Répertoire du corps professoral

Étudier le rôle de la matrice extracellulaire dans la Sclérose Latérale Amyotrophique à l'aide de modèles in vitro 3D personnalisés produits par génie tissulaire
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2025 au 30 septembre 2030

A transcriptomic approach to drug discovery against ARSACS
Organisme(s) subventionnaire(s): Fondation de l'ataxie Charlevoix-Saguenay
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 août 2025 au 31 août 2026

Depicting disease heterogeneity in neurofibromatosis type 1 and the role of dermal fibroblasts in the establishment of microenvironment favouring NF1-associated skin tumor formation using personalized tissue-engineered 3D models
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2023 au 30 septembre 2028

Développement d’un registre de patients sur la neurofibromatose
Organisme(s) subventionnaire(s): L'association de la neurofibromatose du Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 3 août 2023 au 3 août 2026

Comprehensive Analysis Platform To Understand,Remedy and Eliminate ALS
Programme: Subventions de Soutien aux Plateformes
Organisme(s) subventionnaire(s): Brain Canada Foundation
Type de financement: Subvention
Établissement tête: University of Alberta
Du 1 janvier 2021 au 30 juin 2026

Financements des 2 dernières années

L'hyperhomocystéinémie:étude de son potentiel comme biomarqueur du déclin cognitif commun à la démence à corps de Lewy et à la maladie de parkinson pour améliorer le diagnostic et le traitement des patients
Programme: Subvention en recherche clinique (PRCE)
Organisme(s) subventionnaire(s): CHU de Québec – Université Laval – CHUL
Type de financement: Subvention
Établissement tête: Université Laval
Du 23 janvier 2024 au 31 décembre 2024

Étude rétrospective sur le recours à l’aide médicale à mourir en sclérose latérale amyotrophique (SLA/AMM) au CHU de Québec-Université Laval.
Programme: Subvention en recherche clinique (PRCE)
Organisme(s) subventionnaire(s): Fondation du CHU de Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 24 octobre 2023 au 1 novembre 2025

Biobanque PEJ-235
Organisme(s) subventionnaire(s): Fondation du CHU de Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 25 juillet 2023 au 31 mars 2024

Neuro Genomics Patnership (NGP) s’engage à couvrir tous les coûts attribuables au projet pour l’ensemble des activités menées par l’équipe de Dr Dupré relatives au Module 2 du NGP.
Organisme(s) subventionnaire(s): Montreal Neurological Institute
Type de financement: Subvention
Établissement tête: Université McGill
Du 13 avril 2023 au 12 avril 2024

Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2023 au 29 février 2024

Digital measurement of gait as a potential pharmacodynamic/response biomarker for ALS-FTSD
Organisme(s) subventionnaire(s): Target ALS Foundation, Inc.
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 septembre 2022 au 30 juin 2025

The Canadian Parkinson Network
Organisme(s) subventionnaire(s): Parkinson Canada, Brain Canada Foundation
Type de financement: Subvention
Établissement tête: University of Calgary
Du 1 octobre 2018 au 30 mai 2024

Alexandre Paquet, Doctorat en médecine moléculaire

Alexandre Vézina, Doctorat en médecine moléculaire

Encadrements terminés dans les 5 dernières années

Alexandre Paquet, Maîtrise en sciences cliniques et biomédicales - avec mémoire

Alexandre Vézina, Maîtrise en neurosciences - avec mémoire

Vincent Clément, Doctorat en sciences cliniques et biomédicales

Catherine Déry, Maîtrise en sciences cliniques et biomédicales - avec mémoire

Publications des 5 dernières années

Neuroimaging in Cerebellar Ataxias: A Diagnostic Approach The Cerebellum, 2025/09/13. Alex Tiburtino Meira, Thiago Cardoso Vale, Sophia C. G. da Costa, Claudie Gauvreau, Camila Callegari Piccinin, Hélio A. G. Teive, Marcondes C. França, Jr, Nicolas Dupré, Orlando G. Barsottini, José Luiz Pedroso. DOI 10.1007/s12311-025-01908-w

Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation-Based Morphometry Study Annals of Neurology, 2025. Lajoie, I., Kalra, S., Hanstock, C., Wilman, A., Eurich, D., Beaulieu, C., Yang, Y.H., Korngut, L., Frayne, R., Briemberg, H., Zinman, L., Graham, S., Genge, A., Dionne, A., Dupré, N., Shoesmith, C., Benatar, M., Welsh, R., Kalra, S., Dadar, M.. DOI 10.1002/ana.27196

Multimodal Neuroimaging-Guided Stratification in Amyotrophic Lateral Sclerosis Reveals Three Disease Subtypes: A Multi-Cohort Analysis Human Brain Mapping, 2025. Baumeister, T.R., Westeneng, H.-J., van den Berg, L., Wilman, A., Eurich, D., Beaulieu, C., Yang, Y.H., Korngut, L., Frayne, R., Briemberg, H., Zinman, L., Abrahao, A., Graham, S., Genge, A., Dionne, A., Dupré, N., Shoesmith, C., Benatar, M., Welsh, R., Kalra, S., Iturria-Medina, Y.. DOI 10.1002/hbm.70341

Loss-of-Function Variants in CPT1C: No Support for a Causal Role in Hereditary Spastic Paraplegia Movement Disorders, 2025. Zhu, R., Liu, L., Estiar, M.A., Asayesh, F., Ahmad, J., Teferra, M., Yoon, G., Tarnopolsky, M., Boycott, K.M., Dupre, N., Dion, P.A., Suchowersky, O., Jordanova, A., Lee, Y.-C., Stevanin, G., Zuchner, S., Rouleau, G.A., Gan-Or, Z.. DOI 10.1002/mds.70144

Lack of association between G6PD variants and Parkinson’s disease Medrxiv, 2025. Chifamba, L.V., Parlar, S.C., Liu, L., Sokol, L.L., Yu, E., Asayesh, F., Ahmad, J., Ruskey, J.A., Spiegelman, D., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Timofeeva, A., Emelyanov, A., Pchelina, S., Miliukhina, I., Greenbaum, L., Hassin-Baer, S., Alcalay, R.N., Espay, A.J., Gan-Or, Z., Senkevich, K.. DOI 10.1101/2025.04.23.25324774

LRRK2 rare-variant per-domain genetic burden in Parkinson’s Disease: association confined to the kinase domain Npj Parkinson S Disease, 2025. Parlar, S.C., Senkevich, K., Yu, E., Ruskey, J.A., Ahmad, J., Asayesh, F., Spiegelman, D., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Greenbaum, L., Hassin-Baer, S., Miliukhina, I., Timofeeva, A., Emelyanov, A., Pchelina, S., Alcalay, R.N., Fon, E.A., Trempe, J.-F., Gan-Or, Z.. DOI 10.1038/s41531-025-00934-z

Early detection of Parkinson's disease: Retinal functional impairments as potential biomarkers Neurobiology of Disease, 2025. Soto Linan, V., Rioux, V., Peralta, M., Dupré, N., Hébert, M., Lévesque, M.. DOI 10.1016/j.nbd.2025.106872

Comprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study Plos One, 2025. Saunders, N., Magnussen, C., Kang, H., Blais, M., Bhinder, H., Pfeffer, G., Genuis, S.K., Bouvier, L., Anand, T., Abou-Haidar, R., Abrahao, A., Boivin, M.-N., Bowser, R., Bubela, T., Chiappini, J., Das, S., Dhanoa, A., Dupré, N., Evans, A., Ferry, N., Frater, Y., Genge, A., Graham, S.J., Greiner, R., Medina, Y.I., Johnston, W.S., Jones, K.E., Karamchandani, J., Kriz, J., Luth, W., Matte, G., Rogaeva, E., Robertson, J., Seres, P., Tam, F., Taylor, D., Tremblay-Desbiens, C., Velde, C.V., Yunusova, Y., Zinman, L., Kalra, S.. DOI 10.1371/journal.pone.0332430

ARSACS: Clinical Features, Pathophysiology and iPS-Derived Models Cerebellum, 2025. Salem, I.H., Blais, M., Zuluaga-Sánchez, V.M., Rouleau, L., Becker, E.B.E., Dupré, N.. DOI 10.1007/s12311-024-01777-9

ALS, MAiD and Tissue Donation: Case Reports from Six Patients' Care Journeys Canadian Journal of Neurological Sciences, 2025. Trudel, P., Quesnel-Olivo, M.-H., Blais, M., Shoesmith, C., Dupré, N.. DOI 10.1017/cjn.2024.277

ALS patients and PAD: description and comparison of patients from a neuromuscular clinic in Canada Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2025. Trudel, P., Quesnel-Olivo, M.-H., Blais, M., Ramanathan, U., Dupré, N.. DOI 10.1080/21678421.2025.2539894

Oral Levodopa Therapy, Vitamin B6 and Peripheral Neuropathy: A Cross‐Sectional Observational Study Movement Disorders Clinical Practice, 2025/01. Catherine Déry, Charlie Buchmann, Geneviève Labrecque, Vicky Caron, David Simonyan, Mathieu Blais, Manon Bouchard, Nicolas Dupré. DOI 10.1002/mdc3.14243

The neurophysiological brain-fingerprint of Parkinson's disease Ebiomedicine, 2024. da Silva Castanheira, J., Wiesman, A.I., Hansen, J.Y., Misic, B., Baillet, S., Breitner, J., Poirier, J., Bellec, P., Bohbot, V., Chakravarty, M., Collins, L., Etienne, P., Evans, A., Gauthier, S., Hoge, R., Ituria-Medina, Y., Multhaup, G., Münter, L.-M., Rajah, N., Rosa-Neto, P., Soucy, J.-P., Vachon-Presseau, E., Villeneuve, S., Amouyel, P., Appleby, M., Ashton, N., Auld, D., Ayranci, G., Bedetti, C., Beland, M.-L., Blennow, K., Westman, A.B., Cuello, C., Dadar, M., Daoust, L.-A., Das, S., Dauar-Tedeschi, M., De Beaumont, L., Dea, D., Descoteaux, M., Dufour, M., Farzin, S., Ferdinand, F., Fonov, V., Gonneaud, J., Kat, J., Kazazian, C., Labonté, A., Lafaille-Magnan, M.-E., Lalancette, M., Lambert, J.-C., Leoutsakos, J.-M., Mahar, L., Mathieu, A., McSweeney, M., Meyer, P.-F., Miron, J., Near, J., NewboldFox, H., Nilsson, N., Orban, P., Picard, C., Binette, A.P., Poline, J.-B., Rabipour, S., Salaciak, A., Settimi, M., Subramaniapillai, S., Tam, A., Tardif, C., Théroux, L., Tremblay-Mercier, J., Tullo, S., Ulku, I., Vallée, I., Zetterberg, H., Nair, V., Pruessner, J., Aisen, P., Anthal, E., Barkun, A., Beaudry, T., Benbouhoud, F., Brandt, J., Carmo, L., Carrier, C.E., Cheewakriengkrai, L., Courcot, B., Couture, D., Craft, S., Dansereau, C., Debacker, C., Desautels, R., Dubuc, S., Duclair, G., Eisenberg, M., El-Khoury, R., Faubert, A.-M., Fontaine, D., Frappier, J., Frenette, J., Gagné, G., Gervais, V., Giles, R., Gordon, R., Jack, C., Jutras, B., Khachaturian, Z., Knopman, D., Kostopoulos, P., Lapalme, F., Lee, T., Lepage, C., Leppert, I., Madjar, C., Maillet, D., Maltais, J.-R., Mathotaarachchi, S., Mayrand, G., Michaud, D., Montine, T., Morris, J., Pagé, V., Pascoal, T., Peillieux, S., Petkova, M., Pogossova, G., Rioux, P., Sager, M., Saint-Fort, E.F., Savard, M., Sperling, R., Tabrizi, S., Tariot, P., Teigner, E., Thomas, R., Toussaint, P.-J., Tuwaig, M., Venugopalan, V., Verfaillie, S., Vogel, J., Wan, K., Wang, S., Yu, E., Beaulieu-Boire, I., Blanchet, P., Bogard, S., Bouchard, M., Chouinard, S., Cicchetti, F., Cloutier, M., Dagher, A., Degroot, C., Desautels, A., Dion, M.H., Drouin-Ouellet, J., Dufresne, A.-M., Dupré, N., Duquette, A., Durcan, T., Fellows, L.K., Fon, E., Gagnon, J.-F., Gan-Or, Z., Genge, A., Jodoin, N., Karamchandani, J., Lafontaine, A.-L., Langlois, M., Leveille, E., Lévesque, M., Melmed, C., Monchi, O., Montplaisir, J., Panisset, M., Parent, M., Pham-An, M.-T., Postuma, R., Pourcher, E., Rao, T., Rivest, J., Rouleau, G., Sharp, M., Soland, V., Sidel, M., Wing Sun, S.L., Thiel, A., Vitali, P.. DOI 10.1016/j.ebiom.2024.105201

The importance of synthetic pharmacotherapy for recessive cerebellar ataxias Expert Review of Neurotherapeutics, 2024. Beaudin, M., Dupre, N., Manto, M.. DOI 10.1080/14737175.2024.2376840

The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons Research Square, 2024. Jones-Tabah, J., He, K., Senkevich, K., Karpilovsky, N., Deyab, G., Cousineau, Y., Nikanorova, D., Goldsmith, T., Pellitero, E.D.-C., Chen, C.X.Q., Luo, W., You, Z., Abdian, N., Pietrantonio, I., Goiran, T., Ahmad, J., Ruskey, J.A., Asayesh, F., Spiegelman, D., Waters, C., Monchi, O., Dauvilliers, Y., Dupre, N., Miliukhina, I., Timofeeva, A., Emelyanov, A., Pchelina, S., Greenbaum, L., HassinBaer, S., Alcalay, R.N., Milnerwood, A., Durcan, T.M., Gan-Or, Z., Fon, E.A.. DOI 10.21203/rs.3.rs-3979098/v1

The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons Molecular Neurodegeneration, 2024. Jones-Tabah, J., He, K., Karpilovsky, N., Senkevich, K., Deyab, G., Pietrantonio, I., Goiran, T., Cousineau, Y., Nikanorova, D., Goldsmith, T., del Cid Pellitero, E., Chen, C.X.Q., Luo, W., You, Z., Abdian, N., Ahmad, J., Ruskey, J.A., Asayesh, F., Spiegelman, D., Fahn, S., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Miliukhina, I., Timofeeva, A., Emelyanov, A., Pchelina, S., Greenbaum, L., Hassin-Baer, S., Alcalay, R.N., Milnerwood, A., Durcan, T.M., Gan-Or, Z., Fon, E.A.. DOI 10.1186/s13024-024-00779-9

Speech timing and monosyllabic diadochokinesis measures in the assessment of amyotrophic lateral sclerosis in Canadian French International Journal of Speech Language Pathology, 2024. Bouvier, L., McKinlay, S., Truong, J., Genge, A., Dupré, N., Dionne, A., Kalra, S., Yunusova, Y.. DOI 10.1080/17549507.2023.2214706

Reduction of sacsin levels in peripheral blood mononuclear cells as a diagnostic tool for spastic ataxia of Charlevoix-Saguenay Brain Communications, 2024. De Ritis, D., Ferrè, L., De Winter, J., Tremblay-Desbiens, C., Blais, M., Bassi, M.T., Dupré, N., Baets, J., Filippi, M., Maltecca, F.. DOI 10.1093/braincomms/fcae243

Rare-variant and polygenic analyses of amyotrophic lateral sclerosis in the French-Canadian genome Genetics in Medicine, 2024. Ross, J.P., Akçimen, F., Liao, C., Kwan, K., Phillips, D.E., Schmilovich, Z., Spiegelman, D., Genge, A., Dupré, N., Dion, P.A., Farhan, S.M.K., Rouleau, G.A.. DOI 10.1016/j.gim.2023.100967

Mismatch between clinically defined classification of ALS stage and the burden of cerebral pathology Journal of Neurology, 2024. Parnianpour, P., Benatar, M., Briemberg, H., Dey, A., Dionne, A., Dupré, N., Evans, K.C., Frayne, R., Genge, A., Graham, S.J., Korngut, L., McLaren, D.G., Seres, P., Welsh, R.C., Wilman, A., Zinman, L., Kalra, S.. DOI 10.1007/s00415-024-12190-x

Inhibition of NF-κB with an Analog of Withaferin-A Restores TDP-43 Homeostasis and Proteome Profiles in a Model of Sporadic ALS Biomedicines, 2024. Mishra, P.S., Phaneuf, D., Boutej, H., Picher-Martel, V., Dupre, N., Kriz, J., Julien, J.-P.. DOI 10.3390/biomedicines12051017

Correction to: The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons (Molecular Neurodegeneration, (2024), 19, 1, (88), 10.1186/s13024-024-00779-9) Molecular Neurodegeneration, 2024. Jones-Tabah, J., He, K., Karpilovsky, N., Senkevich, K., Deyab, G., Pietrantonio, I., Goiran, T., Cousineau, Y., Nikanorova, D., Goldsmith, T., del Cid Pellitero, E., Chen, C.X.Q., Luo, W., You, Z., Abdian, N., Ahmad, J., Ruskey, J.A., Asayesh, F., Spiegelman, D., Fahn, S., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Miliukhina, I., Timofeeva, A., Emelyanov, A., Pchelina, S., Greenbaum, L., Hassin-Baer, S., Alcalay, R.N., Milnerwood, A., Durcan, T.M., Gan-Or, Z., Fon, E.A.. DOI 10.1186/s13024-024-00791-z

Chronically activated microglia in ALS gradually lose their immune functions and develop unconventional proteome GLIA, 2024. Barreto-Núñez, R., Béland, L.-C., Boutej, H., Picher-Martel, V., Dupré, N., Barbeito, L., Kriz, J.. DOI 10.1002/glia.24531

Are rare heterozygous SYNJ1 variants associated with Parkinson’s disease? Npj Parkinson S Disease, 2024. Senkevich, K., Parlar, S.C., Chantereault, C., Yu, E., Ahmad, J., Ruskey, J.A., Asayesh, F., Spiegelman, D., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Miliukhina, I., Timofeeva, A., Emelyanov, A., Pchelina, S., Greenbaum, L., Hassin-Baer, S., Alcalay, R.N., Gan-Or, Z.. DOI 10.1038/s41531-024-00809-9

Are rare heterozygous SYNJ1 variants associated with Parkinson's disease? Medrxiv, 2024. Senkevich, K., Parlar, S.C., Chantereault, C., Yu, E., Ahmad, J., Ruskey, J.A., Asayesh, F., Spiegelman, D., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Miliukhina, I., Timofeeva, A., Emelyanov, A., Pchelina, S., Greenbaum, L., Hassin-Baer, S., Alcalay, R.N., Gan-Or, Z.. DOI 10.1101/2024.05.29.24307986

Advancing Parkinson's Disease Research in Canada: The Canadian Open Parkinson Network (C-OPN) Cohort Medrxiv, 2024. Cressatti, M., Pinilla-Monsalve, G.D., Blais, M., Normandeau, C.P., Degroot, C., Kathol, I., Bogard, S., Bendas, A., Camicioli, R., Dupré, N., Gan-Or, Z., Grimes, D.A., Kalia, L.V., MacDonald, P.A., McKeown, M.J., Martino, D., Miyasaki, J.M., Schlossmacher, M.G., Stoessl, A.J., Strafella, A.P., Fon, E.A., Monchi, O.. DOI 10.1101/2024.05.29.24307196

Advancing Parkinson's Disease Research in Canada: The Canadian Open Parkinson Network (C-OPN) Cohort Journal of Parkinson S Disease, 2024. Cressatti, M., Pinilla-Monsalve, G.D., Blais, M., Normandeau, C.P., Degroot, C., Kathol, I., Bogard, S., Bendas, A., Camicioli, R., Dupré, N., Gan-Or, Z., Grimes, D.A., Kalia, L.V., MacDonald, P.A., McKeown, M.J., Martino, D., Miyasaki, J.M., Schlossmacher, M.G., Stoessl, A.J., Strafella, A.P., Fon, E.A., Monchi, O.. DOI 10.3233/JPD-240213

Treatment and Management of Autosomal Recessive Cerebellar Ataxias: Current Advances and Future Perspectives CNS and Neurological Disorders Drug Targets, 2023. Salem, I.H., Beaudin, M., Klein, C.J., Dupré, N.. DOI 10.2174/1871527321666220418114846

The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons Biorxiv, 2023. Jones-Tabah, J., He, K., Senkevich, K., Karpilovsky, N., Deyab, G., Cousineau, Y., Nikanorova, D., Goldsmith, T., del Cid Pellitero, E., Chen, C.X.-Q., Luo, W., You, Z., Abdian, N., Pietrantonio, I., Goiran, T., Ahmad, J., Ruskey, J.A., Asayesh, F., Spiegelman, D., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Miliukhina, I., Timofeeva, A., Emelyanov, A., Pchelina, S., Greenbaum, L., Hassin-Baer, S., Alcalay, R.N., Milnerwood, A., Durcan, T.M., Gan-Or, Z., Fon, E.A.. DOI 10.1101/2023.11.11.566693

Scale for Ocular Motor Disorders in Ataxia (SODA): Procedures and Basic Understanding Contemporary Clinical Neuroscience, 2023. Shaikh, A.G., Kim, J.-S., Froment, C., Koo, Y.J., Dupre, N., Hadjivassiliou, M., Honnorat, J., Kothari, S., Mitoma, H., Rodrigue, X., Schmahmann, J., Soong, B.-W., Subramony, S.H., Strupp, M., Manto, M.. DOI 10.1007/978-3-031-24345-5_11

SF2Former: Amyotrophic lateral sclerosis identification from multi-center MRI data using spatial and frequency fusion transformer Computerized Medical Imaging and Graphics, 2023. Kushol, R., Luk, C.C., Dey, A., Benatar, M., Briemberg, H., Dionne, A., Dupré, N., Frayne, R., Genge, A., Gibson, S., Graham, S.J., Korngut, L., Seres, P., Welsh, R.C., Wilman, A.H., Zinman, L., Kalra, S., Yang, Y.-H.. DOI 10.1016/j.compmedimag.2023.102279

SF2Former: Amyotrophic Lateral Sclerosis Identification From Multi-center MRI Data Using Spatial and Frequency Fusion Transformer Arxiv, 2023. Kushol, R., Luk, C.C., Dey, A., Benatar, M., Briemberg, H., Dionne, A., Dupré, N., Frayne, R., Genge, A., Gibson, S., Graham, S.J., Korngut, L., Seres, P., Welsh, R.C., Wilman, A., Zinman, L., Kalra, S., Yang, Y.-H.. DOI 10.48550/arXiv.2302.10859

RNF213 Loss-of-Function Promotes Angiogenesis of Cerebral Microvascular Endothelial Cells in a Cellular State Dependent Manner Cells, 2023. Roy, V., Brodeur, A., Touzel Deschênes, L., Dupré, N., Gros-Louis, F.. DOI 10.3390/cells12010078

In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay Stem Cells International, 2023. Louit, A., Beaudet, M.-J., Blais, M., Gros-Louis, F., Dupré, N., Berthod, F.. DOI 10.1155/2023/1496597

Heterozygous NF1 dermal fibroblasts modulate exosomal content to promote angiogenesis in a tissue-engineered skin model of neurofibromatosis type-1 Journal of Neurochemistry, 2023. Roy, V., Paquet, A., Touzel-Deschênes, L., Khuong, H.T., Dupré, N., Gros-Louis, F.. DOI 10.1111/jnc.15982

GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson’s disease Brain, 2023. Senkevich, K., Zorca, C.E., Dworkind, A., Rudakou, U., Somerville, E., Yu, E., Ermolaev, A., Nikanorova, D., Ahmad, J., Ruskey, J.A., Asayesh, F., Spiegelman, D., Fahn, S., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Greenbaum, L., Hassin-Baer, S., Grenn, F.P., Chiang, M.S.R., Sardi, S.P., Vanderperre, B., Blauwendraat, C., Trempe, J.-F., Fon, E.A., Durcan, T.M., Alcalay, R.N., Gan-Or, Z.. DOI 10.1093/brain/awac413

Distinct Plasma Immune Profile in ALS Implicates sTNFR-II in pAMPK/Leptin Homeostasis International Journal of Molecular Sciences, 2023. Picher-Martel, V., Boutej, H., Vézina, A., Cordeau, P., Kaneb, H., Julien, J.-P., Genge, A., Dupré, N., Kriz, J.. DOI 10.3390/ijms24065065

CAPTURE ALS: the comprehensive analysis platform to understand, remedy and eliminate ALS Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2023. Picher-Martel, V., Magnussen, C., Blais, M., Bubela, T., Das, S., Dionne, A., Evans, A.C., Genge, A., Greiner, R., Iturria-Medina, Y., Johnston, W., Jones, K., Kaneb, H., Karamchandani, J., Moradipoor, S., Robertson, J., Rogaeva, E., Taylor, D.M., Vande Velde, C., Yunusova, Y., Zinman, L., Kalra, S., Dupré, N.. DOI 10.1080/21678421.2022.2041668

Autosomal and X-Linked Degenerative Ataxias: From Genetics to Promising Therapeutics Contemporary Clinical Neuroscience, 2023. Hadji, A., Louit, A., Roy, V., Blais, M., Berthod, F., Gros-Louis, F., Dupré, N.. DOI 10.1007/978-3-031-24345-5_5

Autosomal Recessive Ataxias Essentials of Cerebellum and Cerebellar Disorders A Primer for Graduate Students Second Edition, 2023. Beaudin, M., Salem, I.H., Dupré, N.. DOI 10.1007/978-3-031-15070-8_83

Association of rare variants in ARSA with Parkinson’s disease Medrxiv, 2023. Senkevich, K., Beletskaia, M., Dworkind, A., Yu, E., Ahmad, J., Ruskey, J.A., Asayesh, F., Spiegelman, D., Fahn, S., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Greenbaum, L., Hassin-Baer, S., Nagornov, I., Tyurin, A., Miliukhina, I., Timofeeva, A., Emelyanov, A., Zakharova, E., Alcalay, R.N., Pchelina, S., Gan-Or, Z.. DOI 10.1101/2023.03.08.23286773

Association of Rare Variants in ARSA with Parkinson's Disease Movement Disorders, 2023. Senkevich, K., Beletskaia, M., Dworkind, A., Yu, E., Ahmad, J., Ruskey, J.A., Asayesh, F., Spiegelman, D., Fahn, S., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Greenbaum, L., Hassin-Baer, S., Nagornov, I., Tyurin, A., Miliukhina, I., Timofeeva, A., Emelyanov, A., Trempe, J.-F., Zakharova, E., Alcalay, R.N., Pchelina, S., Gan-Or, Z.. DOI 10.1002/mds.29521

An Exploratory Survey on the Care for Ataxic Patients in the American Continents and the Caribbean Cerebellum, 2023. Jardim, L.B., Hasan, A., Kuo, S.-H., Magaña, J.J., França, M., Marques, W., Camejo, C., Santana-da-Silva, L.C., Leão, E.E., Espíndola, G., Canals, F., Miranda, M., Salvatierra, I., Cornejo-Olivas, M., Fernandez-Ruiz, J., Braga-Neto, P., Dávila-Ortiz de Montellano, D.J., Flores-Lagunes, L.L., Dupré, N., Brais, B., Vargas, F.R., Godeiro, C., Coutinho, L., Teive, H.G., Kaufmann, M., Saffie, P., Furtado, G.V., Saraiva-Pereira, M.L., Barsottini, O., Pedroso, J.L., Rodríguez-Labrada, R., Velázquez-Pérez, L., Gomez, C.. DOI 10.1007/s12311-022-01442-z

A systematic review of the potential consequences of abnormal serum levels of vitamin B6 in people living with Parkinson's disease Journal of the Neurological Sciences, 2023. Modica, J.S., Déry, C., Canissario, R., Logigian, E., Bonno, D., Stanton, M., Dupré, N., McDermott, M.P., Bouchard, M., Lang, A.E., Lizarraga, K.J.. DOI 10.1016/j.jns.2023.120690

Scale for Ocular motor Disorders in Ataxia (SODA) Journal of the Neurological Sciences, 2022. Shaikh, A.G., Kim, J.-S., Froment, C., Koo, Y.J., Dupre, N., Hadjivassiliou, M., Honnorat, J., Kothari, S., Mitoma, H., Rodrigue, X., Soong, B.-W., Subramony, S.H., Strupp, M., Schmahmann, J., Manto, M.. DOI 10.1016/j.jns.2022.120472

Recessive cerebellar and afferent ataxias — clinical challenges and future directions Nature Reviews Neurology, 2022. Beaudin, M., Manto, M., Schmahmann, J.D., Pandolfo, M., Dupre, N.. DOI 10.1038/s41582-022-00634-9

Rare and common variant analyses of amyotrophic lateral sclerosis in the French-Canadian genome Medrxiv, 2022. Ross, J.P., Akçimen, F., Liao, C., Kwan, K., Phillips, D.E., Schmilovich, Z., Spiegelman, D., Genge, A., Dupré, N., Dion, P.A., Farhan, S.M.K., Rouleau, G.A.. DOI 10.1101/2022.08.11.22278628

Questioning the association of the STMN2 dinucleotide repeat with ALS Medrxiv, 2022. Ross, J.P., Akcimen, F., Liao, C., Spiegelman, D., Weisburd, B., Dupré, N., Dion, P.A., Rouleau, G.A., Farhan, S.M.K.. DOI 10.1101/2022.04.30.22273566

Questioning the Association of the STMN2 Dinucleotide Repeat With Amyotrophic Lateral Sclerosis Neurology Genetics, 2022. Ross, J.P., Akçimen, F., Liao, C., Spiegelman, D., Weisburd, B., Dupré, N., Dion, P.A., Rouleau, G.A., Farhan, S.M.K.. DOI 10.1212/NXG.0000000000000678

Persisting chemosensory impairments in 366 healthcare workers following COVID-19: an 11-month follow-up Chemical Senses, 2022. Bussiere, N., Mei, J., Levesque-Boissonneault, C., Blais, M., Carazo, S., Gros-Louis, F., Laforce, R., De Serres, G., Dupre, N., Frasnelli, J.. DOI 10.1093/chemse/bjac010

Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function Stroke, 2022. Roy, V., Ross, J.P., Pépin, R., Cortez Ghio, S., Brodeur, A., Touzel Deschênes, L., Le-Bel, G., Phillips, D.E., Milot, G., Dion, P.A., Guérin, S., Germain, L., Berthod, F., Auger, F.A., Rouleau, G.A., Dupré, N., Gros-Louis, F.. DOI 10.1161/STROKEAHA.120.032691

Goal management training and psychoeducation/mindfulness for treatment of executive dysfunction in Parkinson's disease: A feasibility pilot trial Plos One, 2022. Giguère-Rancourt, A., Plourde, M., Racine, E., Couture, M., Langlois, M., Dupré, N., Simard, M.. DOI 10.1371/journal.pone.0263108

Genetic, structural and clinical analysis of spastic paraplegia 4 Parkinsonism and Related Disorders, 2022. Varghaei, P., Estiar, M.A., Ashtiani, S., Veyron, S., Mufti, K., Leveille, E., Yu, E., Spiegelman, D., Rioux, M.-F., Yoon, G., Tarnopolsky, M., Boycott, K.M., Dupre, N., Suchowersky, O., Trempe, J.-F., Rouleau, G.A., Gan-Or, Z.. DOI 10.1016/j.parkreldis.2022.03.019

Genetic testing for amyotrophic lateral sclerosis in Canada–an assessment of current practices Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2022. Salmon, K., Anoja, N., Breiner, A., Chum, M., Dionne, A., Dupré, N., Fiander, A., Fok, D., Ghavanini, A., Gosselin, S., Izenberg, A., Johnston, W., Kalra, S., Matte, G., Melanson, M., O’Connell, C., Ritsma, B., Schellenberg, K., Shoesmith, C., Tremblay, S., Williams, H., Genge, A.. DOI 10.1080/21678421.2021.1980890

GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson’s disease Medrxiv, 2022. Senkevich, K., Zorca, C.E., Dworkind, A., Rudakou, U., Somerville, E., Yu, E., Ermolaev, A., Nikanorova, D., Ahmad, J., Ruskey, J.A., Asayesh, F., Spiegelman, D., Fahn, S., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Greenbaum, L., Hassin-Baer, S., Grenn, F.P., Ruby Chiang, M.S., Sardi, S.P., Vanderperre, B., Blauwendraat, C., Trempe, J.-F., Fon, E.A., Durcan, T.M., Alcalay, R.N., Gan-Or, Z.. DOI 10.1101/2022.04.30.22274239

Functional alterations in large-scale resting-state networks of amyotrophic lateral sclerosis: A multi-site study across Canada and the United States Plos One, 2022. Bharti, K., Graham, S.J., Benatar, M., Briemberg, H., Chenji, S., Dupré, N., Dionne, A., Frayne, R., Genge, A., Korngut, L., Luk, C., Zinman, L., Kalra, S.. DOI 10.1371/journal.pone.0269154

Environmental risk factors for amyotrophic lateral sclerosis: a case–control study in Canada and France Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2022. Beaudin, M., Salachas, F., Pradat, P.-F., Dupré, N.. DOI 10.1080/21678421.2022.2028167

Distinct patterns of progressive gray and white matter degeneration in amyotrophic lateral sclerosis Human Brain Mapping, 2022. Ishaque, A., Ta, D., Khan, M., Zinman, L., Korngut, L., Genge, A., Dionne, A., Briemberg, H., Luk, C., Yang, Y.-H., Beaulieu, C., Emery, D., Eurich, D.T., Frayne, R., Graham, S., Wilman, A., Dupré, N., Kalra, S.. DOI 10.1002/hbm.25738

Case Report: Acute Necrotizing Encephalopathy Following COVID-19 Vaccine Frontiers in Neurology, 2022. Bensaidane, M.R., Picher-Martel, V., Émond, F., De Serres, G., Dupré, N., Beauchemin, P.. DOI 10.3389/fneur.2022.872734

Association of Essential Tremor with Novel Risk Loci: A Genome-Wide Association Study and Meta-analysis JAMA Neurology, 2022. Liao, C., Castonguay, C.-E., Heilbron, K., Vuokila, V., Medeiros, M., Houle, G., Akçimen, F., Ross, J.P., Catoire, H., Diez-Fairen, M., Kang, J., Mueller, S.H., Girard, S.L., Hopfner, F., Lorenz, D., Clark, L.N., Soto-Beasley, A.I., Klebe, S., Hallett, M., Wszolek, Z.K., Pendziwiat, M., Lorenzo-Betancor, O., Seppi, K., Berg, D., Vilariño-Güell, C., Postuma, R.B., Bernard, G., Dupré, N., Jankovic, J., Testa, C.M., Ross, O.A., Arzberger, T., Chouinard, S., Louis, E.D., Mandich, P., Vitale, C., Barone, P., García-Martín, E., Alonso-Navarro, H., Agúndez, J.A.G., Jiménez-Jiménez, F.J., Pastor, P., Rajput, A., Deuschl, G., Kuhlenbaümer, G., Meijer, I.A., Dion, P.A., Rouleau, G.A.. DOI 10.1001/jamaneurol.2021.4781

Altered Theory of Mind in Parkinson's Disease and Impact on Caregivers: A Pilot Study Canadian Journal of Neurological Sciences, 2022. Giguère-Rancourt, A., Plourde, M., Racine, E., Couture, M., Langlois, M., Dupré, N., Simard, M.. DOI 10.1017/cjn.2021.110

The Canadian Neuromuscular Disease Registry 2010-2019: A Decade of Facilitating Clinical Research Througha Nationwide, Pan-NeuromuscularDisease Registry Journal of Neuromuscular Diseases, 2021. Hodgkinson, V., Lounsberry, J., M'Dahoma, S., Russell, A., Jewett, G., Benstead, T., Brais, B., Campbell, C., Johnston, W., Lochmuller, H., McCormick, A., Nguyen, C.T., O'Ferrall, E., Oskoui, M., Abrahao, A., Briemberg, H., Bourque, P.R., Botez, S., Cashman, N., Chapman, K., Chrestian, N., Crone, M., Dobrowolski, P., Dojeiji, S., Dowling, J.J., Dupre, N., Genge, A., Gonorazky, H., Grant, I., Hasal, S., Izenberg, A., Kalra, S., Katzberg, H., Krieger, C., Leung, E., Linassi, G., Mackenzie, A., Mah, J.K., Marrero, A., Massie, R., Matte, G., McAdam, L., McMillan, H., Melanson, M., Mezei, M.M., O'Connell, C., Pfeffer, G., Phan, C., Plamondon, S., Poulin, C., Rodrigue, X., Schellenberg, K., Selby, K., Sheriko, J., Shoesmith, C., Smith, R.G., Taillon, M., Taylor, S., Venance, S., Warman-Chardon, J., Worley, S., Zinman, L., Korngut, L.. DOI 10.3233/JND-200538

Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associations Brain, 2021. Rudakou, U., Yu, E., Krohn, L., Ruskey, J.A., Asayesh, F., Dauvilliers, Y., Spiegelman, D., Greenbaum, L., Fahn, S., Waters, C.H., Dupré, N., Rouleau, G.A., Hassin-Baer, S., Fon, E.A., Alcalay, R.N., Gan-Or, Z.. DOI 10.1093/brain/awaa401

Persisting Chemosensory Impairments in 366 Healthcare Workers Following COVID-19: An 11-Month Follow-up Medrxiv, 2021. Bussiere, N., Mei, J., Levesque-Boissonneault, C., Blais, M., Carazo, S., Gros-Louis, F., Laforce, R., De Serres, G., Dupre, N., Frasnelli, J.. DOI 10.1101/2021.12.20.21268066

Genetic, structural and clinical analysis of spastic paraplegia 4 Medrxiv, 2021. Varghaei, P., Estiar, M.A., Ashtiani, S., Veyron, S., Mufti, K., Leveille, E., Yu, E., Spiegelman, D., Rioux, M.-F., Yoon, G., Tarnopolsky, M., Boycott, K., Dupre, N., Suchowersky, O., Trempe, J.-F., Rouleau, G.A., Gan-Or, Z.. DOI 10.1101/2021.07.20.21259482

Genetic and Epidemiological Study of Adult Ataxia and Spastic Paraplegia in Eastern Quebec Canadian Journal of Neurological Sciences, 2021. Salem, I.H., Beaudin, M., Stumpf, M., Estiar, M.A., Côté, P.-O., Brunet, F., Gamache, P.-L., Rouleau, G.A., Mourabit-Amari, K., Gan-Or, Z., Dupré, N.. DOI 10.1017/cjn.2020.277

GCH1 mutations in hereditary spastic paraplegia Medrxiv, 2021. Varghaei, P., Yoon, G., Estiar, M.A., Veyron, S., Leveille, E., Dupre, N., Trempe, J.-F., Rouleau, G.A., Gan-Or, Z.. DOI 10.1101/2021.01.14.21249305

GCH1 mutations in hereditary spastic paraplegia Clinical Genetics, 2021. Varghaei, P., Yoon, G., Estiar, M.A., Veyron, S., Leveille, E., Dupré, N., Trempe, J.-F., Rouleau, G.A., Gan-Or, Z.. DOI 10.1111/cge.13955

Evidence for Non-Mendelian Inheritance in Spastic Paraplegia 7 Movement Disorders, 2021. Estiar, M.A., Yu, E., Haj Salem, I., Ross, J.P., Mufti, K., Akçimen, F., Leveille, E., Spiegelman, D., Ruskey, J.A., Asayesh, F., Dagher, A., Yoon, G., Tarnopolsky, M., Boycott, K.M., Dupre, N., Dion, P.A., Suchowersky, O., Trempe, J.-F., Rouleau, G.A., Gan-Or, Z.. DOI 10.1002/mds.28528

Effect of neuroprotective magnesium sulfate treatment on brain transcription response to hypoxia ischemia in neonate mice International Journal of Molecular Sciences, 2021. Le Dieu-Lugon, B., Dupré, N., Derambure, C., Janin, F., Gonzalez, B.J., Marret, S., Arabo, A., Leroux, P.. DOI 10.3390/ijms22084253

Clinical perception and management of Parkinson's disease during the COVID-19 pandemic: A Canadian experience Parkinsonism and Related Disorders, 2021. de Rus Jacquet, A., Bogard, S., Normandeau, C.P., Degroot, C., Postuma, R.B., Dupré, N., Miyasaki, J.M., Monchi, O., Martino, D., Fon, E.A., Cicchetti, F.. DOI 10.1016/j.parkreldis.2021.08.018

Chemosensory dysfunctions induced by COVID-19 can persist up to 7 months: A study of over 700 healthcare workers Medrxiv, 2021. Bussière, N., Mei, J., Lévesque-Boissonneault, C., Blais, M., Carazo, S., Gros-Louis, F., de Serres, G., Dupré, N., Frasnelli, J.. DOI 10.1101/2021.06.28.21259639

Chemosensory Dysfunctions Induced by COVID-19 Can Persist up to 7 Months: A Study of over 700 Healthcare Workers Chemical Senses, 2021. Bussière, N., Mei, J., Lévesque-Boissonneault, C., Blais, M., Carazo, S., Gros-Louis, F., De Serres, G., Dupré, N., Frasnelli, J.. DOI 10.1093/chemse/bjab038

Biofabrication of a three dimensional human-based personalized neurofibroma model Biotechnology Journal, 2021. Roy, V., Lamontagne, R., Talagas, M., Touzel-Deschênes, L., Khuong, H.T., Saikali, S., Dupré, N., Gros-Louis, F.. DOI 10.1002/biot.202000250

Autosomal Recessive Cerebellar Ataxias Handbook of the Cerebellum and Cerebellar Disorders Second Edition Volume 3, 2021. Salem, I.H., Noreau, A., Bouchard, J.-P., Dion, P.A., Rouleau, G.A., Dupre, N.. DOI 10.1007/978-3-030-23810-0_100

Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease Neurobiology of Aging, 2021. Saini, P., Rudakou, U., Yu, E., Ruskey, J.A., Asayesh, F., Laurent, S.B., Spiegelman, D., Fahn, S., Waters, C., Monchi, O., Dauvilliers, Y., Dupré, N., Greenbaum, L., Hassin-Baer, S., Espay, A.J., Rouleau, G.A., Alcalay, R.N., Fon, E.A., Postuma, R.B., Gan-Or, Z.. DOI 10.1016/j.neurobiolaging.2020.10.019

Analysis of Heterozygous PRKN Variants and Copy-Number Variations in Parkinson's Disease Movement Disorders, 2021. Yu, E., Rudakou, U., Krohn, L., Mufti, K., Ruskey, J.A., Asayesh, F., Estiar, M.A., Spiegelman, D., Surface, M., Fahn, S., Waters, C.H., Greenbaum, L., Espay, A.J., Dauvilliers, Y., Dupré, N., Rouleau, G.A., Hassin-Baer, S., Fon, E.A., Alcalay, R.N., Gan-Or, Z.. DOI 10.1002/mds.28299