Répertoire du corps professoral
Simon Duchesne
Professeur titulaire
(418) 656-2131, poste 404777
simon.duchesne@fmed.ulaval.ca
Pavillon Ferdinand-Vandry
1050, avenue de la Médecine
Local 4853
Bourse RBIQ – Lyna ABROUGUI
Programme: Réseaux thématiques de recherche
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: McGill University
Du 1 septembre 2023
au 31 mars 2024
DeepBrain: Approches par apprentissage profond pour la prédiction du fardeau cérébro-vasculaire
Programme: Coopération bilatérale Québec-Pays basque 2023-2024
Organisme(s) subventionnaire(s): Ministère des Relations internationales et de la Francophonie
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023
au 31 mars 2024
Union Neurosciences et Intelligence Artificielle - Québec (UNIQUE)
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Université Laval - Fonds internes, Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université de Montréal
Du 1 avril 2022
au 31 mars 2028
Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2022
au 31 mars 2027
Computational neuroscience modelling of cognitively healthy aging and Alzheimer's disease
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2022
au 31 mars 2026
Health Research Training to Address Vascular Contributions to Cognitive Decline: the Vascular Training (VAST) Platform
Programme: Projet de Plateforme de formation en recherche en santé
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: University of Calgary
Du 1 janvier 2022
au 31 décembre 2027
Télé-NEUROS (Nouvel Environnement Universitaire de Recherche Orchestrée en Santé mentale et cognitive: une télé initiative)
Organisme(s) subventionnaire(s): CIUSSS-CN CERVO, CIUSSS-CN Centre interdisciplinaire de recherche en réadaptation et intégration sociale (CIRRIS), Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 20 octobre 2020
au 31 mars 2026
Integrating Multi-Omics, Multi-Modal Neuroimaging and Artificial intelligence for Biologically-defined Staging and Statification in the Alzheimer's Disease spectrum
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: McGill University
Du 1 octobre 2020
au 3 septembre 2025
Brain Health Model and Simulator
Programme: Subventions à la découverte SD (individuelles et d'équipe)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2019
au 31 mars 2025
Phase Two of the Canadian Consortium on Neurodegeneration in Aging
Programme: Consortium canadien en neurodégénérescence et vieillissement (CCNV)
Organisme(s) subventionnaire(s): Société Alzheimer du Canada, Centre for Aging + Brain Health Innovation, Saskatchewan Health Research Foundation, Hypertension Canada, Instituts de recherche en santé du Canada, Fondation des infirmières et infirmiers du Canada, Brain Canada Foundation, Fondation de la recherche en santé du Nouveau-Brunswick
Type de financement: Subvention
Établissement tête: University of Toronto
Du 1 avril 2019
au 31 mars 2024
Platform 3: Image Acquisition and Quality Control
Programme: Projet subsidiaire d'un consortium (pour fins de gestion au VRRCI)
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: University of Toronto
Du 1 avril 2019
au 31 mars 2024
Observatoire international sur les impacts sociétaux de l'intelligence artificielle et du numérique
Programme: Appel à propositions : création d’un Observatoire international sur les impacts sociétaux de l’intelligence artificielle et du numérique
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Société et culture, Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2018
au 31 mars 2024
Explaining activation changes during the early stages of Alzheimer's disease and promoting processes of compensation and brain plasticity
Programme: Subventions Fondation
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université de Montréal
Du 1 juillet 2017
au 30 juin 2024
Financements des 2 dernières années
The Astronaut Brain Health Data Mining project
Programme: Programme global de subventions et contributions à l'appui de la recherche, de la sensibilisation et de l'éducation en sciences et technologies spatiales
Organisme(s) subventionnaire(s): Agence spatiale canadienne
Type de financement: Subvention
Établissement tête: Université Laval
Du 29 mars 2022
au 31 mars 2023
Une infrastructure IA multi-usagers clé en main pour gérer le cycle de vie complet des données en santé
Programme: BDR - Cas spéciaux et obligations institutionnelles
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2021
au 1 décembre 2023
Deep Learning Histopathological Cerebrovascular Lesions Assessment
Programme: Réseaux thématiques de recherche
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2021
au 31 mars 2023
Combining ex vivo histology and MRI to identify cerebrovascular diseases in vivo
Programme: Consortium canadien en neurodégénérescence et vieillissement (CCNV)
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: University of Toronto
Du 1 avril 2020
au 31 mars 2022
Comparing the effects of cognitive training and physical exercise on cognition, cerebral autoregulation and cerebral vasoreactivity in men and women with heart failure
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Concordia
Du 1 avril 2019
au 31 mars 2023
Union Neurosciences et Intelligence Artificielle Québec
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Université McGill, Fonds de recherche du Québec - Nature et technologies, Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université de Montréal
Du 1 avril 2019
au 31 mars 2022
Impacts of exercise and cognitive training interventions on neurocognitive functions in older adults with cardiovascular risk factors
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université de Montréal
Du 1 octobre 2018
au 30 septembre 2023
An integrative brain health model for the individual prediction of cognitive decline
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2018
au 30 septembre 2022
Encadrements terminés dans les 5 dernières années
Publications des 5 dernières années
White matter hyperintensities mediate the impact of amyloid ß on future freezing of gait in Parkinson's disease Parkinsonism & Related Disorders, 2021/04. Mahsa Dadar, Janis Miyasaki, Simon Duchesne, Richard Camicioli. DOI 10.1016/j.parkreldis.2021.02.031
Patch-wise brain age longitudinal reliability Human Brain Mapping, 2021. Beheshti, I., Potvin, O., Duchesne, S.. DOI 10.1002/hbm.25253
Neural correlates of resilience to the effects of hippocampal atrophy on memory NeuroImage: Clinical, 2021. Belleville, S., Mellah, S., Cloutier, S., Dang-Vu, T.T., Duchesne, S., Maltezos, S., Phillips, N., Hudon, C.. DOI 10.1016/j.nicl.2020.102526
A multiomics approach to heterogeneity in Alzheimer's disease: Focused review and roadmap Brain, 2020. Badhwar, A., Peggy McFall, G., Sapkota, S., Black, S.E., Chertkow, H., Duchesne, S., Masellis, M., Li, L., Dixon, R.A., Bellec, P.. DOI 10.1093/brain/awz384
A novel ex vivo, in situ method to study the human brain through MRI and histology Journal of Neuroscience Methods, 2020. Maranzano, J., Dadar, M., Bertrand-Grenier, A., Frigon, E.-M., Pellerin, J., Plante, S., Duchesne, S., Tardif, C.L., Boire, D., Bronchti, G.. DOI 10.1016/j.jneumeth.2020.108903
Cognitive and motor correlates of grey and white matter pathology in Parkinson's disease NeuroImage: Clinical, 2020. Dadar, M., Gee, M., Shuaib, A., Duchesne, S., Camicioli, R.. DOI 10.1016/j.nicl.2020.102353
Evidence of a relation between hippocampal volume, white matter hyperintensities, and cognition in subjective cognitive decline and mild cognitive impairment Journals of Gerontology - Series B Psychological Sciences and Social Sciences, 2020. Caillaud, M., Hudon, C., Boller, B., Brambati, S., Duchesne, S., Lorrain, D., Gagnon, J.-F., Maltezos, S., Mellah, S., Phillips, N., Belleville, S.. DOI 10.1093/geronb/gbz120
Histopathological assessment and staging of large and small vessel disease associated with normal brain aging: Human neuropathology / vascular AAIC - Alzheimer's Association International Conference, 2020. DOI 10.1002/alz.044067
Multivariate consistency of resting-state fMRI connectivity maps acquired on a single individual over 2.5 years, 13 sites and 3 vendors NeuroImage, 2020. Badhwar, A., Collin-Verreault, Y., Orban, P., Urchs, S., Chouinard, I., Vogel, J., Potvin, O., Duchesne, S., Bellec, P.. DOI 10.1016/j.neuroimage.2019.116210
A quadratic function of activation in individuals at risk of Alzheimer's disease Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020. DOI 10.1002/dad2.12139
Gray and white matter damage are associated with motor symptoms in Parkinson’s disease: Neuroimaging: Other neurodegenerative disorders AAIC - Alzheimer's Association International Conference, 2020. DOI 10.1002/alz.041174
Études d’imagerie métabolique liant les facteurs de risque génétique du diabète de type 2 au déclin cognitif vers la maladie d’Alzheimer Déclin cognitif, obésité, diabète et autres troubles métaboliques, 2020.
A dataset of long-term consistency values of resting-state fMRI connectivity maps in a single individual derived at multiple sites and vendors using the Canadian Dementia Imaging Protocol Data in Brief, 2020. Badhwar, A., Collin-Verreault, Y., Lussier, D., Sharmarke, H., Orban, P., Urchs, S., Chouinard, I., Vogel, J., Potvin, O., Duchesne, S., Bellec, P.. DOI 10.1016/j.dib.2020.105699
Associating Type 2 Diabetes Risk Factor Genes and FDG-PET Brain Metabolism in Normal Aging and Alzheimer’s Disease Frontiers in Aging Neuroscience, 2020. Nugent, S., Potvin, O., Cunnane, S.C., Chen, T.-H., Duchesne, S.. DOI 10.3389/fnagi.2020.580633
Reliability assessment of tissue classification algorithms for multi-center and multi-scanner data NeuroImage, 2020. Dadar, M., Duchesne, S.. DOI 10.1016/j.neuroimage.2020.116928
Selection of the optimal intensity normalization region for FDG-PET studies of normal aging and Alzheimer’s disease Scientific Reports, 2020. Nugent, S., Croteau, E., Potvin, O., Castellano, C.-A., Dieumegarde, L., Cunnane, S.C., Duchesne, S.. DOI 10.1038/s41598-020-65957-3
The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 2020. Dadar, M., Camicioli, R., Duchesne, S., Collins, D.L.. DOI 10.1002/dad2.12091
White matter hyperintensities, gray matter atrophy and cognitive deficits in Parkinson’s disease: Neuroimaging/Optimal neuroimaging measures for tracking disease progression AAIC - Alzheimer's Association International Conference, 2020. DOI 10.1002/alz.041161
Corrigendum to: “FreeSurfer subcortical normative data” [Data in Brief 9 (2016) 732–736] (FreeSurfer subcortical normative data (2016) 9 (732–736), (S235234091630628X), (10.1016/j.dib.2016.10.001)) Data in Brief, 2019. Potvin, O., Mouiha, A., Dieumegarde, L., Duchesne, S.. DOI 10.1016/j.dib.2019.103704
The Consortium for the early identification of Alzheimer's disease–Quebec (CIMA-Q) Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 2019. Belleville, S., LeBlanc, A.C., Kergoat, M.-J., Calon, F., Gaudreau, P., Hébert, S.S., Hudon, C., Leclerc, N., Mechawar, N., Duchesne, S., Gauthier, S., Bellec, P., Bocti, C., Chertkow, H., Collins, L., Cunnane, S., Marie-Jeanne-Kergoat, C.H., Philips, N., Soucy, J.-P., Dang Vu, T.T., Verret, L., Villalpando, J.M.. DOI 10.1016/j.dadm.2019.07.003
FDG-PET Normative Data in Cognitively Healthy Aging AAIC - Alzheimer’s Association International Conference, 2019. DOI 10.1016/j.jalz.2019.06.4227
Association Between Cerebellar Volumes and Cognitive Functioning Alzheimer’s Disease and Associated Disorders, 2019. DOI 10.1097/WAD.0000000000000327
Brain atrophy and patch-based grading in individuals from the CIMA-Q study: a progressive continuum from subjective cognitive decline to AD Scientific Reports, 2019. Marcotte, C., Potvin, O., Collins, D.L., Rheault, S., Duchesne, S.. DOI 10.1038/s41598-019-49914-3
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 2019. Smith, E.E., Biessels, G.J., De Guio, F., de Leeuw, F.E., Duchesne, S., Düring, M., Frayne, R., Ikram, M.A., Jouvent, E., MacIntosh, B.J., Thrippleton, M.J., Vernooij, M.W., Adams, H., Backes, W.H., Ballerini, L., Black, S.E., Chen, C., Corriveau, R., DeCarli, C., Greenberg, S.M., Gurol, M.E., Ingrisch, M., Job, D., Lam, B.Y.K., Launer, L.J., Linn, J., McCreary, C.R., Mok, V.C.T., Pantoni, L., Pike, G.B., Ramirez, J., Reijmer, Y.D., Romero, J.R., Ropele, S., Rost, N.S., Sachdev, P.S., Scott, C.J.M., Seshadri, S., Sharma, M., Sourbron, S., Steketee, R.M.E., Swartz, R.H., van Oostenbrugge, R., van Osch, M., van Rooden, S., Viswanathan, A., Werring, D., Dichgans, M., Wardlaw, J.M.. DOI 10.1016/j.dadm.2019.01.002
Stem Cell-Derived Neurons as Cellular Models of Sporadic Alzheimer's Disease Journal of Alzheimer's Disease, 2019. Foveau, B., Correia, A.S., Hébert, S.S., Rainone, S., Potvin, O., Kergoat, M.-J., Belleville, S., Duchesne, S., LeBlanc, A.C.. DOI 10.3233/JAD-180833
Structural and functional multi-platform MRI series of a single human volunteer over more than fifteen years Scientific Data, 2019. Duchesne, S., Dieumegarde, L., Chouinard, I., Farokhian, F., Badhwar, A., Bellec, P., Tétreault, P., Descoteaux, M., Boré, A., Houde, J.-C., Beaulieu, C., Potvin, O.. DOI 10.1038/s41597-019-0262-8
The comprehensive assessment of neurodegeneration and dementia: Canadian cohort study Canadian Journal of Neurological Sciences, 2019. Chertkow, H., Borrie, M., Whitehead, V., Black, S.E., Feldman, H.H., Gauthier, S., Hogan, D.B., Masellis, M., McGilton, K., Rockwood, K., Tierney, M.C., Andrew, M., Hsiung, G.-Y.R., Camicioli, R., Smith, E.E., Fogarty, J., Lindsay, J., Best, S., Evans, A., Das, S., Mohaddes, Z., Pilon, R., Poirier, J., Phillips, N.A., MacNamara, E., Dixon, R.A., Duchesne, S., MacKenzie, I., Rylett, R.J.. DOI 10.1017/cjn.2019.27
A novel patch-based procedure for estimating brain age across adulthood NeuroImage, 2019. Beheshti, I., Gravel, P., Potvin, O., Dieumegarde, L., Duchesne, S.. DOI 10.1016/j.neuroimage.2019.05.025
Bias-adjustment in neuroimaging-based brain age frameworks: A robust scheme NeuroImage: Clinical, 2019. Beheshti, I., Nugent, S., Potvin, O., Duchesne, S.. DOI 10.1016/j.nicl.2019.102063
Braak neurofibrillary tangle staging prediction from in vivo MRI metrics Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 2019. Dallaire-Théroux, C., Beheshti, I., Potvin, O., Dieumegarde, L., Saikali, S., Duchesne, S.. DOI 10.1016/j.dadm.2019.07.001
Links between metabolic and structural changes in the brain of cognitively normal older adults: A 4-year longitudinal follow-up Frontiers in Aging Neuroscience, 2019. Castellano, C.-A., Hudon, C., Croteau, E., Fortier, M., St-Pierre, V., Vandenberghe, C., Nugent, S., Tremblay, S., Paquet, N., Lepage, M., Fülöp, T., Turcotte, É.E., Dionne, I.J., Potvin, O., Duchesne, S., Cunnane, S.C.. DOI 10.3389/fnagi.2019.00015
Measurement Variability following MRI system upgrade Frontiers in Neurology, 2019. DOI 10.3389/fneur.2019.00726
P4‐251:Similarities between the cognitive profil of individuals with subjective cognitive decline and that of persons with mild cognitive imparement: a study from de CIMA-Q cohort (AAIC) Alzheimer's Association International Conference, 2019. DOI 10.1016/j.jalz.2019.06.3920
The Canadian Dementia Imaging Protocol: Harmonization validity for morphometry measurements NeuroImage: Clinical, 2019. Potvin, O., Chouinard, I., Dieumegarde, L., Bartha, R., Bellec, P., Collins, D.L., Descoteaux, M., Hoge, R., Ramirez, J., Scott, C.J.M., Smith, E.E., Strother, S.C., Black, S.E., Duchesne, S.. DOI 10.1016/j.nicl.2019.101943
The Canadian Dementia Imaging Protocol: Harmonizing National Cohorts Journal of Magnetic Resonance Imaging, 2019. Duchesne, S., Chouinard, I., Potvin, O., Fonov, V.S., Khademi, A., Bartha, R., Bellec, P., Collins, D.L., Descoteaux, M., Hoge, R., McCreary, C.R., Ramirez, J., Scott, C.J.M., Smith, E.E., Strother, S.C., Black, S.E.. DOI 10.1002/jmri.26197
Trajectory analyses of morphometric imaging measures provide novel insights into the dynamics of brain aging as moderated by sex and APOE AAIC - Alzheimer’s Association International Conference, 2019. DOI 10.1016/j.jalz.2019.06.936
Validation of an Magnetic Resonance Imaging Acquisition and Review Protocol for Alzheimer's Disease and Related Disorders Canadian Association of Radiologists Journal, 2019. Asselin, A., Potvin, O., Bouchard, L.-O., Brisson, M., Duchesne, S.. DOI 10.1016/j.carj.2018.10.008
White Matter Damage in the Semantic Variant of Primary Progressive Aphasia Canadian Journal of Neurological Sciences, 2019. Bouchard, L.-O., Wilson, M.A., Laforce, R., Duchesne, S.. DOI 10.1017/cjn.2019.37
Antemortem Longitudinal Mri Metrics As A Biomarker Of Postmortem Braak NFT Staging AAIC - Alzheimer's Association International Conference, 2018. DOI 10.1016/j.jalz.2018.06.2057
Baseline Differences In Brain Morphometry And Image Grading Of Individuals On The Continuum From Subjective Cognitive Decline To AD: Results from the CIMA-Q Study AAIC - Alzheimer's Association International Conference, 2018. DOI 10.1016/j.jalz.2018.06.1736
Corrigendum to ‘Normative data for subcortical regional volumes over the lifetime of the adult human brain’ [NeuroImage 137 (2016) 9–20] (NeuroImage (2016) 137 (9–20), (S1053811916301355) (10.1016/j.neuroimage.2016.05.016)) NeuroImage, 2018. Potvin, O., Mouiha, A., Dieumegarde, L., Duchesne, S.. DOI 10.1016/j.neuroimage.2018.09.020
Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder Journal of Child Psychology and Psychiatry and Allied Disciplines, 2018. Ganzola, R., McIntosh, A.M., Nickson, T., Sprooten, E., Bastin, M.E., Giles, S., Macdonald, A., Sussmann, J., Duchesne, S., Whalley, H.C.. DOI 10.1111/jcpp.12879
Faster progression from MCI to probable AD for carriers of a single-nucleotide polymorphism associated with type 2 diabetes Neurobiology of Aging, 2018. Girard, H., Potvin, O., Nugent, S., Dallaire-Théroux, C., Cunnane, S., Duchesne, S.. DOI 10.1016/j.neurobiolaging.2017.11.013
Guest editorial for the IJCARS special issue on MICCAI 2017 International Journal of Computer Assisted Radiology and Surgery, 2018. Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, L.D., Duchesne, S.. DOI 10.1007/s11548-018-1847-y
Presence Of Task-Related Hyperactivation In Persons With Subjective Cognitive Decline: Evidence From The CIMA-Q Cohort AAIC - Alzheimer's Association International Conference, 2018. DOI 10.1016/j.jalz.2018.06.1734
The Midbrain Is The Optimal Intensity Normalization Region For FEDG-PET Studies Of Normal Aging AAIC - Alzheimer's Association International Conference, 2018.
The relationship between brain markers of neurodegeneration and cognition in persons with subjective cognitive decline: a study from the CIMA-Q cohort Alzheimer's Association International Conference, 2018. DOI 10.1016/j.jalz.2018.06.2492
Corrigendum to ‘Normative morphometric data for cerebral cortical areas over the lifetime of the adult human brain’ [NeuroImage 156 (2017) 315–339] (NeuroImage (2017) 156 (315–339), (S1053811917304135) (10.1016/j.neuroimage.2017.05.019)) NeuroImage, 2018. Potvin, O., Dieumegarde, L., Duchesne, S.. DOI 10.1016/j.neuroimage.2018.09.019
Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer's Disease Journal of Alzheimer's Disease, 2018. Croteau, E., Castellano, C.-A., Richard, M.A., Fortier, M., Nugent, S., Lepage, M., Duchesne, S., Whittingstall, K., Turcotte, É.E., Bocti, C., Fülöp, T., Cunnane, S.C.. DOI 10.3233/JAD-180202
Special Issue on MICCAI 2017 Medical Image Analysis, 2018. Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S.. DOI 10.1016/j.media.2018.07.005
Temporal Lobe Activation Moderates The Detrimental Effect Of Hippocampal Atrophy On Episodic Memory And Contributes To Cognitive Reserve: Results From The CIMA-Qcohort AAIC - Alzheimer's Association International Conference, 2018. DOI 10.1016/j.jalz.2018.06.1693
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