Répertoire du corps professoral

The lung molecular and cellular transition to adenocarcinoma
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2025 au 30 septembre 2030

Identification of specific proteomic and genomic biomarkers for calcific aortic valve stenosis and its progression
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2025 au 31 mars 2029

The lung molecular and cellular transition to adenocarcinoma
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2025 au 28 février 2026

Identification of individuals at high risk of lung cancer at the tail end of the polygenic risk score distribution
Organisme(s) subventionnaire(s): Fondation de l'Université Laval, Fondation de l'Institut universitaire de cardiologie et de pneumologie de Québec
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 janvier 2025 au 31 décembre 2026

Molecular and Genetic Epidemiology to Understand Mitral Valve Prolapse
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2024 au 31 mars 2029

Programme VISION
Programme: Tremplin
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: Université Laval
Du 15 novembre 2022 au 31 mars 2026

Financements des 2 dernières années

Sex and sex-hormones determine pulmonary morphological and single-nucleus transcriptomic responses in an animal model of sleep apnea.
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2024 au 28 février 2025

Différentiation sexuelle des réponses pulmonaires par séquençage d’ARN en cellules uniques
Organisme(s) subventionnaire(s): Fondation J.-D.-Bégin
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 janvier 2023 au 31 décembre 2024

Analyse statistique des liens entre blocs de variables de format mixte. Applications en épidémiologie, génomique et sécurité sanitaire.
Programme: Programme Samuel-De Champlain
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2022 au 31 mars 2024

A transcriptome- and proteome-wide association study of non-alcoholic fatty liver disease
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2021 au 30 septembre 2024

Air pollution, climate and COPD: acute and long-term impacts in Canadian populations
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université McGill
Du 1 avril 2021 au 31 mars 2025

Canada Research Chair in Genomics of Heart and Lung Diseases
Programme: Chaires de recherche du Canada - Fonctionnement
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2020 au 30 juin 2025

Deciphering the role of PTPN6/SHP-1 and its mutant PTPN6/SHP-1Ala455Thr in the development of pulmonary emphysema
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2019 au 30 septembre 2024

Integrative genomics and functional analyses to uncover the molecular mechanisms involved in bicuspid aortic valve disease
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2019 au 31 mars 2024

Genomic predictors of smoking and lung cancer risk
Programme: Subvention de recherche
Organisme(s) subventionnaire(s): National Institute of Health (USA)
Type de financement: Subvention
Établissement tête: Geisel School of Medicine at Dartmouth
Du 1 août 2017 au 31 mars 2024

Ran Xu, Doctorat en médecine moléculaire

Samuel Mathieu, Maîtrise en médecine moléculaire - avec mémoire

Veronique Boumtje, Doctorat en médecine moléculaire

Encadrements terminés dans les 5 dernières années

Mozart Nerva Deneus, Maîtrise en épidémiologie - avec mémoire

Louis-Jacques Ruel, Maîtrise en médecine moléculaire - avec mémoire

Publications des 5 dernières années

RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: a drug-target Mendelian randomization study Cardiovascular Research, 2025/07/08. Eloi Gagnon, Dipender Gill, Jérôme Bourgault, Émilie Gobeil, Patricia L Mitchell, Arnaud Girard, Audrey Paulin, Christian Couture, Yohan Bossé, Sébastien Thériault, Patrick Mathieu, Marie-Claude Vohl, André Tchernof, Kausik K Ray, John J P Kastelein, Benoit J Arsenault. DOI 10.1093/cvr/cvaf078

Frequency of targetable genetic alterations in resectable lung adenocarcinoma: Results from the LORD project Lung Cancer, 2025/05. Yohan Bossé, Dominique K. Boudreau, Victoria Saavedra Armero, Zhonglin Li, Élody Tremblay, Nathalie Gaudreault, Andréanne Gagné, Patrice Desmeules, Philippe Joubert. DOI 10.1016/j.lungcan.2025.108530

Editorial Commentary to Mapping the Monogenic and Polygenic Architecture of Mitral Valve Prolapse Canadian Journal of Cardiology, 2025/05. Yohan Bossé, Sébastien Thériault, Patrick Mathieu. DOI 10.1016/j.cjca.2025.01.022

A Comprehensive Evaluation of Clinicopathologic Characteristics, Molecular Features and Prognosis in Lung Adenocarcinoma with an Acinar Component Cancers, 2025/05. Hanie Abolfathi, Manal Kordahi, Victoria Saavedra Armero, Nathalie Gaudreault, Dominique K. Boudreau, Andréanne Gagné, Michèle Orain, Pierre Oliver Fiset, Patrice Desmeules, Fabien Claude Lamaze, Yohan Bossé, Philippe Joubert. DOI 10.3390/cancers17111825

Genome-wide association study of early-stage non-small cell lung cancer prognosis: a pooled analysis in the International Lung Cancer Consortium Carcinogenesis, 2025/04/03. Mei Dong, Abhinav Thakral, Karl Smith- Byrne, Yohan Bosse, Hufeng Zhou, Yi Zhang, Joshua Atkins, Philip Haycock, M Catherine Brown, Kiera Murison, Wim Timens, Don D Sin, Jui Kothari, Aurélie A G Gabriel, David Zaridze, Milan Savic, Jolanta Lissowska, Beata Świątkowska, Vladimir Janout, Ivana Holcatova, Anush Mukeria, Guillermo Fernandez-Tardon, Michael P A Davies, Matthew Triplette, Matthew B Schabath, Angeline S Andrew, Chu Chen, Fiona Taylor, John K Field, Adonina Tardon, Sanjay S Shete, Paul Brennan, Maria Teresa Landi, James McKay, Christopher I Amos, Xihong Lin, David C Christiani, Rayjean J Hung, Geoffrey Liu, Wei Xu. DOI 10.1093/carcin/bgaf031

Alpha-1-Antitrypsin Deficiency Targeted Testing and Augmentation Therapy: A Canadian Thoracic Society Meta-Analysis and Clinical Practice Guideline CHEST, 2025/04. Paul Hernandez, Yohan Bossé, Pam Bush, Kenneth R. Chapman, François Maltais, Erika D. Penz, Brandie L. Walker, Avtar Lal, Darcy D. Marciniuk. DOI 10.1016/j.chest.2024.08.037

Alpha-1-antitrypsin deficiency targeted testing and augmentation therapy: A Canadian Thoracic Society meta-analysis and clinical practice guideline Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2025/03/04. Paul Hernandez, Yohan Bossé, Pam Bush, Kenneth R. Chapman, François Maltais, Erika D. Penz, Brandie L. Walker, Avtar Lal, Darcy D. Marciniuk. DOI 10.1080/24745332.2024.2443178

Circulating Autoantibodies Targeting TREK-1 in Patients With Short-Coupled Ventricular Fibrillation Circulation, 2024/12/10. Jin Li, Alexandre Janin, Mona Patoughi, Nathalie Gaudreault, Lenke Kis, Hamid Moha Ou Maati, Yohan Bossé, Christian Steinberg. DOI 10.1161/CIRCULATIONAHA.124.070284

Metabolomic Profiling of Pulmonary Neuroendocrine Neoplasms Cancers, 2024/09/17. Clémence Boullier, Fabien C. Lamaze, Jean-François Haince, Rashid Ahmed Bux, Michèle Orain, Jiamin Zheng, Lun Zhang, David S. Wishart, Yohan Bossé, Venkata S. K. Manem, Philippe Joubert. DOI 10.3390/cancers16183179

Efficient molecular mendelian randomization screens with LaScaMolMR.jl 2024/08/30. Samuel Mathieu, Louis-Hippolyte Minvielle Moncla, Mewen Briend, Valentine Duclos, Anne Rufiange, Yohan Bossé, Patrick Mathieu. DOI 10.1101/2024.08.29.24312805

Prognostic implication of methylation-based circulating tumor DNA detection prior to surgery in stage I non-small cell lung cancer Cancer Letters, 2024/07. Yohan Bossé, Abhijit Dasgupta, Michael Abadier, Violeta Guthrie, Florian Song, Victoria Saavedra Armero, Nathalie Gaudreault, Michèle Orain, Fabien C. Lamaze, Collin Melton, Tracy Nance, Tiffany Hung, Darren Hodgson, Chris Abbosh, Philippe Joubert. DOI 10.1016/j.canlet.2024.216984

Lung Tissue Transcriptomics Reveal Associations between Thymic Stromal Lymphopoietin Signaling, Mast Cells, and Airway Obstruction in Active Smokers American Journal of Respiratory Cell and Molecular Biology, 2024/07. Nadia Milad, Sophie Aubin, Christine Racine, François Maltais, Yohan Bossé, Mathieu C. Morissette. DOI 10.1165/rcmb.2023-0416LE

Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse Communications Medicine, 2024/06/06. Louis-Hippolyte Minvielle Moncla, Mewen Briend, Mame Sokhna Sylla, Samuel Mathieu, Anne Rufiange, Yohan Bossé, Patrick Mathieu. DOI 10.1038/s43856-024-00530-x

A Test to Comprehensively Capture the Known Genetic Component of Familial Pulmonary Fibrosis American Journal of Respiratory Cell and Molecular Biology, 2024/06. Judith Villeneuve, Élody Tremblay, Nathalie Gaudreault, Victoria Saavedra Armero, Dominique K. Boudreau, Zhonglin Li, Sébastien Renaut, Geneviève Dion, Yohan Bossé. DOI 10.1165/rcmb.2024-0009MA

Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights PLOS Genetics, 2024/05/30. Sébastien Renaut, Victoria Saavedra Armero, Dominique K. Boudreau, Nathalie Gaudreault, Patrice Desmeules, Sébastien Thériault, Patrick Mathieu, Philippe Joubert, Yohan Bossé. DOI 10.1371/journal.pgen.1011301

Cardiac reverse remodeling in a mouse model with many phenotypical features of heart failure with preserved ejection fraction: effects of modifying lifestyle American Journal of Physiology-Heart and Circulatory Physiology, 2024/04/01. Mohamed Lamine Aidara, Élisabeth Walsh-Wilkinson, Sara-Ève Thibodeau, Emylie-Ann Labbé, Audrey Morin-Grandmont, Geneviève Gagnon, Dominique K. Boudreau, Marie Arsenault, Yohan Bossé, Jacques Couët. DOI 10.1152/ajpheart.00462.2023

Calcific aortic valve disease: mechanisms, prevention and treatment Nature Reviews Cardiology, 2023/08. Louis-Hippolyte Minvielle Moncla, Mewen Briend, Yohan Bossé, Patrick Mathieu. DOI 10.1038/s41569-023-00845-7

Integrative Analysis of the Blood Proteome by Mendelian Randomization Reveals Regulatory Networks in Calcific Aortic Valve Disease 2023/07/28. Mewen Briend, Louis-Hippolyte Minvielle Moncla, Valentine Duclos, Samuel Mathieu, Anne Rufiange, Sébastien Thériault, Benoit Arsenault, Yohan Bossé, Patrick Mathieu. DOI 10.1101/2023.07.26.23293222

A Simplified Version of the IASLC Grading System for Invasive Pulmonary Adenocarcinomas With Improved Prognosis Discrimination American Journal of Surgical Pathology, 2023/06. Yohan Bossé, Andréanne Gagné, Wajd A. Althakfi, Michèle Orain, Christian Couture, Sylvain Trahan, Sylvain Pagé, David Joubert, Pierre O. Fiset, Patrice Desmeules, Philippe Joubert. DOI 10.1097/PAS.0000000000002040

The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis European Heart Journal, 2023/06/01. Sébastien Thériault, Patrick Mathieu, Yohan Bossé. DOI 10.1093/eurheartj/ehad134

Leucocyte-Derived Micro-RNAs as Candidate Biomarkers in Brugada Syndrome 2023/05/25. Christian Steinberg, Alan Spatz, François Philippon, Yohan Bossé. DOI 10.1093/europace/euad145

Prognostic value of complex glandular patterns in invasive pulmonary adenocarcinomas Human Pathology, 2022/10. Yohan Bossé, Andréanne Gagné, Wajd Althakfi, Michèle Orain, Pierre Olivier Fiset, Patrice Desmeules, Philippe Joubert. DOI 10.1016/j.humpath.2022.07.007

The Null Q0Ourém Variant within a Copy-Neutral Loss-of-Heterozygosity Event Causing Alpha-1 Antitrypsin Deficiency American Journal of Respiratory Cell and Molecular Biology, 2022/06. Nathalie Gaudreault, Claudia Blouin, Annie Haillot, Julie Milot, François Maltais, Yohan Bossé. DOI 10.1165/rcmb.2021-0564LE

Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve PLOS Genetics, 2022/01/18. Arnaud Chignon, Déborah Argaud, Marie-Chloé Boulanger, Ghada Mkannez, Valentin Bon-Baret, Zhonglin Li, Sébastien Thériault, Yohan Bossé, Patrick Mathieu. DOI 10.1371/journal.pgen.1010010

Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men Circulation: Genomic and Precision Medicine, 2021/12. Hasanga D. Manikpurage, Aida Eslami, Nicolas Perrot, Zhonglin Li, Christian Couture, Patrick Mathieu, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault. DOI 10.1161/CIRCGEN.121.003452

SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues International Journal of Molecular Sciences, 2021/08/26. Guoshuai Cai, Mulong Du, Yohan Bossé, Helmut Albrecht, Fei Qin, Xizhi Luo, Xiao Michelle Androulakis, Chao Cheng, Mitzi Nagarkatti, Prakash Nagarkatti, David C. Christiani, Michael L. Whitfield, Christopher I. Amos, Feifei Xiao. DOI 10.3390/ijms22179228

Sex-Specific Associations of Genetically-Predicted Circulating Lipoprotein(a) and Hepatic LPA Gene Expression Levels with Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses Circulation: Genomic and Precision Medicine, 2021/07/19. Jakie Guertin, Yannick Kaiser, Hasanga Manikpurage, Nicolas Perrot, Raphaëlle Bourgeois, Christian Couture, Nicholas J. Wareham, Yohan Bossé, Philippe Pibarot, Erik S.G. Stroes, Patrick Mathieu, Marie-Annick Clavel, Sébastien Thériault, S. Matthijs Boekholdt, Benoit J. Arsenault. DOI 10.1161/CIRCGEN.120.003271

Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk 2021/07/13. Yafang Li, Xiangjun Xiao, Jianrong Li, Jinyoung Byun, Chao Cheng, Yohan Bossé, James McKay, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig Bojesen, Maria Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, Erich Wichmann, David Christiani, Gad Rennert, Susanne Arnold, Gary Goodman, John Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnström, Geoffrey Liu, Rayjean Hung, Angeline Andrew, Lambertus Kiemeney, Hongbing Shen, Ryan Sun, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Dawn Teare, Yun-Chul Hong, Michael Davies, Philip Lazarus, Matthew Schabath, Melinda Aldrich, Ann Schwartz, Ivan Gorlov, Kristen Purrington, Ping Yang, Younghun Han, Joan Bailey-Wilson, Yanhong Liu, Susan Pinney, Diptasri Mandal, James Willey, Colette Gaba, Paul Brennan, Christopher Amos. DOI 10.21203/rs.3.rs-647012/v1

A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men 2021/04/27. Hasanga D. Manikpurage, Aida Eslami, Nicolas Perrot, Zhonglin Li, Christian Couture, Patrick Mathieu, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault. DOI 10.1101/2021.04.25.21256083

System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan Circulation: Genomic and Precision Medicine, 2021/04. Valentin Bon-Baret, Arnaud Chignon, Marie-Chloé Boulanger, Zhonglin Li, Deborah Argaud, Benoit J. Arsenault, Sébastien Thériault, Yohan Bossé, Patrick Mathieu. DOI 10.1161/CIRCGEN.120.003196

Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers PLOS Genetics, 2021/03/05. Corina Lesseur, Aida Ferreiro-Iglesias, James D. McKay, Yohan Bossé, Mattias Johansson, Valerie Gaborieau, Maria Teresa Landi, David C. Christiani, Neil C. Caporaso, Stig E. Bojesen, Christopher I. Amos, Sanjay Shete, Geoffrey Liu, Gadi Rennert, Demetrius Albanes, Melinda C. Aldrich, Adonina Tardon, Chu Chen, Liloglou Triantafillos, John K. Field, Marion Dawn Teare, Lambertus A. Kiemeney, Brenda Diergaarde, Robert L. Ferris, Shanbeh Zienolddiny, Stephen Lam, Andrew F. Olshan, Mark C. Weissler, Martin Lacko, Angela Risch, Heike Bickeböller, Andy R. Ness, Steve Thomas, Loic Le Marchand, Matthew B. Schabath, Victor Wünsch-Filho, Eloiza H. Tajara, Angeline S. Andrew, Gary M. Clifford, Philip Lazarus, Kjell Grankvist, Mikael Johansson, Susanne Arnold, Olle Melander, Hans Brunnström, Stefania Boccia, Gabriella Cadoni, Wim Timens, Ma’en Obeidat, Xiangjun Xiao, Richard S. Houlston, Rayjean J. Hung, Paul Brennan. DOI 10.1371/journal.pgen.1009254

Oxyphospholipids in Cardiovascular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology, 2021/01. Arnaud Chignon, Valentin Bon-Baret, Marie-Chloé Boulanger, Yohan Bossé, Patrick Mathieu. DOI 10.1161/ATVBAHA.120.313790