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Vincenzo Di Marzo

Professeur titulaire
vincenzo.dimarzo@criucpq.ulaval.ca
Pavillon des Services
2440, boul Hochelaga
Local 2744

Professeur titulaire
vincenzo.dimarzo@criucpq.ulaval.ca
Pavillon Ferdinand-Vandry
1050, avenue de la Médecine
Local 4211

Unité de rattachement — Faculté
Sciences de l'agriculture et de l'alimentation
Médecine

Affiliations
Centre de recherche de l'Institut universitaire de cardiologie et de pneumonie de Québec
Centre thématique de recherche en neurosciences
Centre de recherche de l'Institut universitaire de cardiologie et de pneumonie de Québec
Centre Nutrition, santé et société

Synthesis, characterization, and in vivo identification of novel oxyendocannabinoidome
Organisme(s) subventionnaire(s): International Human Frontier Science Program Organization
Type de financement: Subvention
Établissement tête: Université Laval
Du 23 avril 2024 au22 avril 2027

Institut sur la nutrition et les aliments fonctionnels (INAF)
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Université Concordia, Institut national de recherche scientifique (INRS), Université du Québec à Rimouski, Fonds de recherche du Québec - Nature et technologies, Université McGill, Université Laval - Fonds internes, Merinov - Centre d'innovation de l'aquaculture et des pêches du Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2024 au31 mars 2030

Effets de lipides polaires laitiers sur l’intégrité intestinale, le système endocannabinoïde et le microbiote fécal chez le porcelet
Programme: Projet subsidiaire d'un regroupement stratégique
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université Laval
Du 16 janvier 2023 au31 mars 2025

Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.1
Programme: Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 novembre 2019 au31 octobre 2024

Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.3
Programme: Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 novembre 2019 au31 octobre 2024

Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.2
Programme: Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 novembre 2019 au31 octobre 2024

Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 3.2
Programme: Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 novembre 2019 au31 octobre 2024

Dissecting host-microbiome modifiers of type 2 diabetes risk
Programme: Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 novembre 2019 au31 octobre 2024

Nutrition and brain health, from predictive biology to disease prevention and treatment - Food4BrainHealth
Programme: Réseau de recherche international (RRI)
Organisme(s) subventionnaire(s): Université Laval - Fonds internes, Université McGill, Université de Toronto, Institut national de la recherche agronomique
Type de financement: Subvention
Établissement tête: Université Laval
Du 18 mars 2019 au17 mars 2025

The role of full-fat dairy products on body weigth control and metabolic health in adults
Programme: Dairy Research Cluster 3
Organisme(s) subventionnaire(s): Les producteurs laitiers du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 septembre 2018 au30 septembre 2025

Canada Excellence Research Chair on the microbiome-endocannabinoidome connection in metabolic health
Programme: Programme de chaires d'excellence en recherche du Canada
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juin 2017 au31 mai 2025

Financements des 2 dernières années

Characterization of the endocannabinoidome of a CDKL5 mouse model
Organisme(s) subventionnaire(s): CDKL5
Type de financement: Subvention
Établissement tête: Université Laval
Du 15 janvier 2023 au15 janvier 2024

Assessment of the direct effects of propolis on the gut microbiome utilizing the Simulator of the Human Intestinal Microbial Ecosystem (SHIME)
Programme: Projet subsidiaire d'un regroupement stratégique
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 février 2022 au31 janvier 2023

Étude de l'impact de la transplantation fécal sur l'amélioration du diabète après la chirurgie bariatrique
Programme: Réseaux thématiques de recherche
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: Université Laval
Du 5 janvier 2022 au31 mars 2023

Role of the Endocannabinoid System (ECS) in HIV-associated chronic inflammation and comorbidities
Programme: Subventions d'équipe : Essai d'intervention sur l'inflammation pour les maladies chroniques - Preuve à impact
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université McGill
Du 1 juin 2021 au31 mai 2024

FMÉD --- Support de Sentinelle Nord à l'Unité mixte internationale sur la recherche chimique et biomoléculaire de microbiome
Programme: Fonds d'excellence en recherche Apogée Canada
Organisme(s) subventionnaire(s): Secrétariat des programmes interorganismes à l’intention des établissements
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juin 2017 au31 août 2023

Institut sur la nutrition et les aliments fonctionnels (INAF)
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Institut national de recherche scientifique (INRS), Fonds de recherche du Québec - Nature et technologies, Université Laval - Fonds internes, Université McGill, Université du Québec à Rimouski, Université de Sherbrooke
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2017 au31 mars 2024

FSAA --- Support de Sentinelle Nord à l'Unité mixte internationale sur la recherche chimique et biomoléculaire de microbiome
Programme: Fonds d'excellence en recherche Apogée Canada
Organisme(s) subventionnaire(s): Secrétariat des programmes interorganismes à l’intention des établissements
Type de financement: Subvention
Établissement tête: Université Laval
Du 29 novembre 2016 au31 août 2023

  • Fabiano Cimmino, Stage postdoctoral en médecine
  • Hayatte-Dounia Mir, Stage postdoctoral en médecine
  • Nayudu Nallabelli, Doctorat en médecine moléculaire
  • Chanté Muller, Stage postdoctoral en médecine
  • Hilal Kalkan, Stage postdoctoral en médecine
  • Giada Giorgini, Doctorat en neurosciences
  • Encadrements terminés dans les 5 dernières années

  • Gabrielle St-Arnaud, Maîtrise en nutrition - avec mémoire
  • Fredy Alexander Guevara Agudelo, Doctorat en nutrition
  • Frédéric Bégin, Maîtrise en nutrition - avec mémoire
  • Rim Ben Necib, Doctorat en médecine moléculaire
  • Armita Abolghasemi, Doctorat en médecine moléculaire
  • Publications des 5 dernières années

    Circulating endocannabinoidome signatures of disease activity in amyotrophic lateral sclerosis European Journal of Neurology, 2024/10. Raffaele Dubbioso, Fabio Arturo Iannotti, Gianmaria Senerchia, Roberta Verde, Valentina Virginia Iuzzolino, Myriam Spisto, Ines Fasolino, Fiore Manganelli, Vincenzo Di Marzo, Fabiana Piscitelli. DOI 10.1111/ene.16400

    The Human Fecal Endocannabinoidome Mediator Profile Is Mainly Defined by the Fecal Microbiota and Diet The Journal of Clinical Endocrinology & Metabolism, 2024/08/22. Sophie Castonguay-Paradis, Lydiane Parent, Gabrielle St-Arnaud, Julie Perron, Élizabeth Dumais, Nicolas Flamand, Frédéric Raymond, Vincenzo Di Marzo, Alain Veilleux. DOI 10.1210/clinem/dgae586

    Synthesis of N-(3-Acyloxyacyl)glycines, Small Molecules with Potential Role in Gut Microbiome-Endocannabinoidome Communication Molecules, 2024/08/05. Rosaria Villano, Vincenzo Di Marzo. DOI 10.3390/molecules29153703

    Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review International Journal of Obesity, 2024/02. Oscar David Lopez-Cortes, Francisco Trujillo-Sánchez, Erika Sierra-Ruelas, Erika Martinez-Lopez, Vincenzo Di Marzo, Barbara Vizmanos. DOI 10.1038/s41366-023-01428-9

    Mathematical modeling of fluid dynamics in in vitro gut fermentation systems: A new tool to improve the interpretation of microbial metabolism The FASEB Journal, 2024/01/31. Jacob Lessard‐Lord, Joseph Lupien‐Meilleur, Charlène Roussel, Benjamin Gosselin‐Cliche, Cristoforo Silvestri, Vincenzo Di Marzo, Denis Roy, Elsa Rousseau, Yves Desjardins. DOI 10.1096/fj.202301739RR

    New role for the anandamide metabolite prostaglandin F2α ethanolamide: Rolling preadipocyte proliferation Journal of Lipid Research, 2023/11. Besma Boubertakh, Olivier Courtemanche, David Marsolais, Vincenzo Di Marzo, Cristoforo Silvestri. DOI 10.1016/j.jlr.2023.100444

    Astrocytes modulate neuronal development by S100A6 signaling 2023/09/05. Valentina Cinquina, Daniela Calvigioni, Fabiana Piscitelli, Erik Keimpema, Vincenzo Di Marzo, Alexei Verkhratsky, Tibor Harkany. DOI 10.1101/2023.09.05.556314

    Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin Cell Death & Disease, 2023/08/23. Hilal Kalkan, Elisabetta Panza, Ester Pagano, Giuseppe Ercolano, Claudia Moriello, Fabiana Piscitelli, Mónika Sztretye, Raffaele Capasso, Vincenzo Di Marzo, Fabio Arturo Iannotti. DOI 10.1038/s41419-023-06080-9

    The emerging role of the endocannabinoidome-gut microbiome axis in eating disorders Psychoneuroendocrinology, 2023/08. Hayatte-Dounia Mir, Giada Giorgini, Vincenzo Di Marzo. DOI 10.1016/j.psyneuen.2023.106295

    Gene-based microbiome representation enhances host phenotype classification mSystems, 2023/07/05. Thomas Deschênes, Fred Wilfried Elom Tohoundjona, Pier-Luc Plante, Vincenzo Di Marzo, Frédéric Raymond. DOI 10.1128/msystems.00531-23

    Cannabinoid receptors in GtoPdb v.2023.1 IUPHAR/BPS Guide to Pharmacology CITE, 2023/04/26. Mary Abood, Stephen P.H. Alexander, Francis Barth, Tom I. Bonner, Heather Bradshaw, Guy Cabral, Pierre Casellas, Ben F. Cravatt, William A. Devane, Vincenzo Di Marzo, Maurice R. Elphick, Christian C. Felder, Peter Greasley, Miles Herkenham, Allyn C. Howlett, George Kunos, Ken Mackie, Raphael Mechoulam, Roger G. Pertwee, Ruth A. Ross. DOI 10.2218/gtopdb/F13/2023.1

    The Effects of Peripubertal THC Exposure in Neurodevelopmental Rat Models of Psychopathology International Journal of Molecular Sciences, 2023/02. Martina Di Bartolomeo, Tibor Stark, Serena Di Martino, Fabio Arturo Iannotti, Jana Ruda-Kucerova, Giovanni Luca Romano, Martin Kuchar, Samuele Laudani, Petr Palivec, Fabiana Piscitelli, Carsten T. Wotjak, Claudio Bucolo, Filippo Drago, Vincenzo Di Marzo, claudio d'addario, Vincenzo Micale. DOI 10.3390/ijms24043907

    A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese (ob/ob) and Diabetic (db/db) Mice: Links with Inflammation and Gut Microbiota Cells, 2023/01/25. Francesco Suriano, Claudia Manca, Nicolas Flamand, Matthias Van Hul, Nathalie M. Delzenne, Cristoforo Silvestri, Patrice D. Cani, Vincenzo Di Marzo. DOI 10.3390/cells12030411

    Validation of a fast and sensitive UPLC-MS/MS quantitative method for N-acyl taurine analysis in biological samples Journal of Pharmaceutical and Biomedical Analysis, 2023. Falascina, G., Bindels, L.B., Di Marzo, V., Cutignano, A.. DOI 10.1016/j.jpba.2023.115252

    The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia BioFactors, 2023. Maia, J., Iannotti, F.A., Piscitelli, F., Fonseca, B.M., Braga, A., Braga, J., Teixeira, N., Di Marzo, V., Correia-da-Silva, G.. DOI 10.1002/biof.1952

    The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population Microbiome, 2023. Bourdeau-Julien, I., Castonguay-Paradis, S., Rochefort, G., Perron, J., Lamarche, B., Flamand, N., Di Marzo, V., Veilleux, A., Raymond, F.. DOI 10.1186/s40168-023-01469-2

    The Gut Microbiome-Endocannabinoidome Axis: A New Way of Controlling Metabolism, Inflammation, and Behavior Function, 2023. Silvestri, C., Di Marzo, V.. DOI 10.1093/function/zqad003

    Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy EMBO Molecular Medicine, 2023. Kalkan, H., Pagano, E., Paris, D., Panza, E., Cuozzo, M., Moriello, C., Piscitelli, F., Abolghasemi, A., Gazzerro, E., Silvestri, C., Capasso, R., Motta, A., Russo, R., Di Marzo, V., Iannotti, F.A.. DOI 10.15252/emmm.202216225

    TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β-catenin signalling British Journal of Pharmacology, 2023. Pagano, E., Romano, B., Cicia, D., Iannotti, F.A., Venneri, T., Lucariello, G., Nanì, M.F., Cattaneo, F., De Cicco, P., D'Armiento, M., De Luca, M., Lionetti, R., Lama, S., Stiuso, P., Zoppoli, P., Falco, G., Marchianò, S., Fiorucci, S., Capasso, R., Di Marzo, V., Borrelli, F., Izzo, A.A.. DOI 10.1111/bph.15960

    Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice Journal of Neuroinflammation, 2023. Santos-García, I., Rodríguez-Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K.J., Di Marzo, V., Fernández-Ruiz, J., de Lago, E.. DOI 10.1186/s12974-023-02792-z

    Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity Molecular Metabolism, 2023. Fernández-Rilo, A.C., Forte, N., Palomba, L., Tunisi, L., Piscitelli, F., Imperatore, R., Di Costanzo, A., Di Marzo, V., Cristino, L.. DOI 10.1016/j.molmet.2023.101713

    Olive oil-derived endocannabinoid-like mediators inhibit palatable food-induced reward and obesity Communications Biology, 2023. Forte, N., Roussel, C., Marfella, B., Lauritano, A., Villano, R., De Leonibus, E., Salviati, E., Khalilzadehsabet, T., Giorgini, G., Silvestri, C., Piscitelli, F., Mollica, M.P., Di Marzo, V., Cristino, L.. DOI 10.1038/s42003-023-05295-y

    Involvement of the Endocannabinoid System in the Control of Pain and Obesity by Exercise in Rodents: A Systematic Review Cannabis and Cannabinoid Research, 2023. Elisei, L., Moraes, T., Malta, I., Rodríguez, J., Di Marzo, V., Galdino, G.. DOI 10.1089/can.2022.0291

    In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists Journal of Medicinal Chemistry, 2023. Romeo, I., Brizzi, A., Pessina, F., Ambrosio, F.A., Aiello, F., Belardo, C., Carullo, G., Costa, G., De Petrocellis, L., Frosini, M., Luongo, L., Maramai, S., Paolino, M., Moriello, A.S., Mugnaini, C., Scorzelli, F., Maione, S., Corelli, F., Di Marzo, V., Alcaro, S., Artese, A.. DOI 10.1021/acs.jmedchem.3c00447

    Hypoabsorptive surgeries cause limb-dependent changes in the gut endocannabinoidome and microbiome in association with beneficial metabolic effects International Journal of Obesity, 2023. Mukorako, P., St-Pierre, D.H., Flamand, N., Biertho, L., Lebel, S., Lemoine, N., Plamondon, J., Roy, M.-C., Tchernof, A., Varin, T.V., Marette, A., Silvestri, C., Di Marzo, V., Richard, D.. DOI 10.1038/s41366-023-01307-3

    Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years Pharmacological Reviews, 2023. Maccarrone, M., Marzo, V.D., Gertsch, J., Grether, U., Howlett, A.C., Hua, T., Makriyannis, A., Piomelli, D., Ueda, N., van der Stelt, M.. DOI 10.1124/pharmrev.122.000600

    Gestational Diabetes Mellitus, Human Milk Composition, and Infant Growth Breastfeeding Medicine, 2023. Dugas, C., Laberee, L., Perron, J., St-Arnaud, G., Richard, V., Perreault, V., Leblanc, N., Marc, I., Di Marzo, V., Doyen, A., Veilleux, A., Robitaille, J.. DOI 10.1089/bfm.2022.0085

    FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects Metabolic Syndrome and Related Disorders, 2023. Sierra-Ruelas, E., Torres-Castillo, N., Vizmanos, B., Campos-Pérez, W., Lopez-Cortes, O.D., Di Marzo, V., Martínez-López, E.. DOI 10.1089/met.2023.0014

    Expanding Research on Cannabis-Based Medicines for Liver Steatosis: A Low-Risk High-Reward Way Out of the Present Deadlock? Cannabis and Cannabinoid Research, 2023. Barré, T., Di Marzo, V., Marcellin, F., Burra, P., Carrieri, P.. DOI 10.1089/can.2022.0014

    Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome British Journal of Pharmacology, 2023. Inserra, A., Giorgini, G., Lacroix, S., Bertazzo, A., Choo, J., Markopolous, A., Grant, E., Abolghasemi, A., De Gregorio, D., Flamand, N., Rogers, G., Comai, S., Silvestri, C., Gobbi, G., Di Marzo, V.. DOI 10.1111/bph.15977

    Dietary food patterns as determinants of the gut microbiome–endocannabinoidome axis in humans Scientific Reports, 2023. Castonguay-Paradis, S., Perron, J., Flamand, N., Lamarche, B., Raymond, F., Di Marzo, V., Veilleux, A.. DOI 10.1038/s41598-023-41650-z

    Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct but Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders Function, 2023. Daniel, N., Le Barz, M., Mitchell, P.L., Varin, T.V., Julien, I.B., Farabos, D., Pilon, G., Gauthier, J., Garofalo, C., Kang, J.X., Trottier, J., Barbier, O., Roy, D., Chassaing, B., Levy, E., Raymond, F., Lamaziere, A., Flamand, N., Silvestri, C., Jobin, C., Di Marzo, V., Marette, A.. DOI 10.1093/function/zqac069

    Cannabis use in relation to Pulse Pressure and Mean Arterial Pressure in US Adults medRxiv, 2023. Ruddy, S., Marzo, V.D., Ngueta, G.. DOI 10.1101/2023.05.12.23289921

    Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer Pharmacological Research, 2023. Mahmoud, A.M., Kostrzewa, M., Marolda, V., Cerasuolo, M., Maccarinelli, F., Coltrini, D., Rezzola, S., Giacomini, A., Mollica, M.P., Motta, A., Paris, D., Zorzano, A., Marzo, V.D., Ronca, R., Ligresti, A.. DOI 10.1016/j.phrs.2023.106683

    Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations Research Square, 2023. Dudek, K.A., Paton, S.E.J., Collignon, A., Lebel, M., Lavoie, O., Bouchard, J., Kaufmann, F.N., Dion-Albert, L., Clavet-Fournier, V., Binder, L.B., Manca, C., Flamand, N., Guzman, M., Campbell, M., Turecki, G., Mechawar, N., Lavoie-Cardinal, F., Silvestri, C., Di Marzo, V., Menard, C.. DOI 10.21203/rs.3.rs-2978353

    Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice Lipids in Health and Disease, 2023. Venneri, T., Giorgini, G., Leblanc, N., Flamand, N., Borrelli, F., Silvestri, C., Di Marzo, V.. DOI 10.1186/s12944-023-01823-1

    Alterations of the endocannabinoid system by endocrine-disrupting chemicals: Effects on metabolism and reproduction Environmental Contaminants and Endocrine Health, 2023. Forner-Piquer, I., Di Marzo, V., Carnevali, O.. DOI 10.1016/B978-0-12-824464-7.00018-0

    Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned medium Frontiers in Cellular Neuroscience, 2023. Paes-Colli, Y., Trindade, P.M.P., Vitorino, L.C., Piscitelli, F., Iannotti, F.A., Campos, R.M.P., Isaac, A.R., de Aguiar, A.F.L., Allodi, S., de Mello, F.G., Einicker-Lamas, M., de Siqueira-Santos, R., Di Marzo, V., Tannous, B.A., Carvalho, L.A., De Melo Reis, R.A., Sampaio, L.S.. DOI 10.3389/fncel.2023.1134130

    First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury Biomolecules, 2022/12/24. Aniello Schiano Moriello, Fiorentina Roviezzo, Fabio Arturo Iannotti, Giuseppina Rea, Marco Allarà, Rosa Camerlingo, Roberta Verde, Vincenzo Di Marzo, Stefania Petrosino. DOI 10.3390/biom13010033

    MicroRNA-mediated repression of endocannabinoid CB1 receptor expression contributes to simvastatin-induced skeletal muscle toxicity 2022/12/19. Hilal Kalkan, Elisabetta Panza, Ester Pagano, Giuseppe Ercolano, Claudia Moriello, Fabiana Piscitelli, Raffaele Capasso, Vincenzo Di Marzo, Fabio Iannotti. DOI 10.21203/rs.3.rs-2328769/v1

    Obesity: The Fat Tissue Disease Version of Cancer Cells, 2022/06/09. Besma Boubertakh, Cristoforo Silvestri, Vincenzo Di Marzo. DOI 10.3390/cells11121872

    Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint Animals, 2022/01/31. Aniello Schiano Moriello, Vincenzo Di Marzo, Stefania Petrosino. DOI 10.3390/ani12030348

    (Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders Lipids in Health and Disease, 2022/01/14. Jyoti Sihag, Vincenzo Di Marzo. DOI 10.1186/s12944-021-01609-3

    Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia Biomolecules, 2022/01/10. Tibor Stark, Fabio Arturo Iannotti, Serena Di Martino, Martina Di Bartolomeo, Jana Ruda-Kucerova, Fabiana Piscitelli, Carsten T. Wotjak, Claudio D’Addario, Filippo Drago, Vincenzo Di Marzo, Vincenzo Micale. DOI 10.3390/biom12010108

    Three of a kind: Control of the expression of liver-expressed antimicrobial peptide 2 (leap2) by the endocannabinoidome and the gut microbiome Molecules, 2022. Shen, M., Manca, C., Suriano, F., Nallabelli, N., Pechereau, F., Allam-Ndoul, B., Iannotti, F.A., Flamand, N., Veilleux, A., Cani, P.D., Silvestri, C., Di Marzo, V.. DOI 10.3390/molecules27010001

    The endocannabinoidome mediator N-oleoylglycine is a novel protective agent against 1-methyl-4-phenyl-pyridinium-induced neurotoxicity Frontiers in Aging Neuroscience, 2022. Lauritano, A., Cipollone, I., Verde, R., Kalkan, H., Moriello, C., Iannotti, F.A., Di Marzo, V., Piscitelli, F.. DOI 10.3389/fnagi.2022.926634

    Short-term supplementation with ω-3 polyunsaturated fatty acids modulates primarily mucolytic species from the gut luminal mucin niche in a human fermentation system Gut Microbes, 2022. Roussel, C., Anunciação Braga Guebara, S., Plante, P.-L., Desjardins, Y., Di Marzo, V., Silvestri, C.. DOI 10.1080/19490976.2022.2120344

    Short and efficient synthesis of alkylresorcinols: a route for the preparation of cannabinoids New Journal of Chemistry, 2022. Rosaria Villano, Hannah Straker, Vincenzo Di Marzo. DOI 10.1039/D2NJ03547B

    Positive association between plasmatic levels of orexin A and the endocannabinoid-derived 2-arachidonoyl lysophosphatidic acid in Alzheimer’s disease Frontiers in Aging Neuroscience, 2022. Forte, N., Fernández-Rilo, A.C., Palomba, L., Marfella, B., Piscitelli, F., De Girolamo, P., Di Costanzo, A., Di Marzo, V., Cristino, L.. DOI 10.3389/fnagi.2022.1004002

    N-Acylethanolamine acid amidase (NAAA) is dysregulated in colorectal cancer patients and its inhibition reduces experimental cancer growth British Journal of Pharmacology, 2022. Romano, B., Pagano, E., Iannotti, F.A., Piscitelli, F., Brancaleone, V., Lucariello, G., Nanì, M.F., Fiorino, F., Sparaco, R., Vanacore, G., Di Tella, F., Cicia, D., Lionetti, R., Makriyannis, A., Malamas, M., De Luca, M., Aprea, G., D'Armiento, M., Capasso, R., Sbarro, B., Venneri, T., Di Marzo, V., Borrelli, F., Izzo, A.A.. DOI 10.1111/bph.15737

    Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study Scientific Reports, 2022. Forteza, F., Bourdeau-Julien, I., Nguyen, G.Q., Guevara Agudelo, F.A., Rochefort, G., Parent, L., Rakotoarivelo, V., Feutry, P., Martin, C., Perron, J., Lamarche, B., Flamand, N., Veilleux, A., Billaut, F., Di Marzo, V., Raymond, F.. DOI 10.1038/s41598-022-10757-0

    Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice Frontiers in Immunology, 2022. Guevara Agudelo, F.A., Leblanc, N., Bourdeau-Julien, I., St-Arnaud, G., Lacroix, S., Martin, C., Flamand, N., Veilleux, A., Di Marzo, V., Raymond, F.. DOI 10.3389/fimmu.2022.1028412

    Human and mouse eosinophils differ in their ability to biosynthesize eicosanoids, docosanoids, the endocannabinoid 2-arachidonoyl-glycerol and its congeners Cells, 2022. Archambault, A.-S., Brassard, J., Bernatchez, É., Martin, C., Di Marzo, V., Laviolette, M., Boulet, L.-P., Blanchet, M.-R., Flamand, N.. DOI 10.3390/cells11010141

    Hemp seed significantly modulates the endocannabinoidome and produces beneficial metabolic effects with improved intestinal barrier function and decreased inflammation in mice under a high-fat, high-sucrose diet as compared with linseed Frontiers in Immunology, 2022. Ben Necib, R., Manca, C., Lacroix, S., Martin, C., Flamand, N., Di Marzo, V., Silvestri, C.. DOI 10.3389/fimmu.2022.882455

    Facile and Sustainable Synthesis of Commendamide and its Analogues Frontiers in Chemistry, 2022. Villano, R., Tinto, F., Di Marzo, V.. DOI 10.3389/fchem.2022.858854

    Expression and Functions of the CB<sub>2</sub> Receptor in Human Leukocytes Frontiers in Pharmacology, 2022. Simard, M., Rakotoarivelo, V., Di Marzo, V., Flamand, N.. DOI 10.3389/fphar.2022.826400

    Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2022. Suriano, F., Manca, C., Flamand, N., Depommier, C., Van Hul, M., Delzenne, N.M., Silvestri, C., Cani, P.D., Di Marzo, V.. DOI 10.1016/j.bbalip.2021.159056

    Cannabinoids and Chronic Liver Diseases International Journal of Molecular Sciences, 2022. Mboumba Bouassa, R.-S., Sebastiani, G., Di Marzo, V., Jenabian, M.-A., Costiniuk, C.T.. DOI 10.3390/ijms23169423

    Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families Biochemical Pharmacology, 2022. Simard, M., Archambault, A.-S., Lavoie, J.-P.C., Dumais, É., Di Marzo, V., Flamand, N.. DOI 10.1016/j.bcp.2022.115261

    Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1 Biomedicine and Pharmacotherapy, 2022. Ten-Blanco, M., Flores, Á., Pereda-Pérez, I., Piscitelli, F., Izquierdo-Luengo, C., Cristino, L., Romero, J., Hillard, C.J., Maldonado, R., Di Marzo, V., Berrendero, F.. DOI 10.1016/j.biopha.2022.112925

    Alterations of the endocannabinoid system and circulating and peripheral tissue levels of endocannabinoids in sarcopenic rats Journal of Cachexia, Sarcopenia and Muscle, 2022. Le Bacquer, O., Salles, J., Piscitelli, F., Sanchez, P., Martin, V., Montaurier, C., Di Marzo, V., Walrand, S.. DOI 10.1002/jcsm.12855

    Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice Molecular Metabolism, 2022. Vilela, V.R., Samson, N., Nachbar, R., Perazza, L.R., Lachance, G., Rokatoarivelo, V., Centano-Baez, C., Zancan, P., Sola-Penna, M., Bellmann, K., Di Marzo, V., Laplante, M., Marette, A.. DOI 10.1016/j.molmet.2022.101437

    Cannabinoids: a class of unique natural products with unique pharmacology Rendiconti Lincei. Scienze Fisiche e Naturali, 2021/03/11. Fabiana Piscitelli, Vincenzo Di Marzo. DOI 10.1007/s12210-020-00966-y

    A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator Cells, 2021/02/20. Emiliano Manzo, Aniello Schiano Moriello, Francesco Tinto, Roberta Verde, Marco Allarà, Luciano De Petrocellis, Ester Pagano, Angelo A. Izzo, Vincenzo Di Marzo, Stefania Petrosino. DOI 10.3390/cells10020450

    Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models Cells, 2021/01/05. Clara Depommier, Nicolas Flamand, Rudy Pelicaen, Dominique Maiter, Jean-Paul Thissen, Audrey Loumaye, Michel P. Hermans, Amandine Everard, Nathalie M. Delzenne, Vincenzo Di Marzo, Patrice D. Cani. DOI 10.3390/cells10010071

    The gut microbiome, endocannabinoids and metabolic disorders Journal of Endocrinology, 2021. Iannotti, F.A., Di Marzo, V.. DOI 10.1530/JOE-20-0444

    Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2021. Tinto, F., Archambault, A.-S., Dumais, É., Rakotoarivelo, V., Kostrzewa, M., Martin, C., Plante, P.-L., Desjardins, Y., Simard, M., Pouliot, R., De Petrocellis, L., Ligresti, A., Di Marzo, V., Flamand, N.. DOI 10.1016/j.bbalip.2021.158954

    Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators Frontiers in Pharmacology, 2021. Ayoub, S.M., Piscitelli, F., Silvestri, C., Limebeer, C.L., Rock, E.M., Smoum, R., Farag, M., de Almeida, H., Sullivan, M.T., Lacroix, S., Boubertakh, B., Nallabelli, N., Lichtman, A.H., Leri, F., Mechoulam, R., Di Marzo, V., Parker, L.A.. DOI 10.3389/fphar.2021.706703

    Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice Frontiers in Synaptic Neuroscience, 2021. Tunisi, L., D'Angelo, L., Fernández-Rilo, A.C., Forte, N., Piscitelli, F., Imperatore, R., de Girolamo, P., Di Marzo, V., Cristino, L.. DOI 10.3389/fnsyn.2021.622405

    Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice Nature Communications, 2021. Forte, N., Boccella, S., Tunisi, L., Fernández-Rilo, A.C., Imperatore, R., Iannotti, F.A., De Risi, M., Iannotta, M., Piscitelli, F., Capasso, R., De Girolamo, P., De Leonibus, E., Maione, S., Di Marzo, V., Cristino, L.. DOI 10.1038/s41467-021-26388-4

    Oral capsaicinoid administration alters the plasma endocannabinoidome and fecal microbiota of reproductive-aged women living with overweight and obesity Biomedicines, 2021. Manca, C., Lacroix, S., Pérusse, F., Flamand, N., Chagnon, Y., Drapeau, V., Tremblay, A., Di Marzo, V., Silvestri, C.. DOI 10.3390/biomedicines9091246

    N-palmitoyl-d-glucosamine, a natural monosaccharide-based glycolipid, inhibits tlr4 and prevents lps-induced inflammation and neuropathic pain in mice International Journal of Molecular Sciences, 2021. Iannotta, M., Belardo, C., Trotta, M.C., Iannotti, F.A., Vitale, R.M., Maisto, R., Boccella, S., Infantino, R., Ricciardi, F., Mirto, B.F., Ferraraccio, F., Panarese, I., Amodeo, P., Tunisi, L., Cristino, L., D’amico, M., Di Marzo, V., Luongo, L., Maione, S., Guida, F.. DOI 10.3390/ijms22031491

    N-Oleoylglycine and N-Oleoylalanine Do Not Modify Tolerance to Nociception, Hyperthermia, and Suppression of Activity Produced by Morphine Frontiers in Synaptic Neuroscience, 2021. Rock, E.M., Limebeer, C.L., Sullivan, M.T., DeVuono, M.V., Lichtman, A.H., Di Marzo, V., Mechoulam, R., Parker, L.A.. DOI 10.3389/fnsyn.2021.620145

    Maternal omega-3 intake differentially affects the endocannabinoid system in the progeny`s neocortex and hippocampus: Impact on synaptic markers Journal of Nutritional Biochemistry, 2021. Isaac, A.R., de Velasco, P.C., Fraga, K.Y.D., Tavares-do-Carmo, M.D.G., Campos, R.M.P., Iannotti, F.A., Verde, R., Martins, D.B.G., Santos, T.A., Ferreira, B.K., de Mello, F.G., Di Marzo, V., Andrade-da-Costa, B.L.D.S., de Melo Reis, R.A.. DOI 10.1016/j.jnutbio.2021.108782

    Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation Brazilian Journal of Medical and Biological Research, 2021. L.S. Guzzo, C.C. Oliveira, R.C.M. Ferreira, D.P.D. Machado, M.G.M. Castor, A.C. Perez, F. Piscitelli, V. Di Marzo, T.R.L. Romero, I.D.G. Duarte. DOI 10.1590/1414-431x2021e11071

    Intuitive eating is associated with elevated levels of circulating omega-3-polyunsaturated fatty acid-derived endocannabinoidome mediators Appetite, 2021. Rochefort, G., Provencher, V., Castonguay-Paradis, S., Perron, J., Lacroix, S., Martin, C., Flamand, N., Di Marzo, V., Veilleux, A.. DOI 10.1016/j.appet.2020.104973

    Identification and characterization of cannabidiol as an ox1r antagonist by computational and in vitro functional validation Biomolecules, 2021. Vitale, R.M., Iannotti, F.A., Moriello, A.S., Tunisi, L., Piscitelli, F., Savopoulos, R., Cristino, L., De Petrocellis, L., Amodeo, P., Gray, R., Di Marzo, V.. DOI 10.3390/biom11081134

    Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB<sub>1</sub>Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster Cannabis and Cannabinoid Research, 2021. Tortoriello, G., Beiersdorf, J., Romani, S., Williams, G., Cameron, G.A., Mackie, K., Williams, M.J., Di Marzo, V., Keimpema, E., Doherty, P., Harkany, T.. DOI 10.1089/can.2020.0010

    Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation Phytotherapy Research, 2021. Pagano, E., Iannotti, F.A., Piscitelli, F., Romano, B., Lucariello, G., Venneri, T., Di Marzo, V., Izzo, A.A., Borrelli, F.. DOI 10.1002/ptr.6831

    Effect of docosahexaenoic acid (DHA) at the enteric level in a synucleinopathy mouse model Nutrients, 2021. Lamontagne‐proulx, J., Coulombe, K., Dahhani, F., Côté, M., Guyaz, C., Tremblay, C., Di Marzo, V., Flamand, N., Calon, F., Soulet, D.. DOI 10.3390/nu13124218

    Editorial on “Cannabis and cannabinoids: history, practice and socio-economical inferences of a controversial plant” Rendiconti Lincei, 2021. Di Marzo, V., Marino, G.. DOI 10.1007/s12210-021-00975-5

    Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure Prostaglandins Leukotrienes and Essential Fatty Acids, 2021. Bertrand, J.A., Woodward, D.F., Sherwood, J.M., Spenlehauer, A., Silvestri, C., Piscitelli, F., Marzo, V.D., Yamazaki, M., Sakimura, K., Inoue, Y., Watanabe, K., Overby, D.R.. DOI 10.1016/j.plefa.2020.102235

    Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Δ9-tetrahydrocannabinol-exposed rats Pharmacological Research, 2021. Di Bartolomeo, M., Stark, T., Maurel, O.M., Iannotti, F.A., Kuchar, M., Ruda-Kucerova, J., Piscitelli, F., Laudani, S., Pekarik, V., Salomone, S., Arosio, B., Mechoulam, R., Maccarrone, M., Drago, F., Wotjak, C.T., Di Marzo, V., Vismara, M., Dell'Osso, B., D'Addario, C., Micale, V.. DOI 10.1016/j.phrs.2020.105357

    Correction to: 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors (Molecular Brain, (2021), 14, 1, (28), 10.1186/s13041-020-00724-z) Molecular Brain, 2021. Boccella, S., Guida, F., Iannotta, M., Iannotti, F.A., Infantino, R., Ricciardi, F., Cristiano, C., Vitale, R.M., Amodeo, P., Marabese, I., Belardo, C., de Novellis, V., Paino, S., Palazzo, E., Calignano, A., Di Marzo, V., Maione, S., Luongo, L.. DOI 10.1186/s13041-021-00772-z

    Biosynthesis of the novel endogenous 15-lipoxygenase metabolites N-13-hydroxy-octodecadienoyl-ethanolamine and 13-hydroxy-octodecadienoyl-glycerol by human neutrophils and Eosinophils Cells, 2021. Archambault, A.-S., Tinto, F., Dumais, É., Rakotoarivelo, V., Kostrzewa, M., Plante, P.-L., Martin, C., Simard, M., Silvestri, C., Pouliot, R., Laviolette, M., Boulet, L.-P., Vitale, R.M., Ligresti, A., Di Marzo, V., Flamand, N.. DOI 10.3390/cells10092322

    Beneficial effects of akkermansia muciniphila are not associated with major changes in the circulating endocannabinoidome but linked to higher mono-palmitoyl-glycerol levels as new pparα agonists Cells, 2021. Depommier, C., Vitale, R.M., Iannotti, F.A., Silvestri, C., Flamand, N., Druart, C., Everard, A., Pelicaen, R., Maiter, D., Thissen, J.-P., Loumaye, A., Hermans, M.P., Delzenne, N.M., de Vos, W.M., Marzo, V.D., Cani, P.D.. DOI 10.3390/cells10010185

    B iological basis of cannabinoid medicines: Mechanistic insights into cannabinoid signaling could improve therapeutic applications Science, 2021. Keimpema, E., Marzo, V.D., Harkany, T.. DOI 10.1126/science.abf6099

    Assessment of the effects of dietary vitamin d levels on olanzapine-induced metabolic side effects: Focus on the endocannabinoidome-gut microbiome axis International Journal of Molecular Sciences, 2021. Abolghasemi, A., Manca, C., Iannotti, F.A., Shen, M., Leblanc, N., Lacroix, S., Martin, C., Flamand, N., Di Marzo, V., Silvestri, C.. DOI 10.3390/ijms222212361

    2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors Molecular Brain, 2021. Boccella, S., Guida, F., Iannotta, M., Iannotti, F.A., Infantino, R., Ricciardi, F., Cristiano, C., Vitale, R.M., Amodeo, P., Marabese, I., Belardo, C., de Novellis, V., Paino, S., Palazzo, E., Calignano, A., Di Marzo, V., Maione, S., Luongo, L.. DOI 10.1186/s13041-020-00724-z

    Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota Cells, 2020/12/17. Niokhor Dione, Sébastien Lacroix, Ulrike Taschler, Thomas Deschênes, Armita Abolghasemi, Nadine Leblanc, Vincenzo Di Marzo, Cristoforo Silvestri. DOI 10.3390/cells9122705

    Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes Marine Drugs, 2020/10/18. Sarah Mazzotta, Gabriele Carullo, Aniello Schiano Moriello, Pietro Amodeo, Vincenzo Di Marzo, Margarita Vega-Holm, Rosa Maria Vitale, Francesca Aiello, Antonella Brizzi, Luciano De Petrocellis. DOI 10.3390/md18100519

    Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen–Glucose Deprivation-Induced Neuronal Injury Cells, 2020/06/20. Letizia Palomba, Andrea Motta, Roberta Imperatore, Fabiana Piscitelli, Raffaele Capasso, Federica Mastroiacovo, Giuseppe Battaglia, Valeria Bruno, Luigia Cristino, Vincenzo Di Marzo. DOI 10.3390/cells9061507

    Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism Cells, 2020/05/18. Charlotte Lefort, Martin Roumain, Matthias Van Hul, Marialetizia Rastelli, Rita Manco, Isabelle Leclercq, Nathalie M. Delzenne, Vincenzo Di Marzo, Nicolas Flamand, Serge Luquet, Cristoforo Silvestri, Giulio G. Muccioli, Patrice D. Cani. DOI 10.3390/cells9051247

    Obesity Affects the Microbiota–Gut–Brain Axis and the Regulation Thereof by Endocannabinoids and Related Mediators International Journal of Molecular Sciences, 2020/02/25. Nicola Forte, Alba Clara Fernández-Rilo, Letizia Palomba, Vincenzo Di Marzo, Luigia Cristino. DOI 10.3390/ijms21051554

    α<sub>2</sub>-Adrenoceptor agonist induces peripheral antinociception via the endocannabinoid system Pharmacological Reports, 2020. Romero, T.R.L., Miranda e Castor, M.G., Parrella, C., Piscitelli, F., Di Marzo, V., Duarte, I.D.G.. DOI 10.1007/s43440-019-00053-6

    Treatment With 2-Pentadecyl-2-Oxazoline Restores Mild Traumatic Brain Injury-Induced Sensorial and Neuropsychiatric Dysfunctions Frontiers in Pharmacology, 2020. Boccella, S., Iannotta, M., Cristiano, C., Iannotti, F.A., Bello, F.D., Guida, F., Belardo, C., Infantino, R., Ricciardi, F., Giannella, M., Calignano, A., Di Marzo, V., Maione, S., Luongo, L.. DOI 10.3389/fphar.2020.00091

    The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders Dialogues in Clinical Neuroscience, 2020. Di Marzo, V.. DOI 10.31887/DCNS.2020.22.3/VDIMARZO

    Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity Bioorganic and Medicinal Chemistry, 2020. Brizzi, A., Aiello, F., Boccella, S., Cascio, M.G., De Petrocellis, L., Frosini, M., Gado, F., Ligresti, A., Luongo, L., Marini, P., Mugnaini, C., Pessina, F., Corelli, F., Maione, S., Manera, C., Pertwee, R.G., Di Marzo, V.. DOI 10.1016/j.bmc.2020.115513

    Protective Effects of N-Oleoylglycine in a Mouse Model of Mild Traumatic Brain Injury ACS Chemical Neuroscience, 2020. Piscitelli, F., Guida, F., Luongo, L., Iannotti, F.A., Boccella, S., Verde, R., Lauritano, A., Imperatore, R., Smoum, R., Cristino, L., Lichtman, A.H., Parker, L.A., Mechoulam, R., Maione, S., Di Marzo, V.. DOI 10.1021/acschemneuro.9b00633

    Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets Biochemical Pharmacology, 2020. Fellous, T., De Maio, F., Kalkan, H., Carannante, B., Boccella, S., Petrosino, S., Maione, S., Di Marzo, V., Iannotti, F.A.. DOI 10.1016/j.bcp.2020.113859

    Oleoyl alanine (HU595): a stable monomethylated oleoyl glycine interferes with acute naloxone precipitated morphine withdrawal in male rats Psychopharmacology, 2020. Ayoub, S.M., Smoum, R., Farag, M., Atwal, H., Collins, S.A., Rock, E.M., Limebeer, C.L., Piscitelli, F., Iannotti, F.A., Lichtman, A.H., Leri, F., Di Marzo, V., Mechoulam, R., Parker, L.A.. DOI 10.1007/s00213-020-05570-4

    Manipulation of dietary amino acids prevents and reverses obesity in mice through multiple mechanisms that modulate energy homeostasis Diabetes, 2020. Ruocco, C., Ragni, M., Rossi, F., Carullo, P., Ghini, V., Piscitelli, F., Cutignano, A., Manzo, E., Ioris, R.M., Bontems, F., Tedesco, L., Greco, C.M., Pino, A., Severi, I., Liu, D., Ceddia, R.P., Ponzoni, L., Tenori, L., Rizzetto, L., Scholz, M., Tuohy, K., Bifari, F., Di Marzo, V., Luchinat, C., Carruba, M.O., Cinti, S., Decimo, I., Condorelli, G., Coppari, R., Collins, S., Valerio, A., Nisoli, E.. DOI 10.2337/db20-0489

    Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy Molecular Psychiatry, 2020. Cinquina, V., Calvigioni, D., Farlik, M., Halbritter, F., Fife-Gernedl, V., Shirran, S.L., Fuszard, M.A., Botting, C.H., Poullet, P., Piscitelli, F., Máté, Z., Szabó, G., Yanagawa, Y., Kasper, S., Di Marzo, V., Mackie, K., McBain, C.J., Bock, C., Keimpema, E., Harkany, T.. DOI 10.1038/s41380-019-0580-4

    Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling Journal of Lipid Research, 2020. Manca, C., Boubertakh, B., Leblanc, N., Deschênes, T., Lacroix, S., Martin, C., Houde, A., Veilleux, A., Flamand, N., Muccioli, G.G., Raymond, F., Cani, P.D., Di Marzo, V., Silvestri, C.. DOI 10.1194/jlr.RA119000424

    Gene deletion studies reveal a critical role for prostamide/prostaglandin F2α synthase in prostamide f2α formation bioRxiv, 2020. Bertrand, J.A., Woodward, D.F., Sherwood, J.M., Spenlehauer, A., Silvestri, C., Piscitelli, F., Di Marzo, V., Yamazaki, M., Sakimura, K., Watanabe, K., Overby, D.R.. DOI 10.1101/2020.04.01.020768

    Fish Oil, Cannabidiol and the Gut Microbiota: An Investigation in a Murine Model of Colitis Frontiers in Pharmacology, 2020. Silvestri, C., Pagano, E., Lacroix, S., Venneri, T., Cristiano, C., Calignano, A., Parisi, O.A., Izzo, A.A., Di Marzo, V., Borrelli, F.. DOI 10.3389/fphar.2020.585096

    Erratum: Correction to Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3- b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo (Journal of Medicinal Chemistry (2020) 63:(13);7369-7391. (DOI: 10.1021/acs.jmedchem.0c00595) Journal of Medicinal Chemistry, 2020. Mugnaini, C., Kostrzewa, M., Bryk, M., Mahmoud, A.M., Brizzi, A., Lamponi, S., Giorgi, G., Ferlenghi, F., Vacondio, F., Maccioni, P., Colombo, G., Mor, M., Starowicz, K., Di Marzo, V., Ligresti, A., Corelli, F.. DOI 10.1021/acs.jmedchem.0c01567

    Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoyl-glycerol and its congeners in human myeloid leukocytes FASEB Journal, 2020. Turcotte, C., Archambault, A.-S., Dumais, É., Martin, C., Blanchet, M.-R., Bissonnette, E., Ohashi, N., Yamamoto, K., Itoh, T., Laviolette, M., Veilleux, A., Boulet, L.-P., Di Marzo, V., Flamand, N.. DOI 10.1096/fj.201902916R

    Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system Environmental Pollution, 2020. Forner-Piquer, I., Beato, S., Piscitelli, F., Santangeli, S., Di Marzo, V., Habibi, H.R., Maradonna, F., Carnevali, O.. DOI 10.1016/j.envpol.2020.114710

    Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat Scientific Reports, 2020. Castonguay-Paradis, S., Lacroix, S., Rochefort, G., Parent, L., Perron, J., Martin, C., Lamarche, B., Raymond, F., Flamand, N., Di Marzo, V., Veilleux, A.. DOI 10.1038/s41598-020-72861-3

    Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo Journal of Medicinal Chemistry, 2020. Mugnaini, C., Kostrzewa, M., Bryk, M., Mahmoud, A.M., Brizzi, A., Lamponi, S., Giorgi, G., Ferlenghi, F., Vacondio, F., MacCioni, P., Colombo, G., Mor, M., Starowicz, K., Di Marzo, V., Ligresti, A., Corelli, F.. DOI 10.1021/acs.jmedchem.0c00595

    Desensitization of transient receptor potential vanilloid type-1 (TRPV1) channel as promising therapy of irritable bowel syndrome: characterization of the action of palvanil in the mouse gastrointestinal tract Naunyn-Schmiedeberg's Archives of Pharmacology, 2020. Szymaszkiewicz, A., Włodarczyk, J., Wasilewski, A., Di Marzo, V., Storr, M., Fichna, J., Zielińska, M.. DOI 10.1007/s00210-020-01829-x

    Comments on Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate – Forner-Piquer et al. (2018)”: rebuttal to Prosser CM. Environmental Pollution, 2020. Forner-Piquer, I., Santangeli, S., Maradonna, F., Rabbito, A., Piscitelli, F., Habibi, H.R., di Marzo, V., Carnevali, O.. DOI 10.1016/j.envpol.2020.114028

    Cannabidiol in sport: Ergogenic or else? Pharmacological Research, 2020. Gamelin, F.-X., Cuvelier, G., Mendes, A., Aucouturier, J., Berthoin, S., Di Marzo, V., Heyman, E.. DOI 10.1016/j.phrs.2020.104764

    Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent Cannabis and Cannabinoid Research, 2020. Gray, R.A., Stott, C.G., Jones, N.A., Di Marzo, V., Di Marzo, V., Whalley, B.J., Whalley, B.J.. DOI 10.1089/can.2019.0028

    Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment Biochemical Pharmacology, 2020. Stark, T., Di Bartolomeo, M., Di Marco, R., Drazanova, E., Platania, C.B.M., Iannotti, F.A., Ruda-Kucerova, J., D'Addario, C., Kratka, L., Pekarik, V., Piscitelli, F., Babinska, Z., Fedotova, J., Giurdanella, G., Salomone, S., Sulcova, A., Bucolo, C., Wotjak, C.T., Starcuk, Z., Drago, F., Mechoulam, R., Di Marzo, V., Micale, V.. DOI 10.1016/j.bcp.2020.114004

    Alterations of brain endocannabinoidome signaling in germ-free mice Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2020. Manca, C., Shen, M., Boubertakh, B., Martin, C., Flamand, N., Silvestri, C., Di Marzo, V.. DOI 10.1016/j.bbalip.2020.158786

    Adverse effects of Δ<sup>9</sup>-tetrahydrocannabinol on neuronal bioenergetics during postnatal development JCI Insight, 2020. Beiersdorf, J., Hevesi, Z., Calvigioni, D., Pyszkowski, J., Romanov, R., Szodorai, E., Lubec, G., Shirran, S., Botting, C.H., Kasper, S., Guy, G.W., Gray, R., Marzo, V.D., Harkany, T., Keimpema, E.. DOI 10.1172/jci.insight.135418

    Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine Psychopharmacology, 2020. Rock, E.M., Ayoub, S.M., Limebeer, C.L., Gene, A., Wills, K.L., DeVuono, M.V., Smoum, R., Di Marzo, V., Lichtman, A.H., Mechoulam, R., Parker, L.A.. DOI 10.1007/s00213-019-05373-2

    Cannabinoids and the expanded endocannabinoid system in neurological disorders Nature Reviews Neurology, 2020/01. Luigia Cristino, Tiziana Bisogno, Vincenzo Di Marzo. DOI 10.1038/s41582-019-0284-z

    Corrigendum to “Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system” [Biochem. Pharmacol. 161 (2019) 37–51] Biochemical Pharmacology, 2019/11. Maciej Salaga, Agata Binienda, Fabiana Piscitelli, Anna Mokrowiecka, Adam I. Cygankiewicz, Roberta Verde, Ewa Malecka-Panas, Radzislaw Kordek, Wanda M. Krajewska, Vincenzo Di Marzo, Jakub Fichna. DOI 10.1016/j.bcp.2019.113636

    Cannabidiol improves vocal learning-dependent recovery from, and reduces magnitude of deficits following, damage to a cortical-like brain region in a songbird pre-clinical animal model Neuropharmacology, 2019/11. Ali Alalawi, Julien C. Dodu, Marie Woolley-Roberts, James Brodie, Vincenzo Di Marzo, Ken Soderstrom. DOI 10.1016/j.neuropharm.2019.107716

    Effects of Dietary Bisphenol A on the Reproductive Function of Gilthead Sea Bream (Sparus aurata) Testes International Journal of Molecular Sciences, 2019/10/10. Isabel Forner-Piquer, Ioannis Fakriadis, Constantinos C Mylonas, Fabiana Piscitelli, Vincenzo Di Marzo, Francesca Maradonna, Josep Calduch-Giner, Jaume Pérez-Sánchez, Oliana Carnevali. DOI 10.3390/ijms20205003

    Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties European Journal of Medicinal Chemistry, 2019/10. Aya E. Ghonim, Alessia Ligresti, Alessandro Rabbito, Ali Mokhtar Mahmoud, Vincenzo Di Marzo, Noha A. Osman, Ashraf H. Abadi. DOI 10.1016/j.ejmech.2019.07.002

    Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database IUPHAR/BPS Guide to Pharmacology CITE, 2019/09/16. Mary Abood, Stephen P.H. Alexander, Francis Barth, Tom I. Bonner, Heather Bradshaw, Guy Cabral, Pierre Casellas, Ben F. Cravatt, William A. Devane, Vincenzo Di Marzo, Maurice R. Elphick, Christian C. Felder, Peter Greasley, Miles Herkenham, Allyn C. Howlett, George Kunos, Ken Mackie, Raphael Mechoulam, Roger G. Pertwee, Ruth A. Ross. DOI 10.2218/gtopdb/F13/2019.4

    The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients Pharmacological Research, 2019/09. E. Pagano, B. Romano, F.A. Iannotti, O.A. Parisi, M. D’Armiento, S. Pignatiello, L. Coretti, M. Lucafò, T. Venneri, G. Stocco, F. Lembo, P. Orlando, R. Capasso, V. Di Marzo, A.A. Izzo, F. Borrelli. DOI 10.1016/j.phrs.2019.104464

    Human leukocytes differentially express endocannabinoid‐glycerol lipases and hydrolyze 2‐arachidonoyl‐glycerol and its metabolites from the 15‐lipoxygenase and cyclooxygenase pathways Journal of Leukocyte Biology, 2019/09. Caroline Turcotte, Élizabeth Dumais, Anne‐Sophie Archambault, Cyril Martin, Marie‐Renée Blanchet, Élyse Bissonnette, Louis‐Philippe Boulet, Michel Laviolette, Vincenzo Di Marzo, Nicolas Flamand. DOI 10.1002/jlb.3a0919-049rrr

    Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment European Journal of Medicinal Chemistry, 2019/09. Serena Montanari, Ali Mokhtar Mahmoud, Letizia Pruccoli, Alessandro Rabbito, Marina Naldi, Sabrina Petralla, Ignacio Moraleda, Manuela Bartolini, Barbara Monti, Isabel Iriepa, Federica Belluti, Silvia Gobbi, Vincenzo Di Marzo, Alessandra Bisi, Andrea Tarozzi, Alessia Ligresti, Angela Rampa. DOI 10.1016/j.ejmech.2019.05.080

    Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome Nutrients, 2019/08/20. Vincenzo Di Marzo, Cristoforo Silvestri. DOI 10.3390/nu11081956

    Targeted Lipidomics Investigation of N ‐acylethanolamines in a Transgenic Mouse Model of AD: A Longitudinal Study European Journal of Lipid Science and Technology, 2019/07. Fabiana Piscitelli, Roberto Coccurello, Antonio Totaro, Alessandro Leuti, Giacomo Giacovazzo, Roberta Verde, Emanuela Rossi, Michele Podaliri Vulpiani, Nicola Ferri, Roberto Giacominelli Stuffler, Vincenzo Di Marzo, Sergio Oddi, Tiziana Bisogno, Mauro Maccarrone. DOI 10.1002/ejlt.201900015

    Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and N-Acylethanolamines in Patients with Mastocytosis Journal of Immunology Research, 2019/07/01. Anne Lise Ferrara, Fabiana Piscitelli, Angelica Petraroli, Roberta Parente, Maria Rosaria Galdiero, Gilda Varricchi, Giancarlo Marone, Massimo Triggiani, Vincenzo Di Marzo, Stefania Loffredo. DOI 10.1155/2019/5836476

    Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice Journal of Psychopharmacology, 2019/05. Erica Zamberletti, Marina Gabaglio, Fabiana Piscitelli, James S Brodie, Marie Woolley-Roberts, Isabella Barbiero, Marco Tramarin, Giorgio Binelli, Nicoletta Landsberger, Charlotte Kilstrup-Nielsen, Tiziana Rubino, Vincenzo Di Marzo, Daniela Parolaro. DOI 10.1177/0269881119844184

    Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier Frontiers in Endocrinology, 2019/04/10. Lea Tunisi, Nicola Forte, Alba Clara Fernández-Rilo, Isabella Mavaro, Raffaele Capasso, Livia D'Angelo, Nataša Milić, Luigia Cristino, Vincenzo Di Marzo, Letizia Palomba. DOI 10.3389/fendo.2019.00219

    Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague–Dawley rats Psychopharmacology, 2019/04. Gavin N. Petrie, Kiri L. Wills, Fabiana Piscitelli, Reem Smoum, Cheryl L. Limebeer, Erin M. Rock, Ashlyn E. Humphrey, Madeleine Sheppard-Perkins, Aron H. Lichtman, Raphael Mechoulam, Vincenzo Di Marzo, Linda A. Parker. DOI 10.1007/s00213-019-05237-9

    N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice Neuropharmacology, 2019/04. Giulia Donvito, Fabiana Piscitelli, Pretal Muldoon, Asti Jackson, Rosa Maria Vitale, Enrico D'Aniello, Catia Giordano, Bogna M. Ignatowska-Jankowska, Mohammed A. Mustafa, Francesca Guida, Gavin N. Petrie, Linda Parker, Reem Smoum, Laura Sim-Selley, Sabatino Maione, Aron H. Lichtman, M. Imad Damaj, Vincenzo Di Marzo, Raphael Mechoulam. DOI 10.1016/j.neuropharm.2018.03.020

    Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain Brain, Behavior, and Immunity, 2019/04. Francesca Guida, Serena Boccella, Carmela Belardo, Monica Iannotta, Fabiana Piscitelli, Francesca De Filippis, Salvatore Paino, Flavia Ricciardi, Dario Siniscalco, Ida Marabese, Livio Luongo, Danilo Ercolini, Vincenzo Di Marzo, Sabatino Maione. DOI 10.1016/j.bbi.2019.04.006

    Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system Biochemical Pharmacology, 2019/03. Maciej Salaga, Agata Binienda, Fabiana Piscitelli, Anna Mokrowiecka, Adam I. Cygankiewicz, Roberta Verde, Ewa Malecka-Panas, Radzislaw Kordek, Wanda M. Krajewska, Vincenzo Di Marzo, Jakub Fichna. DOI 10.1016/j.bcp.2019.01.001

    Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia Neuropharmacology, 2019/03. Tibor Stark, Jana Ruda-Kucerova, Fabio Arturo Iannotti, Claudio D'Addario, Roberta Di Marco, Vladimir Pekarik, Eva Drazanova, Fabiana Piscitelli, Monica Bari, Zuzana Babinska, Giovanni Giurdanella, Martina Di Bartolomeo, Salvatore Salomone, Alexandra Sulcova, Mauro Maccarrone, Carsten T. Wotjak, Zenon Starcuk, Filippo Drago, Raphael Mechoulam, Vincenzo Di Marzo, Vincenzo Micale. DOI 10.1016/j.neuropharm.2018.11.035

    Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach Biochimica et Biophysica Acta (BBA) - General Subjects, 2019/03. Enrico D'Aniello, Tariq Fellous, Fabio Arturo Iannotti, Alessandra Gentile, Marco Allarà, Francesca Balestrieri, Roy Gray, Pietro Amodeo, Rosa Maria Vitale, Vincenzo Di Marzo. DOI 10.1016/j.bbagen.2019.01.002

    In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator Marine Drugs, 2019/02. Enrico D’Aniello, Fabio Arturo Iannotti, Lauren G. Falkenberg, Andrea Martella, Alessandra Gentile, Fabrizia De Maio, Maria Letizia Ciavatta, Margherita Gavagnin, Joshua Waxman, Vincenzo Di Marzo, Pietro Amodeo, ROSA MARIA VITALE. DOI 10.3390/md17020110

    Effects of diisononyl phthalate (DiNP) on the endocannabinoid and reproductive systems of male gilthead sea bream (Sparus aurata) during the spawning season Archives of Toxicology, 2019/01/02. Isabel Forner-Piquer, Constantinos C. Mylonas, Ioannis Fakriadis, Maria Papadaki, Fabiana Piscitelli, Vincenzo Di Marzo, Josep Calduch-Giner, Jaume Pérez-Sánchez, Oliana Carnevali. DOI 10.1007/s00204-018-2378-6

    The Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus Current Diabetes Reports, 2019. Veilleux, A., Di Marzo, V., Silvestri, C.. DOI 10.1007/s11892-019-1248-9

    Summary of the International Conference on Onco-Nephrology: an emerging field in medicine Kidney International, 2019. Capasso, A., Benigni, A., Capitanio, U., Danesh, F.R., Di Marzo, V., Gesualdo, L., Grandaliano, G., Jaimes, E.A., Malyszko, J., Perazella, M.A., Qian, Q., Ronco, P., Rosner, M.H., Trepiccione, F., Viggiano, D., Zoccali, C., Capasso, G., Akitaka, A., Alahoti, A., Alexander, T.R., Altucci, L., Amer, H., Barone, V., Eri, K., Biancone, L., Bonventre, J.V., Camussi, G., Ciardiello, F., Caraglia, M., Cartenì, G., Cervantes, A., Citterio, F., Cosmai, L., Daniele, B., D'Errico, A., De Vita, F., Ereditato, A., Falco, G., Fouque, D., Franco, R., Gallieni, M., Gambaro, G., Kuo, C., Launay-Vacher, V., Maiello, E., Mallamaci, F., Malysxko, J., Marino, G., Martinelli, E., Matarese, G., Matsubara, T., Messa, P., Messina, C., Mirone, V., Morgillo, F., Costa, A.N., Orditura, M., Pani, A., Perazella, M.A., Perna, A., Pisano, C., Pitts, T., Porta, C., Procopio, G., Remuzzi, G., Russo, D., Siu, L.L., Stadler, W., Troiani, T., Weisz, A., Więcek, A., Xiaoqiang, D., Zecchino, O.. DOI 10.1016/j.kint.2019.04.043

    Rapid and concomitant gut microbiota and endocannabinoidome response to diet-induced obesity in mice mSystems, 2019. Lacroix, S., Pechereau, F., Leblanc, N., Boubertakh, B., Houde, A., Martin, C., Flamand, N., Silvestri, C., Raymond, F., Marzo, V.D., Veilleuxa, A.. DOI 10.1128/mSystems.00407-19

    Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity Journal of Neuroinflammation, 2019. Petrosino, S., Schiano Moriello, A., Verde, R., Allarà, M., Imperatore, R., Ligresti, A., Mahmoud, A.M., Peritore, A.F., Iannotti, F.A., Di Marzo, V.. DOI 10.1186/s12974-019-1671-5

    Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway Neurobiology of Disease, 2019/01. Serena Boccella, Claudia Cristiano, Rosaria Romano, Monica Iannotta, Carmela Belardo, Antonio Farina, Francesca Guida, Fabiana Piscitelli, Enza Palazzo, Mariacristina Mazzitelli, Roberta Imperatore, Lea Tunisi, Vito de Novellis, Luigia Cristino, Vincenzo Di Marzo, Antonio Calignano, Sabatino Maione, Livio Luongo. DOI 10.1016/j.nbd.2018.09.023

    Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease European Journal of Medicinal Chemistry, 2019/01. Claudia Mugnaini, Alessandro Rabbito, Antonella Brizzi, Nastasja Palombi, Stefania Petrosino, Roberta Verde, Vincenzo Di Marzo, Alessia Ligresti, Federico Corelli. DOI 10.1016/j.ejmech.2018.09.070

    Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis Nature Communications, 2019/01. Amandine Everard, Hubert Plovier, Marialetizia Rastelli, Matthias Van Hul, Alice de Wouters d’Oplinter, Lucie Geurts, Céline Druart, Sylvie Robine, Nathalie M. Delzenne, Giulio G. Muccioli, Willem M. de Vos, Serge Luquet, Nicolas Flamand, Vincenzo Di Marzo, Patrice D. Cani. DOI 10.1038/s41467-018-08051-7

    Domaines de recherche

    • Pharmacologie fondamentale
    • endocannabinoid, microbiota, TRP, GPCR, obesity
    • Psychopharmacologie
    • obesity, cannabinoid, anxiety, depression,

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