Répertoire du corps professoral
Marie-Ève Tremblay
Professeure associée
(418) 656-3090
marie-eve.tremblay.38@ulaval.ca
Pavillon Ferdinand-Vandry
1050, avenue de la Médecine
Local 3218
Nutrition and brain health, from predictive biology to disease prevention and treatment - Food4BrainHealth
Programme: Réseau de recherche international (RRI)
Organisme(s) subventionnaire(s): Université Laval - Fonds internes, Université McGill, Université de Toronto, Institut national de la recherche agronomique
Type de financement: Subvention
Établissement tête: Université Laval
Du 18 mars 2019
au17 mars 2025
Encadrements terminés dans les 5 dernières années
Publications des 5 dernières années
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal Nature Cell Biology, 2024/02. Laura E. Newman, Sammy Weiser Novak, Gladys R. Rojas, Nimesha Tadepalle, Cara R. Schiavon, Danielle A. Grotjahn, Christina G. Towers, Marie-Ève Tremblay, Matthew P. Donnelly, Sagnika Ghosh, Michaela Medina, Sienna Rocha, Ricardo Rodriguez-Enriquez, Joshua A. Chevez, Ian Lemersal, Uri Manor, Gerald S. Shadel. DOI 10.1038/s41556-023-01343-1
Behavioral as well as hippocampal transcriptomic and microglial responses differ across sexes in adult mouse offspring exposed to a dual genetic and environmental challenge Brain, Behavior, and Immunity, 2024/02. Micaël Carrier, Chin W. Hui, Valérie Watters, Eva Šimončičová, Katherine Picard, Fernando González Ibáñez, Nathalie Vernoux, Arnaud Droit, Michèle Desjardins, Marie-Ève Tremblay. DOI 10.1016/j.bbi.2023.11.025
Disrupting T cell memory to promote stress resilience: A role for CD74? Brain, Behavior, and Immunity, 2023/11. Haley A. Vecchiarelli, Marie-Ève Tremblay. DOI 10.1016/j.bbi.2023.08.011
Local translation in microglial processes Nature Neuroscience, 2023/07. Haley A. Vecchiarelli, Marie-Ève Tremblay. DOI 10.1038/s41593-023-01370-z
An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease Nature Communications, 2023/03/25. Victor Lau, Leanne Ramer, Marie-Ève Tremblay. DOI 10.1038/s41467-023-37304-3
The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring Developmental Neuroscience, 2023. Sophia M. Loewen, Adriano M. Chavesa, Colin J. Murray, Marianela E. Traetta, Sophia E. Burns, Keelin H. Pekarik, Marie-Ève Tremblay. DOI 10.1159/000530185
Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring Communications Biology, 2022/12. DOI 10.1038/s42003-021-02947-9
Plasmalogens and platelet‐activating factor roles in chronic inflammatory diseases BioFactors, 2022/11. Marie‐Ève Tremblay, Zakaria A. Almsherqi, Yuru Deng. DOI 10.1002/biof.1916
Present and future of microglial pharmacology Trends in Pharmacological Sciences, 2022/08. Eva Šimončičová, Elisa Gonçalves de Andrade, Haley A. Vecchiarelli, Ifeoluwa O. Awogbindin, Charlotte I. Delage, Marie-Ève Tremblay. DOI 10.1016/j.tips.2021.11.006
Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys Cells, 2022/02/16. DOI 10.3390/cells11040691
N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice Frontiers in Cellular Neuroscience, 2022/02/10. DOI 10.3389/fncel.2022.802411
Editorial: Role of Neuroinflammation in the Neuropsychiatric and Neurological Aspects of COVID-19 Frontiers in Cellular Neuroscience, 2022/02/09. DOI 10.3389/fncel.2022.840121
Plasticity of microglia Biological Reviews, 2022/02. DOI 10.1111/brv.12797
N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development Glia, 2022/01. DOI 10.1002/glia.24088
Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle Glia, 2022/01. DOI 10.1002/glia.24090
Microglia control glutamatergic synapses in the adult mouse hippocampus Glia, 2022/01. DOI 10.1002/glia.24101
A Systematic, Open-Science Framework for Quantification of Cell-Types in Mouse Brain Sections Using Fluorescence Microscopy Frontiers in Neuroanatomy, 2021/12/06. DOI 10.3389/fnana.2021.722443
Microglia are involved in phagocytosis and extracellular digestion during Zika virus encephalitis in young adult immunodeficient mice Journal of Neuroinflammation, 2021/12. William Enlow, Maude Bordeleau, Jocelyne Piret, Fernando González Ibáñez, Olus Uyar, Marie-Christine Venable, Nathalie Goyette, Julie Carbonneau, Marie-Eve Tremblay, Guy Boivin. DOI 10.1186/s12974-021-02221-z
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice Nature Communications, 2021/12. DOI 10.1038/s41467-021-25590-8
Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner Cannabis and Cannabinoid Research, 2021/12/01. DOI 10.1089/can.2020.0170
Editorial: The Metabolism of the Neuron-Glia Unit Frontiers in Cellular Neuroscience, 2021/11/05. DOI 10.3389/fncel.2021.791389
Psychological Stress as a Risk Factor for Accelerated Cellular Aging and Cognitive Decline: The Involvement of Microglia-Neuron Crosstalk Frontiers in Molecular Neuroscience, 2021/11/04. DOI 10.3389/fnmol.2021.749737
Novel microglia-mediated mechanisms underlying synaptic loss and cognitive impairment after traumatic brain injury Brain, Behavior, and Immunity, 2021/11. DOI 10.1016/j.bbi.2021.08.210
Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice Brain, Behavior, and Immunity, 2021/10. DOI 10.1016/j.bbi.2021.07.022
Microglial functional alteration and increased diversity in the challenged brain: Insights into novel targets for intervention Brain, Behavior, & Immunity - Health, 2021/10. Marie-Ève Tremblay. DOI 10.1016/j.bbih.2021.100301
Microglia contribute to social behavioral adaptation to chronic stress Glia, 2021/10. DOI 10.1002/glia.24053
Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence Brain, Behavior, and Immunity, 2021/10. Lourdes Fernández de Cossío, Chloé Lacabanne, Maude Bordeleau, Garance Castino, Phillip Kyriakakis, Marie-Ève Tremblay. DOI 10.1016/j.bbi.2021.07.025
Purinergic signaling in nervous system health and disease: Focus on pannexin 1 Pharmacology & Therapeutics, 2021/09. DOI 10.1016/j.pharmthera.2021.107840
Editorial: The Crossroads Between Immunological Disorders and Neuropsychiatric Diseases. A Case for Schizophrenia Frontiers in Cellular Neuroscience, 2021/08/05. DOI 10.3389/fncel.2021.733997
Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring Brain, Behavior, & Immunity - Health, 2021/08. Maude Bordeleau, Lourdes Fernández de Cossío, Chloé Lacabanne, Julie C. Savage, Nathalie Vernoux, Mallar Chakravarty, Marie-Ève Tremblay. DOI 10.1016/j.bbih.2021.100281
Microglial heterogeneity in aging and Alzheimer's disease: Is sex relevant? Journal of Pharmacological Sciences, 2021/07. DOI 10.1016/j.jphs.2021.03.006
Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson’s Disease Frontiers in Cellular Neuroscience, 2021/06/15. DOI 10.3389/fncel.2021.670298
Neuroendocrine, neuroinflammatory and pathological outcomes of chronic stress: A story of microglial remodeling Neurochemistry International, 2021/05. Katherine Picard, Marie-Kim St-Pierre, Haley A. Vecchiarelli, Maude Bordeleau, Marie-Ève Tremblay. DOI 10.1016/j.neuint.2021.104987
Editorial: Synaptic Loss and Neurodegeneration Frontiers in Cellular Neuroscience, 2021/04/21. DOI 10.3389/fncel.2021.681029
Parkinson’s Disease–Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance Molecular Neurobiology, 2021/02/24. DOI 10.1007/s12035-021-02327-8
Microglia Fighting for Neurological and Mental Health: On the Central Nervous System Frontline of COVID-19 Pandemic Frontiers in Cellular Neuroscience, 2021/02/18. DOI 10.3389/fncel.2021.647378
Brain Ultrastructure: Putting the Pieces Together Frontiers in Cell and Developmental Biology, 2021/02/18. DOI 10.3389/fcell.2021.629503
Platelets release mitochondrial antigens in systemic lupus erythematosus Science Translational Medicine, 2021/02/17. DOI 10.1126/scitranslmed.aav5928
The Intellicage system provides a reproducible and standardized method to assess behavioral changes in cuprizone-induced demyelination mouse model Behavioural Brain Research, 2021/02. Giulia Cisbani, Silvia Poggini, Nataly Laflamme, Vincent Pons, Marie-Ève Tremblay, Igor Branchi, Serge Rivest. DOI 10.1016/j.bbr.2020.113039
Structural and Functional Features of Developing Brain Capillaries, and Their Alteration in Schizophrenia Frontiers in Cellular Neuroscience, 2021/01/15. DOI 10.3389/fncel.2020.595002
From Maternal Diet to Neurodevelopmental Disorders: A Story of Neuroinflammation Frontiers in Cellular Neuroscience, 2021/01/15. DOI 10.3389/fncel.2020.612705
Sex differences in microglia as a risk factor for Alzheimer’s disease Sex and Gender Differences in Alzheimer's Disease, 2021. DOI 10.1016/b978-0-12-819344-0.00008-9
A Diversity of Cell Types, Subtypes and Phenotypes in the Central Nervous System: The Importance of Studying Their Complex Relationships Frontiers in Cellular Neuroscience, 2020/12/23. DOI 10.3389/fncel.2020.628347
Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models Frontiers in Cellular Neuroscience, 2020/12/17. DOI 10.3389/fncel.2020.592607
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain Nature Communications, 2020/12. DOI 10.1038/s41467-020-19861-z
Neuropathobiology of COVID-19: The Role for Glia Frontiers in Cellular Neuroscience, 2020/11/11. DOI 10.3389/fncel.2020.592214
Levodopa partially rescues microglial numerical, morphological, and phagolysosomal alterations in a monkey model of Parkinson’s disease Brain, Behavior, and Immunity, 2020/11. DOI 10.1016/j.bbi.2020.07.044
Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells Journal of Pharmacological Sciences, 2020/11. DOI 10.1016/j.jphs.2020.07.011
Sex Differences of Microglia and Synapses in the Hippocampal Dentate Gyrus of Adult Mouse Offspring Exposed to Maternal Immune Activation Frontiers in Cellular Neuroscience, 2020/10/15. DOI 10.3389/fncel.2020.558181
Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 VIP Interneurons During Aging Frontiers in Cellular Neuroscience, 2020/10/14. DOI 10.3389/fncel.2020.554405
Imaging the Neuroimmune Dynamics Across Space and Time Frontiers in Neuroscience, 2020/09/23. DOI 10.3389/fnins.2020.00903
Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice Nature Neuroscience, 2020/09. DOI 10.1038/s41593-020-0663-1
Remodeling microglia to a protective phenotype in Parkinson’s disease? Neuroscience Letters, 2020/09. Ifeoluwa Oluleke Awogbindin, Ismail Ogunbayode Ishola, Marie-Kim St-Pierre, Micaël Carrier, Julie C. Savage, Thérèse Di Paolo, Marie-Ève Tremblay. DOI 10.1016/j.neulet.2020.135164
The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation Frontiers in Cellular Neuroscience, 2020/08/27. DOI 10.3389/fncel.2020.00274
Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration Journal of Clinical Investigation, 2020/08/17. Maud Gratuze, Cheryl E.G. Leyns, Andrew D. Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T. Kummer, Marco Colonna, Jason D. Ulrich, David M. Holtzman. DOI 10.1172/JCI138179
Neuronal hypertrophy dampens neuronal intrinsic excitability and stress responsiveness during chronic stress The Journal of Physiology, 2020/07. DOI 10.1113/jp279666
Microglia: Multiple states and multiple roles in the normal and diseased brain and spinal cord Neuroscience Letters, 2020/06. DOI 10.1016/j.neulet.2020.135019
Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet 2020/05/08. Maude Bordeleau, Chloé Lacabanne, Lourdes Fernández de Cossío, Nathalie Vernoux, Julie C. Savage, Fernando González-Ibáñez, Marie-Eve Tremblay. DOI 10.21203/rs.3.rs-25000/v1
Role of Glia in the Regulation of Sleep in Health and Disease Comprehensive Physiology, 2020/03/12. DOI 10.1002/cphy.c190022
Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets Current Behavioral Neuroscience Reports, 2020/03. DOI 10.1007/s40473-020-00199-1
An antibody for analysis of autophagy induction Nature Methods, 2020/02. DOI 10.1038/s41592-019-0661-y
Shedding Light on the Dark Side of the Microglia ASN Neuro, 2020/01. Marie-Kim St-Pierre, Eva Šimončičová, Eszter Bögi, Marie-Ève Tremblay. DOI 10.1177/1759091420925335
Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington's disease pathology 2019/12/23. Julie Savage, Marie-Kim St-Pierre, Micaël Carrier, Hassan El Hajj, Sammy Novak, Maria Gabriela Sanchez, Francesca Cicchetti, Marie-Eve Tremblay. DOI 10.21203/rs.2.19435/v1
Microglial Ultrastructure in the Hippocampus of a Lipopolysaccharide-Induced Sickness Mouse Model Frontiers in Neuroscience, 2019/12/20. DOI 10.3389/fnins.2019.01340
Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology Journal of Neuroinflammation, 2019/12. DOI 10.1186/s12974-019-1473-9
Mitochondrial sub-cellular localization of cAMP-specific phosphodiesterase 8A in ovarian follicular cells Scientific Reports, 2019/12. DOI 10.1038/s41598-019-48886-8
Glial phagocytic clearance in Parkinson’s disease Molecular Neurodegeneration, 2019/12. DOI 10.1186/s13024-019-0314-8
Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations Scientific Reports, 2019/12. DOI 10.1038/s41598-019-40900-3
Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain Journal of Visualized Experiments, 2019/10/27. DOI 10.3791/60510
Microglia along sex lines: From brain colonization, maturation and function, to implication in neurodevelopmental disorders Seminars in Cell & Developmental Biology, 2019/10. DOI 10.1016/j.semcdb.2019.06.001
Microglial subtypes: diversity within the microglial community The EMBO Journal, 2019/09/02. DOI 10.15252/embj.2019101997
Studying Laboratory Mice – Into the Wild Trends in Neurosciences, 2019/09. DOI 10.1016/j.tins.2019.05.004
Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy Molecular Neurobiology, 2019/09. DOI 10.1007/s12035-019-1539-9
Inflammatory mechanisms in neurodegeneration Journal of Neurochemistry, 2019/06. Michael R. Nichols, Marie‐Kim St‐Pierre, Ann‐Christin Wendeln, Nyasha J. Makoni, Lisa K. Gouwens, Evan C. Garrad, Mona Sohrabi, Jonas J. Neher, Marie‐Eve Tremblay, Colin K. Combs. DOI 10.1111/jnc.14674
Microglia and Neonatal Brain Injury Neuroscience, 2019/05. DOI 10.1016/j.neuroscience.2018.01.023
Platelet abnormalities in Huntington’s disease Journal of Neurology, Neurosurgery & Psychiatry, 2019/03. DOI 10.1136/jnnp-2018-318854
Microglia in the developing prefrontal cortex of rats show dynamic changes following neonatal disconnection of the ventral hippocampus Neuropharmacology, 2019/03. DOI 10.1016/j.neuropharm.2018.12.007
Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury Nature Communications, 2019/01/31. Victor Bellver-Landete, Floriane Bretheau, Benoit Mailhot, Nicolas Vallières, Martine Lessard, Marie-Eve Janelle, Nathalie Vernoux, Marie-Ève Tremblay, Tobias Fuehrmann, Molly S. Shoichet, Steve Lacroix. DOI 10.1038/s41467-019-08446-0
Visualizing Dark Microglia Microglia, 2019. DOI 10.1007/978-1-4939-9658-2_8
Ultrastructural Analyses of Microglial Interactions with Synapses Microglia, 2019. DOI 10.1007/978-1-4939-9658-2_7
Physiology of Microglia Neuroglia in Neurodegenerative Diseases, 2019. DOI 10.1007/978-981-13-9913-8_6
Morphology of Microglia Across Contexts of Health and Disease Microglia, 2019. DOI 10.1007/978-1-4939-9658-2_2
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