Répertoire du corps professoral
Steeve Provencher
Médecin clinicien enseignant titulaire
Steeve.Provencher@criucpq.ulaval.ca
The Impact of Chronobiology on Pulmonary Arterial Hypertension: Insights into the Core Clock Protein Rev-Erb
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2025
au 30 septembre 2030
Targeting Integrin Signaling to Alleviate Remodeling in Pulmonary Arteries and the Right Ventricle in Pulmonary Hypertension
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2024
au 30 septembre 2029
Targeting Mitosis and Senescence to Reverse Pulmonary Hypertension: A Promising Therapeutic Strategy
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2023
au 30 septembre 2028
Exploring the Interplay between Metabolic and Epigenetic Signalling Pathways to Regulate Neointima Hyperplasia
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2023
au 30 septembre 2028
Targeting Hypusine signaling: an opportunity to counter pulmonary vascular remodelling in pulmonary arterial hypertension
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023
au 31 mars 2028
ATP Citrate Lyase: an attractive target at the nexus of metabolic and epigenetic alterations in pulmonary arterial hypertension
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2022
au 31 mars 2027
BRD4 Inhibition in Pulmonary Arterial Hypertension: a Phase 2 Clinical Trial
Programme: Subvention de fonctionnement : Application clinique de l’épigénétique
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 février 2019
au 31 mars 2026
Financements des 2 dernières années
Prognostic significance of proteomics-discovered circulating inflammatory biomarkers in patients with PAH
Organisme(s) subventionnaire(s): Fondation de l'Institut de cardiologie de Québec, Fondation J.-D.-Bégin
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 janvier 2023
au 31 décembre 2024
The anti-oxidative DNA damage protein MTH1, the novel pulmonary hypertension Achilles heel
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2020
au 31 mars 2025
Role of the long non-coding RNA H19 as a novel biomarker and therapeutic target in right ventricular failure in pulmonary arterial hypertension
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2019
au 31 mars 2024
PARP inhibition in PAH: A Phase 1 clinical trial
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2018
au 31 mars 2025
Encadrements terminés dans les 5 dernières années
Publications des 5 dernières années
Breast Cancer Reveals Latent <i>BMPR2</i>-Related Susceptibility to Pulmonary Hypertension. Circulation, 2026/01/28. Toro V, Mougin M, Brossat C, Jambon-Barbara C, Hlavaty A, Guay CA, El Kabbout R, Bilodeau C, Grobs Y, Martineau S, Breuils-Bonnet S, Abi-Sleimen A, Ruffenach G, Boucherat O, Bisserier M, Provencher S, Bonnet S, Montani D, Khouri C, Potus F. DOI 10.1161/circulationaha.125.079067
Protein biomarkers in pulmonary arterial hypertension: advances, clinical relevance, and translational challenges. Journal of translational medicine, 2025/11/14. Niu Y, Tian J, Provencher S, Bonnet S, Boucherat O, Potus F, Gou D. DOI 10.1186/s12967-025-07257-w
Response to the letter to the Editor on "The Changing Landscape of Lung Cancer Resection Outcomes Over the Past Two Decades". Clinical lung cancer, 2025/11/11. Guay CA, Suhani A, Perreault L, Mai V, Laliberté AS, Labbé C, Provencher S. DOI 10.1016/j.cllc.2025.11.004
Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation. The European respiratory journal, 2025/10/16. Jankowski K, Lemay SE, Lozano-Ojalvo D, Pérez-Rodríguez L, Sauvaget M, Breuils-Bonnet S, Formoso K, Jagana V, Ochoa MT, Zhang S, Milara J, Cortijo J, Turnbull IC, Provencher S, Bonnet S, Ochando J, Lezoualc'h F, Bisserier M, Hadri L. DOI 10.1183/13993003.02250-2024
Transitioning From Parenteral Prostanoids to Oral Selexipag in Pulmonary Arterial Hypertension: A Multicenter Retrospective Cohort Study. Pulmonary circulation, 2025/10/01. Budhram B, Alrasheed SK, Rashad M, Chandy G, Dvorkin-Gheva A, Fox GA, Foxall J, Gardner A, Helmersen D, Hirani N, Kemp K, Kularatne M, Langleben D, Lesenko L, Provencher S, Spence E, Swiston JR, Thakrar M, Wadden D, Weatherald J, Hambly N. DOI 10.1002/pul2.70220
The Changing Landscape of Lung Cancer Resection Outcomes Over the Past two Decades. Clinical lung cancer, 2025/08/13. Guay CA, Suhani A, Perreault L, Mai V, Laliberté AS, Labbé C, Provencher S. DOI 10.1016/j.cllc.2025.08.006
Prognostic impacts of interstitial lung abnormalities on outcomes following resection for lung cancer BMJ Open Respiratory Research, 2025/08. Charles-Antoine Guay, Pierre-Emile Charest, Frederic-Thomas Caron, Louis Laflamme, Laurie Perreault, Anne-Sophie Laliberté, Elisabeth Albert, Genevieve Dion, Steeve Provencher. DOI 10.1136/bmjresp-2024-002981
Exploratory Study of Prognostic Plasma Biomarkers in Patients with Pulmonary Arterial Hypertension The American Journal of Pathology, 2025/08. Yukimitsu Kuwabara, Tetsuro Yokokawa, Sarah-Eve Lemay, Mélanie Sauvaget, Sandra Martineau, Sandra Breuils-Bonnet, François Potus, Sébastien Bonnet, Steeve Provencher, Olivier Boucherat. DOI 10.1016/j.ajpath.2025.04.018
A critical contribution of cardiac myofibroblasts in right ventricular failure and the role of UCP2 SNPs in the predisposition to RV decompensation in pulmonary arterial hypertension 2025/07/29. Yongneng Zhang, Sébastien Bonnet, Steeve Provencher, Alois Haromy, Yongsheng Liu, Yuan-Yuan Zhao, Sandra Breuils-Bonnet, Dawn E. Bowles, Michelle Mendiola Pla, Gopinath Sutendra, Evangelos D. Michelakis. DOI 10.1101/2025.07.25.666908
Cellular senescence in adult pulmonary hypertension: current state and future challenges. European respiratory review : an official journal of the European Respiratory Society, 2025/07/01. Lemay SE, Kuwabara Y, Bonnet S, Potus F, Provencher S, Adnot S, Boucherat O. DOI 10.1183/16000617.0030-2025
Anti-remodeling therapies in pulmonary arterial hypertension. Trends in pharmacological sciences, 2025/06/19. Boucherat O, Bonnet S, Provencher S, Potus F. DOI 10.1016/j.tips.2025.05.004
Polycystic Ovary Syndrome, Endometriosis, and Venous Thromboembolism: A Population-Based Study. Gynecologic and obstetric investigation, 2025/04/03. Provencher S, Nassiri Kigloo H, Mai V, Suarthana E, Tulandi T, Provencher S. DOI 10.1159/000545518
Diagnostic Accuracy of Ultrasound Guidance in Transthoracic Needle Biopsy: A Systematic Review and Meta-Analysis. Journal of thoracic imaging, 2025/03/01. Lemieux S, Pinard L, Marchand R, Kali S, Altmayer S, Mai V, Provencher S. DOI 10.1097/rti.0000000000000811
Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies. Cell reports. Medicine, 2025/02/10. Lemay SE, Mougin M, Sauvaget M, El Kabbout R, Valasarajan C, Yamamoto K, Martineau S, Pelletier A, Bilodeau C, Grobs Y, Bourgeois A, Romanet C, Breuils-Bonnet S, Montesinos MS, Lu M, Chen H, Gilbert M, Théberge C, Potus F, Pullamsetti S, Provencher S, Bonnet S, Boucherat O. DOI 10.1016/j.xcrm.2025.101964
Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights From Comprehensive Multicenter Preclinical Studies. Circulation, 2025/01/20. Lemay SE, Montesinos MS, Grobs Y, Yokokawa T, Shimauchi T, Mougin M, Romanet C, Sauvaget M, Breuils-Bonnet S, Bourgeois A, Théberge C, Pelletier A, El Kabbout R, Martineau S, Yamamoto K, Akram M, Ray AS, Lippa B, Goodwin B, Lin FY, Wang H, Dowling JE, Lu M, Qiao Q, McTeague TA, Moy TI, Potus F, Provencher S, Boucherat O, Bonnet S. DOI 10.1161/circulationaha.124.070693
ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes. Science translational medicine, 2024/12/11. Grobs Y, Romanet C, Lemay SE, Bourgeois A, Voisine P, Theberge C, Sauvaget M, Breuils-Bonnet S, Martineau S, El Kabbout R, Valasarajan C, Chelladurai P, Pelletier A, Mougin M, Dumais E, Perron J, Flamand N, Potus F, Provencher S, Pullamsetti SS, Boucherat O, Bonnet S. DOI 10.1126/scitranslmed.ado7824
Trends in COPD severe exacerbations, and all-cause and respiratory mortality, before and after implementation of newer long-acting bronchodilators in a large population-based cohort. BMC pulmonary medicine, 2024/09/13. Guay CA, Maltais F, Beaudoin C, Carmichael PH, Laouan Sidi EA, Perreault L, Sirois C, Provencher S. DOI 10.1186/s12890-024-03277-2
Unraveling the Impact of miR-146a in Pulmonary Arterial Hypertension Pathophysiology and Right Ventricular Function. International journal of molecular sciences, 2024/07/24. Santos-Gomes J, Mendes-Ferreira P, Adão R, Maia-Rocha C, Rego B, Poels M, Saint-Martin Willer A, Masson B, Provencher S, Bonnet S, Montani D, Perros F, Antigny F, Leite-Moreira AF, Brás-Silva C. DOI 10.3390/ijms25158054
Prognostic Significance of Proteomics-Discovered Circulating Inflammatory Biomarkers in Patients With Pulmonary Arterial Hypertension. Journal of the American Heart Association, 2024/06/14. Yokokawa T, Boucherat O, Martineau S, Lemay SE, Breuils-Bonnet S, Krishna V, Krishna V, Kalyana-Sundaram S, Jeyaseelan J, Potus F, Bonnet S, Provencher S. DOI 10.1161/jaha.123.032888
Hypusine Signaling Promotes Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension. American journal of respiratory and critical care medicine, 2024/06/01. Lemay SE, Grobs Y, Romanet C, Martineau S, Salem M, Shimauchi T, Breuils-Bonnet S, Bourgeois A, Théberge C, Pelletier A, Potus F, Provencher S, Bonnet S, Boucherat O. DOI 10.1164/rccm.202305-0909oc
A HIF-2α-dependent KMT2E-AS1/KMT2E axis orchestrates endothelial epigenetic and metabolic dysfunction in pulmonary hypertension Annals of translational medicine, 2024/05/28. Lemay SE, Provencher S, Bonnet S, Potus F, Boucherat O. DOI 10.21037/atm-24-54
Mendelian Randomization in Pulmonary Arterial Hypertension: Unveiling Early Insights With Promise for Future Discoveries Journal of the American Heart Association, 2024/03/19. Steeve Provencher, Benoit J. Arsenault, Sebastien Bonnet. DOI 10.1161/JAHA.123.033446
Managing Pulmonary Arterial Hypertension With Cardiopulmonary Comorbidities CHEST, 2024/03. Steeve Provencher, Vicky Mai, Sebastien Bonnet. DOI 10.1016/j.chest.2023.08.023
Time Is Running Out in Pulmonary Arterial Hypertension: The Epigenetic Clock Is Clicking. American journal of respiratory cell and molecular biology, 2024/02/01. El Kabbout R, Azhar N, Breuils-Bonnet S, Martineau S, Krishna V, Kalyana-Sundaram S, Boucherat O, Provencher S, Bonnet S, Potus F. DOI 10.1165/rcmb.2023-0335le
Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: an estimate. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2024/01/02. Pradelle A, Mainbourg S, Provencher S, Massy E, Grenet G, Lega JC. DOI 10.1016/j.biopha.2023.116055
Automated O<sub>2</sub> Titration Alone or With High-Flow Nasal Cannula During Walking Exercise in Chronic Lung Diseases. Respiratory care, 2023/12/28. Vézina FA, Bouchard PA, Breton-Gagnon É, Dion G, Viglino D, Roy P, Bilodeau L, Provencher S, Denault MH, Saey D, Lellouche F, Maltais F. DOI 10.4187/respcare.10810
Right Ventricle and Epigenetics: A Systematic Review Cells, 2023/11/23. Victoria Toro, Naomie Jutras-Beaudoin, Olivier Boucherat, Sebastien Bonnet, Steeve Provencher, François Potus. DOI 10.3390/cells12232693
Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. Nature cardiovascular research, 2023/09/28. Khassafi F, Chelladurai P, Valasarajan C, Nayakanti SR, Martineau S, Sommer N, Yokokawa T, Boucherat O, Kamal A, Kiely DG, Swift AJ, Alabed S, Omura J, Breuils-Bonnet S, Kuenne C, Potus F, Günther S, Savai R, Seeger W, Looso M, Lawrie A, Zaugg JB, Tello K, Provencher S, Bonnet S, Pullamsetti SS. DOI 10.1038/s44161-023-00338-3
Defining the clinical validity of genes reported to cause pulmonary arterial hypertension. Genetics in medicine : official journal of the American College of Medical Genetics, 2023/07/05. Welch CL, Aldred MA, Balachandar S, Dooijes D, Eichstaedt CA, Gräf S, Houweling AC, Machado RD, Pandya D, Prapa M, Shaukat M, Southgate L, Tenorio-Castano J, ClinGen PH VCEP, Chung WK, International Consortium for Genetic Studies in Pulmonary Arterial Hypertension (PAH-ICON) at the Pulmonary Vascular Research Institute (PVRI). DOI 10.1016/j.gim.2023.100925
Patients’ perceptions on clinical trials outcomes in pulmonary arterial hypertension therapy Thorax, 2023/07. Vicky Mai, Camille Gosselin, Élodie Tremblay, Gabrielle Rompré, Annie Christine Lajoie, Jason Weatherald, Jean-Christophe Lega, Sébastien Bonnet, Steeve Provencher. DOI 10.1136/thorax-2022-219490
Effect of reverse Trendelenburg position and positive pressure ventilation on safe non-hypoxic apnea period in obese, a randomized-control trial. BMC anesthesiology, 2023/06/08. Couture EJ, Carrier-Boucher A, Provencher S, Tanoubi I, Marceau S, Bussières JS. DOI 10.1186/s12871-023-02128-7
Transbronchial Lung Cryobiopsy and Surgical Lung Biopsy: A Prospective Multi-Centre Agreement Clinical Trial (CAN-ICE). American journal of respiratory and critical care medicine, 2023/06/01. Fortin M, Liberman M, Delage A, Dion G, Martel S, Rolland F, Soumagne T, Trahan S, Assayag D, Albert E, Kelly MM, Johannson KA, Guenther Z, Leduc C, Manganas H, Prenovault J, Provencher S. DOI 10.1164/rccm.202209-1812oc
The future of group 2 pulmonary hypertension: Exploring clinical trials and therapeutic targets. Vascular pharmacology, 2023/05/12. Awada C, Boucherat O, Provencher S, Bonnet S, Potus F. DOI 10.1016/j.vph.2023.107180
G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension. American journal of respiratory cell and molecular biology, 2023/05/01. Awada C, Bourgeois A, Lemay SE, Grobs Y, Yokokawa T, Breuils-Bonnet S, Martineau S, Krishna V, Potus F, Jeyaseelan J, Provencher S, Bonnet S, Boucherat O. DOI 10.1165/rcmb.2022-0300oc
Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling. Circulation research, 2023/04/12. Nayakanti SR, Friedrich A, Sarode P, Jafari L, Maroli G, Boehm M, Bourgeois A, Grobs Y, Khassafi F, Kuenne C, Guenther S, Dabral S, Wilhelm J, Weiss A, Wietelmann A, Kojonazarov B, Janssen W, Looso M, de Man F, Provencher S, Tello K, Seeger W, Bonnet S, Savai R, Schermuly RT, Pullamsetti SS. DOI 10.1161/circresaha.122.321725
Progression of Pulmonary Fibrosis According to Radiological Pattern in Asbestosis. Annals of the American Thoracic Society, 2023/02/01. Millaire É, Lévesque M, Lemière C, Cartier A, Provencher S, Dion G. DOI 10.1513/annalsats.202206-474rl
DNA-Protein Kinase Catalytic Subunit as a Potential Target for Pulmonary Arterial Hypertension. American journal of respiratory cell and molecular biology, 2023/01/01. Yamamoto K, Lemay SE, Yokokawa T, Breuils-Bonnet S, Salem M, Potus F, Provencher S, Boucherat O, Bonnet S. DOI 10.1165/rcmb.2022-0239le
Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics. Hypertension (Dallas, Tex. : 1979), 2022/10/24. Zelt JGE, Cadete V, Deng Y, Godoy R, Cuillerier A, Rowe K, Abdul-Ghani M, Megeney L, Burelle Y, Giulivi A, Stewart AFR, Provencher S, Breuils-Bonnet S, Bonnet S, deKemp R, Beanlands R, Mielniczuk LM, Stewart DJ. DOI 10.1161/hypertensionaha.122.19300
Priorities for pulmonary hypertension research: A James Lind Alliance priority setting partnership. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2022/10/03. Weatherald J, Iqbal H, Mielniczuk L, Syed AR, Legkaia L, Howard J, Dempsey N, Rader T, Swiston J, Provencher S. DOI 10.1016/j.healun.2022.09.015
Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension. American journal of respiratory and critical care medicine, 2022/09/01. Al-Qazazi R, Lima PDA, Prisco SZ, Potus F, Dasgupta A, Chen KH, Tian L, Bentley RET, Mewburn J, Martin AY, Wu D, Jones O, Maurice DH, Bonnet S, Provencher S, Prins KW, Archer SL. DOI 10.1164/rccm.202110-2274oc
Assessment of Clinical Worsening End Points as a Surrogate for Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Circulation, 2022/08/23. Élodie Tremblay, Camille Gosselin, Vicky Mai, Annie C. Lajoie, Roubi Kilo, Jason Weatherald, Yves Lacasse, Sebastien Bonnet, Jean-Christophe Lega, Steeve Provencher. DOI 10.1161/CIRCULATIONAHA.121.058635
Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension. Nature cardiovascular research, 2022/08/11. Boucherat O, Yokokawa T, Krishna V, Kalyana-Sundaram S, Martineau S, Breuils-Bonnet S, Azhar N, Bonilla F, Gutstein D, Potus F, Lawrie A, Jeyaseelan J, Provencher S, Bonnet S. DOI 10.1038/s44161-022-00113-w
A Systematic Evaluation of the Quality, Accuracy, and Reliability of Internet Websites about Pulmonary Arterial Hypertension. Annals of the American Thoracic Society, 2022/08/01. Saleh D, Fisher JH, Provencher S, Liang Z, Ryerson CJ, Weatherald J. DOI 10.1513/annalsats.202103-325oc
BET Protein Inhibition for Pulmonary Arterial Hypertension: A Pilot Clinical Trial American Journal of Respiratory and Critical Care Medicine, 2022/06/01. Steeve Provencher, François Potus, Pascale Blais-Lecours, Sarah Bernard, Sandra Martineau, Sandra Breuils-Bonnet, Jason Weatherald, Mike Sweeney, Ewelina Kulikowski, Olivier Boucherat, Sebastien Bonnet. DOI 10.1164/rccm.202109-2182LE
PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension. JACC. Basic to translational science, 2022/03/16. Shimauchi T, Boucherat O, Yokokawa T, Grobs Y, Wu W, Orcholski M, Martineau S, Omura J, Tremblay E, Shimauchi K, Nadeau V, Breuils-Bonnet S, Paulin R, Potus F, Provencher S, Bonnet S. DOI 10.1016/j.jacbts.2022.01.005
Outcomes Following Surgical Lung Biopsy for Interstitial Lung Diseases: A Monocenter Experience. The Thoracic and cardiovascular surgeon, 2022/02/12. Millaire É, Ouellet É, Fortin M, Martel S, Milot J, Bilodeau L, Conti M, Provencher S, Dion G. DOI 10.1055/s-0041-1740548
Risk Factors for Venous Thromboembolism in Severe COVID-19: A Study-Level Meta-Analysis of 21 Studies. International journal of environmental research and public health, 2021/12/08. Lobbes H, Mainbourg S, Mai V, Douplat M, Provencher S, Lega JC. DOI 10.3390/ijerph182412944
Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension. Science advances, 2021/10/20. Negi V, Yang J, Speyer G, Pulgarin A, Handen A, Zhao J, Tai YY, Tang Y, Culley MK, Yu Q, Forsythe P, Gorelova A, Watson AM, Al Aaraj Y, Satoh T, Sharifi-Sanjani M, Rajaratnam A, Sembrat J, Provencher S, Yin X, Vargas SO, Rojas M, Bonnet S, Torrino S, Wagner BK, Schreiber SL, Dai M, Bertero T, Al Ghouleh I, Kim S, Chan SY. DOI 10.1126/sciadv.abh3794
Meta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality. Scientific reports, 2021/07/19. Kilo R, Laporte S, Arab R, Mainbourg S, Provencher S, Grenet G, Bertoletti L, Villeneuve L, Cucherat M, Lega JC, META-EMBOL Group. DOI 10.1038/s41598-021-94160-1
Potential for inhibition of checkpoint kinases 1/2 in pulmonary fibrosis and secondary pulmonary hypertension. Thorax, 2021/07/05. Wu WH, Bonnet S, Shimauchi T, Toro V, Grobs Y, Romanet C, Bourgeois A, Vitry G, Omura J, Tremblay E, Nadeau V, Orcholski M, Breuils-Bonnet S, Martineau S, Ferraro P, Potus F, Paulin R, Provencher S, Boucherat O. DOI 10.1136/thoraxjnl-2021-217377
Fetal Gene Reactivation in Pulmonary Arterial Hypertension: GOOD, BAD, or BOTH? Cells, 2021/06/11. Lemay SE, Awada C, Shimauchi T, Wu WH, Bonnet S, Provencher S, Boucherat O. DOI 10.3390/cells10061473
Significant Major Bleeding in Hospitalized Patients with COVID-19 Receiving Thromboprophylaxis. Thrombosis and haemostasis, 2021/06/06. Mai V, Mainbourg S, Tan BK, Lega JC, Provencher S. DOI 10.1055/a-1477-4027
Venous thromboembolism in COVID-19 compared to non-COVID-19 cohorts: A systematic review with meta-analysis. Vascular pharmacology, 2021/06/02. Mai V, Tan BK, Mainbourg S, Potus F, Cucherat M, Lega JC, Provencher S. DOI 10.1016/j.vph.2021.106882
R-Crizotinib predisposes to and exacerbates pulmonary arterial hypertension in animal models. The European respiratory journal, 2021/05/13. Awada C, Grobs Y, Wu WH, Habbout K, Romanet C, Breuils-Bonnet S, Tremblay E, Martineau S, Paulin R, Bonnet S, Provencher S, Potus F, Boucherat O. DOI 10.1183/13993003.03271-2020
Ultrasound-guided transthoracic needle biopsy of the lung: sensitivity and safety variables. European radiology, 2021/04/21. Lemieux S, Kim T, Pothier-Piccinin O, Racine LC, Firoozi F, Drolet M, Pasian S, Kennedy KF, Provencher S, Ugalde P. DOI 10.1007/s00330-021-07888-9
Exercise intolerance in pulmonary arterial hypertension: insight into central and peripheral pathophysiological mechanisms. European respiratory review : an official journal of the European Respiratory Society, 2021/04/13. Malenfant S, Lebret M, Breton-Gagnon É, Potus F, Paulin R, Bonnet S, Provencher S. DOI 10.1183/16000617.0284-2020
Non-ventilated lung deflation during one-lung ventilation with a double-lumen endotracheal tube: a randomized-controlled trial of occluding the non-ventilated endobronchial lumen before pleural opening. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2021/04/02. Somma J, Couture ÉJ, Pelletier S, Provencher S, Moreault O, Lohser J, Ugalde PA, Vigneault L, Lemieux J, Somma A, Guay SE, Bussières JS. DOI 10.1007/s12630-021-01957-9
Impact of the new definition for pulmonary hypertension in patients with lung disease: an analysis of the United Network for Organ Sharing database. Pulmonary circulation, 2021/03/30. Nathan SD, Barnett SD, King CS, Provencher S, Barbera JA, Pastre J, Shlobin OA, Seeger W. DOI 10.1177/2045894021999960
Effect of Yttrium-90 transarterial radioembolization in patients with non-surgical hepatocellular carcinoma: A systematic review and meta-analysis. PloS one, 2021/03/04. Lemieux S, Buies A, F Turgeon A, Hallet J, Daigle G, Côté F, Provencher S. DOI 10.1371/journal.pone.0247958
Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension International Journal of Molecular Sciences, 2021/03. Yann Grobs, Charifa Awada, Sarah-Eve Lemay, Charlotte Romanet, Alice Bourgeois, Victoria Toro, Valérie Nadeau, Kana Shimauchi, Mark Orcholski, Sandra Breuils-Bonnet, Eve Tremblay, Steeve Provencher, Roxane Paulin, Olivier Boucherat, Sébastien Bonnet. DOI 10.3390/ijms22062919
Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach International Journal of Molecular Sciences, 2021/03. Karima Habbout, Junichi Omura, Charifa Awada, Alice Bourgeois, Yann Grobs, Vinod Krishna, Sandra Breuils-Bonnet, Eve Tremblay, Ghada Mkannez, Sandra Martineau, Valérie Nadeau, Florence Roux-Dalvai, Mark Orcholski, Jey Jeyaseelan, David Gutstein, François Potus, Steeve Provencher, Sébastien Bonnet, Roxane Paulin, Olivier Boucherat. DOI 10.3390/ijms22062957
Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension. American journal of respiratory and critical care medicine, 2021/03/01. Vitry G, Paulin R, Grobs Y, Lampron MC, Shimauchi T, Lemay SE, Tremblay E, Habbout K, Awada C, Bourgeois A, Nadeau V, Paradis R, Breuils-Bonnet S, Roux-Dalvai F, Orcholski M, Potus F, Provencher S, Boucherat O, Bonnet S. DOI 10.1164/rccm.202003-0627oc
17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin. The Journal of clinical investigation, 2021/03/01. Frump AL, Albrecht M, Yakubov B, Breuils-Bonnet S, Nadeau V, Tremblay E, Potus F, Omura J, Cook T, Fisher A, Rodriguez B, Brown RD, Stenmark KR, Rubinstein CD, Krentz K, Tabima DM, Li R, Sun X, Chesler NC, Provencher S, Bonnet S, Lahm T. DOI 10.1172/jci129433
Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis. Thorax, 2021/02/23. Tan BK, Mainbourg S, Friggeri A, Bertoletti L, Douplat M, Dargaud Y, Grange C, Lobbes H, Provencher S, Lega JC. DOI 10.1136/thoraxjnl-2020-215383
Validity of the Modified Dyspnea Index for the French-Canadian Population. Journal of nursing measurement, 2021/02/16. Dore M, Provencher S, Poirier P, Gélinas C, Stoller JK, de Oliveira EM, Gallani MC. DOI 10.1891/jnm-d-19-00042
Double-lumen endotracheal tubes and bronchial blockers exhibit similar lung collapse physiology during lung isolation. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2021/02/16. Moreault O, Couture EJ, Provencher S, Somma J, Lohser J, Ugalde PA, Lemieux J, Lellouche F, Bussières JS. DOI 10.1007/s12630-021-01938-y
Pulmonary Disease, Pulmonary Hypertension and Atrial Fibrillation. Cardiac electrophysiology clinics, 2021/01/08. Hiram R, Provencher S. DOI 10.1016/j.ccep.2020.10.001
Pulmonary tumor thrombotic microangiopathy: A systematic review of the literature Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2021/01/02. L. V. Morin-Thibault, D. Wiseman, P. Joubert, R. Paulin, S. Bonnet, S. Provencher. DOI 10.1080/24745332.2020.1724061
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