil, Vladimir Gilca, Mariana Baz, Guy Boivin, Caroline Quach, Hélène Decaluwe. DOI 10.3389/fimmu.2022.930252
A Candidate Therapeutic Monoclonal Antibody Inhibits Both HRSV and HMPV Replication in Mice Biomedicines, 2022/10/08. Hugues Fausther-Bovendo, Marie-Eve Hamelin, Julie Carbonneau, Marie-Christine Venable, Liva Checkmahomed, Pierre-Olivier Lavoie, Marie-Ève Ouellet, Guy Boivin, Marc-André D’Aoust, Gary P. Kobinger. DOI 10.3390/biomedicines10102516
Generation and Characterization of Drug-Resistant Influenza B Viruses Selected In Vitro with Baloxavir Acid Pathogens, 2022/09/15. Amel Saim-Mamoun, Yacine Abed, Julie Carbonneau, Guy Boivin. DOI 10.3390/pathogens11091048
The REinfection in COVID‐19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers Influenza and Other Respiratory Viruses, 2022/09. Étienne Racine, Guy Boivin, Yves Longtin, Deirdre McCormack, Hélène Decaluwe, Patrice Savard, Matthew P. Cheng, Marie‐Ève Hamelin, Julie Carbonneau, Fazia Tadount, Kelsey Adams, Benoîte Bourdin, Sabryna Nantel, Vladimir Gilca, Jacques Corbeil, Gaston De Serres, Caroline Quach‐Thanh. DOI 10.1111/irv.12997
Reinfection with SARS-CoV-2 in a patient undergoing chemotherapy for lymphoma: Case report Official Journal of the Association of Medical Microbiology and Infectious Disease Canada, 2022/09/01. Florence Côté, Julie Bestman-Smith, Marie Gourdeau, Shawn M Simpson, Marie-Ève Hamelin, Julie Carbonneau, Antoine Chiasson, Marieke Rozendaal, Martin A Smith, Guy Boivin. DOI 10.3138/jammi-2021-0036
The Changing Landscape of Respiratory Viruses Contributing to Hospitalizations in Quebec, Canada: Results From an Active Hospital-Based Surveillance Study (Preprint) 2022/07/05. Rodica Gilca, Rachid Amini, Sara Carazo, Radhouene Doggui, Charles Frenette, Guy Boivin, Hugues Charest, Jeannot Dumaresq. DOI 10.2196/preprints.40792
The changing landscape of respiratory viruses contributing to respiratory hospitalisations: results from a hospital-based surveillance in Quebec, Canada, 2012-13 to 2021-22 2022/07/02. Rodica Gilca, Rachid Amini, Sara Carazo, Charles Frenette, Guy Boivin, Hugues Charest, Jeannot Dumaresq. DOI 10.1101/2022.07.01.22277061
In vitro activity of letermovir against human cytomegalovirus isolates with different drug susceptibility phenotypes Antiviral Research, 2022/06. Jocelyne Piret, Nathalie Goyette, Guy Boivin. DOI 10.1016/j.antiviral.2022.105328
Older Age and Frailty are Associated with Higher Mortality but Lower ICU Admission with COVID-19 Canadian Geriatrics Journal, 2022/06/01. Melissa Andrew, Judith Godin, Jason LeBlanc, Guy Boivin, Louis Valiquette, Allison McGeer, Janet E. McElhaney, Todd F. Hatchette, May ElSherif, Donna MacKinnon-Cameron, Kevin Wilson, Ardith Ambrose, Sylvie Trottier, Mark Loeb, Stephanie W. Smith, Kevin Katz, Anne McCarthy, Shelly A. McNeil. DOI 10.5770/cgj.25.546
Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response Journal of Neuroinflammation, 2022/04/06. Olus Uyar, Juan Manuel Dominguez, Maude Bordeleau, Lina Lapeyre, Fernando González Ibáñez, Luc Vallières, Marie-Eve Tremblay, Jacques Corbeil, Guy Boivin. DOI 10.1186/s12974-022-02437-7
Recalibrated estimates of non-bacteremic and bacteremic pneumococcal community acquired pneumonia in hospitalized Canadian adults from 2010 to 2017 with addition of an extended spectrum serotype-specific urine antigen detection assay Vaccine, 2022/04. Jason J. LeBlanc, May ElSherif, Lingyun Ye, Donna MacKinnon-Cameron, Ardith Ambrose, Todd F. Hatchette, Amanda L.S. Lang, Hayley D. Gillis, Irene Martin, Walter H.B. Demczuk, Melissa K. Andrew, Guy Boivin, William Bowie, Karen Green, Jennie Johnstone, Mark Loeb, Anne E. McCarthy, Allison McGeer, Makeda Semret, Sylvie Trottier, Louis Valiquette, Duncan Webster, Shelly A. McNeil. DOI 10.1016/j.vaccine.2022.02.081
Predictive risk factors for hospitalization and response to colchicine in patients with COVID-19 International Journal of Infectious Diseases, 2022/03. Jean-Claude Tardif, Mariève Cossette, Marie-Claude Guertin, Nadia Bouabdallaoui, Marie-Pierre Dubé, Guy Boivin. DOI 10.1016/j.ijid.2022.01.020
Influenza A(H1N1)pdm09 Virus but Not Respiratory Syncytial Virus Interferes with SARS-CoV-2 Replication during Sequential Infections in Human Nasal Epithelial Cells Viruses, 2022/02/15. Clément Fage, Mathilde Hénaut, Julie Carbonneau, Jocelyne Piret, Guy Boivin. DOI 10.3390/v14020395
In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance 2022/02/12. Liva Checkmahomed, Venice Du Pont, Nicholas C. Riola, Jason K. Perry, Jiani Li, Danielle P. Porter, Guy Boivin. DOI 10.1101/2022.02.07.479493
The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers 2022/02/10. Étienne Racine, Guy Boivin, Yves Longtin, Deirde McCormack, Hélène Decaluwe, Patrice Savard, Matthew P. Cheng, Marie-Ève Hamelin, Fazia Tadount, Kelsey Adams, Benoîte Bourdin, Sabryna Nantel, Vladimir Gilca, Jacques Corbeil, Gaston De Serres, Caroline Quach. DOI 10.1101/2022.02.10.22269967
Viral Interference between Respiratory Viruses. Emerging infectious diseases, 2022/02. Piret J, Boivin G. DOI 10.3201/eid2802.211727
1325. Recalibrating Estimates of Pneumococcal Disease in Hospitalized Canadian adults from 2010 to 2017 with Use of an Extended Spectrum Serotype-specific Urine Antigen Detection Open Forum Infectious Diseases, 2021/12/04. Jason J LeBlanc, May ElSherif, Lingyun Ye, Donna MacKinnon-Cameron, Ardith Ambrose, Todd F Hatchette, Amanda L S Lang, Hayley D Gillis, Irene Martin, Walter Demczuk, Melissa K Andrew, Guy Boivin, William Bowie, Karen Green, Jennie Johnstone, Mark Loeb, Anne McCarthy, Allison McGeer, Makeda Semret, Sylvie Trottier, Louis Valiquette, Duncan Webster, Shelly McNeil. DOI 10.1093/ofid/ofab466.1517
Microglia are involved in phagocytosis and extracellular digestion during Zika virus encephalitis in young adult immunodeficient mice Journal of Neuroinflammation, 2021/12. William Enlow, Maude Bordeleau, Jocelyne Piret, Fernando González Ibáñez, Olus Uyar, Marie-Christine Venable, Nathalie Goyette, Julie Carbonneau, Marie-Eve Tremblay, Guy Boivin. DOI 10.1186/s12974-021-02221-z
Seroprevalence of SARS-CoV-2 Antibodies Among Children in School and Day Care in Montreal, Canada JAMA Network Open, 2021/11/23. Kate Zinszer, Britt McKinnon, Noémie Bourque, Laura Pierce, Adrien Saucier, Alexandra Otis, Islem Cheriet, Jesse Papenburg, Marie-Ève Hamelin, Katia Charland, Julie Carbonneau, Monica Zahreddine, Ashley Savard, Geneviève Fortin, Alexander Apostolatos, Nancy Haley, Nathalie Ratté, Isabel Laurin, Cat Tuong Nguyen, Patrica Conrod, Guy Boivin, Gaston De Serres, Caroline Quach. DOI 10.1001/jamanetworkopen.2021.35975
High and low flowrate sampling of airborne influenza in hospital rooms during three outbreaks Journal of Aerosol Science, 2021/11. Marie-Eve Dubuis, Jodelle Degois, Marc Veillette, Nathalie Turgeon, Bianka Paquet-Bolduc, Guy Boivin, Caroline Duchaine. DOI 10.1016/j.jaerosci.2021.105824
Replication and transmission of an influenza A(H3N2) virus harboring the polymerase acidic I38T substitution, in guinea pigs. Journal of General Virology, 2021/10/18. Zeineb Mhamdi, Julie Carbonneau, Marie-Christine Venable, Mariana Baz, Yacine Abed, Guy Boivin. DOI 10.1099/jgv.0.001659
Avian Cell Line DuckCelt®-T17 Is an Efficient Production System for Live-Attenuated Human Metapneumovirus Vaccine Candidate Metavac® Vaccines, 2021/10/16. Caroline Chupin, Andrés Pizzorno, Aurelien Traversier, Pauline Brun, Daniela Ogonczyk-Makowska, Blandine PADEY, Cédrine Milesi, Victoria Dulière, Emilie Laurent, Thomas Julien, Marie Galloux, Bruno Lina, Jean-François ELéouët, karen moreau, Marie-Eve Hamelin, Olivier Terrier, Guy Boivin, Julia Dubois, Manuel Rosa-calatrava. DOI 10.3390/vaccines9101190
A novel bioluminescent herpes simplex virus 1 for in vivo monitoring of herpes simplex encephalitis Scientific Reports, 2021/09/21. Olus Uyar, Pier-Luc Plante, Jocelyne Piret, Marie-Christine Venable, Julie Carbonneau, Jacques Corbeil, Guy Boivin. DOI 10.1038/s41598-021-98047-z
Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes PLOS ONE, 2021/07/12. Marie-Eve Dubuis, Étienne Racine, Jonathan M. Vyskocil, Nathalie Turgeon, Christophe Tremblay, Espérance Mukawera, Guy Boivin, Nathalie Grandvaux, Caroline Duchaine. DOI 10.1371/journal.pone.0253022
Seroprevalence of anti-SARS-CoV-2 antibodies among school and daycare children and personnel: protocol for a cohort study in Montreal, Canada BMJ Open, 2021/07. Kate Zinszer, Britt McKinnon, Noémie Bourque, Monica Zahreddine, Katia Charland, Jesse Papenburg, Geneviève Fortin, Marie-Ève Hamelin, Adrien Saucier, Alex Apostolatos, Laura Pierce, Ashley Savard-Lamothe, Julie Carbonneau, Patricia Conrod, Nancy Haley, Isabelle Laurin, Guy Boivin, Gaston De Serres, Caroline Quach. DOI 10.1136/bmjopen-2021-053245
Antiviral Drugs Against Herpesviruses Antiviral Drug Discovery and Development, 2021/07. Jocelyne Piret, Guy Boivin. DOI 10.1007/978-981-16-0267-2_1
Inhibition of the 3CL Protease and SARS-CoV-2 Replication by Dalcetrapib ACS Omega, 2021/06/17. Eric Niesor, Guy Boivin, Eric Rhéaume, Rong Shi, Véronique Lavoie, Nathalie Goyette, Marie-Eve Picard, Anne Perez, Fouzia Laghrissi-Thode, Jean-Claude Tardif. DOI 10.1021/acsomega.1c01797
Older Age and Frailty Are Associated With Higher Mortality but Lower Intensive Care Unit Admission Among Adults Admitted to Canadian Hospitals With COVID-19: A Report From the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance Network 2021/05. Andrew M, Godin J, LeBlanc J, Boivin G, Valiquette L, McElhaney JE, Hatchette TF, ElSherif M, MacKinnon-Cameron D, Ambrose A, Trottier S, Loeb M, McNeil S. DOI 10.2139/ssrn.3844895
Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial. The Lancet. Respiratory medicine, 2021/05. Tardif JC, Bouabdallaoui N, L'Allier PL, Gaudet D, Shah B, Pillinger MH, Lopez-Sendon J, da Luz P, Verret L, Audet S, Dupuis J, Denault A, COLCORONA Investigators. DOI 10.1016/s2213-2600(21)00222-8
Seroprevalence of anti-SARS-CoV-2 antibodies among school and daycare children and personnel: Protocol for a cohort study in Montreal, Canada 2021/04. Zinszer K, McKinnon B, Bourque N, Zahreddine M, Charland K, Papenburg J, Fortin G, Hamelin M, Saucier A, Apostolatos A, Pierce L, Savard-Lamothe A, Quach C. DOI 10.1101/2021.04.14.21255499
Impact of Amino Acid Substitutions in Region II and Helix K of HSV-1 and HCMV DNA Polymerases on Resistance to Foscarnet. Antimicrobial agents and chemotherapy, 2021/04. Zarrouk K, Zhu X, Pham VD, Goyette N, Piret J, Shi R, Boivin G. DOI 10.1128/aac.00390-21
Zika virus and impact on male fertility Zika Virus Biology, Transmission, and Pathology, 2021. Jocelyne Piret, Guy Boivin. DOI 10.1016/b978-0-12-820268-5.00026-2
RSV and HMPV Infections in 3D Tissue Cultures: Mechanisms Involved in Virus-Host and Virus-Virus Interactions Viruses, 2021. Geiser, J., Boivin, G., Huang, S., Constant, S., Kaiser, L., Tapparel, C., Essaidi-Laziosi, M.. DOI 10.3390/v13010139
Pandemics Throughout History Frontiers in Microbiology, 2021. Piret, J., Boivin, G.. DOI 10.3389/fmicb.2020.631736
Human Respiratory Syncytial Virus-Induced Immune Signature of Infection Revealed by Transcriptome Analysis of Clinical Pediatric Nasopharyngeal Swab Samples Journal of Infectious Diseases, 2021. Nicolas De Lamballerie, C., Pizzorno, A., Dubois, J., Padey, B., Julien, T., Traversier, A., Carbonneau, J., Orcel, E., Lina, B., Hamelin, M.-E., Roche, M., Textoris, J., Boivin, G., Legras-Lachuer, C., Terrier, O., Rosa-Calatrava, M.. DOI 10.1093/infdis/jiaa468
Genetics of symptom remission in outpatients with COVID-19 Scientific Reports, 2021. Dubé, M.-P., Lemaçon, A., Barhdadi, A., Lemieux Perreault, L.-P., Oussaïd, E., Asselin, G., Provost, S., Sun, M., Sandoval, J., Legault, M.-A., Mongrain, I., Dubois, A., Valois, D., Dedelis, E., Lousky, J., Choi, J., Goulet, E., Savard, C., Chicoine, L.-M., Cossette, M., Chabot-Blanchet, M., Guertin, M.-C., de Denus, S., Bouabdallaoui, N., Marchand, R., Bassevitch, Z., Nozza, A., Gaudet, D., L’Allier, P.L., Hussin, J., Boivin, G., Busseuil, D., Tardif, J.-C.. DOI 10.1038/s41598-021-90365-6
Fitness of influenza A and B viruses with reduced susceptibility to baloxavir: A mini-review Reviews in Medical Virology, 2021. Abed, Y., Saim-Mamoun, A., Boivin, G.. DOI 10.1002/rmv.2175
Differential impact of various substitutions at codon 715 in region II of HSV-1 and HCMV DNA polymerases Antiviral Research, 2021. Zarrouk, K., Zhu, X., Goyette, N., Piret, J., Shi, R., Boivin, G.. DOI 10.1016/j.antiviral.2021.105046
DNA polymerases of herpesviruses and their inhibitors Viral Replication Enzymes and their Inhibitors Part B, 2021. Jocelyne Piret, Guy Boivin. DOI 10.1016/bs.enz.2021.07.003
Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19 2021/01. Tardif J, Bouabdallaoui N, L’Allier PL, Gaudet D, Shah B, Pillinger MH, Lopez-Sendon J, da Luz P, Verret L, Audet S, Dupuis J, Denault A, for the COLCORONA Investigators. DOI 10.1101/2021.01.26.21250494
Validation of the Seegene RV15 multiplex PCR for the detection of influenza A subtypes and influenza B lineages during national influenza surveillance in hospitalized adults Journal of Medical Microbiology, 2020. LeBlanc, J.J., ElSherif, M., Mulpuru, S., Warhuus, M., Ambrose, A., Andrew, M., Boivin, G., Bowie, W., Chit, A., Dos Santos, G., Green, K., Halperin, S.A., Hatchette, T.F., Ibarguchi, B., Johnstone, J., Katz, K., Langley, J.M., Lagacé-Wiens, P., Loeb, M., Lund, A., MacKinnon-Cameron, D., McCarthy, A., McElhaney, J.E., McGeer, A., Poirier, A., Powis, J., Richardson, D., Semret, M., Shinde, V., Smyth, D., Trottier, S., Valiquette, L., Webster, D., Ye, L., McNeil, S.A.. DOI 10.1099/jmm.0.001032
Novel calixarene-based surfactant enables low dose split inactivated vaccine protection against influenza infection Vaccine, 2020. Mandon, E.D., Pizzorno, A., Traversier, A., Champagne, A., Hamelin, M.E., Lina, B., Boivin, G., Dejean, E., Rosa-Calatrava, M., Jawhari, A.. DOI 10.1016/j.vaccine.2019.10.018
Molecular pathway of influenza pan-neuraminidase inhibitor resistance in an immunocompromised patient Antiviral Therapy, 2020. Abed, Y., Schibler, M., Checkmahomed, L., Carbonneau, J., Venable, M.-C., Fage, C., Giannotti, F., Goncalves, A.R., Kaiser, L., Boivin, G.. DOI 10.3851/imp3344
Modified cyclodextrins as broad-spectrum antivirals Science Advances, 2020. Jones, S.T., Cagno, V., Janeček, M., Ortiz, D., Gasilova, N., Piret, J., Gasbarri, M., Constant, D.A., Han, Y., Vuković, L., Král, P., Kaiser, L., Huang, S., Constant, S., Kirkegaard, K., Boivin, G., Stellacci, F., Tapparel, C.. DOI 10.1126/sciadv.aax9318
Infectivity of healthcare workers diagnosed with SARS-CoV-2 infection approximately 2 weeks after onset of symptoms: A cross-sectional study Infection Control and Hospital Epidemiology, 2020. Longtin, Y., Charest, H., Quach, C., Savard, P., Baz, M., Boivin, G., Farfard, J., Villeneuve, J., Roger, M., de Serres, G.. DOI 10.1017/ice.2020.1420
In vitro combinations of baloxavir acid and other inhibitors against seasonal influenza a viruses Viruses, 2020. Checkmahomed, L., Padey, B., Pizzorno, A., Terrier, O., Rosa-Calatrava, M., Abed, Y., Baz, M., Boivin, G.. DOI 10.3390/v12101139
Impact of the Baloxavir-Resistant Polymerase Acid I38T Substitution on the Fitness of Contemporary Influenza A(H1N1)pdm09 and A(H3N2) Strains The Journal of infectious diseases, 2020. Checkmahomed, L., M'hamdi, Z., Carbonneau, J., Venable, M.-C., Baz, M., Abed, Y., Boivin, G.. DOI 10.1093/infdis/jiz418
Immunomodulatory strategies in herpes simplex virus encephalitis Clinical Microbiology Reviews, 2020. Piret, J., Boivin, G.. DOI 10.1128/CMR.00105-19
Hypersusceptibility of human cytomegalovirus to foscarnet induced by mutations in helices K and P of the viral DNA polymerase Antimicrobial Agents and Chemotherapy, 2020. Zarrouk, K., Pham, V.D., Piret, J., Shi, R., Boivin, G.. DOI 10.1128/AAC.01910-19
Frailty hinders recovery from influenza and acute respiratory illness in older adults Journal of Infectious Diseases, 2020. Lees, C., Godin, J., McElhaney, J.E., McNeil, S.A., Loeb, M., Hatchette, T.F., LeBlanc, J., Bowie, W., Boivin, G., McGeer, A., Poirier, A., Powis, J., Semret, M., Webster, D., Andrew, M.K.. DOI 10.1093/infdis/jiaa092
Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice Vaccine, 2020. Pilaev, M., Shen, Y., Carbonneau, J., Venable, M.-C., Rhéaume, C., Lavigne, S., Couture, C., Guarné, A., Hamelin, M.-È., Boivin, G.. DOI 10.1016/j.vaccine.2020.01.047
Engineering of live chimeric vaccines against human metapneumovirus Pathogens, 2020. Makowska, D.O., Hamelin, M.-È., Boivin, G.. DOI 10.3390/pathogens9020135
Effects of different drug combinations in immunodeficient mice infected with an influenza a/h3n2 virus Microorganisms, 2020. Mhamdi, Z., Fausther-Bovendo, H., Uyar, O., Carbonneau, J., Venable, M.-C., Abed, Y., Kobinger, G., Boivin, G., Baz, M.. DOI 10.3390/microorganisms8121968
Droplet Digital PCR and Immunohistochemistry Techniques to Detect Zika Virus in the Central Nervous System of Mice Methods in Molecular Biology, 2020. Enlow, W., Piret, J., Boivin, G.. DOI 10.1007/978-1-0716-0581-3_4
Cytomegalovirus seropositivity is associated with increased microbial translocation in people living with human immunodeficiency virus and uninfected controls Clinical Infectious Diseases, 2020. Ramendra, R., Isnard, S., Lin, J., Fombuena, B., Ouyang, J., Mehraj, V., Zhang, Y., Finkelman, M., Costiniuk, C., Lebouché, B., Chartrand-Lefebvre, C., Durand, M., Tremblay, C., Ancuta, P., Boivin, G., Routy, J.-P.. DOI 10.1093/cid/ciz1001
Characterization of contemporary influenza B recombinant viruses harboring mutations of reduced susceptibility to baloxavir marboxil, in vitro and in mice Antiviral Research, 2020. Abed, Y., Fage, C., Checkmahomed, L., Venable, M.-C., Boivin, G.. DOI 10.1016/j.antiviral.2020.104807
An Early Microglial Response Is Needed to Efficiently Control Herpes Simplex Virus Encephalitis Journal of Virology, 2020. Uyar, O., Laflamme, N., Piret, J., Venable, M.-C., Carbonneau, J., Zarrouk, K., Rivest, S., Boivin, G.. DOI 10.1128/JVI.01428-20
Age-stratified burden of pneumococcal community acquired pneumonia in hospitalised Canadian adults from 2010 to 2015 BMJ Open Respiratory Research, 2020. Leblanc, J., Elsherif, M., Ye, L., Mackinnon-Cameron, D., Ambrose, A., Hatchette, T.F., Lang, A.L.S., Gillis, H.D., Martin, I., Demczuk, W.H., Laferriere, C., Andrew, M.K., Boivin, G., Bowie, W., Green, K., Johnstone, J., Loeb, M., McCarthy, A., McGeer, A., Semret, M., Trottier, S., Valiquette, L., Webster, D., McNeil, S.A.. DOI 10.1136/bmjresp-2019-000550
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