Répertoire du corps professoral
Vincenzo Di Marzo
Professeur titulaire
vincenzo.dimarzo@criucpq.ulaval.ca
Pavillon Ferdinand-Vandry
1050, avenue de la Médecine
Local 4211
Professeur titulaire
vincenzo.dimarzo@criucpq.ulaval.ca
Pavillon des Services
2440, boul Hochelaga
Local 2744
FMED --- Unité mixte internationale sur la recherche chimique et biomoléculaire de microbiome
Programme: BDR - Contributions
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 31 mars 2025
au 30 mars 2030
FSAA --- Unité mixte internationale sur la recherche chimique et biomoléculaire de microbiome
Programme: BDR - Contributions
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 31 mars 2025
au 30 mars 2030
Synthesis, characterization, and in vivo identification of novel oxyendocannabinoidome
Organisme(s) subventionnaire(s): International Human Frontier Science Program Organization
Type de financement: Subvention
Établissement tête: Université Laval
Du 23 avril 2024
au 22 avril 2027
Institut sur la nutrition et les aliments fonctionnels (INAF)
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Université Concordia, Institut national de recherche scientifique (INRS), Université du Québec à Rimouski, Fonds de recherche du Québec - Nature et technologies, Université McGill, Université Laval - Fonds internes, Merinov - Centre d'innovation de l'aquaculture et des pêches du Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2024
au 31 mars 2030
Nutrition and brain health, from predictive biology to disease prevention and treatment - Food4BrainHealth
Programme: Réseau de recherche international (RRI)
Organisme(s) subventionnaire(s): Université Laval - Fonds internes, Université McGill, Université de Toronto, Institut national de la recherche agronomique
Type de financement: Subvention
Établissement tête: Université Laval
Du 18 mars 2019
au 17 mars 2026
The role of full-fat dairy products on body weigth control and metabolic health in adults
Programme: Dairy Research Cluster 3
Organisme(s) subventionnaire(s): Les producteurs laitiers du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 septembre 2018
au 30 septembre 2025
Canada Excellence Research Chair on the microbiome-endocannabinoidome connection in metabolic health
Programme: Programme de chaires d'excellence en recherche du Canada
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juin 2017
au 31 mai 2025
Financements des 2 dernières années
Effets de lipides polaires laitiers sur l’intégrité intestinale, le système endocannabinoïde et le microbiote fécal chez le porcelet
Programme: Projet subsidiaire d'un regroupement stratégique
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université Laval
Du 16 janvier 2023
au 31 mars 2025
Characterization of the endocannabinoidome of a CDKL5 mouse model
Organisme(s) subventionnaire(s): CDKL5
Type de financement: Subvention
Établissement tête: Université Laval
Du 15 janvier 2023
au 15 janvier 2024
Role of the Endocannabinoid System (ECS) in HIV-associated chronic inflammation and comorbidities
Programme: Subventions d'équipe : Essai d'intervention sur l'inflammation pour les maladies chroniques - Preuve à impact
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université McGill
Du 1 juin 2021
au 31 mai 2024
Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.3
Programme: Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 novembre 2019
au 31 octobre 2024
Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.2
Programme: Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 novembre 2019
au 31 octobre 2024
Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.1
Programme: Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 novembre 2019
au 31 octobre 2024
Dissecting host-microbiome modifiers of type 2 diabetes risk
Programme: Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 novembre 2019
au 31 octobre 2024
Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 3.2
Programme: Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 novembre 2019
au 31 octobre 2024
FMÉD --- Support de Sentinelle Nord à l'Unité mixte internationale sur la recherche chimique et biomoléculaire de microbiome
Programme: Fonds d'excellence en recherche Apogée Canada
Organisme(s) subventionnaire(s): Secrétariat des programmes interorganismes à l’intention des établissements
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juin 2017
au 31 août 2023
Institut sur la nutrition et les aliments fonctionnels (INAF)
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Institut national de recherche scientifique (INRS), Fonds de recherche du Québec - Nature et technologies, Université Laval - Fonds internes, Université McGill, Université du Québec à Rimouski, Université de Sherbrooke
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2017
au 31 mars 2024
FSAA --- Support de Sentinelle Nord à l'Unité mixte internationale sur la recherche chimique et biomoléculaire de microbiome
Programme: Fonds d'excellence en recherche Apogée Canada
Organisme(s) subventionnaire(s): Secrétariat des programmes interorganismes à l’intention des établissements
Type de financement: Subvention
Établissement tête: Université Laval
Du 29 novembre 2016
au 31 août 2023
Encadrements terminés dans les 5 dernières années
Publications des 5 dernières années
Enhanced visualization of endocannabinoids spatial distribution in mouse brain via MALDI-2 mass spectrometry imaging Talanta, 2025/08. Emanuela Salviati, Francesca Guida, Danila La Gioia, Fabrizio Merciai, Sabatino Maione, Vincenzo Di Marzo, Pietro Campiglia, Fabiana Piscitelli, Eduardo Sommella. DOI 10.1016/j.talanta.2025.127811
Circulating endocannabinoids and brain anatomy: unraveling the weight loss connection through lifestyle and surgery approaches Exploration of Endocrine and Metabolic Diseases, 2025/04/07. Gabrielle St-Arnaud, Tristan Rocheleau, Alain Veilleux, Volatiana Rakotoarivelo, Vincenzo Di Marzo. DOI 10.37349/eemd.2025.101427
The Human Fecal Endocannabinoidome Mediator Profile Is Mainly Defined by the Fecal Microbiota and Diet The Journal of Clinical Endocrinology & Metabolism, 2025/02/18. Sophie Castonguay-Paradis, Lydiane Parent, Gabrielle St-Arnaud, Julie Perron, Élizabeth Dumais, Nicolas Flamand, Frédéric Raymond, Vincenzo Di Marzo, Alain Veilleux. DOI 10.1210/clinem/dgae586
Altered levels of phospholipases C, diacylglycerols, endocannabinoids, and <i>N</i>-acylethanolamines in patients with hereditary angioedema due to FXII mutation Allergy, 2025. Ferrara, Anne Lise, Palestra, Francesco, Piscitelli, Fabiana, Petraroli, Angelica, Suffritti, Chiara, Firinu, Davide, Lopez-Lera, Alberto, Caballero, Teresa, Bork, Konrad, Spadaro, Giuseppe, Marone, Gianni, Di Marzo, Vincenzo, Bova, Maria, Loffredo, Stefania. DOI 10.1111/ALL.16197
Circulating endocannabinoidome signatures of disease activity in amyotrophic lateral sclerosis European Journal of Neurology, 2024/10. Raffaele Dubbioso, Fabio Arturo Iannotti, Gianmaria Senerchia, Roberta Verde, Valentina Virginia Iuzzolino, Myriam Spisto, Ines Fasolino, Fiore Manganelli, Vincenzo Di Marzo, Fabiana Piscitelli. DOI 10.1111/ene.16400
Synthesis of N-(3-Acyloxyacyl)glycines, Small Molecules with Potential Role in Gut Microbiome-Endocannabinoidome Communication Molecules, 2024/08/05. Rosaria Villano, Vincenzo Di Marzo. DOI 10.3390/molecules29153703
Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review International Journal of Obesity, 2024/02. Oscar David Lopez-Cortes, Francisco Trujillo-Sánchez, Erika Sierra-Ruelas, Erika Martinez-Lopez, Vincenzo Di Marzo, Barbara Vizmanos. DOI 10.1038/s41366-023-01428-9
Mathematical modeling of fluid dynamics in in vitro gut fermentation systems: A new tool to improve the interpretation of microbial metabolism The FASEB Journal, 2024/01/31. Jacob Lessard‐Lord, Joseph Lupien‐Meilleur, Charlène Roussel, Benjamin Gosselin‐Cliche, Cristoforo Silvestri, Vincenzo Di Marzo, Denis Roy, Elsa Rousseau, Yves Desjardins. DOI 10.1096/fj.202301739RR
The short-chain fatty acid acetate modulates orexin/hypocretin neurons: A novel mechanism in gut-brain axis regulation of energy homeostasis and feeding Biochemical Pharmacology, 2024. Forte, Nicola, Marfella, Brenda, Nicois, Alessandro, Palomba, Letizia, Paris, Debora, Motta, Andrea, Mollica, Maria Pina, Di Marzo, Vincenzo, Cristino, Luigia. DOI 10.1016/J.BCP.2024.116383
The human milk endocannabinoidome and neonatal growth in gestational diabetes Frontiers in Endocrinology, 2024. Fradet, Alice, Castonguay-Paradis, Sophie, Dugas, Camille, Perron, Julie, St-Arnaud, Gabrielle, Marc, Isabelle, Doyen, Alain, Flamand, Nicolas, Dahhani, Fadil, Di Marzo, Vincenzo, Veilleux, Alain, Robitaille, Julie. DOI 10.3389/FENDO.2024.1415630
The Impact of the CB<sub>2</sub> Cannabinoid Receptor in Inflammatory Diseases: An Update Molecules, 2024. Rakotoarivelo, Volatiana, Mayer, Thomas Z., Simard, Melissa, Flamand, Nicolas, Di Marzo, Vincenzo. DOI 10.3390/MOLECULES29143381
Postprandial Circulating Endocannabinoidome Mediators-Impact of Host's Metabolic Health and Dietary Fatty Acid Profile Diabetes, 2024. Rocheleau, Tristan, Amzil, Loubna, Mayer, Thomas, Leblanc, Nadine, Flamand, Nicolas, Raymond, Frederic, Di Marzo, Vincenzo, Veilleux, Alain. DOI 10.2337/DB24-517-P
Plasma endocannabinoidome and fecal microbiota interplay in people with HIV and subclinical coronary artery disease: Results from the Canadian HIV and Aging Cohort Study IScience, 2024. Bouassa, Ralph-Sydney Mboumba, Giorgini, Giada, Silvestri, Cristoforo, Muller, Chante, Nallabelli, Nayudu, Alexandrova, Yulia, Durand, Madeleine, Tremblay, Cecile, El-Far, Mohamed, Chartrand-Lefebvre, Carl, Messier-Peet, Marc, Margolese, Shari, Flamand, Nicolas, Costiniuk, Cecilia T., Di Marzo, Vincenzo, Jenabian, Mohammad-Ali. DOI 10.1016/J.ISCI.2024.110456
Pharmacological evidence that the inhibitory effects of prostaglandin E<sub>2</sub> are mediated by the EP<sub>2</sub> and EP<sub>4</sub> receptors in human neutrophils Journal of Leukocyte Biology, 2024. Lavoie, Jean-Philippe C., Simard, Melissa, Kalkan, Hilal, Rakotoarivelo, Volatiana, Huot, Sandrine, Di Marzo, Vincenzo, Cote, Andreanne, Pouliot, Marc, Flamand, Nicolas. DOI 10.1093/JLEUKO/QIAE029
PEA-OXA restores cognitive impairments associated with vitamin D deficiency-dependent alterations of the gut microbiota Biomedicine & Pharmacotherapy, 2024. Guida, Francesca, Iannotta, Monica, Perrone, Michela, Infantino, Rosmara, Giorgini, Giada, Fusco, Antimo, Marabese, Ida, Manzo, Iolanda, Belardo, Carmela, Di Martino, Emanuele, Pagano, Salvatore, Boccella, Serena, Silvestri, Cristoforo, Luongo, Livio, Di Marzo, Vincenzo, Maione, Sabatino. DOI 10.1016/J.BIOPHA.2024.116600
Oral ultramicronized palmitoylethanolamide: plasma and tissue levels and spinal antihyperalgesic effect (Vol 9, 249, 2018) Frontiers in Pharmacology, 2024. Petrosino, Stefania, Cordaro, Marika, Verde, Roberta, Moriello, Aniello Schiano, Marcolongo, Gabriele, Schievano, Carlo, Siracusa, Rosalba, Piscitelli, Fabiana, Peritore, Alessio F., Crupi, Rosalia, Impellizzeri, Daniela, Esposito, Emanuela, Cuzzocrea, Salvatore, Di Marzo, Vincenzo. DOI 10.3389/FPHAR.2024.1441203
Investigating the alterations of endocannabinoidome signaling in the human small intestine in the context of obesity and type 2 diabetes Heliyon, 2024. Rakotoarivelo, Volatiana, Allam-Ndoul, Benedicte, Martin, Cyril, Biertho, Laurent, Di Marzo, Vincenzo, Flamand, Nicolas, Veilleux, Alain. DOI 10.1016/J.HELIYON.2024.E26968
Human gut microbiota and their production of endocannabinoid-like mediators are directly affected by a dietary oil Gut Microbes, 2024. Roussel, Charlene, Sola, Mathilde, Lessard-Lord, Jacob, Nallabelli, Nayudu, Genereux, Pamela, Cavestri, Camille, Azeggouar Wallen, Oumaima, Villano, Rosaria, Raymond, Frederic, Flamand, Nicolas, Silvestri, Cristoforo, Di Marzo, Vincenzo. DOI 10.1080/19490976.2024.2335879
Effect of a Probiotic Beverage Enriched with Cricket Proteins on the Gut Microbiota: Composition of Gut and Correlation with Nutritional Parameters Foods, 2024. Dridi, Chaima, Millette, Mathieu, Salmieri, Stephane, Aguilar Uscanga, Blanca R., Lacroix, Sebastien, Venneri, Tommaso, Sarmast, Elham, Allahdad, Zahra, Di Marzo, Vincenzo, Silvestri, Cristoforo, Lacroix, Monique. DOI 10.3390/FOODS13020204
Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice Cellular and Molecular Life Sciences, 2024. Forte, Nicola, Nicois, Alessandro, Marfella, Brenda, Mavaro, Isabella, D'Angelo, Livia, Piscitelli, Fabiana, Scandurra, Anna, De Girolamo, Paolo, Baldelli, Pietro, Benfenati, Fabio, Di Marzo, Vincenzo, Cristino, Luigia. DOI 10.1007/S00018-023-05029-7
Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI Acta Neuropathologica Communications, 2024. Guida, Francesca, Iannotta, Monica, Lauritano, Anna, Infantino, Rosmara, Salviati, Emanuela, Verde, Roberta, Luongo, Livio, Sommella, Eduardo Maria, Iannotti, Fabio Arturo, Campiglia, Pietro, Maione, Sabatino, Di Marzo, Vincenzo, Piscitelli, Fabiana. DOI 10.1186/S40478-024-01820-0
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization Journal of Medicinal Chemistry, 2024. Butini, Stefania, Grether, Uwe, Jung, Kwang-Mook, Ligresti, Alessia, Allara, Marco, Postmus, Annemarieke G. J., Maramai, Samuele, Brogi, Simone, Papa, Alessandro, Carullo, Gabriele, Sykes, David, Veprintsev, Dmitry, Federico, Stefano, Grillo, Alessandro, Di Guglielmo, Bruno, Ramunno, Anna, Stevens, Anna Floor, Heer, Dominik, Lamponi, Stefania, Gemma, Sandra, Benz, Jorg, Di Marzo, Vincenzo, van der Stelt, Mario, Piomelli, Daniele, Campiani, Giuseppe. DOI 10.1021/ACS.JMEDCHEM.3C01278
Cannabidiol reduces intraventricular hemorrhage brain damage, preserving myelination and preventing blood brain barrier dysfunction in immature rats Neurotherapeutics, 2024. Del Pozo, Aaron, de Hoz-Rivera, Maria, Romero, Angela, Villa, Maria, Martinez, Maria, Silva, Laura, Piscitelli, Fabiana, Di Marzo, Vincenzo, Gutierrez-Rodriguez, Ana, Hind, William, Martinez-Orgado, Jose. DOI 10.1016/J.NEUROT.2024.E00326
Astrocytic Cannabinoid Receptor 1 Promotes Resilience by Dampening Stress-Induced Blood-Brain Barrier Alterations and Inflammation Biological Psychiatry, 2024. Dudek, Katarzyna Anna, Paton, Sam E. J., Collignon, Adeline, Lebel, Manon, Lavoie, Olivier, Bouchard, Jonathan, Kaufmann, Fernanda Neutzling, Dion-Albert, Laurence, Clavet-Fournier, Valerie, Binder, Luisa B., Manca, Claudia, Flamand, Nicolas, Guzman, Manuel, Campbell, Matthew, Turecki, Gustavo, Mechawar, Naguib, Lavoie-Cardinal, Flavie, Silvestri, Cristoforo, Di Marzo, Vincenzo, Menard, Caroline.
Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin Cell Death & Disease, 2023/08/23. Hilal Kalkan, Elisabetta Panza, Ester Pagano, Giuseppe Ercolano, Claudia Moriello, Fabiana Piscitelli, Mónika Sztretye, Raffaele Capasso, Vincenzo Di Marzo, Fabio Arturo Iannotti. DOI 10.1038/s41419-023-06080-9
The emerging role of the endocannabinoidome-gut microbiome axis in eating disorders Psychoneuroendocrinology, 2023/08. Hayatte-Dounia Mir, Giada Giorgini, Vincenzo Di Marzo. DOI 10.1016/j.psyneuen.2023.106295
Gene-based microbiome representation enhances host phenotype classification mSystems, 2023/07/05. Thomas Deschênes, Fred Wilfried Elom Tohoundjona, Pier-Luc Plante, Vincenzo Di Marzo, Frédéric Raymond. DOI 10.1128/msystems.00531-23
Cannabinoid receptors in GtoPdb v.2023.1 IUPHAR/BPS Guide to Pharmacology CITE, 2023/04/26. Mary Abood, Stephen P.H. Alexander, Francis Barth, Tom I. Bonner, Heather Bradshaw, Guy Cabral, Pierre Casellas, Ben F. Cravatt, William A. Devane, Vincenzo Di Marzo, Maurice R. Elphick, Christian C. Felder, Peter Greasley, Miles Herkenham, Allyn C. Howlett, George Kunos, Ken Mackie, Raphael Mechoulam, Roger G. Pertwee, Ruth A. Ross. DOI 10.2218/gtopdb/F13/2023.1
The Effects of Peripubertal THC Exposure in Neurodevelopmental Rat Models of Psychopathology International Journal of Molecular Sciences, 2023/02. Martina Di Bartolomeo, Tibor Stark, Serena Di Martino, Fabio Arturo Iannotti, Jana Ruda-Kucerova, Giovanni Luca Romano, Martin Kuchar, Samuele Laudani, Petr Palivec, Fabiana Piscitelli, Carsten T. Wotjak, Claudio Bucolo, Filippo Drago, Vincenzo Di Marzo, claudio d'addario, Vincenzo Micale. DOI 10.3390/ijms24043907
A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese (ob/ob) and Diabetic (db/db) Mice: Links with Inflammation and Gut Microbiota Cells, 2023/01/25. Francesco Suriano, Claudia Manca, Nicolas Flamand, Matthias Van Hul, Nathalie M. Delzenne, Cristoforo Silvestri, Patrice D. Cani, Vincenzo Di Marzo. DOI 10.3390/cells12030411
Validation of a fast and sensitive UPLC-MS/MS quantitative method for N-acyl taurine analysis in biological samples Journal of Pharmaceutical and Biomedical Analysis, 2023. Falascina, G., Bindels, L.B., Di Marzo, V., Cutignano, A.. DOI 10.1016/j.jpba.2023.115252
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia BioFactors, 2023. Maia, J., Iannotti, F.A., Piscitelli, F., Fonseca, B.M., Braga, A., Braga, J., Teixeira, N., Di Marzo, V., Correia-da-Silva, G.. DOI 10.1002/biof.1952
The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population Microbiome, 2023. Bourdeau-Julien, I., Castonguay-Paradis, S., Rochefort, G., Perron, J., Lamarche, B., Flamand, N., Di Marzo, V., Veilleux, A., Raymond, F.. DOI 10.1186/s40168-023-01469-2
The Gut Microbiome-Endocannabinoidome Axis: A New Way of Controlling Metabolism, Inflammation, and Behavior Function, 2023. Silvestri, C., Di Marzo, V.. DOI 10.1093/function/zqad003
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy EMBO Molecular Medicine, 2023. Kalkan, H., Pagano, E., Paris, D., Panza, E., Cuozzo, M., Moriello, C., Piscitelli, F., Abolghasemi, A., Gazzerro, E., Silvestri, C., Capasso, R., Motta, A., Russo, R., Di Marzo, V., Iannotti, F.A.. DOI 10.15252/emmm.202216225
TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β-catenin signalling British Journal of Pharmacology, 2023. Pagano, E., Romano, B., Cicia, D., Iannotti, F.A., Venneri, T., Lucariello, G., Nanì, M.F., Cattaneo, F., De Cicco, P., D'Armiento, M., De Luca, M., Lionetti, R., Lama, S., Stiuso, P., Zoppoli, P., Falco, G., Marchianò, S., Fiorucci, S., Capasso, R., Di Marzo, V., Borrelli, F., Izzo, A.A.. DOI 10.1111/bph.15960
Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice Journal of Neuroinflammation, 2023. Santos-García, I., Rodríguez-Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K.J., Di Marzo, V., Fernández-Ruiz, J., de Lago, E.. DOI 10.1186/s12974-023-02792-z
Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity Molecular Metabolism, 2023. Fernández-Rilo, A.C., Forte, N., Palomba, L., Tunisi, L., Piscitelli, F., Imperatore, R., Di Costanzo, A., Di Marzo, V., Cristino, L.. DOI 10.1016/j.molmet.2023.101713
Olive oil-derived endocannabinoid-like mediators inhibit palatable food-induced reward and obesity Communications Biology, 2023. Forte, N., Roussel, C., Marfella, B., Lauritano, A., Villano, R., De Leonibus, E., Salviati, E., Khalilzadehsabet, T., Giorgini, G., Silvestri, C., Piscitelli, F., Mollica, M.P., Di Marzo, V., Cristino, L.. DOI 10.1038/s42003-023-05295-y
Oleoylethanolamide in the treatment of obesity and insulin resistance: Modulation of energy balance, mitochondrial bioenergetics and gut microbiome Acta Physiologica, 2023. Cimmino, Fabiano, Trinchese, Giovanna, Petrella, Lidia, Cavaliere, Gina, Catapano, Angela, Sihag, Jyoti, Silvestri, Cristoforo, Di Marzo, Vincenzo, Mollica, Maria Pina.
New role for the anandamide metabolite prostaglandin F2α ethanolamide: Rolling preadipocyte proliferation Journal of Lipid Research, 2023. Boubertakh, Besma, Courtemanche, Olivier, Marsolais, David, Di Marzo, Vincenzo, Silvestri, Cristoforo. DOI 10.1016/J.JLR.2023.100444
MODULATION OF BLOOD PRESSURE THROUGH MICROBIOME EXCHANGE BETWEEN MILAN NORMOTENSIVE AND HYPERTENSIVE STRAINS OF RATS Nephrology Dialysis Transplantation, 2023. Suzumoto, Yoko, Shams, Abbas, D'apolito, Luciano, Longobardi, Consiglia, Trepiccione, Francesco, Glorieux, Griet, Silvestri, Cristoforo, Di Marzo, Vincenzo, Capasso, Giovambattista.
Involvement of the Endocannabinoid System in the Control of Pain and Obesity by Exercise in Rodents: A Systematic Review Cannabis and Cannabinoid Research, 2023. Elisei, L., Moraes, T., Malta, I., Rodríguez, J., Di Marzo, V., Galdino, G.. DOI 10.1089/can.2022.0291
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists Journal of Medicinal Chemistry, 2023. Romeo, I., Brizzi, A., Pessina, F., Ambrosio, F.A., Aiello, F., Belardo, C., Carullo, G., Costa, G., De Petrocellis, L., Frosini, M., Luongo, L., Maramai, S., Paolino, M., Moriello, A.S., Mugnaini, C., Scorzelli, F., Maione, S., Corelli, F., Di Marzo, V., Alcaro, S., Artese, A.. DOI 10.1021/acs.jmedchem.3c00447
Hypoabsorptive surgeries cause limb-dependent changes in the gut endocannabinoidome and microbiome in association with beneficial metabolic effects International Journal of Obesity, 2023. Mukorako, P., St-Pierre, D.H., Flamand, N., Biertho, L., Lebel, S., Lemoine, N., Plamondon, J., Roy, M.-C., Tchernof, A., Varin, T.V., Marette, A., Silvestri, C., Di Marzo, V., Richard, D.. DOI 10.1038/s41366-023-01307-3
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years Pharmacological Reviews, 2023. Maccarrone, M., Marzo, V.D., Gertsch, J., Grether, U., Howlett, A.C., Hua, T., Makriyannis, A., Piomelli, D., Ueda, N., van der Stelt, M.. DOI 10.1124/pharmrev.122.000600
Gestational Diabetes Mellitus, Human Milk Composition, and Infant Growth Breastfeeding Medicine, 2023. Dugas, C., Laberee, L., Perron, J., St-Arnaud, G., Richard, V., Perreault, V., Leblanc, N., Marc, I., Di Marzo, V., Doyen, A., Veilleux, A., Robitaille, J.. DOI 10.1089/bfm.2022.0085
FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects Metabolic Syndrome and Related Disorders, 2023. Sierra-Ruelas, E., Torres-Castillo, N., Vizmanos, B., Campos-Pérez, W., Lopez-Cortes, O.D., Di Marzo, V., Martínez-López, E.. DOI 10.1089/met.2023.0014
Expanding Research on Cannabis-Based Medicines for Liver Steatosis: A Low-Risk High-Reward Way Out of the Present Deadlock? Cannabis and Cannabinoid Research, 2023. Barré, T., Di Marzo, V., Marcellin, F., Burra, P., Carrieri, P.. DOI 10.1089/can.2022.0014
Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome British Journal of Pharmacology, 2023. Inserra, A., Giorgini, G., Lacroix, S., Bertazzo, A., Choo, J., Markopolous, A., Grant, E., Abolghasemi, A., De Gregorio, D., Flamand, N., Rogers, G., Comai, S., Silvestri, C., Gobbi, G., Di Marzo, V.. DOI 10.1111/bph.15977
Dietary food patterns as determinants of the gut microbiome–endocannabinoidome axis in humans Scientific Reports, 2023. Castonguay-Paradis, S., Perron, J., Flamand, N., Lamarche, B., Raymond, F., Di Marzo, V., Veilleux, A.. DOI 10.1038/s41598-023-41650-z
Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders Function, 2023. Daniel, Noemie, Le Barz, Melanie, Mitchell, Patricia L., Varin, Thibault V., Julien, Isabelle Bourdeau, Farabos, Dominique, Pilon, Genevieve, Gauthier, Josee, Garofalo, Carole, Kang, Jing X., Trottier, Jocelyn, Barbier, Olivier, Roy, Denis, Chassaing, Benoit, Levy, Emile, Raymond, Frederic, Lamaziere, Antonin, Flamand, Nicolas, Silvestri, Cristoforo, Jobin, Christian, Di Marzo, Vincenzo, Marette, Andre. DOI 10.1093/FUNCTION/ZQAC069
Cannabis use in relation to Pulse Pressure and Mean Arterial Pressure in US Adults MedRxiv, 2023. Ruddy, Stella, Di Marzo, Vincenzo, Ngueta, Gerard. DOI 10.1101/2023.05.12.23289921
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer Pharmacological Research, 2023. Mahmoud, A.M., Kostrzewa, M., Marolda, V., Cerasuolo, M., Maccarinelli, F., Coltrini, D., Rezzola, S., Giacomini, A., Mollica, M.P., Motta, A., Paris, D., Zorzano, A., Marzo, V.D., Ronca, R., Ligresti, A.. DOI 10.1016/j.phrs.2023.106683
Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations Research Square, 2023. Dudek, K.A., Paton, S.E.J., Collignon, A., Lebel, M., Lavoie, O., Bouchard, J., Kaufmann, F.N., Dion-Albert, L., Clavet-Fournier, V., Binder, L.B., Manca, C., Flamand, N., Guzman, M., Campbell, M., Turecki, G., Mechawar, N., Lavoie-Cardinal, F., Silvestri, C., Di Marzo, V., Menard, C.. DOI 10.21203/rs.3.rs-2978353
Astrocytic Cannabinoid Receptor 1 Promotes Resilience by Dampening Stress-Induced Blood-Brain Barrier Alterations Neuropsychopharmacology, 2023. Dudek, Katarzyna, Paton, Sam, Collignon, Adeline, Lavoie, Olivier, Bouchard, Jonathan, Kaufmann, Fernanda Neutzling, Dion-Albert, Laurence, Clavet-Fournier, Valerie, Lebel, Manon, Manca, Claudia, Flamand, Nicolas, Guzman, Manuel, Campbell, Matthew, Turecki, Gustavo, Mechawar, Naguib, Lavoie-Cardinal, Flavie, Silvestri, Cristoforo, Di Marzo, Vincenzo, Menard, Caroline.
Astrocytes modulate neuronal development by S100A6 signaling BioRxiv, 2023. Cinquina, Valentina, Calvigioni, Daniela, Piscitelli, Fabiana, Keimpema, Erik, Di Marzo, Vincenzo, Verkhratsky, Alexei, Harkany, Tibor. DOI 10.1101/2023.09.05.556314
Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice Lipids in Health and Disease, 2023. Venneri, T., Giorgini, G., Leblanc, N., Flamand, N., Borrelli, F., Silvestri, C., Di Marzo, V.. DOI 10.1186/s12944-023-01823-1
Alterations of the endocannabinoid system by endocrine-disrupting chemicals: Effects on metabolism and reproduction Environmental Contaminants and Endocrine Health, 2023. Forner-Piquer, I., Di Marzo, V., Carnevali, O.. DOI 10.1016/B978-0-12-824464-7.00018-0
Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned medium Frontiers in Cellular Neuroscience, 2023. Paes-Colli, Y., Trindade, P.M.P., Vitorino, L.C., Piscitelli, F., Iannotti, F.A., Campos, R.M.P., Isaac, A.R., de Aguiar, A.F.L., Allodi, S., de Mello, F.G., Einicker-Lamas, M., de Siqueira-Santos, R., Di Marzo, V., Tannous, B.A., Carvalho, L.A., De Melo Reis, R.A., Sampaio, L.S.. DOI 10.3389/fncel.2023.1134130
First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury Biomolecules, 2022/12/24. Aniello Schiano Moriello, Fiorentina Roviezzo, Fabio Arturo Iannotti, Giuseppina Rea, Marco Allarà, Rosa Camerlingo, Roberta Verde, Vincenzo Di Marzo, Stefania Petrosino. DOI 10.3390/biom13010033
MicroRNA-mediated repression of endocannabinoid CB1 receptor expression contributes to simvastatin-induced skeletal muscle toxicity 2022/12/19. Hilal Kalkan, Elisabetta Panza, Ester Pagano, Giuseppe Ercolano, Claudia Moriello, Fabiana Piscitelli, Raffaele Capasso, Vincenzo Di Marzo, Fabio Iannotti. DOI 10.21203/rs.3.rs-2328769/v1
Obesity: The Fat Tissue Disease Version of Cancer Cells, 2022/06/09. Besma Boubertakh, Cristoforo Silvestri, Vincenzo Di Marzo. DOI 10.3390/cells11121872
Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint Animals, 2022/01/31. Aniello Schiano Moriello, Vincenzo Di Marzo, Stefania Petrosino. DOI 10.3390/ani12030348
(Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders Lipids in Health and Disease, 2022/01/14. Jyoti Sihag, Vincenzo Di Marzo. DOI 10.1186/s12944-021-01609-3
Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia Biomolecules, 2022/01/10. Tibor Stark, Fabio Arturo Iannotti, Serena Di Martino, Martina Di Bartolomeo, Jana Ruda-Kucerova, Fabiana Piscitelli, Carsten T. Wotjak, Claudio D’Addario, Filippo Drago, Vincenzo Di Marzo, Vincenzo Micale. DOI 10.3390/biom12010108
Three of a kind: Control of the expression of liver-expressed antimicrobial peptide 2 (leap2) by the endocannabinoidome and the gut microbiome Molecules, 2022. Shen, M., Manca, C., Suriano, F., Nallabelli, N., Pechereau, F., Allam-Ndoul, B., Iannotti, F.A., Flamand, N., Veilleux, A., Cani, P.D., Silvestri, C., Di Marzo, V.. DOI 10.3390/molecules27010001
The endocannabinoidome mediator N-oleoylglycine is a novel protective agent against 1-methyl-4-phenyl-pyridinium-induced neurotoxicity Frontiers in Aging Neuroscience, 2022. Lauritano, A., Cipollone, I., Verde, R., Kalkan, H., Moriello, C., Iannotti, F.A., Di Marzo, V., Piscitelli, F.. DOI 10.3389/fnagi.2022.926634
Short-term supplementation with ω-3 polyunsaturated fatty acids modulates primarily mucolytic species from the gut luminal mucin niche in a human fermentation system Gut Microbes, 2022. Roussel, C., Anunciação Braga Guebara, S., Plante, P.-L., Desjardins, Y., Di Marzo, V., Silvestri, C.. DOI 10.1080/19490976.2022.2120344
Short and efficient synthesis of alkylresorcinols: a route for the preparation of cannabinoids New Journal of Chemistry, 2022. Rosaria Villano, Hannah Straker, Vincenzo Di Marzo. DOI 10.1039/D2NJ03547B
Positive association between plasmatic levels of orexin A and the endocannabinoid-derived 2-arachidonoyl lysophosphatidic acid in Alzheimer’s disease Frontiers in Aging Neuroscience, 2022. Forte, N., Fernández-Rilo, A.C., Palomba, L., Marfella, B., Piscitelli, F., De Girolamo, P., Di Costanzo, A., Di Marzo, V., Cristino, L.. DOI 10.3389/fnagi.2022.1004002
N-Acylethanolamine acid amidase (NAAA) is dysregulated in colorectal cancer patients and its inhibition reduces experimental cancer growth British Journal of Pharmacology, 2022. Romano, B., Pagano, E., Iannotti, F.A., Piscitelli, F., Brancaleone, V., Lucariello, G., Nanì, M.F., Fiorino, F., Sparaco, R., Vanacore, G., Di Tella, F., Cicia, D., Lionetti, R., Makriyannis, A., Malamas, M., De Luca, M., Aprea, G., D'Armiento, M., Capasso, R., Sbarro, B., Venneri, T., Di Marzo, V., Borrelli, F., Izzo, A.A.. DOI 10.1111/bph.15737
Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study Scientific Reports, 2022. Forteza, F., Bourdeau-Julien, I., Nguyen, G.Q., Guevara Agudelo, F.A., Rochefort, G., Parent, L., Rakotoarivelo, V., Feutry, P., Martin, C., Perron, J., Lamarche, B., Flamand, N., Veilleux, A., Billaut, F., Di Marzo, V., Raymond, F.. DOI 10.1038/s41598-022-10757-0
Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice Frontiers in Immunology, 2022. Guevara Agudelo, F.A., Leblanc, N., Bourdeau-Julien, I., St-Arnaud, G., Lacroix, S., Martin, C., Flamand, N., Veilleux, A., Di Marzo, V., Raymond, F.. DOI 10.3389/fimmu.2022.1028412
Human and mouse eosinophils differ in their ability to biosynthesize eicosanoids, docosanoids, the endocannabinoid 2-arachidonoyl-glycerol and its congeners Cells, 2022. Archambault, A.-S., Brassard, J., Bernatchez, É., Martin, C., Di Marzo, V., Laviolette, M., Boulet, L.-P., Blanchet, M.-R., Flamand, N.. DOI 10.3390/cells11010141
Hemp seed significantly modulates the endocannabinoidome and produces beneficial metabolic effects with improved intestinal barrier function and decreased inflammation in mice under a high-fat, high-sucrose diet as compared with linseed Frontiers in Immunology, 2022. Ben Necib, R., Manca, C., Lacroix, S., Martin, C., Flamand, N., Di Marzo, V., Silvestri, C.. DOI 10.3389/fimmu.2022.882455
Facile and Sustainable Synthesis of Commendamide and its Analogues Frontiers in Chemistry, 2022. Villano, R., Tinto, F., Di Marzo, V.. DOI 10.3389/fchem.2022.858854
Expression and Functions of the CB<sub>2</sub> Receptor in Human Leukocytes Frontiers in Pharmacology, 2022. Simard, M., Rakotoarivelo, V., Di Marzo, V., Flamand, N.. DOI 10.3389/fphar.2022.826400
Exploring the interaction between lipid mediators, inflammation, and microbiota composition in dairy cows under heat stress Journal of Dairy Science, 2022. Ruiz-Gonzalez, A., Flammand, N., Petri, R., Ronholm, J., Chouinard, P. Y., Gervais, R., Di Marzo, V., Rico, D. E..
Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2022. Suriano, F., Manca, C., Flamand, N., Depommier, C., Van Hul, M., Delzenne, N.M., Silvestri, C., Cani, P.D., Di Marzo, V.. DOI 10.1016/j.bbalip.2021.159056
Cannabinoids and Chronic Liver Diseases International Journal of Molecular Sciences, 2022. Mboumba Bouassa, R.-S., Sebastiani, G., Di Marzo, V., Jenabian, M.-A., Costiniuk, C.T.. DOI 10.3390/ijms23169423
Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families Biochemical Pharmacology, 2022. Simard, M., Archambault, A.-S., Lavoie, J.-P.C., Dumais, É., Di Marzo, V., Flamand, N.. DOI 10.1016/j.bcp.2022.115261
Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1 Biomedicine and Pharmacotherapy, 2022. Ten-Blanco, M., Flores, Á., Pereda-Pérez, I., Piscitelli, F., Izquierdo-Luengo, C., Cristino, L., Romero, J., Hillard, C.J., Maldonado, R., Di Marzo, V., Berrendero, F.. DOI 10.1016/j.biopha.2022.112925
Alterations of the endocannabinoid system and circulating and peripheral tissue levels of endocannabinoids in sarcopenic rats Journal of Cachexia, Sarcopenia and Muscle, 2022. Le Bacquer, O., Salles, J., Piscitelli, F., Sanchez, P., Martin, V., Montaurier, C., Di Marzo, V., Walrand, S.. DOI 10.1002/jcsm.12855
Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice Molecular Metabolism, 2022. Vilela, V.R., Samson, N., Nachbar, R., Perazza, L.R., Lachance, G., Rokatoarivelo, V., Centano-Baez, C., Zancan, P., Sola-Penna, M., Bellmann, K., Di Marzo, V., Laplante, M., Marette, A.. DOI 10.1016/j.molmet.2022.101437
Cannabinoids: a class of unique natural products with unique pharmacology Rendiconti Lincei. Scienze Fisiche e Naturali, 2021/03/11. Fabiana Piscitelli, Vincenzo Di Marzo. DOI 10.1007/s12210-020-00966-y
A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator Cells, 2021/02/20. Emiliano Manzo, Aniello Schiano Moriello, Francesco Tinto, Roberta Verde, Marco Allarà, Luciano De Petrocellis, Ester Pagano, Angelo A. Izzo, Vincenzo Di Marzo, Stefania Petrosino. DOI 10.3390/cells10020450
Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models Cells, 2021/01/05. Clara Depommier, Nicolas Flamand, Rudy Pelicaen, Dominique Maiter, Jean-Paul Thissen, Audrey Loumaye, Michel P. Hermans, Amandine Everard, Nathalie M. Delzenne, Vincenzo Di Marzo, Patrice D. Cani. DOI 10.3390/cells10010071
The gut microbiome, endocannabinoids and metabolic disorders Journal of Endocrinology, 2021. Iannotti, F.A., Di Marzo, V.. DOI 10.1530/JOE-20-0444
Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2021. Tinto, F., Archambault, A.-S., Dumais, É., Rakotoarivelo, V., Kostrzewa, M., Martin, C., Plante, P.-L., Desjardins, Y., Simard, M., Pouliot, R., De Petrocellis, L., Ligresti, A., Di Marzo, V., Flamand, N.. DOI 10.1016/j.bbalip.2021.158954
Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators Frontiers in Pharmacology, 2021. Ayoub, S.M., Piscitelli, F., Silvestri, C., Limebeer, C.L., Rock, E.M., Smoum, R., Farag, M., de Almeida, H., Sullivan, M.T., Lacroix, S., Boubertakh, B., Nallabelli, N., Lichtman, A.H., Leri, F., Mechoulam, R., Di Marzo, V., Parker, L.A.. DOI 10.3389/fphar.2021.706703
Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice Frontiers in Synaptic Neuroscience, 2021. Tunisi, L., D'Angelo, L., Fernández-Rilo, A.C., Forte, N., Piscitelli, F., Imperatore, R., de Girolamo, P., Di Marzo, V., Cristino, L.. DOI 10.3389/fnsyn.2021.622405
Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice Nature Communications, 2021. Forte, N., Boccella, S., Tunisi, L., Fernández-Rilo, A.C., Imperatore, R., Iannotti, F.A., De Risi, M., Iannotta, M., Piscitelli, F., Capasso, R., De Girolamo, P., De Leonibus, E., Maione, S., Di Marzo, V., Cristino, L.. DOI 10.1038/s41467-021-26388-4
Oral capsaicinoid administration alters the plasma endocannabinoidome and fecal microbiota of reproductive-aged women living with overweight and obesity Biomedicines, 2021. Manca, C., Lacroix, S., Pérusse, F., Flamand, N., Chagnon, Y., Drapeau, V., Tremblay, A., Di Marzo, V., Silvestri, C.. DOI 10.3390/biomedicines9091246
N-palmitoyl-d-glucosamine, a natural monosaccharide-based glycolipid, inhibits tlr4 and prevents lps-induced inflammation and neuropathic pain in mice International Journal of Molecular Sciences, 2021. Iannotta, M., Belardo, C., Trotta, M.C., Iannotti, F.A., Vitale, R.M., Maisto, R., Boccella, S., Infantino, R., Ricciardi, F., Mirto, B.F., Ferraraccio, F., Panarese, I., Amodeo, P., Tunisi, L., Cristino, L., D’amico, M., Di Marzo, V., Luongo, L., Maione, S., Guida, F.. DOI 10.3390/ijms22031491
N-Oleoylglycine and N-Oleoylalanine Do Not Modify Tolerance to Nociception, Hyperthermia, and Suppression of Activity Produced by Morphine Frontiers in Synaptic Neuroscience, 2021. Rock, E.M., Limebeer, C.L., Sullivan, M.T., DeVuono, M.V., Lichtman, A.H., Di Marzo, V., Mechoulam, R., Parker, L.A.. DOI 10.3389/fnsyn.2021.620145
Maternal omega-3 intake differentially affects the endocannabinoid system in the progeny`s neocortex and hippocampus: Impact on synaptic markers Journal of Nutritional Biochemistry, 2021. Isaac, A.R., de Velasco, P.C., Fraga, K.Y.D., Tavares-do-Carmo, M.D.G., Campos, R.M.P., Iannotti, F.A., Verde, R., Martins, D.B.G., Santos, T.A., Ferreira, B.K., de Mello, F.G., Di Marzo, V., Andrade-da-Costa, B.L.D.S., de Melo Reis, R.A.. DOI 10.1016/j.jnutbio.2021.108782
Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation Brazilian Journal of Medical and Biological Research, 2021. L.S. Guzzo, C.C. Oliveira, R.C.M. Ferreira, D.P.D. Machado, M.G.M. Castor, A.C. Perez, F. Piscitelli, V. Di Marzo, T.R.L. Romero, I.D.G. Duarte. DOI 10.1590/1414-431x2021e11071
Intuitive eating is associated with elevated levels of circulating omega-3-polyunsaturated fatty acid-derived endocannabinoidome mediators Appetite, 2021. Rochefort, G., Provencher, V., Castonguay-Paradis, S., Perron, J., Lacroix, S., Martin, C., Flamand, N., Di Marzo, V., Veilleux, A.. DOI 10.1016/j.appet.2020.104973
Identification and characterization of cannabidiol as an ox1r antagonist by computational and in vitro functional validation Biomolecules, 2021. Vitale, R.M., Iannotti, F.A., Moriello, A.S., Tunisi, L., Piscitelli, F., Savopoulos, R., Cristino, L., De Petrocellis, L., Amodeo, P., Gray, R., Di Marzo, V.. DOI 10.3390/biom11081134
Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB<sub>1</sub>Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster Cannabis and Cannabinoid Research, 2021. Tortoriello, G., Beiersdorf, J., Romani, S., Williams, G., Cameron, G.A., Mackie, K., Williams, M.J., Di Marzo, V., Keimpema, E., Doherty, P., Harkany, T.. DOI 10.1089/can.2020.0010
Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation Phytotherapy Research, 2021. Pagano, E., Iannotti, F.A., Piscitelli, F., Romano, B., Lucariello, G., Venneri, T., Di Marzo, V., Izzo, A.A., Borrelli, F.. DOI 10.1002/ptr.6831
Effect of docosahexaenoic acid (DHA) at the enteric level in a synucleinopathy mouse model Nutrients, 2021. Lamontagne‐proulx, J., Coulombe, K., Dahhani, F., Côté, M., Guyaz, C., Tremblay, C., Di Marzo, V., Flamand, N., Calon, F., Soulet, D.. DOI 10.3390/nu13124218
Editorial on “Cannabis and cannabinoids: history, practice and socio-economical inferences of a controversial plant” Rendiconti Lincei, 2021. Di Marzo, V., Marino, G.. DOI 10.1007/s12210-021-00975-5
Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure Prostaglandins Leukotrienes and Essential Fatty Acids, 2021. Bertrand, J.A., Woodward, D.F., Sherwood, J.M., Spenlehauer, A., Silvestri, C., Piscitelli, F., Marzo, V.D., Yamazaki, M., Sakimura, K., Inoue, Y., Watanabe, K., Overby, D.R.. DOI 10.1016/j.plefa.2020.102235
Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Δ9-tetrahydrocannabinol-exposed rats Pharmacological Research, 2021. Di Bartolomeo, M., Stark, T., Maurel, O.M., Iannotti, F.A., Kuchar, M., Ruda-Kucerova, J., Piscitelli, F., Laudani, S., Pekarik, V., Salomone, S., Arosio, B., Mechoulam, R., Maccarrone, M., Drago, F., Wotjak, C.T., Di Marzo, V., Vismara, M., Dell'Osso, B., D'Addario, C., Micale, V.. DOI 10.1016/j.phrs.2020.105357
Correction to: 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors (Molecular Brain, (2021), 14, 1, (28), 10.1186/s13041-020-00724-z) Molecular Brain, 2021. Boccella, S., Guida, F., Iannotta, M., Iannotti, F.A., Infantino, R., Ricciardi, F., Cristiano, C., Vitale, R.M., Amodeo, P., Marabese, I., Belardo, C., de Novellis, V., Paino, S., Palazzo, E., Calignano, A., Di Marzo, V., Maione, S., Luongo, L.. DOI 10.1186/s13041-021-00772-z
Biosynthesis of the novel endogenous 15-lipoxygenase metabolites N-13-hydroxy-octodecadienoyl-ethanolamine and 13-hydroxy-octodecadienoyl-glycerol by human neutrophils and Eosinophils Cells, 2021. Archambault, A.-S., Tinto, F., Dumais, É., Rakotoarivelo, V., Kostrzewa, M., Plante, P.-L., Martin, C., Simard, M., Silvestri, C., Pouliot, R., Laviolette, M., Boulet, L.-P., Vitale, R.M., Ligresti, A., Di Marzo, V., Flamand, N.. DOI 10.3390/cells10092322
Beneficial effects of akkermansia muciniphila are not associated with major changes in the circulating endocannabinoidome but linked to higher mono-palmitoyl-glycerol levels as new pparα agonists Cells, 2021. Depommier, C., Vitale, R.M., Iannotti, F.A., Silvestri, C., Flamand, N., Druart, C., Everard, A., Pelicaen, R., Maiter, D., Thissen, J.-P., Loumaye, A., Hermans, M.P., Delzenne, N.M., de Vos, W.M., Marzo, V.D., Cani, P.D.. DOI 10.3390/cells10010185
B iological basis of cannabinoid medicines: Mechanistic insights into cannabinoid signaling could improve therapeutic applications Science, 2021. Keimpema, E., Marzo, V.D., Harkany, T.. DOI 10.1126/science.abf6099
Assessment of the effects of dietary vitamin d levels on olanzapine-induced metabolic side effects: Focus on the endocannabinoidome-gut microbiome axis International Journal of Molecular Sciences, 2021. Abolghasemi, A., Manca, C., Iannotti, F.A., Shen, M., Leblanc, N., Lacroix, S., Martin, C., Flamand, N., Di Marzo, V., Silvestri, C.. DOI 10.3390/ijms222212361
2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors Molecular Brain, 2021. Boccella, S., Guida, F., Iannotta, M., Iannotti, F.A., Infantino, R., Ricciardi, F., Cristiano, C., Vitale, R.M., Amodeo, P., Marabese, I., Belardo, C., de Novellis, V., Paino, S., Palazzo, E., Calignano, A., Di Marzo, V., Maione, S., Luongo, L.. DOI 10.1186/s13041-020-00724-z
Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota Cells, 2020/12/17. Niokhor Dione, Sébastien Lacroix, Ulrike Taschler, Thomas Deschênes, Armita Abolghasemi, Nadine Leblanc, Vincenzo Di Marzo, Cristoforo Silvestri. DOI 10.3390/cells9122705
Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes Marine Drugs, 2020/10/18. Sarah Mazzotta, Gabriele Carullo, Aniello Schiano Moriello, Pietro Amodeo, Vincenzo Di Marzo, Margarita Vega-Holm, Rosa Maria Vitale, Francesca Aiello, Antonella Brizzi, Luciano De Petrocellis. DOI 10.3390/md18100519
Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen–Glucose Deprivation-Induced Neuronal Injury Cells, 2020/06/20. Letizia Palomba, Andrea Motta, Roberta Imperatore, Fabiana Piscitelli, Raffaele Capasso, Federica Mastroiacovo, Giuseppe Battaglia, Valeria Bruno, Luigia Cristino, Vincenzo Di Marzo. DOI 10.3390/cells9061507
Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism Cells, 2020/05/18. Charlotte Lefort, Martin Roumain, Matthias Van Hul, Marialetizia Rastelli, Rita Manco, Isabelle Leclercq, Nathalie M. Delzenne, Vincenzo Di Marzo, Nicolas Flamand, Serge Luquet, Cristoforo Silvestri, Giulio G. Muccioli, Patrice D. Cani. DOI 10.3390/cells9051247
Obesity Affects the Microbiota–Gut–Brain Axis and the Regulation Thereof by Endocannabinoids and Related Mediators International Journal of Molecular Sciences, 2020/02/25. Nicola Forte, Alba Clara Fernández-Rilo, Letizia Palomba, Vincenzo Di Marzo, Luigia Cristino. DOI 10.3390/ijms21051554
α<sub>2</sub>-Adrenoceptor agonist induces peripheral antinociception via the endocannabinoid system Pharmacological Reports, 2020. Romero, T.R.L., Miranda e Castor, M.G., Parrella, C., Piscitelli, F., Di Marzo, V., Duarte, I.D.G.. DOI 10.1007/s43440-019-00053-6
Treatment With 2-Pentadecyl-2-Oxazoline Restores Mild Traumatic Brain Injury-Induced Sensorial and Neuropsychiatric Dysfunctions Frontiers in Pharmacology, 2020. Boccella, S., Iannotta, M., Cristiano, C., Iannotti, F.A., Bello, F.D., Guida, F., Belardo, C., Infantino, R., Ricciardi, F., Giannella, M., Calignano, A., Di Marzo, V., Maione, S., Luongo, L.. DOI 10.3389/fphar.2020.00091
The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders Dialogues in Clinical Neuroscience, 2020. Di Marzo, V.. DOI 10.31887/DCNS.2020.22.3/VDIMARZO
Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity Bioorganic and Medicinal Chemistry, 2020. Brizzi, A., Aiello, F., Boccella, S., Cascio, M.G., De Petrocellis, L., Frosini, M., Gado, F., Ligresti, A., Luongo, L., Marini, P., Mugnaini, C., Pessina, F., Corelli, F., Maione, S., Manera, C., Pertwee, R.G., Di Marzo, V.. DOI 10.1016/j.bmc.2020.115513
Protective Effects of N-Oleoylglycine in a Mouse Model of Mild Traumatic Brain Injury ACS Chemical Neuroscience, 2020. Piscitelli, F., Guida, F., Luongo, L., Iannotti, F.A., Boccella, S., Verde, R., Lauritano, A., Imperatore, R., Smoum, R., Cristino, L., Lichtman, A.H., Parker, L.A., Mechoulam, R., Maione, S., Di Marzo, V.. DOI 10.1021/acschemneuro.9b00633
Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets Biochemical Pharmacology, 2020. Fellous, T., De Maio, F., Kalkan, H., Carannante, B., Boccella, S., Petrosino, S., Maione, S., Di Marzo, V., Iannotti, F.A.. DOI 10.1016/j.bcp.2020.113859
Oleoyl alanine (HU595): a stable monomethylated oleoyl glycine interferes with acute naloxone precipitated morphine withdrawal in male rats Psychopharmacology, 2020. Ayoub, S.M., Smoum, R., Farag, M., Atwal, H., Collins, S.A., Rock, E.M., Limebeer, C.L., Piscitelli, F., Iannotti, F.A., Lichtman, A.H., Leri, F., Di Marzo, V., Mechoulam, R., Parker, L.A.. DOI 10.1007/s00213-020-05570-4
Manipulation of dietary amino acids prevents and reverses obesity in mice through multiple mechanisms that modulate energy homeostasis Diabetes, 2020. Ruocco, C., Ragni, M., Rossi, F., Carullo, P., Ghini, V., Piscitelli, F., Cutignano, A., Manzo, E., Ioris, R.M., Bontems, F., Tedesco, L., Greco, C.M., Pino, A., Severi, I., Liu, D., Ceddia, R.P., Ponzoni, L., Tenori, L., Rizzetto, L., Scholz, M., Tuohy, K., Bifari, F., Di Marzo, V., Luchinat, C., Carruba, M.O., Cinti, S., Decimo, I., Condorelli, G., Coppari, R., Collins, S., Valerio, A., Nisoli, E.. DOI 10.2337/db20-0489
Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy Molecular Psychiatry, 2020. Cinquina, V., Calvigioni, D., Farlik, M., Halbritter, F., Fife-Gernedl, V., Shirran, S.L., Fuszard, M.A., Botting, C.H., Poullet, P., Piscitelli, F., Máté, Z., Szabó, G., Yanagawa, Y., Kasper, S., Di Marzo, V., Mackie, K., McBain, C.J., Bock, C., Keimpema, E., Harkany, T.. DOI 10.1038/s41380-019-0580-4
Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling Journal of Lipid Research, 2020. Manca, C., Boubertakh, B., Leblanc, N., Deschênes, T., Lacroix, S., Martin, C., Houde, A., Veilleux, A., Flamand, N., Muccioli, G.G., Raymond, F., Cani, P.D., Di Marzo, V., Silvestri, C.. DOI 10.1194/jlr.RA119000424
Gene deletion studies reveal a critical role for prostamide/prostaglandin F2α synthase in prostamide f2α formation bioRxiv, 2020. Bertrand, J.A., Woodward, D.F., Sherwood, J.M., Spenlehauer, A., Silvestri, C., Piscitelli, F., Di Marzo, V., Yamazaki, M., Sakimura, K., Watanabe, K., Overby, D.R.. DOI 10.1101/2020.04.01.020768
Fish Oil, Cannabidiol and the Gut Microbiota: An Investigation in a Murine Model of Colitis Frontiers in Pharmacology, 2020. Silvestri, C., Pagano, E., Lacroix, S., Venneri, T., Cristiano, C., Calignano, A., Parisi, O.A., Izzo, A.A., Di Marzo, V., Borrelli, F.. DOI 10.3389/fphar.2020.585096
Erratum: Correction to Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3- b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo (Journal of Medicinal Chemistry (2020) 63:(13);7369-7391. (DOI: 10.1021/acs.jmedchem.0c00595) Journal of Medicinal Chemistry, 2020. Mugnaini, C., Kostrzewa, M., Bryk, M., Mahmoud, A.M., Brizzi, A., Lamponi, S., Giorgi, G., Ferlenghi, F., Vacondio, F., Maccioni, P., Colombo, G., Mor, M., Starowicz, K., Di Marzo, V., Ligresti, A., Corelli, F.. DOI 10.1021/acs.jmedchem.0c01567
Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoyl-glycerol and its congeners in human myeloid leukocytes FASEB Journal, 2020. Turcotte, C., Archambault, A.-S., Dumais, É., Martin, C., Blanchet, M.-R., Bissonnette, E., Ohashi, N., Yamamoto, K., Itoh, T., Laviolette, M., Veilleux, A., Boulet, L.-P., Di Marzo, V., Flamand, N.. DOI 10.1096/fj.201902916R
Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system Environmental Pollution, 2020. Forner-Piquer, I., Beato, S., Piscitelli, F., Santangeli, S., Di Marzo, V., Habibi, H.R., Maradonna, F., Carnevali, O.. DOI 10.1016/j.envpol.2020.114710
Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat Scientific Reports, 2020. Castonguay-Paradis, S., Lacroix, S., Rochefort, G., Parent, L., Perron, J., Martin, C., Lamarche, B., Raymond, F., Flamand, N., Di Marzo, V., Veilleux, A.. DOI 10.1038/s41598-020-72861-3
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo Journal of Medicinal Chemistry, 2020. Mugnaini, C., Kostrzewa, M., Bryk, M., Mahmoud, A.M., Brizzi, A., Lamponi, S., Giorgi, G., Ferlenghi, F., Vacondio, F., MacCioni, P., Colombo, G., Mor, M., Starowicz, K., Di Marzo, V., Ligresti, A., Corelli, F.. DOI 10.1021/acs.jmedchem.0c00595
Desensitization of transient receptor potential vanilloid type-1 (TRPV1) channel as promising therapy of irritable bowel syndrome: characterization of the action of palvanil in the mouse gastrointestinal tract Naunyn-Schmiedeberg's Archives of Pharmacology, 2020. Szymaszkiewicz, A., Włodarczyk, J., Wasilewski, A., Di Marzo, V., Storr, M., Fichna, J., Zielińska, M.. DOI 10.1007/s00210-020-01829-x
Comments on Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate – Forner-Piquer et al. (2018)”: rebuttal to Prosser CM. Environmental Pollution, 2020. Forner-Piquer, I., Santangeli, S., Maradonna, F., Rabbito, A., Piscitelli, F., Habibi, H.R., di Marzo, V., Carnevali, O.. DOI 10.1016/j.envpol.2020.114028
Cannabidiol in sport: Ergogenic or else? Pharmacological Research, 2020. Gamelin, F.-X., Cuvelier, G., Mendes, A., Aucouturier, J., Berthoin, S., Di Marzo, V., Heyman, E.. DOI 10.1016/j.phrs.2020.104764
Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent Cannabis and Cannabinoid Research, 2020. Gray, R.A., Stott, C.G., Jones, N.A., Di Marzo, V., Di Marzo, V., Whalley, B.J., Whalley, B.J.. DOI 10.1089/can.2019.0028
Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment Biochemical Pharmacology, 2020. Stark, T., Di Bartolomeo, M., Di Marco, R., Drazanova, E., Platania, C.B.M., Iannotti, F.A., Ruda-Kucerova, J., D'Addario, C., Kratka, L., Pekarik, V., Piscitelli, F., Babinska, Z., Fedotova, J., Giurdanella, G., Salomone, S., Sulcova, A., Bucolo, C., Wotjak, C.T., Starcuk, Z., Drago, F., Mechoulam, R., Di Marzo, V., Micale, V.. DOI 10.1016/j.bcp.2020.114004
Alterations of brain endocannabinoidome signaling in germ-free mice Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2020. Manca, C., Shen, M., Boubertakh, B., Martin, C., Flamand, N., Silvestri, C., Di Marzo, V.. DOI 10.1016/j.bbalip.2020.158786
Adverse effects of Δ<sup>9</sup>-tetrahydrocannabinol on neuronal bioenergetics during postnatal development JCI Insight, 2020. Beiersdorf, J., Hevesi, Z., Calvigioni, D., Pyszkowski, J., Romanov, R., Szodorai, E., Lubec, G., Shirran, S., Botting, C.H., Kasper, S., Guy, G.W., Gray, R., Marzo, V.D., Harkany, T., Keimpema, E.. DOI 10.1172/jci.insight.135418
Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine Psychopharmacology, 2020. Rock, E.M., Ayoub, S.M., Limebeer, C.L., Gene, A., Wills, K.L., DeVuono, M.V., Smoum, R., Di Marzo, V., Lichtman, A.H., Mechoulam, R., Parker, L.A.. DOI 10.1007/s00213-019-05373-2
Cannabinoids and the expanded endocannabinoid system in neurological disorders Nature Reviews Neurology, 2020/01. Luigia Cristino, Tiziana Bisogno, Vincenzo Di Marzo. DOI 10.1038/s41582-019-0284-z
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