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Philippe Joubert

Médecin clinicien enseignant agrégé

philippe.joubert@criucpq.ulaval.ca
Pavillon Ferdinand-Vandry
1050, avenue de la Médecine
Local 4835

Unité de rattachement — Faculté
Médecine

Affiliations
Centre de recherche de l'Institut universitaire de cardiologie et de pneumonie de Québec
Centre de recherche sur le cancer
Groupe de recherche en santé respiratoire
Centre de recherche de l'Institut universitaire de cardiologie et de pneumonie de Québec

Identification de biomarqueurs prédictifs en oncologie thoracique afin d'améliorer le diagnostic et la prise en charge des patients
Programme: Chercheurs-boursiers cliniciens - Juniors 1 et 2, Seniors
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2022 au30 juin 2026

Potentiation of PRRT by chemotherapy-mediated upregulation of somatostatin receptor 2 in NET cell lines-derived tumors in mice and in Lung NET patient-derived tumor explants
Organisme(s) subventionnaire(s): Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2022 au31 décembre 2024

Guiding community-based lung cancer diagnostic follow-ups through Artificial Intelligence Tools
Programme: Nouvelles frontières en recherche
Organisme(s) subventionnaire(s): Secrétariat des programmes interorganismes à l’intention des établissements
Type de financement: Subvention
Établissement tête: Université du Québec à Trois-Rivières - UQTR
Du 1 mars 2022 au28 février 2024

Deciphering the role of the immune microenvironment in the response of lung cancer to immunotherapy
Programme: Nouvelles frontières en recherche
Organisme(s) subventionnaire(s): Secrétariat des programmes interorganismes à l’intention des établissements
Type de financement: Subvention
Établissement tête: Université Laval
Du 31 mars 2021 au30 mars 2024

Financements des 2 dernières années

Linking clinical, research and imaging data in lung cancer: towards FAIR and AI-ready datasets
Programme: Subventions de transformation de données sur le cancer
Organisme(s) subventionnaire(s): Société canadienne du cancer
Type de financement: Subvention
Établissement tête: Université Laval
Du 15 mars 2022 au14 mars 2023

Targeting BMP signaling in the tumor endothelium to improve cancer immunotherapy
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université de Montréal
Du 1 mars 2022 au28 février 2023

Defining the role of ZNF768 overexpression in lung cancer development
Programme: Subvention de fonctionnement
Organisme(s) subventionnaire(s): Société de recherche sur le cancer
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 septembre 2021 au31 août 2023

Caractérisation pathologique et moléculaire des adénocarcinomes pulmonaires multiples synchrones et des patients atteints de DIPNECH
Programme: Chercheurs-boursiers cliniciens - Juniors 1 et 2, Seniors
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2018 au30 juin 2022

Caractérisation pathologique et moléculaire des adénocarcinomes pulmonaires multiples synchrones et des patients atteints de DIPNECH
Programme: Établissement de jeunes chercheurs - Juniors 1
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2018 au30 juin 2022

Stage d'été « Carrière été »
Programme: Emplois d'été Canada
Organisme(s) subventionnaire(s): Emploi et Développement Social Canada (EDSC)
Type de financement: Subvention
Établissement tête: Université Laval
Du 5 mai 2014 au22 juillet 2022

  • Fatemeh Vahidian, Maîtrise en sciences cliniques et biomédicales - avec mémoire
  • Arnaud Driussi, Doctorat en médecine moléculaire
  • Clémence Boullier, Doctorat en sciences cliniques et biomédicales
  • Olga Sazonova, Doctorat en sciences cliniques et biomédicales
  • Hanie Abolfathi, Doctorat en médecine moléculaire
  • Anne-Sophie Desgagnés, Maîtrise en sciences cliniques et biomédicales - avec mémoire
  • Manal Kordahi, Maîtrise en sciences cliniques et biomédicales - avec mémoire
  • Encadrements terminés dans les 5 dernières années

  • Andréanne Gagné, Doctorat en sciences cliniques et biomédicales
  • Nathan Dumont-Leblond, Maîtrise en microbiologie - avec mémoire
  • Publications des 5 dernières années

    CXCL13 Positive Cells Localization Predict Response to Anti-PD-1/PD-L1 in Pulmonary Non-Small Cell Carcinoma Cancers, 2024/02. Fatemeh Vahidian, Fabien C. Lamaze, Cédrik Bouffard, Francois Coulombe, Andréanne Gagné, Florence Blais, MARION TONNEAU, Michèle Orain, Bertrand Routy, Venkata S. K. Manem, Philippe Joubert. DOI 10.3390/cancers16040708

    The Cross-Scale Association between Pathomics and Radiomics Features in Immunotherapy-Treated NSCLC Patients: A Preliminary Study Cancers, 2024/01. ABDOU KHADIR DIA, Leyla Ebrahimpour, Sevinj Yolchuyeva, Marion Tonneau, Fabien C. Lamaze, Michèle Orain, Francois Coulombe, Julie Malo, Wiam Belkaid, Bertrand Routy, Philippe Joubert, Philippe Després, Venkata S. K. Manem. DOI 10.3390/cancers16020348

    Canadian Consensus Recommendations for the Management of Operable Stage II/III Non-Small-Cell Lung Cancer: Results of a Modified Delphi Process Current Oncology, 2023/12/06. James Tankel, Jonathan Spicer, Quincy Chu, Pierre Olivier Fiset, Biniam Kidane, Natasha B. Leighl, Philippe Joubert, Donna Maziak, David Palma, Anna McGuire, Barbara Melosky, Stephanie Snow, Houda Bahig, Normand Blais. DOI 10.3390/curroncol30120755

    Single-cell spatial landscapes of the lung tumour immune microenvironment. Nature, 2023/02/01. Sorin M, Rezanejad M, Karimi E, Benoit Fiset, Desharnais L, Perus LJM, Milette S, Miranda Yu, Maritan SM, Doré S, Pichette É, William Enlow, Andréanne Gagné, Wei Y, Orain M, Manem VSK, Rayes R, Peter Siegel, Camilleri-Broët S, Fiset PO, Desmeules P, Spicer JD, Spicer JD, Philippe Joubert, Logan Walsh. DOI 10.1038/s41586-022-05672-3

    Single-cell spatial landscape of immunotherapy response reveals mechanisms of CXCL13 enhanced antitumor immunity. Journal for immunotherapy of cancer, 2023/02/01. Sorin M, Karimi E, Rezanejad M, Yu MW, Desharnais L, McDowell SAC, Doré S, Arabzadeh A, Breton V, Benoit Fiset, Wei Y, Rayes R, Orain M, Coulombe F, Manem VSK, Gagne A, Quail DF, Joubert P, Spicer JD, Logan Walsh. DOI 10.1136/jitc-2022-005545

    Retrospective Assessment of Complementary Liquid Biopsy on Tissue Single-Gene Testing for Tumor Genotyping in Advanced NSCLC Current Oncology, 2023/01/01. Patrice Desmeules, Matthieu Dusselier, Cédrik Bouffard, Josée Bafaro, Marc Fortin, Catherine Labbé, Philippe Joubert. DOI 10.3390/curroncol30010045

    Age-associated Differences in the Human Lung Extracellular Matrix 2022/06/16. M.L. Koloko Ngassie, M. De Vries, T. Borghuis, W. Timens, Don D. Sin, D. Nickle, P. Joubert, P. Horvatovich, G. Marko-Varga, J.J. Teske, J.M. Vonk, R. Gosens, Y.S. Prakash, J.K. Burgess, C.A. Brandsma. DOI 10.1101/2022.06.16.496465

    Wait Times and Survival in Lung Cancer Patients across the Province of Quebec, Canada Current Oncology, 2022/04/29. Marie-Hélène Denault, Catherine Labbé, Carolle St-Pierre, Brigitte Fournier, Andréanne Gagné, Claudia Morillon, Philippe Joubert, Serge Simard, Simon Martel. DOI 10.3390/curroncol29050259

    Prognostic Impact of Ground-Glass Opacity/Lepidic Component in Pulmonary Adenocarcinoma: A Hazy Staging Dilemma Journal of Thoracic Oncology, 2022/01. Philippe Joubert, William D. Travis. DOI 10.1016/j.jtho.2021.10.012

    ZNF768 Expression Associates with High Proliferative Clinicopathological Features in Lung Adenocarcinoma Cancers, 2021/08/17. Audrey Poirier, Andréanne Gagné, Philippe Laflamme, Meagan Marcoux, Michèle Orain, Sophie Plante, David Joubert, Philippe Joubert, Mathieu Laplante. DOI 10.3390/cancers13164136

    Mapping the human genetic architecture of COVID-19. Nature, 2021/07/08. COVID-19 Host Genetics Initiative. DOI 10.1038/s41586-021-03767-x

    Use of amantadine in the evaluation of response to chemotherapy in lung cancer: a pilot study Future Science OA, 2021/04. Andrew W Maksymiuk, Paramjit S Tappia, Rashid Ahmed Bux, Dante Moyer, Guoyu Huang, Philippe Joubert, Donald W Miller, Bram Ramjiawan, Daniel S Sitar. DOI 10.2144/fsoa-2020-0176

    Pulmonary tumor thrombotic microangiopathy: A systematic review of the literature Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2021/01/02. L. V. Morin-Thibault, D. Wiseman, P. Joubert, R. Paulin, S. Bonnet, S. Provencher. DOI 10.1080/24745332.2020.1724061

    Venous thrombotic events in patients treated with immune checkpoint inhibitors for non-small cell lung cancer: A retrospective multicentric cohort study Thrombosis Research, 2021. Deschênes-Simard, X., Richard, C., Galland, L., Blais, F., Desilets, A., Malo, J., Cvetkovic, L., Belkaid, W., Elkrief, A., Gagné, A., Hamel, M.-A., Orain, M., Joubert, P., Ghiringhelli, F., Routy, B., Blais, N.. DOI 10.1016/j.thromres.2021.06.018

    ZNF768 links oncogenic RAS to cellular senescence Nature Communications, 2021. Villot, R., Poirier, A., Bakan, I., Boulay, K., Fernández, E., Devillers, R., Gama-Braga, L., Tribouillard, L., Gagné, A., Duchesne, É., Caron, D., Bérubé, J.-S., Bérubé, J.-C., Coulombe, Y., Orain, M., Gélinas, Y., Gobeil, S., Bossé, Y., Masson, J.-Y., Elowe, S., Bilodeau, S., Manem, V., Joubert, P., Mallette, F.A., Laplante, M.. DOI 10.1038/s41467-021-24932-w

    Development of a robust protocol for the characterization of the pulmonary microbiota Communications Biology, 2021. Dumont-Leblond, N., Veillette, M., Racine, C., Joubert, P., Duchaine, C.. DOI 10.1038/s42003-021-01690-5

    Expression of programmed death ligand-1 (PD-L1) in metastatic and postchemotherapy viable testicular germ cell tumors Urologic Oncology: Seminars and Original Investigations, 2021. Al-Hogbani, M., Duguay, J., Wagner, D.-C., Haferkamp, A., Joubert, P., Frees, S., Rendon, R., Power, N., Périgny, M., Toren, P.. DOI 10.1016/j.urolonc.2021.02.014

    Genomic and evolutionary classification of lung cancer in never smokers Nature Genetics, 2021. Zhang, T., Joubert, P., Ansari-Pour, N., Zhao, W., Hoang, P.H., Lokanga, R., Moye, A.L., Rosenbaum, J., Gonzalez-Perez, A., Martínez-Jiménez, F., Castro, A., Muscarella, L.A., Hofman, P., Consonni, D., Pesatori, A.C., Kebede, M., Li, M., Gould Rothberg, B.E., Peneva, I., Schabath, M.B., Poeta, M.L., Costantini, M., Hirsch, D., Heselmeyer-Haddad, K., Hutchinson, A., Olanich, M., Lawrence, S.M., Lenz, P., Duggan, M., Bhawsar, P.M.S., Sang, J., Kim, J., Mendoza, L., Saini, N., Klimczak, L.J., Islam, S.M.A., Otlu, B., Khandekar, A., Cole, N., Stewart, D.R., Choi, J., Brown, K.M., Caporaso, N.E., Wilson, S.H., Pommier, Y., Lan, Q., Rothman, N., Almeida, J.S., Carter, H., Ried, T., Kim, C.F., Lopez-Bigas, N., Garcia-Closas, M., Shi, J., Bossé, Y., Zhu, B., Gordenin, D.A., Alexandrov, L.B., Chanock, S.J., Wedge, D.C., Landi, M.T.. DOI 10.1038/s41588-021-00920-0

    Non-invasive diagnostic imaging tests largely underdiagnose cardiac cirrhosis in patients undergoing advanced therapy evaluation: How can we identify the high-risk patient? Clinical Transplantation, 2021. Belzile, D., Turgeon, P.Y., Leblanc, E., Massot, M., Bourgault, C., Morin, J., Dupuis, C., Bilodeau, M., Laflamme, M., Charbonneau, E., Trahan, S., Pagé, S., Joubert, P., Couture, C., Sénéchal, M.. DOI 10.1111/ctr.14277

    Unravelling actionable biology using transcriptomic data to integrate mitotic index and Ki-67 in the management of lung neuroendocrine tumors Oncotarget, 2021. Manem, V.S.K., Sazonova, O., Gagné, A., Orain, M., Khoshkrood-Mansoori, B., Gaudreault, N., Bossé, Y., Joubert, P.. DOI 10.18632/ONCOTARGET.27874

    A Pan-Canadian Validation Study for the Detection of EGFR T790M Mutation Using Circulating Tumor DNA From Peripheral Blood JTO Clinical and Research Reports, 2021. Selvarajah, S., Plante, S., Speevak, M., Vaags, A., Hamelinck, D., Butcher, M., McCready, E., Grafodatskaya, D., Blais, N., Tran-Thanh, D., Weng, X., Nassabein, R., Greer, W., Walton, R.N., Lo, B., Demetrick, D., Santos, S., Sadikovic, B., Zhang, X., Zhang, T., Spence, T., Stockley, T., Feilotter, H., Joubert, P.. DOI 10.1016/j.jtocrr.2021.100212

    Follicular helper-T cells restore CD8 + -dependent antitumor immunity and anti-PD-L1/PD-1 efficacy Journal for ImmunoTherapy of Cancer, 2021. Niogret, J., Berger, H., Rebe, C., Mary, R., Ballot, E., Truntzer, C., Thibaudin, M., Derangère, V., Hibos, C., Hampe, L., Rageot, D., Accogli, T., Joubert, P., Routy, B., Harker, J., Vegran, F., Ghiringhelli, F., Chalmin, F.. DOI 10.1136/jitc-2020-002157

    Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19 Human Genetics, 2021. Hernández Cordero, A.I., Li, X., Milne, S., Yang, C.X., Bossé, Y., Joubert, P., Timens, W., van den Berge, M., Nickle, D., Hao, K., Sin, D.D.. DOI 10.1007/s00439-021-02264-5

    Non-small cell lung cancer microbiota characterization: Prevalence of enteric and potentially pathogenic bacteria in cancer tissues PLoS ONE, 2021. Dumont-Leblond, N., Veillette, M., Racine, C., Joubert, P., Duchaine, C.. DOI 10.1371/journal.pone.0249832

    Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank Communications Biology, 2021. Valette, K., Li, Z., Bon-Baret, V., Chignon, A., Bérubé, J.-C., Eslami, A., Lamothe, J., Gaudreault, N., Joubert, P., Obeidat, M., van den Berge, M., Timens, W., Sin, D.D., Nickle, D.C., Hao, K., Labbé, C., Godbout, K., Côté, A., Laviolette, M., Boulet, L.-P., Mathieu, P., Thériault, S., Bossé, Y.. DOI 10.1038/s42003-021-02227-6

    Transcriptomic data helps refining classification of pulmonary carcinoid tumors with increased mitotic counts Modern Pathology, 2020/09. Olga Sazonova, Venkata Manem, Michèle Orain, Babak Khoshkrood-Mansoori, Nathalie Gaudreault, Patrice Desmeules, Yohan Bossé, Philippe Joubert. DOI 10.1038/s41379-020-0538-8

    Efficacy of immune checkpoint inhibitors in older patients with non-small cell lung cancer: Real-world data from multicentric cohorts in Canada and France Journal of Geriatric Oncology, 2020. Elkrief, A., Richard, C., Malo, J., Cvetkovic, L., Florescu, M., Blais, N., Tehfe, M., Messaoudene, M., Gagné, A., Orain, M., Medjebar, S., Wan-Chow-Wah, D., Joubert, P., Labbé, C., Ghiringhelli, F., Routy, B.. DOI 10.1016/j.jgo.2020.01.002

    Erratum to: Therapeutic landscape of metastatic non-small-cell lung cancer in canada in 2020 (Curr Oncol 2020, 27, 52–60), 10.3747/co.27.5953 Current Oncology, 2020. Elkrief, A., Joubert, P., Florescu, M., Tehfe, M., Blais, N., Routy, B.. DOI 10.3747/co.27.6577

    Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis American Journal of Respiratory and Critical Care Medicine, 2020. Allen, R.J., Guillen-Guio, B., Oldham, J.M., Ma, S.-F., Dressen, A., Paynton, M.L., Kraven, L.M., Obeidat, M., Li, X., Ng, M., Braybrooke, R., Molina-Molina, M., Hobbs, B.D., Putman, R.K., Sakornsakolpat, P., Booth, H.L., Fahy, W.A., Hart, S.P., Hill, M.R., Hirani, N., Hubbard, R.B., McAnulty, R.J., Millar, A.B., Navaratnam, V., Oballa, E., Parfrey, H., Saini, G., Whyte, M.K.B., Zhang, Y., Kaminski, N., Adegunsoye, A., Strek, M.E., Neighbors, M., Sheng, X.R., Gudmundsson, G., Gudnason, V., Hatabu, H., Lederer, D.J., Manichaikul, A., Newell, J.D., O'Connor, G.T., Ortega, V.E., Xu, H., Fingerlin, T.E., Bossé, Y., Hao, K., Joubert, P., Nickle, D.C., Sin, D.D., Timens, W., Furniss, D., Morris, A.P., Zondervan, K.T., Hall, I.P., Sayers, I., Tobin, M.D., Toby, M., Cho, M.H., Hunninghake, G.M., Schwartz, D.A., Yaspan, B.L., Molyneaux, P.L., Flores, C., Noth, I., Jenkins, R.G., Wain, L.V.. DOI 10.1164/rccm.201905-1017OC

    Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19 medRxiv, 2020. Hernández Cordero, A.I., Li, X., Milne, S., Yang, C.X., Bossé, Y., Joubert, P., Timens, W., van den Berge, M., Nickle, D., Hao, K., Sin, D.D.. DOI 10.1101/2020.10.05.20207118

    Phospho-histone-H3 immunostaining for pulmonary carcinoids: impact on clinical appraisal, interobserver correlation, and diagnostic processing efficiency Human Pathology, 2020. Laflamme, P., Mansoori, B.K., Sazanova, O., Orain, M., Couture, C., Simard, S., Trahan, S., Manem, V., Joubert, P.. DOI 10.1016/j.humpath.2020.09.009

    The Quebec respiratory health network biobank Open Journal of Bioresources, 2020. Biardel, S., Racine, C., Fortier, Y., Mogas, A.K., Maillé, É., Brochiero, E., Maltais, F., Lauzon, A.-M., Tse, S.M., Laprise, C., Joubert, P., Rousseau, É., Bissonnette, É., Laviolette, M., Bossé, Y., Rousseau, S.. DOI 10.5334/OJB.39

    Therapeutic landscape of metastatic non-small-cell lung cancer in Canada in 2020 Current Oncology, 2020. Elkrief, A., Joubert, P., Florescu, M., Tehfe, M., Blais, N., Routy, B.. DOI 10.3747/co.27.5953

    Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage Science, 2020. Fluckiger, A., Daillère, R., Sassi, M., Sixt, B.S., Liu, P., Loos, F., Richard, C., Rabu, C., Alou, M.T., Goubet, A.-G., Lemaitre, F., Ferrere, G., Derosa, L., Duong, C.P.M., Messaoudene, M., Gagné, A., Joubert, P., de Sordi, L., Debarbieux, L., Simon, S., Scarlata, C.-M., Ayyoub, M., Palermo, B., Facciolo, F., Boidot, R., Wheeler, R., Boneca, I.G., Sztupinszki, Z., Papp, K., Csabai, I., Pasolli, E., Segata, N., Lopez-Otin, C., Szallasi, Z., Andre, F., Iebba, V., Quiniou, V., Klatzmann, D., Boukhalil, J., Khelaifia, S., Raoult, D., Albiges, L., Escudier, B., Eggermont, A., Mami-Chouaib, F., Nistico, P., Ghiringhelli, F., Routy, B., Labarrière, N., Cattoir, V., Kroemer, G., Zitvogel, L.. DOI 10.1126/science.aax0701

    Development and Validation of Diffuse Idiopathic Pulmonary Neuroendocrine Hyperplasia Diagnostic Criteria JTO Clinical and Research Reports, 2020. Sazonova, O., Manem, V., Béland, C., Hamel, M.-A., Lacasse, Y., Lévesque, M.-H., Orain, M., Joubert, D., Provencher, S., Simonyan, D., Joubert, P.. DOI 10.1016/j.jtocrr.2020.100078

    Gene expression network analysis provides potential targets against SARS-CoV-2 Scientific Reports, 2020. Hernández Cordero, A.I., Li, X., Yang, C.X., Milne, S., Bossé, Y., Joubert, P., Timens, W., van den Berge, M., Nickle, D., Hao, K., Sin, D.D.. DOI 10.1038/s41598-020-78818-w

    Genetic regulation of gene expression of MIF family members in lung tissue Scientific Reports, 2020. Florez-Sampedro, L., Brandsma, C.-A., de Vries, M., Timens, W., Bults, R., Vermeulen, C.J., van den Berge, M., Obeidat, M., Joubert, P., Nickle, D.C., Poelarends, G.J., Faiz, A., Melgert, B.N.. DOI 10.1038/s41598-020-74121-w

    A high-performing plasma metabolite panel for early-stage lung cancer detection Cancers, 2020. Zhang, L., Zheng, J., Ahmed, R., Huang, G., Reid, J., Mandal, R., Maksymuik, A., Sitar, D.S., Tappia, P.S., Ramjiawan, B., Joubert, P., Russo, A., Rolfo, C.D., Wishart, D.S.. DOI 10.3390/cancers12030622

    ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: A Mendelian randomization study medRxiv, 2020. Gill, D., Arvanitis, M., Carter, P., Hernández Cordero, A.I., Jo, B., Karhunen, V., Larsson, S.C., Li, X., Lockhart, S.M., Mason, A., Pashos, E., Saha, A., Tan, V.Y., Zuber, V., Bossé, Y., Fahle, S., Hao, K., Jiang, T., Joubert, P., Lunt, A.C., Ouwehand, W.H., Roberts, D.J., Timens, W., van den Berge, M., Watkins, N.A., Battle, A., Butterworth, A.S., Danesh, J., Engelhardt, B.E., Peters, J.E., Sin, D.D., Burgess, S.. DOI 10.1101/2020.04.10.20059121

    ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: A Mendelian randomization study: ACE inhibition and ACE2 expression Royal Society Open Science, 2020. Gill, D., Arvanitis, M., Carter, P., Hernández Cordero, A.I., Jo, B., Karhunen, V., Larsson, S.C., Li, X., Lockhart, S.M., Mason, A., Pashos, E., Saha, A., Tan, V.Y., Zuber, V., Bossé, Y., Fahle, S., Hao, K., Jiang, T., Joubert, P., Lunt, A.C., Ouwehand, W.H., Roberts, D.J., Timens, W., Van Den Berge, M., Watkins, N.A., Battle, A., Butterworth, A.S., Danesh, J., Di Angelantonio, E., Engelhardt, B.E., Peters, J.E., Sin, D.D., Burgess, S.. DOI 10.1098/rsos.200958rsos200958

    Comprehensive assessment of PD-L1 immunohistochemistry on paired tissue and cytology specimens from non-small cell lung cancer Lung Cancer, 2020. Gagné, A., Orain, M., Ionescu, D., Tsao, M.-S., Joubert, D., Joubert, P.. DOI 10.1016/j.lungcan.2020.06.002

    Consensus recommendations for optimizing biomarker testing to identify and treat advanced EGFR-mutated non-small-cell lung cancer Current Oncology, 2020. Cheema, P.K., Gomes, M., Banerji, S., Joubert, P., Leighl, N.B., Melosky, B., Sheffield, B.S., Stockley, T., Ionescu, D.N.. DOI 10.3747/co.27.7297

    Dietary sucrose induces metabolic inflammation and atherosclerotic cardiovascular diseases more than dietary fat in LDLr<sup>−/−</sup> ApoB<sup>100/100</sup> mice Atherosclerosis, 2020. Perazza, L.R., Mitchell, P.L., Jensen, B.A.H., Daniel, N., Boyer, M., Varin, T.V., Bouchareb, R., Nachbar, R.T., Bouchard, M., Blais, M., Gagné, A., Joubert, P., Sweeney, G., Roy, D., Arsenault, B.J., Mathieu, P., Marette, A.. DOI 10.1016/j.atherosclerosis.2020.05.002

    Gene expression network analysis provides potential targets against SARS-CoV-2 bioRxiv, 2020. Hernández Cordero, A.I., Li, X., Xi Yang, C., Milne, S., Bossé, Y., Joubert, P., Timens, W., van den Berge, M., Nickle, D., Hao, K., Sin, D.D.. DOI 10.1101/2020.07.06.182634

    Is heart transplantation a valuable option in patients with diffuse systemic sclerosis and primary cardiac involvement? Clinical Case Reports, 2020. Turcotte-Gosselin, F., Turgeon, P.Y., Ikic, A., Beaudoin, J., Joubert, P., Dubois, M., Voisine, P., Sénéchal, M.. DOI 10.1002/ccr3.2600

    Protein-altering germline mutations implicate novel genes related to lung cancer development Nature Communications, 2020. Ji, X., Mukherjee, S., Landi, M.T., Bosse, Y., Joubert, P., Zhu, D., Gorlov, I., Xiao, X., Han, Y., Gorlova, O., Hung, R.J., Brhane, Y., Carreras-Torres, R., Christiani, D.C., Caporaso, N., Johansson, M., Liu, G., Bojesen, S.E., Le Marchand, L., Albanes, D., Bickeböller, H., Aldrich, M.C., Bush, W.S., Tardon, A., Rennert, G., Chen, C., Byun, J., Dragnev, K.H., Field, J.K., Kiemeney, L.F., Lazarus, P., Zienolddiny, S., Lam, S., Schabath, M.B., Andrew, A.S., Bertazzi, P.A., Pesatori, A.C., Diao, N., Su, L., Song, L., Zhang, R., Leighl, N., Johansen, J.S., Mellemgaard, A., Saliba, W., Haiman, C., Wilkens, L., Fernandez-Somoano, A., Fernandez-Tardon, G., Heijden, E.H.F.M., Kim, J.H., Davies, M.P.A., Marcus, M.W., Brunnström, H., Manjer, J., Melander, O., Muller, D.C., Overvad, K., Trichopoulou, A., Tumino, R., Goodman, G.E., Cox, A., Taylor, F., Woll, P., Wichmann, E., Muley, T., Risch, A., Rosenberger, A., Grankvist, K., Johansson, M., Shepherd, F., Tsao, M.-S., Arnold, S.M., Haura, E.B., Bolca, C., Holcatova, I., Janout, V., Kontic, M., Lissowska, J., Mukeria, A., Ognjanovic, S., Orlowski, T.M., Scelo, G., Swiatkowska, B., Zaridze, D., Bakke, P., Skaug, V., Butler, L.M., Offit, K., Srinivasan, P., Bandlamudi, C., Hellmann, M.D., Solit, D.B., Robson, M.E., Rudin, C.M., Stadler, Z.K., Taylor, B.S., Berger, M.F., Houlston, R., McLaughlin, J., Stevens, V., Nickle, D.C., Obeidat, M., Timens, W., Artigas, M.S., Shete, S., Brenner, H., Chanock, S., Brennan, P., McKay, J.D., Amos, C.I.. DOI 10.1038/s41467-020-15905-6

    The IASLC Lung Cancer Staging Project: Analysis of Resection Margin Status and Proposals for Residual Tumor Descriptors for Non–Small Cell Lung Cancer Journal of Thoracic Oncology, 2020. Edwards, J.G., Chansky, K., Van Schil, P., Nicholson, A.G., Boubia, S., Brambilla, E., Donington, J., Galateau-Sallé, F., Hoffmann, H., Infante, M., Marino, M., Marom, E.M., Nakajima, J., Ostrowski, M., Travis, W.D., Tsao, M.-S., Yatabe, Y., Giroux, D.J., Shemanski, L., Crowley, J., Krasnik, M., Asamura, H., Rami-Porta, R., Rusch, V., Araujo, L.H., Beer, D., Bertoglio, P., Beyruti, R., Bille, A., Bolejack, V., Brierley, J.D., Cangir, A.K., Carbone, D., Darling, G., Detterbeck, F., D'Journo, X.B., Donnington, J., Eberhardt, W., Edwards, J., Erasmus, J., Falkson, C., Fang, W., Fennell, D., Fong, K., Galateau-Salle, F., Gautschi, O., Gill, R., Giroux, D., Giuliani, M., Goo, J.M., Hasegawa, S., Hirsch, F., Hoffman, H., Hofstetter, W., Huang, J., Joubert, P., Kernstine, K., Kerr, K., Kim, Y.T., Kim, H.K., Kindler, H., Lievens, Y., Liu, H., Low, D.E., Lyons, G., MacMahon, H., Marom, E., Matilla, J.-M., van Meerbeeck, J., Montuenga, L.M., Nicholson, A., Nishimura, K., Nowak, A., Opitz, I., Okumura, M., Osarogiagbon, R.U., Pass, H., de Perrot, M., Prosch, H., Rice, D., Rimner, A., Ruffini, E., Sakai, S., Singh, N., Stoll-D'Astice, A., Su´rez, F., Terra, R.M., Tsao, M.S., Ugalde, P., Waller, D., Watanabe, S.-I., Wiens, J., Wistuba, I., Jiang, L., Kubota, K., Turna, A., Weksler, B., Tzukazan, M.T., Tammemägi, M., Powell, C., Naidich, D., Liu, H., Armato, S., Brunelli, A., Cardillo, G., David, E., Fournier, B., Krasnik, M., Kubota, K., Labbe, C., Lim, E., Putora, P.M., Rocco, G., Filosso, P.L., Kondo, K., Kim, D.K., Giaccone, G., Lucchi, M., Rice, T., Ferguson, M., Adsusmilli, P., Travis, W., Suárez, F., Kubota, K., Shun-ichi, Watanabe, H.A., Ramón, Rami-Porta, E.M., Tsao, M., Shun-ichi, Watanabe, M.T., Guiliani, M., Brierley, J., Terra, R., Osarogiagbon, R., Montuenga, L., Wang, H., Galateau, F., Goo, J.M., Travis, B., Matilla, J.M., St. Pierre, C., Tzukazan, M.T., Girard, N., Rimmer, A., Galateau, F., Adusumilli, P., D'Journo, X., Low, D., Rosenthal, A.. DOI 10.1016/j.jtho.2019.10.019

    Transcriptome-wide association study reveals candidate causal genes for lung cancer International Journal of Cancer, 2020. Bossé, Y., Li, Z., Xia, J., Manem, V., Carreras-Torres, R., Gabriel, A., Gaudreault, N., Albanes, D., Aldrich, M.C., Andrew, A., Arnold, S., Bickeböller, H., Bojesen, S.E., Brennan, P., Brunnstrom, H., Caporaso, N., Chen, C., Christiani, D.C., Field, J.K., Goodman, G., Grankvist, K., Houlston, R., Johansson, M., Johansson, M., Kiemeney, L.A., Lam, S., Landi, M.T., Lazarus, P., Le Marchand, L., Liu, G., Melander, O., Rennert, G., Risch, A., Rosenberg, S.M., Schabath, M.B., Shete, S., Song, Z., Stevens, V.L., Tardon, A., Wichmann, H.-E., Woll, P., Zienolddiny, S., Obeidat, M., Timens, W., Hung, R.J., Joubert, P., Amos, C.I., McKay, J.D.. DOI 10.1002/ijc.32771

    Impact of Specimen Characteristics on PD-L1 Testing in Non–Small Cell Lung Cancer: Validation of the IASLC PD-L1 Testing Recommendations Journal of Thoracic Oncology, 2019/12. Andréanne Gagné, Emily Wang, Nathalie Bastien, Michèle Orain, Patrice Desmeules, Sylvain Pagé, Sylvain Trahan, Christian Couture, David Joubert, Philippe Joubert. DOI 10.1016/j.jtho.2019.08.2503

    High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma Journal of Lipid Research, 2019/10/13. Anne-Marie Lemay, Olivier Courtemanche, Timothy A. Couttas, Giuleta Jamsari, Andréanne Gagné, Yohan Bossé, Philippe Joubert, Anthony S. Don, David Marsolais. DOI 10.1194/jlr.M093955

    Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis bioRxiv, 2019. Allen, R.J., Guillen-Guio, B., Oldham, J.M., Ma, S.-F., Dressen, A., Paynton, M.L., Kraven, L.M., Obeidat, M., Li, X., Ng, M., Braybrooke, R., Molina-Molina, M., Hobbs, B.D., Putman, R.K., Sakornsakolpat, P., Booth, H.L., Fahy, W.A., Hart, S.P., Hill, M.R., Hirani, N., Hubbard, R.B., McAnulty, R.J., Millar, A.B., Navaratnam, V., Oballa, E., Parfrey, H., Saini, G., Whyte, M.K.B., Gudmundsson, G., Gudnason, V., Hatabu, H., Lederer, D.J., Manichaikul, A., Newell, J.D., O’Connor, G.T., Ortega, V.E., Xu, H., Fingerlin, T.E., Bossé, Y., Hao, K., Joubert, P., Nickle, D.C., Sin, D.D., Timens, W., Furniss, D., Morris, A.P., Zondervan, K., Hall, I.P., Sayers, I., Tobin, M.D., Maher, T.M., Cho, M.H., Hunninghake, G.M., Schwartz, D.A., Yaspan, B.L., Molyneaux, P.L., Flores, C., Noth, I., Jenkins, R.G., Wain, L.V.. DOI 10.1101/636761

    Genome-wide interaction study of gene-by-occupational exposures on respiratory symptoms Environment International, 2019. Zeng, X., Vonk, J.M., van der Plaat, D.A., Faiz, A., Paré, P.D., Joubert, P., Nickle, D., Brandsma, C.-A., Kromhout, H., Vermeulen, R., Xu, X., Huo, X., de Jong, K., Boezen, H.M.. DOI 10.1016/j.envint.2018.11.017

    Coronary artery fixation at iso-arterial pressure: impacts on histologic evaluation and clinical management Cardiovascular Pathology, 2019. Laflamme, P., Vaucher, J., Turmel-Roy, J., Orain, M., Sazonova, O., Bertrand, O.F., Dagenais, F., Couture, C., Pagé, S., Trahan, S., Bilodeau, S., Joubert, P.. DOI 10.1016/j.carpath.2019.06.005

    Persistent reduction of mucin production after bronchial thermoplasty in severe asthma American Journal of Respiratory and Critical Care Medicine, 2019. Salem, I.H., Gras, D., Joubert, P., Boulet, L.-P., Lampron, N., Martel, S., Godbout, K., Chanez, P., Laviolette, M., Chakir, J.. DOI 10.1164/rccm.201811-2064LE

    The pharmacogenomics of inhaled corticosteroids and lung function decline in COPD European Respiratory Journal, 2019. Obeidat, M., Faiz, A., Li, X., Van Den Berge, M., Hansel, N.N., Joubert, P., Hao, K., Brandsma, C.-A., Rafaels, N., Mathias, R., Ruczinski, I., Beaty, T.H., Barnes, K.C., Paul Man, S.F., Paré, P.D., Sin, D.D.. DOI 10.1183/13993003.00521-2019

    Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (Nature Genetics, (2019), 51, 3, (481-493), 10.1038/s41588-018-0321-7) Nature Genetics, 2019. Shrine, N., Guyatt, A.L., Erzurumluoglu, A.M., Jackson, V.E., Hobbs, B.D., Melbourne, C.A., Batini, C., Fawcett, K.A., Song, K., Sakornsakolpat, P., Li, X., Boxall, R., Reeve, N.F., Obeidat, M., Zhao, J.H., Wielscher, M., Weiss, S., Kentistou, K.A., Cook, J.P., Sun, B.B., Zhou, J., Hui, J., Karrasch, S., Imboden, M., Harris, S.E., Marten, J., Enroth, S., Kerr, S.M., Surakka, I., Vitart, V., Lehtimäki, T., Allen, R.J., Bakke, P.S., Beaty, T.H., Bleecker, E.R., Bossé, Y., Brandsma, C.-A., Chen, Z., Crapo, J.D., Danesh, J., DeMeo, D.L., Dudbridge, F., Ewert, R., Gieger, C., Gulsvik, A., Hansell, A.L., Hao, K., Hoffman, J.D., Hokanson, J.E., Homuth, G., Joshi, P.K., Joubert, P., Langenberg, C., Li, X., Li, L., Lin, K., Lind, L., Locantore, N., Luan, J., Mahajan, A., Maranville, J.C., Murray, A., Nickle, D.C., Packer, R., Parker, M.M., Paynton, M.L., Porteous, D.J., Prokopenko, D., Qiao, D., Rawal, R., Runz, H., Sayers, I., Sin, D.D., Smith, B.H., Artigas, M.S., Sparrow, D., Tal-Singer, R., Timmers, P.R.H.J., Van den Berge, M., Whittaker, J.C., Woodruff, P.G., Yerges-Armstrong, L.M., Troyanskaya, O.G., Raitakari, O.T., Kähönen, M., Polašek, O., Gyllensten, U., Rudan, I., Deary, I.J., Probst-Hensch, N.M., Schulz, H., James, A.L., Wilson, J.F., Stubbe, B., Zeggini, E., Jarvelin, M.-R., Wareham, N., Silverman, E.K., Hayward, C., Morris, A.P., Butterworth, A.S., Scott, R.A., Walters, R.G., Meyers, D.A., Cho, M.H., Strachan, D.P., Hall, I.P., Tobin, M.D., Wain, L.V.. DOI 10.1038/s41588-019-0438-3

    Correction: Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy (British Journal of Cancer, (2018), 119, 8, (950-960), 10.1038/s41416-018-0220-9) British Journal of Cancer, 2019. Fumet, J.-D., Richard, C., Ledys, F., Klopfenstein, Q., Joubert, P., Routy, B., Truntzer, C., Gagné, A., Hamel, M.-A., Guimaraes, C.F., Coudert, B., Arnould, L., Favier, L., Lagrange, A., Ladoire, S., Saintigny, P., Ortiz-Cuaran, S., Perol, M., Foucher, P., Hofman, P., Ilie, M., Chevrier, S., Boidot, R., Derangere, V., Ghiringhelli, F.. DOI 10.1038/s41416-019-0512-8

    New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries Nature Genetics, 2019. Shrine, N., Guyatt, A.L., Erzurumluoglu, A.M., Jackson, V.E., Hobbs, B.D., Melbourne, C.A., Batini, C., Fawcett, K.A., Song, K., Sakornsakolpat, P., Li, X., Boxall, R., Reeve, N.F., Obeidat, M., Zhao, J.H., Wielscher, M., Weiss, S., Kentistou, K.A., Cook, J.P., Sun, B.B., Zhou, J., Hui, J., Karrasch, S., Imboden, M., Harris, S.E., Marten, J., Enroth, S., Kerr, S.M., Surakka, I., Vitart, V., Lehtimäki, T., Allen, R.J., Bakke, P.S., Beaty, T.H., Bleecker, E.R., Bossé, Y., Brandsma, C.-A., Chen, Z., Crapo, J.D., Danesh, J., DeMeo, D.L., Dudbridge, F., Ewert, R., Gieger, C., Gulsvik, A., Hansell, A.L., Hao, K., Hoffman, J.D., Hokanson, J.E., Homuth, G., Joshi, P.K., Joubert, P., Langenberg, C., Li, X., Li, L., Lin, K., Lind, L., Locantore, N., Luan, J., Mahajan, A., Maranville, J.C., Murray, A., Nickle, D.C., Packer, R., Parker, M.M., Paynton, M.L., Porteous, D.J., Prokopenko, D., Qiao, D., Rawal, R., Runz, H., Sayers, I., Sin, D.D., Smith, B.H., Soler Artigas, M., Sparrow, D., Tal-Singer, R., Timmers, P.R.H.J., Van den Berge, M., Whittaker, J.C., Woodruff, P.G., Yerges-Armstrong, L.M., Troyanskaya, O.G., Raitakari, O.T., Kähönen, M., Polašek, O., Gyllensten, U., Rudan, I., Deary, I.J., Probst-Hensch, N.M., Schulz, H., James, A.L., Wilson, J.F., Stubbe, B., Zeggini, E., Jarvelin, M.-R., Wareham, N., Silverman, E.K., Hayward, C., Morris, A.P., Butterworth, A.S., Scott, R.A., Walters, R.G., Meyers, D.A., Cho, M.H., Strachan, D.P., Hall, I.P., Tobin, M.D., Wain, L.V.. DOI 10.1038/s41588-018-0321-7

    The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis Molecular Metabolism, 2019. Mouchiroud, M., Camiré, É., Aldow, M., Caron, A., Jubinville, É., Turcotte, L., Kaci, I., Beaulieu, M.-J., Roy, C., Labbé, S.M., Varin, T.V., Gélinas, Y., Lamothe, J., Trottier, J., Mitchell, P.L., Guénard, F., Festuccia, W.T., Joubert, P., Rose, C.F., Karvellas, C.J., Barbier, O., Morissette, M.C., Marette, A., Laplante, M.. DOI 10.1016/j.molmet.2019.09.014

    The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis JCI Insight, 2019. Mouchiroud, M., Camiré, É., Aldow, M., Caron, A., Jubinville, É., Turcotte, L., Kaci, I., Beaulieu, M.-J., Roy, C., Labbé, S.M., Varin, T.V., Gélinas, Y., Lamothe, J., Trottier, J., Mitchell, P.L., Guénard, F., Festuccia, W.T., Joubert, P., Rose, C.F., Karvellas, C.J., Barbier, O., Morissette, M.C., Marette, A., Laplante, M.. DOI 10.1172/jci.insight.129492


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