Répertoire du corps professoral

Publications des 5 dernières années

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis Immunity, 2025/08. Carlos H. Hiroki, Mortaza F. Hassanabad, Manon Defaye, Nicole Sarden, Alexandria Bartlett, Raquel Farias, Angela P. Nguyen, Idaira M. Guerrero-Fonseca, Grace Yoon, Luke Brown, Caixia Ma, Hyungjun Yang, Darrel Belke, Ali Fatehi Hassanabad, Christopher McCoy, Nicole L. Rosin, Dennis J. Orton, Paul W.M. Fedak, Bruce A. Vallance, Hongbing Yu, Kevan Jacobson, Nargis Khan, Christophe Altier, Margaret M. Kelly, Bryan G. Yipp. DOI 10.1016/j.immuni.2025.05.002

The gut microbiota promotes pain in fibromyalgia Neuron, 2025/07. Weihua Cai, May Haddad, Rana Haddad, Inbar Kesten, Tseela Hoffman, Reut Laan, Susan Westfall, Manon Defaye, Nasser S. Abdullah, Calvin Wong, Nicole Brown, Shannon Tansley, Kevin C. Lister, Mehdi Hooshmandi, Feng Wang, Louis-Etienne Lorenzo, Volodya Hovhannisyan, David Ho-Tieng, Vibhu Kumar, Behrang Sharif, Bavanitha Thurairajah, Jonathan Fan, Tali Sahar, Charlotte Clayton, Neil Wu, Ji Zhang, Haggai Bar-Yoseph, Milena Pitashny, Emerson Krock, Jeffrey S. Mogil, Masha Prager-Khoutorsky, Philippe Séguéla, Christophe Altier, Irah L. King, Yves De Koninck, Nicholas J.B. Brereton, Emmanuel Gonzalez, Yoram Shir, Amir Minerbi, Arkady Khoutorsky. DOI 10.1016/j.neuron.2025.03.032

Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer Proceedings of the National Academy of Sciences, 2025/06/17. Mélissa Delanne-Cuménal, Manon Defaye, Améline Delanne-Cuménal, Mansoor Ahmed, Valerie Ho, Nasser S. Abdullah, Mohamad Alhassoun, Kristofer Svendsen, Lukas Mager, Joseph Schlessinger, Simon Hirota, Christophe Altier. DOI 10.1073/pnas.2500632122

Mo1318: ALKAL2/ALK AXIS MEDIATES PERSISTENT VISCERAL HYPERSENSITIVITY FOLLOWING COLITIS Gastroenterology, 2025/05. Manon Defaye, Nasser Abdullah, Kristofer Svendsen, Aye Ozmaeian, Anabel Dickemann, Lucie Gentil, Lisa Soussi, Christophe Altier. DOI 10.1016/s0016-5085(25)03430-4

Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells Mucosal Immunology, 2025/04. Nasser S. Abdullah, Amyaouch Bradaia, Manon Defaye, Christina Ohland, Kristofer Svendsen, Anabel Dickemann, Melissa Delanne-Cumenal, Ahmed Hassan, Mircea Iftinca, Kathy D. McCoy, Christophe Altier. DOI 10.1016/j.mucimm.2024.12.002

Uncovering the therapeutic potential of anti-tuberculoid agent Isoniazid in a model of microbial-driven Crohn’s disease Journal of Crohn's and Colitis, 2025/03/05. Matthew Stephens, Keith Keane, Simon Roizes, Manon Defaye, Christophe Altier, Pierre-Yves von der Weid. DOI 10.1093/ecco-jcc/jjaf032

Entourage effects of nonpsychotropic cannabinoids on visceral sensitivity in experimental colitis The Journal of Pharmacology and Experimental Therapeutics, 2025/03. Kristofer Svendsen, Amyaouch Bradaia, Maria A. Gandini, Manon Defaye, Chelsea Matisz, Nasser S. Abdullah, Aaron Gruber, Gerald W. Zamponi, Keith A. Sharkey, Christophe Altier. DOI 10.1016/j.jpet.2025.103389

Sex-specific post-inflammatory dysbiosis mediates chronic visceral pain in colitis Gut Microbes, 2024/12/31. Maria J. Arzamendi, Yasaman B. Habibyan, Manon Defaye, Adam Shute, Cristiane H. Baggio, Ronald Chan, Christina Ohland, Dominique G. Bihan, Ian A. Lewis, Keith A. Sharkey, Kathy D. McCoy, Christophe Altier, Markus B. Geuking, Yasmin Nasser. DOI 10.1080/19490976.2024.2409207

Spare the pain for your gut Treg cells! Trends in Pharmacological Sciences, 2024/10. Manon Defaye, Christophe Altier. DOI 10.1016/j.tips.2024.08.008

Neuroimmunophysiology of the gastrointestinal tract American Journal of Physiology-Gastrointestinal and Liver Physiology, 2024/06/01. Derek M. McKay, Manon Defaye, Sruthi Rajeev, Wallace K. MacNaughton, Yasmin Nasser, Keith A. Sharkey. DOI 10.1152/ajpgi.00075.2024

Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice Journal of Clinical Investigation, 2024/05/01. Manon Defaye, Amyaouch Bradaia, Nasser S. Abdullah, Francina Agosti, Mircea Iftinca, Mélissa Delanne-Cuménal, Vanessa Soubeyre, Kristofer Svendsen, Gurveer Gill, Aye Ozmaeian, Nadine Gheziel, Jérémy Martin, Gaetan Poulen, Nicolas Lonjon, Florence Vachiery-Lahaye, Luc Bauchet, Lilian Basso, Emmanuel Bourinet, Isaac M. Chiu, Christophe Altier. DOI 10.1172/jci176474

Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection Cell, 2024/04. Elise Granton, Luke Brown, Manon Defaye, Parisa Moazen, Henrik Almblad, Trevor E. Randall, Jacquelyn D. Rich, Andrew Geppert, Nasser S. Abdullah, Mortaza F. Hassanabad, Carlos H. Hiroki, Raquel Farias, Angela P. Nguyen, Courtney Schubert, Yuefei Lou, Graciela Andonegui, Mircea Iftinca, Deepa Raju, Mario A. Vargas, P. Lynne Howell, Tamás Füzesi, Jaideep Bains, Deborah Kurrasch, Joe Jonathan Harrison, Christophe Altier, Bryan G. Yipp. DOI 10.1016/j.cell.2024.03.001

A199 ALKAL2/ALK AXIS PROMOTE PERSISTENT VISCERAL PAIN Journal of the Canadian Association of Gastroenterology, 2024/02/14. M Defaye, N Abdullah, K Svendsen, L Soussi, A Dickemann, C Altier. DOI 10.1093/jcag/gwad061.199

29 SEX-SPECIFIC GUT MICROBIOTA DIFFERENCES IN POST-INFLAMMATORY VISCERAL PAIN Gastroenterology, 2023/05. Maria J. Arzamendi, Adam Shute, Ronald Chan, Manon Defaye, Dominique G. Bihan, Ian Lewis, Christophe Altier, Keith A. Sharkey, Markus B. Geuking, Yasmin Nasser. DOI 10.1016/s0016-5085(23)00976-9

A52 SEX DIFFERENCES IN POST-INFLAMMATORY VISCERAL PAIN IN A MOUSE MODEL OF INFLAMMATORY BOWEL DISEASE (IBD) Journal of the Canadian Association of Gastroenterology, 2023/03/07. M Arzamendi, A Shute, R Chan, M Defaye, C Altier, K A Sharkey, M B Geuking, Y Nasser. DOI 10.1093/jcag/gwac036.052

Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain Visceral Pain, 2023. Manon Defaye, Christophe Altier. DOI 10.1007/978-3-031-25702-5_15

AhR/IL-22 pathway as new target for the treatment of post-infectious irritable bowel syndrome symptoms Gut Microbes, 2022/12/31. Maëva Meynier, Elodie Baudu, Nathalie Rolhion, Manon Defaye, Marjolène Straube, Valentine Daugey, Morgane Modoux, Ivan Wawrzyniak, Frédéric Delbac, Romain Villéger, Mathieu Méleine, Esther Borras Nogues, Catherine Godfraind, Nicolas Barnich, Denis Ardid, Philippe Poirier, Harry Sokol, Jean-Marc Chatel, Philippe Langella, Valérie Livrelli, Mathilde Bonnet, Frédéric Antonio Carvalho. DOI 10.1080/19490976.2021.2022997

The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain Journal of Clinical Investigation, 2022/06/15. Manon Defaye, Mircea C. Iftinca, Vinicius M. Gadotti, Lilian Basso, Nasser S. Abdullah, Mélissa Cuménal, Francina Agosti, Ahmed Hassan, Robyn Flynn, Jérémy Martin, Vanessa Soubeyre, Gaetan Poulen, Nicolas Lonjon, Florence Vachiery-Lahaye, Luc Bauchet, Pierre Francois Mery, Emmanuel Bourinet, Gerald W. Zamponi, Christophe Altier. DOI 10.1172/jci154317

A52 GUT-INNERVATING TRPV1+ NEURONS DRIVE CHRONIC VISCERAL PAIN VIA MICROGLIAL P2Y12 RECEPTOR Journal of the Canadian Association of Gastroenterology, 2022/02/21. M Defaye, N Abdullah, M Iftinca, A Hassan, F Agosti, Z Zhang, M Cumenal, G W Zamponi, C Altier. DOI 10.1093/jcag/gwab049.051

A36 NON-PSYCHOTROPIC PHYTOCANNABINOIDS ATTENUATE VISCERAL HYPERSENSITIVITY IN DEXTRAN SULFATE SODIUM (DSS)-INDUCED COLITIS Journal of the Canadian Association of Gastroenterology, 2022/02/21. K Svendsen, M Defaye, K A Sharkey, C Altier. DOI 10.1093/jcag/gwab049.035

A230 THE ROLE OF THE MICROBIOTA IN NOCICEPTOR DEVELOPMENT AND PAIN SENSITIVITY Journal of the Canadian Association of Gastroenterology, 2022/02/21. N Abdullah, M Defaye, A Hassan, M Cumenal, M Iftinca, D Young, C L Ohland, A Dufour, K McCoy, C Altier. DOI 10.1093/jcag/gwab049.229

Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons Proceedings of the National Academy of Sciences, 2022/01/25. Jaqueline Raymondi Silva, Mircea Iftinca, Francisco I. Fernandes Gomes, Julia P. Segal, Olivia M. A. Smith, Courtney A. Bannerman, Atlante Silva Mendes, Manon Defaye, Madeline E. C. Robinson, Ian Gilron, Thiago Mattar Cunha, Christophe Altier, Nader Ghasemlou. DOI 10.1073/pnas.2118238119

Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 Receptor Cellular and Molecular Gastroenterology and Hepatology, 2022. Manon Defaye, Nasser S. Abdullah, Mircea Iftinca, Ahmed Hassan, Francina Agosti, Zizhen Zhang, Melissa Cumenal, Gerald W. Zamponi, Christophe Altier. DOI 10.1016/j.jcmgh.2021.12.012

Influence du microbiote sur la douleur Douleur et Analgésie, 2021/06. S. Gervason, M. Defaye, D. Ardid, J.-Y. Berthon, C. Altier, E. Filaire, F.A. Carvalho. DOI 10.3166/dea-2021-0144

A38 TRPV1 VISCERAL AFFERENTS CONTROL CENTRAL SENSITIZATION IN IBD Journal of the Canadian Association of Gastroenterology, 2021/03/04. M Defaye, N Abdullah, M Iftinca, C Altier. DOI 10.1093/jcag/gwab002.036

TRPV1 Activation Promotes β-arrestin2 Interaction with the Ribosomal Biogenesis Machinery in the Nucleolus: Implications for p53 Regulation and Neurite Outgrowth International Journal of Molecular Sciences, 2021/02/25. Ahmed Hassan, Mircea Iftinca, Daniel Young, Robyn Flynn, Francina Agosti, Nasser Abdullah, Manon Defaye, Mark G. H. Scott, Antoine Dufour, Christophe Altier. DOI 10.3390/ijms22052280

TRPV1-Targeted Drugs in Development for Human Pain Conditions Drugs, 2021/01. Mircea Iftinca, Manon Defaye, Christophe Altier. DOI 10.1007/s40265-020-01429-2

Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling Molecular Brain, 2020/12. Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang, Christophe Altier. DOI 10.1186/s13041-020-00599-0

Neural control of gut homeostasis American Journal of Physiology-Gastrointestinal and Liver Physiology, 2020/12/01. Nasser Abdullah, Manon Defaye, Christophe Altier. DOI 10.1152/ajpgi.00293.2020

Fecal dysbiosis associated with colonic hypersensitivity and behavioral alterations in chronically Blastocystis-infected rats Scientific Reports, 2020/06/04. Manon Defaye, Céline Nourrisson, Elodie Baudu, Amandine Lashermes, Maëva Meynier, Mathieu Meleine, Ivan Wawrzyniak, Virginie Bonnin, Julie Barbier, Benoit Chassaing, Catherine Godfraind, Agathe Gelot, Nicolas Barnich, Denis Ardid, Mathilde Bonnet, Frédéric Delbac, Frédéric Antonio Carvalho, Philippe Poirier. DOI 10.1038/s41598-020-66156-w

Microbiota: a novel regulator of pain Journal of Neural Transmission, 2020/04. Manon Defaye, Sandie Gervason, Christophe Altier, Jean-Yves Berthon, Denis Ardid, Edith Filaire, Frédéric Antonio Carvalho. DOI 10.1007/s00702-019-02083-z

Factors Regulating Murine Tuft cell Hyperplasia in the Small Intestine during Infection with <i>Hymenolepis Diminuta</i> The FASEB Journal, 2020/04. Sruthi Rajeev, Manon Defaye, Adam Shute, Arthur Wang, Susan Wang, Christophe Altier, Derek Mark McKay. DOI 10.1096/fasebj.2020.34.s1.03739

A47 ENTERIC TUFT CELL HYPERPLASIA FOLLOWING INFECTION WITH THE TAPEWORM HYMENOLEPIS DIMINUTA IS AFFECTED BY NEURONAL BUT NOT BACTERIAL FACTORS Journal of the Canadian Association of Gastroenterology, 2020/02/26. S Rajeev, M Defaye, A J Shute, A Wang, S J Wang, C Altier, D M McKay. DOI 10.1093/jcag/gwz047.046

Colitis-Induced Microbial Perturbation Promotes Postinflammatory Visceral Hypersensitivity Cellular and Molecular Gastroenterology and Hepatology, 2020. Nicolas Esquerre, Lilian Basso, Manon Defaye, Fernando A. Vicentini, Nina Cluny, Dominique Bihan, Simon A. Hirota, Alana Schick, Humberto B. Jijon, Ian A. Lewis, Markus B. Geuking, Keith A. Sharkey, Christophe Altier, Yasmin Nasser. DOI 10.1016/j.jcmgh.2020.04.003