Répertoire du corps professoral

Modification génomique thérapeutique de précision pour le traitement du déficit en ZAP70.
Programme: Excellence en recherche - Démarrage en recherche
Organisme(s) subventionnaire(s): Fondation du CHU de Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 15 mai 2026 au 31 mai 2028

Publications des 5 dernières années

CRISPR-based therapeutic genome editing for inherited blood disorders   Nature Reviews Drug Discovery, 2025/12. Sébastien Levesque, Daniel E. Bauer. DOI 10.1038/s41573-025-01236-y

In cellulo DNA assembly for targeted genomic integration and rearrangement in human cells 2025/06/16. Sébastien Levesque, Nozomu Kawashima, GueHo Hwang, Basheer Becerra, Vivien A.C. Schoonenberg, William Mannherz, Luke Homfeldt, Luca Pinello, Suneet Agarwal, Daniel E. Bauer. DOI 10.1101/2025.06.16.659926

Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism Nature Biotechnology, 2025/04. Sébastien Levesque, Andrea Cosentino, Archana Verma, Pietro Genovese, Daniel E. Bauer. DOI 10.1038/s41587-024-02266-4

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells Cell Stem Cell, 2025/02. Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Levesque, Linda Y. Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, Esther Mintzer, Stacy A. Maitland, Selami Demirci, Hye Ji Cha, Stuart H. Orkin, John F. Tisdale, David A. Williams, Lihua Julie Zhu, Shondra M. Pruett-Miller, Luca Pinello, J. Keith Joung, Vikram Pattanayak, John P. Manis, Myriam Armant, Danilo Pellin, Christian Brendel, Scot A. Wolfe, Daniel E. Bauer. DOI 10.1016/j.stem.2024.11.001

Improving prime editing with an endogenous small RNA-binding protein Nature, 2024/04/18. Jun Yan, Paul Oyler-Castrillo, Purnima Ravisankar, Carl C. Ward, Sébastien Levesque, Yangwode Jing, Danny Simpson, Anqi Zhao, Hui Li, Weihao Yan, Laine Goudy, Ralf Schmidt, Sabrina C. Solley, Luke A. Gilbert, Michelle M. Chan, Daniel E. Bauer, Alexander Marson, Lance R. Parsons, Britt Adamson. DOI 10.1038/s41586-024-07259-6

Dairy phages escape CRISPR defence of Streptococcus thermophilus via the anti-CRISPR AcrIIA3 International Journal of Food Microbiology, 2023/12. Adeline Pastuszka, Geneviève M. Rousseau, Vincent Somerville, Sébastien Levesque, Jean-Philippe Fiset, Adeline Goulet, Yannick Doyon, Sylvain Moineau. DOI 10.1016/j.ijfoodmicro.2023.110414

Gene correction for sickle cell disease hits its prime Nature Biomedical Engineering, 2023/05/19. Sébastien Levesque, Daniel E. Bauer. DOI 10.1038/s41551-023-01040-2

Marker-free co-selection for successive rounds of prime editing in human cells. Nature communications, 2022/10/07. Levesque S, Mayorga D, Fiset JP, Goupil C, Duringer A, Loiselle A, Bouchard E, Agudelo D, Doyon Y. DOI 10.1038/s41467-022-33669-z

Marker-free coselection for successive rounds of prime editing in human cells 2021/11/02. Sébastien Levesque, Diana Mayorga, Jean-Philippe Fiset, Claudia Goupil, Alexis Duringer, Andréanne Loiselle, Eva Bouchard, Daniel Agudelo, Yannick Doyon. DOI 10.1101/2021.11.02.464583